Cancer Research

<p>Applications 4-[(4-Bromo-2-fluorophenyl)amino]-6-methoxy-7-Quinazolinol is used in the synthesis of [18F]-(R)-FEPAQ, a potential PET imaging agent for VEGFR2. This would be helpful in the imaging of VEGFR in cancer patients.<br>References Gao, M. et al.: Bioorg. Med. Chem. Lett., 21, 3222 (2011); Prabhakaran, J. et al.: Bioorg. Med. Chem. Lett., 22, 5104 (2012);<br></p>

<p>Applications An intermediate in the syntheis of a metabolite of the anti-cancer drug Tamoxifen.<br></p>

<p>Stability Light Sensitive<br>Applications A metabolite of Bexarotene (B336750).<br>References Hashimoto, S., et al.: Xenobiotica, 24, 1177 ( 1994), Boehm, M., et al.: J. Med. Chem., 38, 3146 (1995), Shirley, M.A., et al.: Drug Metab. Dispos., 25, 1144 (1997),<br></p>

<p>Applications 1-Chloro-1-desmethylpiperazinyl-bosutinib is a useful intermediate in the green preparation of the anti-tumor agent Bosutinib (B676095). It is a COVID19-related research product.<br>References Mao, Y., et al.: Synthesis, 47, 3133 (2015); Chen, H., et al.: Zhongguo Yiyao Gongye Zazhi, 44, 1086 (2013); Yin, X. J., et al.: Molecules, 4261 (2010)<br></p>

<p>Applications Chloroethylnitrosourea derivative with antitumor activity. Similar to carmustine, chlorozotocin, nimustine, ranimustine. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Johnston, T.P., et al.: J. Med. Chem., 9, 892 (1966), Oliverio, V.T., et al.: Cancer Res., 30, 1330 (1970), Thompson, G.R., et al.: Toxicol. Appl. Pharmacol., 21, 405 (1972), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 315 (1990),<br></p>

<p>Stability Light Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications A major metabolite of Irinotecan.<br>References Canal, P., et al.: J. Clin. Oncol., 14, 2688 (1996), Haaz, M., et al.: Cancer Res., 58, 468 (1998), Kehrer, D., et al.: Clin. Cancer Res., 6, 3451 (2000), Hanioka, N., et al.: Xenobiotica, 31, 687 (2001), Satoh, T., et al.: Drug Metab. Dispos., 30, 488 (2002),<br></p>

<p>Applications rel-(R*,R*)-Bicalutamide Sulfoxide is an diastereomeric bicalutamide (B382000) derivative.<br>References Li, Wei., et al.: Chirality., 21, 578 (2009);<br></p>

<p>Fluoromisonidazole, a Radiation-Sensitizing Agent, can be used for imaging tumor hypoxia: imaging the microenvironment for personalized cancer therapy.</p>