Toxicology

<p>Applications 6,8-Difluoro-1,4-dihydro-1-(N-methylformamido)-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid-d8 Ethyl Ester is an isotope labelled intermediate in the synthesis of Marbofloxacin (M197000), a fluorinated quinolone antibacterial agent.<br>References Gruet, P., et al.: Vet. Rec., 140, 199 (1977), Lefebvre, H.P., et al.: J. Vet. Pharmacol. Ther., 21, 453 (1998),<br></p>

<p>Applications Isotope labelled intermediate in the synthesis of the metabolites of Nitazoxanide (N490100), an anthelmintic (cestodes), antiprotozoal (cryptosporidium) agent.<br>References Honma, K., et al.: Chem. Pharm. Bull., 24, 394 (1976), Dubreuil, L., et al.: Antimicrob. Agents Chemother., 40, 2266 (1996), Stockis, A., et al.: Int. J. Clin. Pharmacol. Ther., 34, 349 (1996),<br></p>

<p>Applications 3-tert-Butyldimethylsilyloxyoleyl Carnitine 4-Methoxybenzyl Ester is an analog of Carnitine (C184110), an essential cofactor for the metabolism of fatty acids.<br></p>

<p>Applications (3aα,4β,7aα)-4-(Acetyloxy)-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of (3aα,4β,7aα)-3a,4,7,7a-Tetrahydro-4-hydroxy-1H-isoindole-1,3(2H)-dione (T293630), which is a metabolite of Captan (C175725), a fungicide, often added to pesticide mixtures used to control diseases among fruits, vegetables.<br>References Kukla, D. et al.: J. Agri. Food Chem., 43, 1224 (1995); Afful, S., et al.: Res. J. App. Sci., Eng. Technol., 2, 592 (2010), Engelen, K., et al.: J. Prot. Res., 9, 4919 (2010), Lagunas-Allue, L., et al.: Anal. Bioanal. Chem., 398, 1509 (2010),<br></p>

<p>Applications rac-Naproxen Methyl Ester-13C,d3 is an Labelled Naproxen (N377525) intermediate, an anti-inflammatory, analgesic and antipyretic agent.<br></p>

<p>Applications 4-Chlororesorcinol-d3 is a labeled analogue of 4-Chlororesorcinol (C427755), which can be used as hair dye formulation, and in the synthesis of series of six coumarin compounds carrying halogen and trifluoromethyl, having antifungal activities.<br>References Hui-juan, Zh., et al.: Huanjing Yu Jiankang Zazhi, 27, 513 (2010); Hai-yun, Xh., et al.: Baoji Wenli Xueyuan Xuebao, Ziran Kexueban, 31, 12 (2011)<br></p>

<p>Stability Moisture Sensitive<br>Applications An unknown impurity from the synthesis of Telmisartan (T017000).<br>References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998);<br></p>

<p>Applications A receptor antagonist for the treatment of respiratory diseases.<br>References Morgenstern, R., et al.: Biochem. J., 260, 577 (1989), Armstrong, R., et al.: Chem. Res. Toxicol., 10, 2 (1997), Larsen, J., et al.: Ann. Allergy, 71, 103 (1993),<br></p>

<p>Applications N-[(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester Mixture is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.<br>References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)<br></p>

<p>Applications (Z)-3-Methylpent-2-en-4-yn-1-ol is used as a reagent in organic synthesis of many compounds including that of prolycopene which is a tangerine-colored tetra-Z-isomer of lycopene that is found in fruits of the tangerine tomato. Z)-3-Methylpent-2-en-4-yn-1-ol is also used in the synthesis of Leucosceptroids A and B which have potent antifungal properties.<br>References Pattenden, G., et al.: Tetrahedron Lett., 28, 5751 (1987); Guo, S., et al.: Angew. Chem. Int. Edit., 54, 1298 (2015);<br></p>

<p>Applications O-Benzyl Ganciclovir N-Formyl Diacetate Dimer is an intermediate used in the synthesis of Valganciclovir N3,N3'-Methylene Dimer (&gt;90%) (V092015), which is an impurity of Valganciclovir (V092000), a pro-drug of Ganciclovir (G235000) . Used in treatment of retro-virus.<br>References Acosta, E., et al.: Clin. Pharmacol. Ther., 81, 867 (2007), Nassetta, L., et al.: J. Antimicrob. Chemother., 63, 862 (2009),<br></p>

<p>Applications Used in the preparation of triazole antifungal agents.<br></p>

<p>Impurity Fusidic Acid EP Impurity O<br>Applications 16-Deacetyl Fusidic Acid Sodium Salt (Fusidic Acid EP Impurity O) is an impurity of Fusidic acid.<br>References Godtfredsen, W.O., et al.: Antimicrob. Agents Chemother.,132, 1965 (1961),<br></p>

<p>Applications Intermediate in the preparation of Simvastatin (S485000) derivatives.<br>References Stokker, G.; J. Org. Chem. 59, 5983 (1994)<br></p>

<p>Applications A labelled degradation product of Desloratadine. Desloratadine impurity.<br>References ,Billah., et al.: Lipids, 26, 1172 (1991), Piwinski., et al.: J. Med. Chem., 34(1), 457 (1991)<br></p>

<p>Applications (4S-cis)-4-(1-Hydroxy-1-methylethyl)-2,2,5-trimethyl-1,3-dioxolane-4-carboxylic Acid is an intermediate in the synthesis of (+)-Echimidine N-Oxide, which is a hepatotoxic pyrrolizidine alkaloid. Different extracts and echimidine-N-oxide from Symphytum sylvaticum Boiss. Subsp. sepulcrale, has been shown to have Antifungal activity.<br>References Kartal, M., et al.: Turkish, J. Med. Sci., 31, 487 (2001); Cao, Y., J. Food Comp. Anal., 29, 106 (2013);<br></p>