Toxicology

Applications N-Desmethyl Sorafenib (Pyridine)-N-oxide is a metabolite of Sorafenib (S676850) and has anti-proliferative activity in human breast cancer cells.
References Tolcher, A.W., et al.: Cancer Chemoth. Pharm., 67, 751 (2011); Cui, P.H., et al.: Biochem. Pharmacol., 86, 419 (2013); Ghassabian, S., et al.: Biochem. Pharmacol., 84, 215 (2012)

Applications Reserpine (R144600) derivative as a neuroleptic compound. Reserpine and SU 9064 prolonged the duration for the larva development and only SU 9064 had a mortal effect on larvae.
References Schafer, E.W., Jr., et al.: Arch. Environ. Contam. Toxicol., 12, 355 (1983),

Applications Gallocatechin ethanol is an antioxidant with free radical scavenging ability; a potential cancer chemopreventive agent. It inhibits the growth and adherence of P. gingivalis onto the buccal epithelial cells. An epimer of (-)-Epigallocatechin (E588940).
References Guo, Q. et al.: Biochim. Biophys. Acta, 1427, 13 (1999); Sakanaka, S. et al.: Biosci. Biotechnol. Biochem., 60, 745 (1996);

Applications 3-(Ethylsulfonyl)pyridine-2-sulfonamide (cas# 117671-01-9) is a useful research chemical.

Applications A metabolite of Midazolam (M343000).

Applications Micafungin-d11 Sodium is the isotope labelled analog of Micafungin Sodium (M342350); an echinocandin antifungal drug which inhibits the synthesis of 1,3-β-D-glucan, an essential component of the fungal cell wall. Micafungin Sodium also represents a valuable treatment option for fungal infections.
References Chen, S.C. et al.: Drugs, 71, 11 (2011); Groll, A.H. et al.: Opin. Anti-Infect. Invest. Drugs, 2, 405 (2000); Tomishima, M. et al.: J. Antibiot., 52, 674 (1999)

Applications (4S)-4-Hydroxy Pravastatin Lactone is an intermediate in the synthesis of Pravastatin 6'-Ketone Sodium Salt (P702050), which is an impurity of Pravastatin Sodium (P702000), which is a competitive inhibitor of HMG-CoA reductase. It can be used as a drug to for lowering cholesterol and preventing cardiovascular disease.
References Serizawa, N., et al.: J. Antibiot., 36, 604 (1983), Yoshino, G., et al.: Lancet, 2, 740 (1986), White, H.D, et al.: N. Engl. J. Med., 343, 317 (2000);

Applications Cefdinir Thiazine Analog is hydrolytic degradation product of Cefdinir (C242670).
References Okamoto, Y., et al.: J. Pharm. Sci., 85, 976 (1996)

Applications Mometasone Furoate-d8 is the isotope labelled analog of Mometasone Furoate (M490000); a topical corticosteroid used as an anti-inflammatory.
References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987); Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996)

Applications Shows antioxidant effects. Antiseptic.
References Wong, S., et al.: Clin. Chem., 33, 214 (1987), Daood, H., et al.: Food Chem., 55, 365 (1996), Zainol, M., et al.: Food Chem., 81, 575 (2003),

Applications Used as an antiparkinsonian.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hai, N., et al.: Int. J. Pharm., 357, 55 (2008), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),

Applications: A metabolite of the fluorinated quinolone antibacterial Ciprofloxacin.

Applications Simeprevir, is a hepatitis C virus (NS3/4A) protease inhibitor, used for the cure and treatment of hepatitis C.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lin, T., et al.: Antimicrobial Agents and chemotherapy, 53 (4), 1377 (2009); J. Hepatology, 55 (2), 1377 (2011);

Applications 9-(2-Hydroxypropyl)adenine-13C5 is an intermediate used in the synthesis of rac Tenofovir-13C5 (>90%) (T018501), which is he isotope labelled analog of Tenofovir (T018500); an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor. Also used as an anti-HIV agent and antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005); Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

Applications CP 55,940 is a cannabinoid agonist which is considerably more potent than Δ9-THC in both behavioral tests and receptor binding assays. Displays high and roughly equal affinity for both central and peripheral cannabinoid receptors (Ki = 0.6 - 5.0 and 0.7 - 2.6 nM at CB1 and CB2 respectively; EC50 values are 0.2, 0.3 and 5 nM at CB1, CB2 and GRP55 respectively).Controlled substance. Synthetic Cannabinoids
References Wiley, et al.: Neuropharmacology, 34, 669 (1995); Griffin, et al.: J. Pharmacol. Exp. Ther., 285, 553 (1998); Thomas, et al.: J. Pharmacol. Exp. Ther., 285, 285 (1998); Ryberg, et al.: Br. J. Pharmacol., 152, 1092 (2007);

Applications 7,8,9,10-Tetrahydro-8-methyl-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is a secondary amine drug varenicline impurity. It is a part of the pharmaceutical formulation of varenicline tartrate tablet.
References Waterman, K., et al.: J. Pharm. Sci., 97, 1499 (2008); Watheesh, B., et al.: Acta Chromatogr., 22, 207 (2010);