Toxicology

<p>Applications ((2S,4R)-2-(Chloromethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-Methylbenzenesulfonate is an intermediate in the synthesis of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal.<br>References Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993)<br></p>

<p>Applications 3-[[(1,1-Dimethylethyl)diphenylsilyl]oxy] Ergosta-7,24(28)-diene is an intermediate in the synthesis of Episterol which is a compound influencing ergosterol biosynthesis, and thus acting as an antifungal agent.<br>References Mallory, J. et al.: Pharmacol., 3, 179 (2012); Mueller, C. et al.: Steroids, 78, 483 (2013);<br></p>

<p>Applications Octahydro-6-(phenylmethyl)-1H-Pyrrolo[3,4-b]pyridine-d4 is an isotope labelled intermediate in the synthesis of moxifoxacin (M745000), a fluorinated quinolone antibacterial.<br>References Somisetti, N. et al.: Org. Chem. Indian J., 7, 123 (2011);<br></p>

<p>Applications (1S,2R)-1-((2S,3R,4S,6R)-3-Acetamido-4,6-diacetoxy-6-(methoxycarbonyl)tetrahydro-2H-pyran-2-yl)propane-1,2,3-triyl Triacetate is an intermediate in synthesizing 2-O-Methyl-α-D-N-acetylneuraminic Acid (M275400), which is a model compound for studies of binding of influenza virus hemagglutinin and metal ions.<br>References Sauter, N.K., et al.: Biochemistry, 28, 8388 (1989); Sharon, N., et al.: Science, 246, 227 (1989); Nagy, J.O., et al.: J. Med. Chem., 35 (23), (1992); Knibbs, R.N., et al.: J. Biol. Chem., 268 (25), 18524 (1993)<br></p>

<p>Applications (2S,3S,4aR,6R,8R,8aS)-8-[[(2E)-3-[4-(Acetyloxy)-3-methoxyphenyl]-1-oxo-2-propen-1-yl]oxy]octahydro-6-hydroxy-2,3-dimethoxy-2,3-dimethyl-1,4-benzodioxin-6-carboxylic Acid Methyl Ester is an intermediate in the synthesis of 5-O-(E)-Feruloylquinic Acid (F308990). 5-O-(E)-Feruloylquinic Acid is a phenolic acid with potential antioxidant and antifungal activities. Secondary metabolite in the coffee brewing process.<br>References Matei, M. et al.: J. Agri. Food Chem., 60, 12105 (2012); Dokli, I. et al.: Tetrahedron Asymm., 24, 785 (2013)<br></p>

<p>Applications Intermediate in the preparation of ribose sugar derivatives.<br></p>

<p>Stability Moisture Sensitive<br>Applications An unknown impurity from the synthesis of Telmisartan (T017000).<br>References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998);<br></p>

<p>Applications ((2R,4S)-2-(Chloromethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methyl 4-Methylbenzenesulfonate is an intermediate in the synthesis of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal.<br>References Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993)<br></p>

<p>Stability Unstable in solution (DMSO or Methanol)<br>Applications Moxalactam Sodium is an oxacephem antibiotic. Moxalactam Sodium is more effective against Escherichia coli and Pseudomonas aeruginosa than cephalosporins.<br>References Yamamoto, K. et al.: Chemotherapy, 28, 1158 (1980); Toyonaga, Y. et al.: Jap. J. Antibiot., 34, 764 (1981); Nishimura, T. et al.: Jap. J. Antibiot., 34, 800 (1981):<br></p>

<p>Applications A deuterated intermediate in the synthesis of Carisoprodol.<br></p>

<p>Applications FR 179642 is an impurity of Micafungin (M342350), a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species.<br>References Denning, D., et al.: J. Infection, 53, 337 (2006); Queiroz-Telles, F., et al.: Pediatr. Infect. Dis. J., 27, 820 (2008)<br></p>

<p>Applications (3R,5S)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptane acid (+)-phenylethylamine salt (CAS# 147511-70-4) is a useful research chemical compound.<br></p>

<p>Applications O-3,6-Di-Benzyl Ganciclovir is a byproduct in the synthesis of Valganciclovir N3,N3'-Methylene Dimer (&gt;90%) (V092015), which is an impurity of Valganciclovir (V092000), a pro-drug of Ganciclovir (G235000) . Used in treatment of retro-virus.<br>References Acosta, E., et al.: Clin. Pharmacol. Ther., 81, 867 (2007), Nassetta, L., et al.: J. Antimicrob. Chemother., 63, 862 (2009),<br></p>

<p>Applications Tolbutamide derivative.<br>References Relling, et al.: J. Pharmacol. Exp. Ther., 252, 442 (1990), Parent, et al.: J. Pharmacol. Exp. Ther., 261, 780 (1992), Ho, et al.: Life Sci., 52, 21 (1993),<br></p>