Toxicology

<p>Applications N-Acetylpiperazine-d4 is labelled N-Acetylpiperazine-d4 which was used to prepare (aryl)sulfanyltriazoles with HIV-1 non-nucleoside reverse transcriptase inhibiting activities. It was also used to synthesize diphenylpyrazolecarboxamides as heat shock protein chaperone inhibitors and anticancer agents.<br>References Wang, Z., et al.: Bioorg. Med. Chem. Lett., 16, 4174 (2006); Brough, P., et al.: J. Med. Chem, 51, 196 (2008)<br></p>

<p>Applications (E)-1,1'-[2-(2,4-Difluorophenyl)-1-propene-1,3-diyl]bis-1H-1,2,4-triazole is an impurity of Fluconazole (F421000), an antifungal.<br>References Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985),<br></p>

<p>Stability Hygroscopic<br>Applications p-Nitrophenyl 6-Sulfo-2-acetamido-2-deoxy-β-D-glucopyranoside Sodium Salt is used in the design of N-acetyl-6-sulfo-β-D-glucosaminide-based inhibitors of influenza virus sialidase.<br>References Sasaki, K., et al.: Bioorg. Med. Chem., 12, 1367 (2004)<br></p>

<p>Applications (Z)-2'-Deschloro Luliconazole is a Luliconazole (L473770) impurity. Luliconazole is an azole antifungal drug.<br>References Uhida, K., et al.: J. Infect. Chemother., 10, 216 (2004); Niwano, ., et al.: Antimicro. Agents Chemother., 42, 967 (1998)<br></p>

<p>Applications Methyl 3,5-dichlorobenzoate (cas# 2905-67-1) is a useful research chemical.<br></p>

<p>Applications 5-(Hydroxymethyl)furfuryl Alcohol is a secondary metabolite of Xylaramide, a new antifungal compound.<br>References Schneider, G., et al.: Biosciences, 51, 802 (1996),<br></p>

<p>Applications Sesamol-d2 is the isotope labelled analog of Sesamol (S280600), which is a natural component of sesame oil with antioxidant activity. Sesamol has potential protective effects against free radicals as well as some antifungal activity. Sesamol can also be used as an intermediate in the preparation of antidepressants such as Paroxetine (P205750).<br>References Kim, J.Y. et al.: J. Agric. Food Chem., 51, 3460 (2003); Toshiko, O.: New Food Indust., 33, 1 (1991); Wynn, J.P. et al.: Lipids, 32, 605 (1997);<br></p>

<p>Applications Propoxur is a non-systematic carbamate insecticide. Propoxur is used against a wide range of insects such as fleas, mosquitoes, ants, gypsy moths, and other agricultural pests. Propoxur functions by reversibly inactivating the enzyme acetylcholinesterase in insects. It is also used in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Voss, G.: Anzeig. Schaedling., 40, 73 (1967); Fraser, J. et al.: J. Sci. Food. Agric., 8 (1968); Corbel, V. et al.: Neurotoxicology, 27, 508 (2006);<br></p>

<p>Applications Protected Morphine, a principal alkaloid of opium.<br>References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988),<br></p>

<p>Impurity Clarithromycin Impurity O EP<br>Stability Hygroscopic<br>Applications Clarithromycin (9Z)-O-Methyloxime is an impurity of Clarithromycin (C559750); a semi-synthetic macrolide antibiotic and derivative of Erythromycin (E650000).<br>References Morgan, D., et al.: J. Chromatogr., 502, 351 (1990); Benson, C., et al.: Eur. J. Clin. Microbiol., 6, 173 (1987); Boyanova, L., et al.: J. Med. Microb., 61, 85 (2012); Lin, Z., et al.: Toxicol. Sci., 126, 114 (2012)<br></p>

<p>Applications Fenoxaprop<br></p>

<p>Applications n-Nonanoic-9,9,9-d3 acid is labelled n-Nonanoic Acid (N649385) which is commonly used in conjunction with glyphosate, a non-selective herbicide, for a quick burn-down effect in the control of weeds in turfgrass. It is also used in the preparation of plasticizers and lacquers.<br>References Pline, W., et al.: Weed Technol., 14, 667 (2000); Frade, J., et al.: Anal. Bioanal. Chem., 395, 2167 (2009)<br></p>

<p>Applications 2-epi-Darunavir is a stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Rao, R.N., et. al.: J. Sep. Sci., 35, 2671 (2012); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003); Arasteh, K., et al.: AIDS, 19, 943 (2005); Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005)<br></p>

<p>Applications Labelled 3'-N-[[4-(acetylamino)phenyl]sulfonyl]-3'-N-demethyl Azithromycin, an impurity of Azithromycin (A927000).<br>References Debremaeker, D. et al.: Rap. Comm. Mass. Spec., 17, 342 (2003);<br></p>

<p>Applications Sulfamonomethoxine-N1-glucosiduronic Acid, is a metabolite of Sulfamonomethoxine (S699145), found in human urine, after its administration. Sulfamonomethoxine is used as an antibacterial agent.<br>References Ueda, M.m et al.: Yakugaku Zasshi, 87, 455 (1967); Bridges, et al.: Biochem. J., et al.: 96, 829 (1965), Hong, Y.-L., et al.: Antimicrob. Agents Chemother., 39, 1756 (1995);<br></p>

<p>Applications Isomer of (-)-(3S)-3-Hydroxy Quinine-vinyl-d3.<br></p>

<p>Applications 9,10-Phenanthrenequinone is used in the formation of spirophosphoranes containing acyclic 5-methyl-2-phenyl-2H-1,2,3-diazaphosphol-4-yl substituent.<br>References Mironov, V. F., et al.: Russ. J. Electrochem., 88, 430-438 (2018)<br></p>

<p>Applications Ethyl 3-(4-bromo-2-chlorophenyl)-3-oxopropionate (CAS# 131994-22-4) is a useful research chemical compound.<br></p>

<p>Applications (S)-3-Aminobutan-1-ol can be used as an intermediate in the preparation of compounds having HIV integrase inhibitory activity.<br>References Johns, B. et al.: J. Med. Chem., 56, 5901 (2013);<br></p>

<p>Applications This product is deuterated at the 1 position and on the ajacent methyl. The 1 position is the benylic position of the bis(trifluoromethyl) phenyl. This compound has a mixture of 1 to 4 deuterium atoms, there is no detectable unlabeled material.Aprepitant is a structurally novel substance P neurokinin 1 (NK1) receptor antagonist. In vitro studies using human liver microsomes indicate that aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1.<br>References Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002), Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006),<br></p>

<p>Applications 3-Cyano-6,7-dihydro-4-trifluoromethyl-1,5H-cyclopenta-[b]-pyrid-2-one (cas# 371967-27-0) is a useful research chemical.<br></p>

<p>Applications 3,4-O-(Diethylmethylidene) Shikimic Acid Ethyl Ester is a reactant used in the preparation of oseltamivir analogs as neuraminidase inhibitors against avian influenza virus.<br>References Kongkamnerd, J. et al.: Bioorg. Med. Chem., 20, 2152 (2012)<br></p>

<p>Applications Intermediate in the preparation of Testosterone metabolites.<br></p>

<p>Applications 6-O-Methyl-2',4''-bis-O-(trimethylsilyl)-9-[O-(1-ethoxy-1-methylethyl)oxime]-Erythromycin (CAS# 119665-62-2) is a derivative of erythromycin (E649950), an antibiotic.<br>References Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979),<br></p>

<p>Applications Docosatetraenoyl Ethanolamide-d4 is the labelled analogue of (7Z,10Z,13Z,16Z)-N-(2-Hydroxyethyl)-7,10,13,16-docosatetraenamide (H943240), which is an endocannabinoid and an analog of anandamide, which is an endogenous cannabinoid and TRPV1 receptor agonist.<br>References Donovan, J. and Grundy D. Neurogastroenterol Motil. 23, 567 (2011); Walter, L., et al.: J. Biol. Chem. 277, 20869 (2002)<br></p>

<p>Applications Emtricitabine N,N’-Methylene Dimer is a derivative compound of Emtricitabine (E525000), a reverse transcriptase inhibitor. It is effective antiviral agent against HIV, and other viruses replicating in a similiar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>

<p>Impurity Levofloxacin USP Related Compound E<br>Applications Levofloxacin (L360000) impurity. A photodegradation product of Levofloxacin (L360000) in aqueous solution. Levofloxacin USP Related Compound E.<br>References Yoshida, Y., et al.: Arzneim.-Forsch., 43, 601 (1993),<br></p>

<p>Applications Prometon-d14 (di-iso-propyl-d14) (CAS# 1219803-45-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Methyl-1,3,5-triazine-2,4(1H,3H)-dione is a metabolite of metsulfuron methyl that has been found in soil.<br>References Ye, Q., Sun, J., Wu, J.: Environ. Pollut., 126, 417 (2003)<br></p>

<p>Stability Unstable in Solution<br>Applications Desphenyl Tenofovir Alafenamide-d7 Ammonium Salt is labeled form of Desphenyl Tenofovir Alafenamide (D297043), which belongs to a group of tenofovir diesters compounds, which can inhibit HIV-1 virus replication. Desphenyl Tenofovir Alafenamide can also be used to investigate the effect of oral absorption and lymphoid cell loading of GS-7340 (a prodrug of tenofovir)<br>References You, G., et al.: PCT Int. Appl. WO 2014026582 A1 2014022 (2014); Babusis, D., et al.: Mol. Pharm. 10, 459 (2013)<br></p>

<p>Applications 2,4,5-Trichlorophenoxyacetic Acid Isobutyl Ester is a component in herbicide formulation used in the protection of crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Noble, A. et al.: Pest. Sci., 28, 203 (1990);<br></p>