Toxicology

<p>Applications Atorvastatin (A791750) impurity.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996);<br></p>

<p>References Zeun, R., et al.: Pest Manag. Sci., 69, 527 (2013); Oostendorp, M., et al.: Phytopathology, 101, S133 (2011); Olaya, G., et al.: Phytopathology, 101, S132 (2011)<br></p>

<p>Applications Tranexamic-d2 acid is deuterium labelled tranexamic acid (T714505), which is an antifibrinolytic agent that blocks lysine binding sites of plasminogen. Hemostatic.<br>References Andersson, et al.: Scand. J. Haematol. 2, 230 (1965), Melander, B., et al.: Acta Pharmacol. Toxicol., 22, 340 (1965), Bonnar, J., et al.: Br. Med. J., 313, 579 (1996), Dunn, C.J., et al.: Drugs, 57, 1005 (1999),<br></p>

<p>Applications Isotope labelled Metolachlor (M338702), which is an acyanilide herbicide similar to selective pre-emergence herbicides (1). It is a contaminant in the groundwater and potential pollutant (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. McGahen, L. et al.: J. Agric. Food Chem. 1978 26 (2), pp 414–4192. Chesters, G. et al.: Rev. Environ Contam Toxicol. 1989;110:1-74.<br></p>

<p>Applications Irbesartan-d6 is deuterium labelled Irbesartan (I751000) which is an angiotensin II type 1 (AII1)-receptor antagonist.<br>References Gillis, J.C. and Markham, A.: Drugs, 54, 885 (1997); Chando, T.J., et al.: Drug. Metabol. Dispos., 26, 408 (1998),<br></p>

<p>Applications A bronchodilator.<br>References Daly, J. W., et al.: J. Med. Chem., 9(3), 273 (1966).<br></p>

<p>Applications 6α-Methyl-9α-fluoro-11β,17α-dihydroxyprogesterone is an impurity of Fluorometholone (F593145), a glucocorticoid; anti-inflammatory.<br>References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982), Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984),<br></p>

<p>Applications A major metabolite of Phenytoin, an anticonvulsant.<br>References Bowmer, C., et al.: Biochem. Pharmacol., 27, 937 (1978), Kober, A., et al.: Mol. Pharmacol., 18, 237 (1980), Dasgupta, A., et al.: Ther. Drug Monit., 21, 625 (1999),<br></p>

<p>Applications The 5-hydroxy analogue of the bronchodilator, Albuterol (A514500).<br></p>

<p>Applications Chlorfluazuron is benzoyl(pyridiyloxyphenyl)urea based pesticide that acts as a chitin synthesis inhibitor. Chlorfluazuron is commonly used in agriculture as an insect growth regulator for controlling the major insect pests in crops<br>References Perveen, F.: J. Life Sci., 5, 933 (2011); Elek, J.A.: Entomol. Exp. Appl., 88, 31 (1998); Osbrink, W.L.A. et al.: J. Econ. Entomol., 104, 1009 (2011);<br></p>

<p>Impurity Azithromycin EP Impurity M<br>Applications Azithromycin (A927000) impurity. A degradation products of Azithromycin.<br>References Anon., et al.: Pharmaeuropa, 13, 750 (2001),<br></p>

<p>Impurity Albendazole EP Impurity F<br>Applications 5-(S-Methyl) Albendazole is a metabolite of Albendazole (A511610). Albendazole EP Impurity F<br>References Gyurik, R.J., et al.: Drug Metab. Dispos., 9, 503 (1981),<br></p>

<p>Impurity Tenofovir Disoproxil USP Related Compound A<br>Applications The S-enantiomeric impurity of the antiviral Tenofovir Disoproxil Fumarate (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor and used as an anti-HIV agent.Tenofovir Disoproxil USP Related Compound A.<br>References Shaw, J. P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)<br></p>

<p>Applications Labelled Tylosin (T947650). Tylosin is a macrolide antibiotic isolated from a strain of Streptomycetes fradiae found in soil from Thailand. Antibacterial.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hamill, et al.: Antibiot. Chemother., 11, 328 (1961), Corcoran, J.W., et al.: J. Antibiot., 30, 1012 (1977), Seno, E.T., et al.: Antimicrob. Agents. Chemother., 11, 455 (1977),<br></p>

<p>Applications A labelled metabolite of Isoniazid (I821450) in plasma.<br>References Peloquin, C., et al.: Antimicrob. Agents Chemother., 41, 2670 (1997), Peloquin, C., et al.: Drugs, 62, 2169 (2002),<br></p>

<p>Applications A broad spectrum insecticide which actively disrupts the CNS of contacted insects by blocking the passage of chloride ions through GABA receptors. Fipronil is also useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ling, S., et al.: App. Entomol. Zool., 44, 543 (2009), Li, X., et al.: Environ. Toxicol. Chem., 29, 127 (2010), Savant, R., et al.: J. Agric. Food Chem., 58, 1447 (2010),<br></p>