Toxicology

<p>Applications A tricyclic carbamate compound for inhibition of Cell proliferation.<br>References Villani, et al.: J. Med. Chem., 15, 750 (1972), Anon, et al.: J. Biol. Chem., 266, 15575 (1991),<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications Intermediate for the synthesis of Furosemide Acyl-β-D-glucuronide.<br></p>

<p>Applications Itraconazole Desethylene-seco-piperazine Mono-N-formyl Impurity of Itraconazole (I937500). Itraconazole is an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>

<p>Applications 2-O-Methyl-β-D-N-acetylneuraminic Acid Sodium Salt, is a model compound for studies of binding of influenza virus hemaglutinin and metal ions.<br>References Sauter, N.K., et al.: Biochemistry, 28, 8388 (1989), Sharon, N., et al.: Science, 246, 227 (1989), Nagy, J.O., et al.: J. Med. Chem., 35 (23), (1992), Knibbs, R.N., et al.: J. Biol. Chem., 268 (25), 18524 (1993)<br></p>

<p>Applications N-[(1R,2R)-2-Hydroxy-3-[(2-methylpropyl)[(4-nitrophenyl)sulfonyl]amino]-1-(phenylmethyl)propyl]carbamic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of 1-epi-Darvunavir (D193505), a second generation HIV-1-protease inhibitor.<br></p>

<p>Applications A reactant used in the preparation of carbocyclic deoxyguanosine analog with potent and selective anti-hepatitis B virus.<br>References Bisacchi, G. et al.: Bioorg. Med. Chem. Lett., 7, 127 (1997)<br></p>

<p>Applications An intermediate in the preparation of antifungal agents such as Ketoconazole (K186000), Itraconazole (I937500) and Terconazole.<br></p>

<p>Applications Streptamine Sulfate is the sulfate salt of streptamine, which is a subunit used in the synthesis of Streptomycin (S687500), an antibiotic substance produced by aerobic fermentation that is also antibacterial (tuberculostatic).<br>References Weiss, et al.: Antibiot. Chemother., 7, 374 (1957), Umezawa, et al.: J. Antibiot., 27, 997 (1974), Mossa, J., et al.: Anal. Profiles Drug Subs., 16, 507 (1986)<br></p>

<p>Applications 3-​Methoxy-​4-​methyl-​1H-​1,​2,​4-​triazol-​5(4H)​-​one Hydrate, is a Triazole (T767410) derivative that was used in microwave synthesis of 1,2,4-triazolone derivatives possessing antifungal activity. 3-​Methoxy-​4-​methyl-​1H-​1,​2,​4-​triazol-​5(4H)​-​one is also a key intermediate for sulfonylurea herbicides, such as flucarbazone.<br>References Su, J., Shang, Z.: Nongyao, 49, 563 (2010); Sun, N., et al.: BioMed Res. Int., 1 (2015);<br></p>

<p>Applications Propoxur is a non-systematic carbamate insecticide. Propoxur is used against a wide range of insects such as fleas, mosquitoes, ants, gypsy moths, and other agricultural pests. Propoxur functions by reversibly inactivating the enzyme acetylcholinesterase in insects. It is also used in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Voss, G.: Anzeig. Schaedling., 40, 73 (1967); Fraser, J. et al.: J. Sci. Food. Agric., 8 (1968); Corbel, V. et al.: Neurotoxicology, 27, 508 (2006);<br></p>

<p>Applications Carboxytolbutamide-d9 (butyl-d9) (CAS# 1219802-95-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-(Trifluoromethoxy)benzoic Acid-13C is labeled 4-(Trifluoromethoxy)benzoic Acid (T790720) which is a substituted benzoic acid used in the preparation of a various biologically active compounds such as antifungal and antimalarial agents.<br>References Jiang, Y. et al.: Bioorg. Med. Chem. Lett., 21, 4471 (2011); Herrin, T.R. et al.: J. Med. Chem., 18, 1216 (1975);<br></p>

<p>Applications Isotope labelled d3; 1,4-Dihydro-1,4-dioxo-2-methylnaphthalene-d3; (Vitamin K3), precursor to various types of Vitamin K. Used as a micronutrient for livestock and pet foods.<br>References Sakamoto, S., et al.: Anal. Bioanal. Chem., 396, 2955 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Hu, W., et al.: Anal. Biochem., 398, 245 (2010),<br></p>

<p>Applications Labelled Dapoxetine (D185700). Selective serotonin reuptake inhibitor (SSRI).<br>References Feret, B., et al.: Formulary, 40, 227 (2005),<br></p>

<p>Applications Fenoxaprop<br></p>

<p>Applications n-Nonanoic-9,9,9-d3 acid is labelled n-Nonanoic Acid (N649385) which is commonly used in conjunction with glyphosate, a non-selective herbicide, for a quick burn-down effect in the control of weeds in turfgrass. It is also used in the preparation of plasticizers and lacquers.<br>References Pline, W., et al.: Weed Technol., 14, 667 (2000); Frade, J., et al.: Anal. Bioanal. Chem., 395, 2167 (2009)<br></p>

<p>Applications Antihistaminic.<br>References Casy, A.F., et al.: J. Pharm. Pharmacol., 22, 270 (1970),<br></p>

<p>Applications 2-epi-Darunavir is a stereoisomer to Darunavir (D193500), a second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.<br>References Rao, R.N., et. al.: J. Sep. Sci., 35, 2671 (2012); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003); Arasteh, K., et al.: AIDS, 19, 943 (2005); Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005)<br></p>

<p>Applications Labelled 3'-N-[[4-(acetylamino)phenyl]sulfonyl]-3'-N-demethyl Azithromycin, an impurity of Azithromycin (A927000).<br>References Debremaeker, D. et al.: Rap. Comm. Mass. Spec., 17, 342 (2003);<br></p>

<p>Applications Delachlor is a herbicide for weed control.<br>References Klassen, M., et al.: J. Am. Soc. Sugar Beet Technol., 16, 552 (1971), Mishra, R. K., et al.: Pesticides, 22, 10 (1988)<br></p>

<p>Applications Testosterone Heptanoate-6,6,7,7,7-d5 (CAS# 1263095-31-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Ethyl 3,5-Didemethyl Memantine is an impurity of Memantine (HCl salt, M218000) which is used as an antiparkinsonian and antispasmodic.<br>References Rohde, H., et al.: Fortschr. Med., 100, 2023 (1982), Kornhuber, J., et al.: Eur. J. Pharmacol., 166, 589 (1989), Gortelmeyer, R. and Erbler, H.: Arzneimittel-Forsch., 42, 904 (1992)<br></p>