Toxicology

Stability Hygroscopic
Applications Dipotassium Glycyrrhizinate is used in improving the dissolution property of amphotericin B (AMB) and the bioavailability of the drug incorporated in suppositories.
References Tanaka, M., et. al.: Chem. Pharm. Bull., 40, 1559 (1992);

Applications Mebutizide is a thiazide diuretic.
References Madrid A.J. et al.: Rev. Clin. Esp., 114, 143 (1969);

Applications Labelled Dodecyl Phthalate (D525380). Dodecyl Phthalate is used in the preparation of Cytarabine (C998100) derivatives as anticancer agents.
References Aoshima, M., et al.: Cancer Res., 36, 2726 (1976), Wang, N., et al.: Bioorg. Med. Chem. Lett., 15, 4064 (2005), Marie-Helene, G., et al.: Bioorg. Med. Chem., 2009, 17, 6340 (2009),

Applications A metabolite of the fluorinated quinolone antibacterial Ciprofloxacin.

Impurity Mometasone Furoate EP Impurity B
Stability Light Sensitive
Applications (11β,16α,17α)-9-Chloro-17-(2,2-dioxido-5H-1,2-oxathiol-4-yl)-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methyl-androsta-1,4-dien-3-one (Mometasone EP Impurity B) is an impurity of Mometasone Furoate, a topical corticosteroid used as an anti-inflammatory.
References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987); Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996)

Impurity Azithromycin EP Impurity M
Applications Azithromycin (A927000) impurity. A degradation products of Azithromycin.
References Anon., et al.: Pharmaeuropa, 13, 750 (2001),

Stability Hygroscopic
Applications Used in the preparation of indolizine compounds for use in antifungal combination therapy.

Stability Hygroscopic
Applications Piperacillin sodium is an antibiotic related to penicillin. Also, it possesses anti-microbial activity against enterobacteria.
References Zhang, Y., et al.: Linchuang Wuzhen Wuzhi, 27, 63-65 (2014)

Applications 4-(4-(4-(4H-1,2,4-Triazol-4-yl)phenyl)piperazin-1-yl)phenyl Acetate is an intermediate in the synthesis of Deoxo Anhydro Itraconazole Bromide (D231675). Deoxo Anhydro Itraconazole Bromide is an impurity of Itraconazole (I937500), which is orally active antimycotic drug structurally related to Ketoconazole (K186000). Antifungal.
References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984); Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989); Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993)

Applications The S,S-stereoisomer of Chloramphenicol (C325030). Broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial.
References Bartz, et al.: J. Biol. Chem., et al.: 172, 445 (1948), Gottlieb, et al.: J. Bacteriol., 55, 409 (1948), Szulczewski, D., et al.: Anal. Profiles Drug Subs., 4, 47 (1975), Price, A., et al.: J. Antibiot., 43, 118 (1981), Shalit, I., et al.: Drugs, 28, 281 (1984),

Applications Prednienic Acid is a glucocorticoid steroid. It is used to synthesize various anti-inflammatory compounds such as macrolactonolides by conjugating Prednienic Acid with macrolides.
References Tomaskovic, L., et al.: Bioorg. Med. Chem., 21, 321 (2013);

Stability Hygroscopic
Applications Desacetyl Rifampicin Quinone is an impurity of Rifampicin (R508000).
References Wilson, W.L. et al.: J. Chrom., 144, 270 (1977);

Applications An impurity of Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis and inhibits mycolic acid biosynthesis. Intermediate used for the synthesis of analogs of antitumor agent 1-acetyl-2-picolinoylhydrazine.
References Brewer, G.A., et al.: Anal. Profiles. Drug. Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979); Rutner, H., et al.: Cancer. Chem. Rep., 58, 803 (1974)

Applications Acridine analog. DNA intercalating agent.
References Hansch, C. et al.: Compr. Med. Chem. 2, 703 (1990)

Applications (3aR,4R,6S,6aS)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-(1-ethylpropyl)-3a,5,6,6a-tetrahydro-4H-cyclopent[d]isoxazole-6-carboxylic Acid Methyl Ester is an intermediate used in the synthesis of peramivir (P285500), a neuraminidase inhibitor developed as an antiviral agent for the treatment of influenza.
References Hansen, T., et al.: Europ. J. Med. Chem., 58, 22 (2012);