Toxicology

<p>Applications (S)-2-Benzyl-N,N-dimethylaziridine-1-sulfonamide is a reagent for the synthesis of N-alkylsulfamic acid derivatives. It also has utility for preparing pharmaceutical peptide analog agents.<br>References Sherman, E. S., et al. Science of Synthesis 40b, 1285 (2008); Polniaszek, R., et al.: PCT Int. Appl. WO 2010115000 A2 20101007 (2010)<br></p>

<p>Applications 2-Iodo-4-(1-methylethyl)-6-(trifluoromethyl)pyrimidine is a pyrimidine compound, generally used in the synthesis of pharmaceutical compounds, it may be used in the synthesis of cycloindoles for the treatment of hepatitis C.<br></p>

<p>Applications Sofosbuvir 3',5'-Bis-(S)-phosphate is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.<br>References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)<br></p>

<p>Applications 4-(2-Propyn-1-yloxy) Trimethoprim is an analog of T795615, which is an antibacterial compound and a contaminant of emerging concern (CECs).<br>References Manius, G.J., et al.: Anal. Profiles Drug Subs., 7, 445 (1978), Roth, B., et al.: J. Med. Chem., 23, 379 (1980), Brogden, R.N., et al.: Drugs, 23, 405 (1982),<br></p>

<p>Applications Ganciclovir derivative.<br>References Albers, E., et al.: J. Pharm. Sci., 81, 756 (1992), Dias, C., et al.: J. Pharm. Sci., 91, 6607 (2002), Macha, S., et al.: Drug Metab. Dispos., 30, 670 (2002),<br></p>

<p>Applications Cycloester Erythromycin Enol Ether is derived from Erythromycin A Enol Ether (E649970), which is an impurity of Erythromycin.<br>References McGuire, J.M., et al.: Antibiot. Chemother., 6, 281 (1952), Steffansen, B., et al.: Int. J. Pharm., 56, 159 (1989), Goldman, R.C., et al.: Antimicrob. Agents Chemother., 34, 1973 (1990)<br></p>

<p>Applications Trichloro[2-(chloromethyl)-2-propen-1-yl]silane is an intermediate used in the synthesis of 2-​(Chloromethyl)​allyl-​trimethylsilane (C371430), which is one of the reagents to synthesize Leucasandrolide A Macrolide (I) via Mukaiyama aldol coupling.2-​(Chloromethyl)​allyl-​trimethylsilane was used in catalytic Sakurai reaction of α,​β-​enones.<br>References Kopecky, D., et al.: J. Am. Chem. Soc., 123, 8420 (2001).Lee, P., et al.: J. Org. Chem., 66, 8646 (2001).<br></p>

<p>Applications Erythromycin Glucoheptonate is a derivative of Erythromycin (E649950), an antibiotic.<br>References Delaforge, M. et al.: Biochem. Pharm., 32, 2309 (1983); Niederau, W. et al.: Chemother., 26, 121 (1980);<br></p>

<p>Applications 4-Amino-1-(10-phthalimidodecyl)quinaldinium Iodide is an intermediate for the synthesis of 4-Amino-1-[10-[(2-methyl-4-quinolyl)amino]decyl]quinaldinium Iodide Hydriodide (M493250), which is an impurity of Dequalinium (D288335); the active ingredient in various medications including antiseptic and anti-malarial agents.<br>References Kunisada, Y., et al.: J. Biomolec. Screen., 17, 140 (2012); Zeder-Lutz., G., et al.: Anal. Biochem., 421, 417 (2012)<br></p>

<p>Applications Amoxycilloic Acid Trimer is an impurity of Amoxycilloic Acid (A634265); a degradation product/impurity of Amoxicillin (A634235, 3H2O) which is a semi-synthetic antibiotic related to Penicillin and an antibacterial.<br>References Connor, S., et al.: J. Pharm. Pharmacol., 46, 128 (1994); Van G., et al.: J. Vet. Pharmacol. Ther., 26, 139 (2003); Brogden, R.N., et al.: Drugs, 18, 169 (1979); Bird, A.E., et al.: Anal. Profiles Drug Subs. Excip., 23, 1 (1994)<br></p>

<p>Applications 2-Ethoxy-4-ethoxysulfonylbenzoic Acid is a derivative of Methyl 2-Ethoxybenzoate (M220113), a useful chemical reagent, used in the synthesis and antibacterial triazoles and oxadiazoles, as well as sulfonamide compounds.<br>References Shi, Z. et al.: Compt. Rend. Chim., 18, 1320 (2015);<br></p>

<p>Applications 1-Dehydro-chloramphenicol is metabolite of the drug Chloramphenicol (C325030). It can also be used in biological study fungicidal preparation for treatment of dermatomycosis in farm animals.<br>References Popluhar, L., et al.: Czech., CS 267192 B1 19900212 (1990)<br></p>

<p>Applications β-Amyrin is used as a protein tyrosine phosphatase 1B inhibitor with potential treatment towards diabetes. Also used in the synthesis of HIV-1 integrase inhibitory compounds based upon plant extracts.<br>References Zhang, Y. et al.: Bioorg, Med. Chem., 16, 8697 (2008); Tewtrakul, S. et al.: Phytother. Res., 17, 232 (2003);<br></p>

<p>Stability Hygroscopic<br>Applications 4-Chloro-5-chlorosulfonyl Salicylic acid is used in the synthesis of Xipamide (X745150), a diuretic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liebenow, W., et al.: Arzneim.-Forsch., 25, 240 (1975),<br></p>

<p>Applications A novel C-11 epoxy fatty acid, from timothy chokes, stromata of E. typhina, has antifungal activity against Cladosporium herbarum.<br>References Koshino, H., et al.: Agric. Biol. Chem., 53, 2527 (1989),<br></p>

<p>Applications Sulfamonomethoxine-N1-glucosiduronic Acid, is a metabolite of Sulfamonomethoxine (S699145), found in human urine, after its administration. Sulfamonomethoxine is used as an antibacterial agent.<br>References Ueda, M.m et al.: Yakugaku Zasshi, 87, 455 (1967); Bridges, et al.: Biochem. J., et al.: 96, 829 (1965), Hong, Y.-L., et al.: Antimicrob. Agents Chemother., 39, 1756 (1995);<br></p>

<p>Applications Ethyl 3-(4-bromo-2-chlorophenyl)-3-oxopropionate (CAS# 131994-22-4) is a useful research chemical compound.<br></p>

<p>Applications di-Val-L-dC Trihydrochloride is a β-L-2'-Deoxynucleoside for treatment of resistant hepatitis B virus strains, and combination therapies.<br>References Standring, D. et al.: PCT Int. Appl. (2004)<br></p>