Nitrosamines

Stability Very Volatile
Applications Isotope labelled N-Nitrosodimethylamine is a highly toxic semi-volatile organic compound and a suspected human carcinogen. It induces liver tumors in rats after chronic exposure to low doses (1,2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.
Dangerous Goods Info This compound is forbidden to ship by air under IATA regulations.
References 1. Peto, R. et al.: Cancer Res.1991 Dec 1;51(23 Pt 2):6415-51.2. Lee, ES. et al.: J. Pharm. Pharmacol., 2003 Aug;55(8):1169-74

Applications (R)-8-Chloro-1-methyl-3-nitroso-2,3,4,5-tetrahydro-1H-benzo[d]azepine-D4 is an intermediate in the synthesis of Lorcaserin hydrochloride (L469897), which is a highly selective 5-HT2C receptor agonist developed for the treatment of obesity.
References Wang, Y., et al.: Drugs. Future., 32, 766 (2007);

Applications Produced concentration-related relaxations of mouse anococcygeus, in a range similar to that already found for NO and other nitrovasodilators. A potent relaxant of non-vascular smooth muscle. Serves as an NO donor.
References Bauer & Fung: J. Pharmacol. Exp. Ther., 256, 249 (1991), Gibson, A., et al.: Brit. J. Pharm., 107, 715 (1992), Shaffer, et al.: J. Pharm. Exper. Ther., 260, 286 (1992), Jansen, A., et al.: J. Pharmacol. Exp. Ther., 261, 154 (1992), Lander, H.M. et al.: J. Immunol., 150, 1509 (1993)

Applications Isonitrosoacetone