Toxicology

<p>Applications Intermediate in the preparation of Mifepristone derivatives.<br>References Jiang, W., et al.: Bioorg. Med. Chem. Lett., 17, 1471 (2007),<br></p>

<p>Applications The labelled aglucon of apiin and of apigenin-7-glucoside.<br>References Chaumontet, C., et al.: Carcinogenesis, 15, 2325 (1994), Sato, F., et al.: Biochem. Biophys. Res. Commun., 204, 578 (1994), Kuo, M.L. et al.: Biochem. Biophys. Res. Commun., 212, 767 (1995)<br></p>

<p>Applications Carnitine Methoxymethyl Ester Chloride Salt is an analog of Carnitine (C184110), an essential cofactor for the metabolism of fatty acids.<br></p>

<p>Applications Used as a herbicide<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Davis, V., et al.: Weed Sci., 57, 494 (2009), Bellaloui, N., et al.: J. Agric. Food Chem., 57, 9050 (2009),<br></p>

<p>Applications Gemfibrozil 1-O-β-D-(3,4,5-O-Triacetyl)glucuronide is an intermediate for the synthesis of Gemfibrozil 1-O-β-Glucuronide (G305755), which is the pure form of Gemfibrozil 1-O-β-Glucuronide (contains up to 15% α isomer) (G305760), and it is the major metabolite of Gemfibrozil. Gemfibrozil is a serum lipid regulating agent used as an antihyperlipoproteinemic.<br>References Kissebach, A.H., et al.: Atherosclerosis, 24, 199 (1976); Lewis, J.E., et al.: Pract. Cardiol., 9, 99 (1983); Rubins, H.B., et al.: N. Engl. J. Med., 341, 410 (1999)<br></p>

<p>Applications Trimazosin is useful in therapy as potent antihypertensive agents.<br>References Andrews, C., et al.: Pharm. Res., 17, 639 (2000), Davis, A., et al.: Curr. Opin. Chem. Biol., 8, 378 (2004), Votano, J., et al.: J. Med. Chem., 49, 7169 (2006),<br></p>

<p>Applications 17β-Estradiol (E888000) metabolite. An inhibitor of androstenedione aromatization, which is responsible for the conversion of androgens to estrogens. Agonistic ligands for the estrogen receptor in MCF-7 breast cancer cells.<br>References Numazawa, M. et al.: J. Steroid. Biochem. Mol. Biol., 96, 51 (2005); Vollmer, G. et al.: J. Seroid. Biochem. Mol. Biol., 39, 359 (1991); Brueggemeier, R. et al.: J. Steroid. Biochem., 21, 709 (1984)<br></p>

<p>Applications Coproporphyrin I Tetramethyl Ester is a methyl ester derivative of Coproporphyrin I (C685400). Coproporphyrin I Tetramethyl Ester is a nutritional requirement for the development of N. brasiliensis egg to third stage larvae. Coproporphyrin I Tetramethyl Ester is a tetrapyrrole compound excreted by Rhodobacter sphaeroides. Dyes and metabolites.<br>References Lida, K. et al.: Chem. Pharm. Bull., 55, 1067 (2007); Bolla, R. et al.: Comp. Biochem. Physiol. Part B, 48, 147 (1974)<br></p>

<p>Stability Moisture, Temperature Sensitive - Seal Tightly, Store in Freezer, Hygroscopic<br>Applications 3,3-Dibromo Cotinine is a Cotinine derivative used in the synthesis of 4,4-Ditritio-(+)-nicotine, a nicotine enantiomer binding to brain.<br></p>

<p>Applications A receptor antagonist for the treatment of respiratory diseases.<br>References Morgenstern, R., et al.: Biochem. J., 260, 577 (1989), Armstrong, R., et al.: Chem. Res. Toxicol., 10, 2 (1997), Larsen, J., et al.: Ann. Allergy, 71, 103 (1993),<br></p>

<p>Applications Digoxin-4’’’-O-tetra-O-acetyl β-D-Glucopyranoside is an intermediate in the synthesis of Digoxigenin Tetradigitoxoside (D446510), which is a digoxin (Dx) (D446575) impurity.<br>References Fujii, Y., et al.: Clin. Chem., 37, 476 (1991), Salphati, L., et al.: Xenobiotica, 29, 171 (1999), Song, S., et al.: Drug Metab. Dispos., 27, 689 (1999),<br></p>

<p>Applications Moxifloxacin-13C,D3 N-Allyloxycarbonate 3’-Ethyl Ester is an intermediate in the synthesis of isotope labelled fluorinated quinolone antibacterial.<br></p>

<p>Applications Protected Paclitaxel.<br></p>

<p>Applications Labelled Ethyl Alcohol, used in alcoholic beverages in suitable dilutions. Other uses are as solvent in laboratory and industry , in the manufacture of denatured alcohol, pharmaceuticals, in perfumery, in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, R. et al.: Green Chem., 15, 1155 (2013); Zhao, D. et al.: Chem. Eng. J., 221, 99 (2013); Huang, C. et al.: J. Agri. Food Chem., 61, 4326 (2013); Joichi, A. et al.: Aroma Res., 11, 256 (2010); Wiberg, G.S., et al.: Toxicol. Appl. Pharmacol., 16, 718 (1970), Brown, N.A., et al.: Science, 206, 573 (1979),<br></p>

<p>Applications Tolbutamide derivative.<br>References Relling, et al.: J. Pharmacol. Exp. Ther., 252, 442 (1990), Parent, et al.: J. Pharmacol. Exp. Ther., 261, 780 (1992), Ho, et al.: Life Sci., 52, 21 (1993),<br></p>