Toxicology

Applications Intermediate in the preparation of Simvastatin (S485000) analogs.

Applications 3-tert-Butyldimethylsilyloxyoleyl Carnitine 4-Methoxybenzyl Ester is an analog of Carnitine (C184110), an essential cofactor for the metabolism of fatty acids.

Stability Hygroscopic
Applications Dihydroxyacetone Phosphate Lithium Salt, is a metabolic intermediate involved in involved in a wide variety of metabolic pathways including glycolysis and lipid biosynthesis. In plants, Dihydroxyacetone phosphate is involved with the synthesis of vitamin B6.
References Jun Ogawa et. al.: et al.: Bioscience, biotechnology, and biochemistry, 67(4), undefined (2003-6-6); John P Richard, Biochemistry, 51(13), undefined (2012-3-14);

Applications Used in the preparation of labeled cocaine analogs.
References Carroll, F.I., et al.: J. Med. Chem., 35, 2497 (1992),

Applications Protected metabolite of Chloramphenicol (C325030).
References Simons, P., et al.: Xenobiotica, 22, 1267 (1992), Kaji, H., et al.: Drug Metab. Dispos., 33, 60 (2005),

Applications (4S-cis)-4-(1-Hydroxy-1-methylethyl)-2,2,5-trimethyl-1,3-dioxolane-4-carboxylic Acid is an intermediate in the synthesis of (+)-Echimidine N-Oxide, which is a hepatotoxic pyrrolizidine alkaloid. Different extracts and echimidine-N-oxide from Symphytum sylvaticum Boiss. Subsp. sepulcrale, has been shown to have Antifungal activity.
References Kartal, M., et al.: Turkish, J. Med. Sci., 31, 487 (2001); Cao, Y., J. Food Comp. Anal., 29, 106 (2013);

Applications (2S,3S,4aR,6R,8R,8aS)-8-[[(2E)-3-[4-(Acetyloxy)-3-methoxyphenyl]-1-oxo-2-propen-1-yl]oxy]octahydro-6-hydroxy-2,3-dimethoxy-2,3-dimethyl-1,4-benzodioxin-6-carboxylic Acid Methyl Ester is an intermediate in the synthesis of 5-O-(E)-Feruloylquinic Acid (F308990). 5-O-(E)-Feruloylquinic Acid is a phenolic acid with potential antioxidant and antifungal activities. Secondary metabolite in the coffee brewing process.
References Matei, M. et al.: J. Agri. Food Chem., 60, 12105 (2012); Dokli, I. et al.: Tetrahedron Asymm., 24, 785 (2013)

Applications FR 179642 is an impurity of Micafungin (M342350), a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species.
References Denning, D., et al.: J. Infection, 53, 337 (2006); Queiroz-Telles, F., et al.: Pediatr. Infect. Dis. J., 27, 820 (2008)

Applications (9Z)-Erythromycin A Oxime is a metabolite of Roxithromycin (R700850) in humans.
References Zhong, D. et al.: Drug Metab. Dispos., 28, 552 (2000)

Applications 9-(2-Hydroxypropyl)adenine is the unlabeled form of 9-(2-Hydroxypropyl)adenine-13C5 (H952012), which is an intermediate used in the synthesis of rac Tenofovir-13C5 (>90%) (T018501), the isotope labelled analog of Tenofovir (T018500); an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. Also used as an anti-HIV agent and antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005); Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

Applications (3β,5α)-3-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-cholest-7-en-24-one is an intermediate in the synthesis of Episterol which is a compound influencing ergosterol biosynthesis, and thus acting as an antifungal agent.
References Mallory, J. et al.: Pharmacol., 3, 179 (2012); Mueller, C. et al.: Steroids, 78, 483 (2013);

Applications A metabolite of Quinine (Q694000).
References Small, D.L., et al.: J. Chem. Med., 22, 1014 (1979), Guentert, T.W., et al.: Eur. J. Drug Metab. Pharmacokinet., 7, 31 (1982), Rakhir, A., et al.: J. Pharmacokinet. Biopharm., 12, 1 (1984), Christie, D.J., et al.: J. Lab. Clin. Med., 112, 92 (1988),

Applications (1S,2R,6R)-6-Acetoxy-2-(bis(4-methoxyphenyl)(phenyl)methoxy)-4-(ethoxycarbonyl)cyclohex-3-en-1-yl Benzoate is an intermediate in the synthesis of Shikimate-3-phosphate (S357026), an substrate for 5-Enolpyruvoyl-shikimate-3-phosphate synthase (EPSPS), the target for the board-spectrum herbicide N-(phosphonomethyl)glycine(glyphosate).