Toxicology

<p>Applications 6α-Methyl-9α-fluoro-11β,17α-dihydroxyprogesterone is an impurity of Fluorometholone (F593145), a glucocorticoid; anti-inflammatory.<br>References Kupferman, A., et al.: Arch. Ophthlmol., 640, 100 (1982), Tokunaga H., et al.: Chem. Pharm. Bull., 32, 4012 (1984),<br></p>

<p>Applications Atorvastatin (A791750) impurity.<br>References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996);<br></p>

<p>Applications 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carboxylic acid (cas# 144059-86-9) is a useful research chemical.<br></p>

<p>Applications Droxicam is a non-steroidal anti-inflammatory drug.<br>References Lapeyre-Mestre, M., et. al.: Fundam. Clin. Pharm., 20, 391 (2006)<br></p>

<p>Applications Dicobalt Edetate is used as a cyanide antidote.<br>References Hall, A.H., et. al.: Crit. Rev. Toxicol., 39, 541 (2009); Higgins, M.A., Evans, R.: Hum. Exp. Toxicol., 19, 485 (2000); Krovzov, J., et. al.: P. W. Pharmacol. Soc., 37, 43 (1994)<br></p>

<p>Stability Temperature and Light Sensitive, unstable in solution<br>Applications Vitamin K1 Hydroxide is a derivative of Vitamin K1 (V676080), which occurs widely in green plants, algae, and photosynthetic bacteria.<br>References Hassan, M.M.A., et al.: Anal. Profiles Drug Subs., 17, 449 (1988), Breton, J., et al.: Biochemistry, 33, 12405 (1994), Dowd, P., et al.: Science, 269, 1684 (1995),<br></p>

<p>Stability Hygroscopic<br>Applications Antihistaminic.<br>References Berthon, B., et al.: Biochem. Pharmacol., 47, 789 (1994), Hu, Q., et al.: J. Biol. Chem., 274, 33995 (1999),<br></p>

<p>Applications Caffeidine Acid is a potential degradation product from the hydrolysis of Caffeine (C080100) under alkaline environment.<br>References Zubair, U.M., et al.: Anal. Profiles Drug Subs., 15, 71 (1986); Cherrah, Y., et al.: Biochem. Pharmacol., 37, 1311 (1988);<br></p>

<p>Applications A major metabolite of Irinotecan.<br>References Canal, P., et al.: J. Clin. Oncol., 14, 2688 (1996), Haaz, M., et al.: Cancer Res., 58, 468 (1998), Kehrer, D., et al.: Clin. Cancer Res., 6, 3451 (2000), Hanioka, N., et al.: Xenobiotica, 31, 687 (2001), Satoh, T., et al.: Drug Metab. Dispos., 30, 488 (2002),<br></p>

<p>Applications 6β-Hydroxy Betamethasone can be used as analyte in analytical study for detecting betamethasone metabolites in human urine using liquid chromatography coupled to tandem mass spectrometry.<br>References Matabosch, X., et al.: Drug Testing and Analysis, 7, 663-672 (2015)<br></p>

<p>Applications The major metabolite of Boldenone, an anabolic steroid.<br>References Fotsis, T., et al.: J. Steroid Biochem., 28, 203 (1987), Song, Y., et al.: Arch. Pharm. Res., 23, 599 (2000), Buiarelli, F., et al.: Anal. Chim. Acta, 526, 113 (2004), Poelmans, S., et al.: Food Addit. Contam., 22, 808 (2005),<br></p>

<p>Applications Surfactin is a lipopeptide antibiotic and biosurfactant.<br></p>

<p>Applications A bile acid derivative as anti-inflammatory and antitumor agent.<br>References Yasukawa, K., et al.: Chem. Pharm. Bull, 19, 573 (1996), Yasukawa, K., et al.: J. Pharm. Pharmacol., 52, 119 (2000), Iida, T., et al.: Lipids, 38, 281 (2003),<br></p>

<p>Applications Antihistaminic.<br>References Roth, F.E., et al.: J. Pharmacol. Exp. Ther., 124, 347 (1958), Smith, R.B., et al.: Toxicol. Appl. Pharmacol., 28, 240 (1974), Eckhart, C.G., et al.: Anal. Profiles Drug Subs., 7, 43 (1978)<br></p>

<p>Applications A major active metabolite related to the adverse effects of Sulfasalazine in human serum.<br>References Stenson, W., et al.: J. Clin. Invest., 69, 494 (1982), Bissonnette, E., et al.: J. Immunol., 156, 218 (1996), Hirohata, S., et al.: J. Neurol. Sci., 67, 115 (1985), Pullar, T., et al.: Br. Med. J., 290, 1535 (1985), Ireland, A., et al.: Clin. Sci., 78, 119 (1990),<br></p>

<p>Impurity Valproic Acid USP Related Compound B<br>Applications A constitutional isomer of Valproic acid; a potent anticonvulsant. Sodium valproate impurity C. Valproic Acid USP Related Compound B.<br>References Levy, R., et al.: Pharm. Res., 8, 551 (1991), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Fox, A., et al.: Pain, 105, 355 (2003), Archer, D., et al.: Anesth. Analg., 104, 180 (2007),<br></p>