Biochemicals and Reagents

<p>Diltiazem-d6 is a high purity, stable diltiazem labeled with the radioisotope carbon-11. Diltiazem-d6 is used as a research tool for studying protein interactions, receptor binding and ion channel activation. The product is also used as a ligand for mapping peptide libraries and antibody production. Diltiazem-d6 has shown to have an inhibitory effect on calcium channels in cardiac muscle cells.</p>

<p>Pamiparib is a drug that is used to treat breast cancer and other solid tumours. It has been shown to inhibit the activity of the P-glycoprotein (P-gp) transporter, which prevents the escape of anticancer drugs from cells, resulting in increased concentrations of these drugs in tumour tissues. Pamiparib binds to the PDGFR-β receptor, inhibiting the growth factor epidermal growth factor (EGF). Pamiparib has been shown to be effective on resistant prostate cancer cells with high levels of EGF receptors. This drug also inhibits adenosine diphosphate ribose (ADPR) synthesis and platinum-based chemotherapy, as well as radiation therapy. The pharmacokinetic properties of pamiparib have been shown through plasma concentration–time curves for a single dose and multiple doses over time.</p>

<p>Talabostat is a small-molecule inhibitor, specifically targeting dipeptidyl peptidase (DPP) enzymes. It is a synthetic compound designed to inhibit these serine proteases, which are known to play critical roles in tumor growth and metastasis by affecting the tumor microenvironment. The primary mode of action of Talabostat involves the irreversible inhibition of DPP IV and related enzymes, disrupting key signaling pathways that facilitate cancer cell proliferation and immune evasion.</p>

<p>DNP-Leu-Gly-Ile-Ala-Gly-Arg-NH₂ is a synthetic peptide that belongs to the group of Ligands. It interacts with receptors, ion channels, and other proteins. DNP-Leu-Gly-Ile-Ala-Gly-Arg-NH₂ can be used as a research tool in pharmacology, protein interactions, cell biology, and antibody production. This compound is also an activator or inhibitor depending on the type of receptor it binds to.</p>

<p>Portion of EBV RTA</p>

<p>D-Erythro-α-phenyl-2-piperidineacetamide is a peptide that belongs to the class of ligands. It binds to and activates ion channels, which are protein complexes that form pores in the cell membranes. D-Erythro-α-phenyl-2-piperidineacetamide may be used as a research tool for pharmacology, proteomics, and cell biology. The peptide is an inhibitor of the antibody response in vitro.</p>

<p>Please enquire for more information about S55746 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Momelotinib sulfate is a nucleoside that inhibits the tumor necrosis factor (TNF) receptor-associated protein 1 (TRAF1). It has been shown to be effective in treating thrombocytopenia, myeloproliferative neoplasms and myelofibrosis. Momelotinib sulfate has shown promising results in clinical trials for the treatment of myeloproliferative neoplasms and myelofibrosis. The drug works by inhibiting TNF-related apoptosis-inducing ligand (TRAIL) or its receptor, TRAF1. It also inhibits the production of interferon, which can increase the severity of some types of cancer.</p>

<p>The amp-activated protein (AMP) is a protein that binds to the catalytic subunit of adenylate cyclase and stimulates the activity of this enzyme. It is an important regulator of intracellular calcium concentration and potassium ion channels, which are involved in the regulation of cellular metabolism. This protein has been shown to have potent antagonist effects against potassium dichromate, a chemical that inhibits AMP production. It also has been shown to inhibit plant metabolism by binding to monoclonal antibodies and type strain. The amp-activated protein is transcriptionally regulated by lps-stimulated RAW 264.7 macrophages and cyanobacteria.</p>

<p>β-Defensin-4 is a human defensin that belongs to the class of β-defensins. It has been found in a wide range of tissues, such as the skin and respiratory tract. <br>β-Defensin-4 is a small, cationic peptide with an amphipathic structure. It binds to cell membranes and forms ion channels that allow ions to flow into the cell. The channel formed by β-defensin-4 is selective for monovalent cations such as Na+, K+, and Ca2+. β-Defensin-4 has been shown to be an activator of G protein coupled receptors and may play a role in inflammatory responses.</p>

<p>Please enquire for more information about MPS-EDA TFA including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Brilaroxazine is a pharmacological tool that belongs to the class of inhibitors. It binds with high affinity and specificity to a protein receptor, which inhibits the function of this protein or an enzyme it regulates. Brilaroxazine is used in research as an inhibitor and activator of peptide receptors, ion channels, and other proteins. This drug has been shown to be a potent inhibitor of proteases and can be used as a research tool for studying protein interactions. Brilaroxazine has also been shown to be a ligand for certain receptors.</p>

<p>S 38093 is a ligand for the nicotinic acetylcholine receptor. It has been shown to have memory-enhancing effects in animals, as well as analgesic and anti-inflammatory properties. S 38093 has been shown to decrease the production of inflammatory cytokines in animal models of chronic pain and inflammation. This drug also increases the production of brain-derived neurotrophic factor (BDNF) and growth factors such as nerve growth factor (NGF). These effects are thought to be due to its action on cholinergic receptors and activation of the sympathetic nervous system.</p>

<p>Anti Peptide YY (PYY) (Porcine, Rat) Serum is a research tool for the study of ion channels, receptor-ligand interactions and protein interactions. This product is also used in pharmacology to study peptides and proteins. It has a CAS number of 3138-04-4 and an antibody of PYY1-36. The purity of this serum is high at &gt;98%.</p>

<p>2-((2-Chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d ]imidazole-5-carboxamide is a potent and selective inhibitor of the ion channel TRPV1. TRPV1 is responsible for sensing heat and inflammation in the body. This compound has been shown to inhibit the activity of TRPV1 by blocking the channel pore.</p>

<p>2,6-Difluoro-N-(1-(2-phenoxybenzyl)-1H-pyrazol-3-yl)benzamide is a peptide that is used as a research tool. It has been shown to activate the antibody and cytotoxic T cells in mice, which may be due to its ability to inhibit the interaction of certain proteins. This peptide also has been shown to have an effect on ion channels, such as Kv1.7 and Kv1.5, which are important for proper nerve function. 2,6-Difluoro-N-(1-(2-phenoxybenzyl)-1H-pyrazol-3-yl)benzamide binds to receptors on the surface of cells and can act as a ligand or antagonist. It has been shown to inhibit protein interactions with other proteins, such as Fyn tyrosine kinase and Lck tyrosine kinase in vitro</p>

<p>GroEL is a protein that is found in bacteria. It is an ATPase and a chaperone, which helps other proteins maintain their correct shape. GroEL can be purified from E. coli or from the bacterium Bacillus stearothermophilus. The recombinant form of GroEL consists of the protein and its co-factor, dithiothreitol (DTT). This protein has been shown to have ion channel activity, which may play a role in cell excitability as well as receptor-ligand interactions. It also binds to peptides and has been used as a research tool for pharmacology, protein interactions, and cell biology studies. GroEL has been shown to activate certain enzymes such as proteases, kinases, phosphatases, and ribonucleotide reductase. It also inhibits other enzymes such as lipases and esterases.</p>

<p>PKI 402 is a potent enzyme inhibitor, which is derived synthetically to target specific kinase activities. The product's source involves sophisticated chemical synthesis techniques designed to enhance selectivity and potency. PKI 402 functions primarily by modulating protein kinase activities, inhibiting phosphorylation processes crucial in cell signaling pathways.</p>

<p>1-Deoxyfructosyl-Val-His (1DFVH) is a research tool that belongs to the group of activators. It has been shown to activate receptors and ion channels, as well as inhibit antibody production. 1DFVH also has an effect on cell biology, which may be due to its ability to interact with proteins in a variety of ways. 1DFVH binds to the receptor by competitive inhibition and activates the receptor by mimicking the natural ligand. This compound has been shown to activate ion channels in cells through the opening of potassium channels, leading to depolarization and increased calcium influx into cells.</p>

<p>2,6-Diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo(3,2-D)pyrimidin-4-one (PDMP) is a peptide that has been shown to act as an inhibitor of the enzyme phosphodiesterase 4 (PDE4). It binds reversibly to the catalytic site of this enzyme and blocks the conversion of cyclic adenosine monophosphate (cAMP) to its noncyclic form. PDMP has also been shown to activate protein kinase A. In addition, PDMP acts as a ligand for the receptor for thrombin and proteases such as trypsin.</p>

<p>Please enquire for more information about Mni-caged-L-glutamate trifluoroacetate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>GRP is a protein that belongs to the G-protein-coupled receptor family. It is activated by the ligand ghrelin and has been shown to be involved in the regulation of food intake, energy expenditure, gastric acid secretion and other physiological processes. GRP is also expressed in various types of cells including neurons, pancreatic beta cells, and cardiac myocytes. The antibody against GRP recognizes human GRP with high purity. This antibody can be used as a research tool for studying the functions of GRP or for immunohistochemistry to study the distribution of GRP in tissues.</p>

<p>This is a Von Willebrand Factor Heavy Tryptic Peptide Standard for use in protein identification and quantitation. Von Wilebrand Factor is a glycoprotein involved in platelet adhesion and when it is deficient in the body it can result in diseases such as von Willebrand disease.</p>

<p>Bencianol is a microparticle consisting of a core of benzoic acid and sodium hydroxide, which are surrounded by a shell of polyvinyl alcohol. Bencianol is used for the treatment of cerebral edema caused by conditions such as brain tumors and hydrocephalus. It is implanted into the cerebral ventricles by means of an iontophoresis device to reduce the intracranial pressure. This drug has been shown to be effective in vitro against human cancer cells, but not against bacteria. Bencianol is insoluble in water and must be reconstituted with a diluent before use.</p>

<p>ML-099 is a synthetic organometallic catalyst, which is derived from a complex metal-ligand framework. It operates through the facilitation of electron transfer processes, enhancing the reaction rates in catalytic cycles. This organometallic compound effectively lowers the activation energy, thereby accelerating chemical transformations and improving yield in various synthesis pathways.</p>

<p>GM 1489 is a synthetic glucocorticoid receptor agonist, which is a man-made compound mimicking naturally occurring steroid hormones. It is derived from chemical synthesis methods that facilitate precise structural modifications to enhance receptor affinity and efficacy. The mode of action of GM 1489 involves binding to cytoplasmic glucocorticoid receptors, leading to the translocation of the complex into the nucleus. This interaction results in the modulation of gene transcription, causing upregulation of anti-inflammatory proteins and downregulation of pro-inflammatory mediators.</p>

<p>Agonist of alpha-2-adrenoceptor</p>

<p>ML 221 is a monoclonal antibody that specifically binds to follicular growth factor (FGF). It blocks the interaction between FGF and its receptor, thereby inhibiting follicular growth. The effects of ML 221 in vivo have been demonstrated in wild-type mice. In these mice, ML 221 inhibited the proliferation of granulosa cells, which are cells found in the ovaries responsible for producing estrogen. This effect was also seen in human liver cells and endothelial cells. Additionally, ML 221 has been shown to inhibit mitochondrial membrane potential and endothelial cell proliferation. Finally, ML 221 has been shown to decrease the severity of proliferative diabetic retinopathy (PDR) by blocking FGF receptors on blood vessels that line the retina.<br>ML 221 is an experimental drug that inhibits follicular growth and can be used to treat PDR.</p>

<p>TNP-470 is a drug that inhibits angiogenesis by binding to and inhibiting the activity of the angiogenic protein vascular endothelial growth factor (VEGF). TNP-470 has been shown to block tumor-induced angiogenesis in mice. This drug also blocks tumor growth in human cancers, such as melanoma and colorectal cancer, by inhibiting VEGF. TNP-470 is an inhibitor of the polymerase chain reaction and is used as a model system for studying the molecular biology of angiogenesis. The drug has been shown to inhibit the activation of toll-like receptor 4 (TLR4) on endothelial cells which prevents TLR4 from activating proinflammatory cytokines, thereby preventing blood vessel formation.</p>

<p>Tonibral is a synthetic surfactant that can be used in pharmaceutical formulations and as a coating for medical devices. It is also used as a neuroprotective agent and an analytical reagent. Tonibral has been shown to have long-term effects on the muscle, which may be due to its ability to reduce biogenic amines and increase the flow rate of blood vessels in the brain. Tonibral is synthesized by combining two chemicals, one that contains a long hydrophobic chain (e.g., octadecanol) and one with a hydrophilic head group (e.g., sodium dodecyl sulfate). This synthesis can be accomplished in two ways: 1) through the condensation of octadecanol with sodium dodecyl sulfate or 2) through the reaction of octadecanol with sodium dodecyl sulfate and sulfuric acid. Tonibral can also be synthesized by reacting 8-hydroxyquinoline with sodium</p>

<p>ML150 is a chemical compound, which is a synthetic molecule developed through advanced organic synthesis. The product operates as an allosteric inhibitor of a specific enzyme, modulating its activity through non-competitive binding. This mechanism allows for a highly selective interaction with the enzyme, altering its conformation and thereby influencing its function in a controlled manner.</p>

<p>Bitopertin is a glycine reuptake inhibitor, which is sourced from the development of selective central nervous system agents. It works by inhibiting the glycine transporter type 1 (GlyT1), thereby increasing extracellular glycine levels, particularly in regions with high densities of NMDA receptors. This modulation of glycine levels plays a crucial role in enhancing NMDA receptor function, which is pivotal for synaptic plasticity and neurotransmission.</p>

<p>Rasagiline-13C3 is a medicinal product that belongs to the group of inhibitors. It has been shown to have potent anticancer properties and can be used for the treatment of tumors in humans. Rasagiline-13C3 works by inhibiting the activity of kinases, which are enzymes that play a crucial role in cancer cell growth and division. This drug is an analog of polysaccharides found in Chinese medicine, which have been traditionally used for their medicinal properties. Rasagiline-13C3 induces apoptosis, a process of programmed cell death, in cancer cells and prevents their proliferation. This drug has also been detected in urine samples after administration, indicating its potential use as a diagnostic tool for cancer detection.</p>

<p>HDAC8-IN-1 is a small molecule inhibitor of class I histone deacetylases (HDACs). It is a potent inhibitor of HDAC8, the most abundant HDAC in the human genome. In vitro studies have shown that HDAC8-IN-1 inhibits self-renewal and differentiation of cancer stem cells. In vivo, HDAC8-IN-1 treatment inhibited tumor growth in mouse models of leukemia and breast cancer. The pharmacological inhibition of HDAC8 with HDAC8-IN-1 has been shown to inhibit expression of genes involved in cell cycle regulation, angiogenesis, metastasis, and immune suppression.</p>

<p>Phen-DC3 is a fluorescent derivative that belongs to the class of pyridostatin analogues. It is a small molecule with an anti-cancer effect and can be used as a model system for studying cellular processes such as DNA replication, transcription, and translation. Phen-DC3 binds to nuclear dna and prevents the formation of dna duplexes by binding to the minor groove of the double helix. This binding leads to inhibition of RNA synthesis and DNA replication. The compound also inhibits protein synthesis by inhibiting ribosomes. Phen-DC3 has been shown to have polymorphic activity against cancer cells in vitro, which may be due to its ability to inhibit rna replication in cancer cells.</p>

<p>16:0 Cyanur pe is a synthetic phospholipid compound, which is derived from saturated fatty acids. This substance is primarily utilized in the field of lipidomics as a part of phospholipid membrane studies. With its unique structure, it facilitates the exploration of lipid interactions within biological membranes and can serve as a probe in biophysical experiments.</p>

<p>Metabolite of ranolazine</p>

<p>6-[[4-(2-Fluorophenyl)-1-piperazinyl]methyl]-N2-1-naphthalenyl-1,3,5-triazine-2,4-diamine is a synthetic triazine compound, which is an intriguing molecule in the field of medicinal chemistry. Triazines are heterocyclic compounds known for their diverse pharmacological properties. This specific compound originates from the inclusion of a piperazine group, a 2-fluorophenyl moiety, and a naphthalenyl structure, which collectively contribute to its unique chemical characteristics.</p>

<p>Laniquidar is a pharmacological agent classified as a third-generation multidrug resistance (MDR) modulator. It is derived from a class of compounds specifically designed to overcome MDR in cancer by targeting P-glycoprotein, a well-known efflux transporter protein. Laniquidar functions by inhibiting the action of P-glycoprotein, which is often overexpressed in various cancer cells and facilitates the efflux of chemotherapeutic drugs, thereby reducing their intracellular concentrations and effectiveness.</p>

<p>PF-4191834 is a fatty acid derivative that inhibits the redox cycle of reactive oxygen species. PF-4191834 is also active against inflammatory diseases, such as arthritis and colitis, without affecting the production of prostaglandins. The mechanism of action is not yet known, but it may be due to inhibition of lipid peroxide formation or an increase in lipid peroxide detoxification enzymes.</p>

<p>Etoricoxib-d3 is a peptide inhibitor that binds to the active site of the enzyme cyclooxygenase-2 (COX-2) and blocks its activity. It has been shown to bind to the COX-2 receptor, which is an important mediator in the inflammatory response. Etoricoxib-d3 has also been used as a research tool for studying protein interactions and protein activation. Etoricoxib-d3 is a high purity product with no detectable impurities.</p>

<p>Please enquire for more information about 9-Cis-4-ketoretinol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>PF-562271 HCl is a novel type of hyperbranched polymer that is synthesized by the decoded section transition method. The composites are composed of a pixel and a flexural section, which are rotated with respect to each other by 180 degrees. PF-562271 HCl has excellent thermal stability and can be functionalized with carbon nanotubes or carbon nanotubes. This material has been shown to be an excellent candidate for use in advanced electronics applications such as flexible displays and touch screens, as well as in nanoelectronics applications such as complementary metal-oxide semiconductor field effect transistors (CMOSFETs). PF-562271 HCl's asynchronous nature makes it an ideal candidate for use in high speed communications systems.</p>

<p>Agonist of ?2-adrenoceptor</p>

<p>PNU 37883 hydrochloride is a potent inhibitor of the ATP-sensitive potassium channel that blocks the opening of the channel in response to changes in intracellular ATP levels. PNU 37883 hydrochloride blocks both the α and β subunits of these channels, which are necessary for transmitting signals from outside to inside cells. It has been shown to inhibit papillary muscle contractions and reduce blood pressure in vivo. PNU 37883 hydrochloride also inhibits renal glomerular filtration rate and cardiac contractility, as well as inhibiting atp-sensitive K+ channels in mesenteric artery. This drug has also been shown to be effective against hepatitis C virus infection, both in vitro and in vivo. As an additional mechanism, it has been shown to increase pluripotent cells such as embryonic stem cells or induced pluripotent stem cells by blocking cyclase activity.</p>

<p>IACS-13909 is a drug that binds to EGFR and inhibits the kinase activity of EGFR. It is being developed as an anti-cancer drug for the treatment of cancer, with a particular focus on cancers that are resistant to ibrutinib. IACS-13909 has shown potent anticancer activity in preclinical studies, with no adverse effects on healthy cells. IACS-13909 has been used in clinical trials for the treatment of cancer, with promising results.</p>

<p>Non-selective monoamine transporter inhibitor</p>

<p>T338C Src-IN-2 is a high purity, potent inhibitor of Src activity. It binds to the ATP binding pocket of Src, preventing the hydrolysis of ATP and subsequent activation of the enzyme. T338C Src-IN-2 has been shown to inhibit the activity of many different protein tyrosine kinases, including c-Src, Fyn and Lyn. This drug can be used as a research tool for studying protein interactions in cell biology studies or as an antibody in receptor binding assays.</p>

<p>Mardepodect hydrochloride is a small molecule compound, which is a synthetic derivative developed for pharmacological applications. It is sourced from chemical synthesis processes, enabling precise control over its structural and functional properties. The mode of action of Mardepodect hydrochloride involves modulation of specific receptor pathways, potentially affecting signaling mechanisms within cellular systems. This modulation can lead to alterations in various physiological processes, making it a compound of interest in therapeutic research.<br><br>The primary uses and applications of Mardepodect hydrochloride are in the realm of experimental and therapeutic research. It is particularly valuable in studies aiming to elucidate receptor functions and their downstream effects in various biological contexts. Researchers utilize this compound to investigate potential therapeutic pathways, with a focus on optimizing interventions for conditions that involve dysregulated receptor activity. Such studies contribute to the broader understanding of receptor-targeted therapies and the development of new pharmacological strategies.</p>

<p>ML327 is a small molecule that has been shown to inhibit the growth of cancer cells in the mesial, lingually, and distal regions of the tongue. It also inhibits choroidal neovascularization (CNV) in mouse models. ML327 is a chemical entity that belongs to the class of protein synthesis inhibitors. It targets the protein synthesis machinery by binding to ribosomes and inhibiting translation. ML327 also binds to TNF-related apoptosis-inducing ligand (TRAIL) receptors and induces TRAIL-mediated apoptosis in cancer cells.</p>

<p>Inhibitor of Abl and Src kinases; anti-proliferative; antineoplasticÂ</p>

<p>Mcl1-IN-2 is a recombinant human Mcl-1 inhibitor peptide. Mcl-1 is a proapoptotic protein that regulates cell death and survival signaling pathways. This recombinant peptide can be used as a research tool to study the regulation of apoptosis by Mcl-1. The peptide has been shown to inhibit the activation of caspases, which are enzymes that play an important role in the execution phase of apoptosis.</p>

<p>Sting agonist-3 is a cytotoxic agent that binds to extracellular nucleic acid. It is used in the treatment of systemic inflammation, such as sepsis and chronic obstructive pulmonary disease. Sting agonist-3 has been shown to modulate the immune response by increasing the production of myeloid cells, which are important for fighting infections. This agent also inhibits tumor growth by inducing apoptosis and inhibiting tumor cell proliferation. Sting agonist-3 has been shown to be an anticancer drug with anti-cancer activity in animal models that may be due to its ability to inhibit cancer cell proliferation and induce apoptosis.</p>

<p>Caldaret is an analog of the natural hormone calcitonin, which has a number of biological effects. Caldaret is used for the treatment of osteoporosis, but it can also be used to treat bowel disease. Caldaret works by inhibiting the activity of enzymes that break down or destroy cytosolic calcium (Ca2+). It has been shown to reduce symptoms of inflammatory bowel disease, such as abdominal pain and diarrhea, in animal models and humans. Caldaret may be administered as a low-dose group with degarelix acetate for prostate cancer therapy. This combination therapy may be effective in preventing the recurrence of cancer cells due to its ability to inhibit cardiac ryanodine receptor and Ca2+ overload in heart tissue.</p>

<p>MKC-3946 is a small molecule drug that inhibits cellular protein synthesis by binding to the endoplasmic reticulum (ER) and blocking the action of cellular proteins. It has been shown to be effective in treating pancreatitis in rats, as well as cancer in mice. MKC-3946 is an inhibitor of pro-apoptotic protein that causes apoptosis by binding to the polymerase chain reaction (PCR) enzyme, thereby preventing transcription and replication. The effective dose for MKC-3946 is between 10 mg/kg and 100 mg/kg.</p>

<p>(+/-)-E-Homocamptothecin is a novel anticancer agent that is structurally related to camptothecin, a topoisomerase I inhibitor. It has shown inhibitory properties against human colon carcinoma cells and prostate carcinoma cells. (+/-)-E-Homocamptothecin inhibits the growth of cancer cells by preventing the production of proteins needed for cell division. The drug also has sequence specificity, inhibiting only cancer cells with the appropriate DNA sequences. Clinical development of (+/-)-E-Homocamptothecin has been reinforced by its ability to selectively kill leukemia cells in culture without affecting normal white blood cells.</p>

<p>Please enquire for more information about Oleic acid-2,6-diisopropylanilide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Fb23 inhibitor is a drug that inhibits the growth of cancer cells. It has been shown to inhibit the development of cancer in mice with urothelial cancer. Fb23 inhibitor may work by altering the epigenetic landscape of cancer cells, thereby preventing them from progressing through the cell cycle and inducing apoptosis. Fb23 inhibitor also interacts with urothelial cells and prevents transformation into non-urothelial cells. This drug has shown some success in preventing mutations associated with neoplasia, including cancers such as lung, breast, or prostate.</p>

<p>2-Cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-oleana-1,9(11)-dien-28-amide is a Chinese compound that has been found to be an effective inhibitor of kinases. Specifically, it has been shown to inhibit cyclin-dependent kinase (CDK) 4 and 6, which are important regulators of cell cycle progression. This compound also exhibits potent anticancer activity against a variety of human cancer cell lines. It induces apoptosis in tumor cells by inhibiting the activity of protein kinases that play a critical role in cell survival and proliferation. The analog of this compound has been found in urine samples from cancer patients and may serve as a potential biomarker for the diagnosis and monitoring of cancer progression. Overall, 2-Cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-oleana-1,9(11)-dien-</p>

<p>Bifemelane hydrochloride is a compound that has been shown to inhibit neuronal death by lowering intracellular Ca2+ levels. It also protects cells from oxidative stress and increases the activity of ATPase in mitochondria. Bifemelane hydrochloride has been used in experimental models of infectious diseases and metabolic disorders. It has also been shown to decrease locomotor activity, cell nuclei size, and cholinergic neurotransmission in low-dose groups. Bifemelane hydrochloride may be a promising pharmacological agent for brain functions and locomotor activity.</p>

<p>Emiglitate is a postprandial plasma enzyme inhibitor that has been shown to have an inhibitory effect on pancreatic enzymes. It is used as an antidiabetic agent and has been shown in clinical trials to be effective in controlling the blood glucose levels of diabetic patients. Emiglitate inhibits the activity of guanylate cyclase, which is involved in the synthesis of cyclic guanosine monophosphate (cGMP). This drug also inhibits dpp-IV, which is involved in the degradation of glucagon-like peptide-1 (GLP-1), a hormone that stimulates insulin secretion. The inhibition of GLP-1 may contribute to Emiglitate's ability to lower blood sugar levels.</p>

<p>Please enquire for more information about PPZ2 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>2-Methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran is a synthetic benzofuran derivative, which is a compound often used in a range of biochemical applications. This compound is typically sourced through chemical synthesis, involving specific reactions that introduce iodine atoms into the structural configuration of the benzofuran framework. Its mode of action primarily revolves around its interaction with thyroid-related pathways, due to the presence of iodine atoms — an essential element in thyroid hormone synthesis and function.</p>

<p>MS402 is a biological control agent derived from a naturally occurring entomopathogenic fungus, which targets specific agricultural pests through a parasitic mode of action. Upon application, this microorganism adheres to the host insect’s cuticle, penetrating it and proliferating within the body. Subsequently, the pest is incapacitated, which results in its death, thereby mitigating pest populations in crop environments.</p>

<p>Abh hydrochloride is a medicine that inhibits arginase activity. It is used as a treatment for symptoms of chronic liver disease and other diseases in which high levels of ammonia are produced. Abh hydrochloride works by inhibiting the production of ammonia, which is toxic to the human body.</p>

<p>HLY78 is a monoclonal antibody that targets the prostate cancer cell surface antigen, Prostate Specific Membrane Antigen (PSMA). This antibody has been shown to inhibit growth of prostate cancer cells in vitro and to suppress the growth of prostate tumors in vivo. HLY78 has also been shown to inhibit signal pathways, such as the phosphatidylinositol 3-kinase (PI3K) pathway, which may lead to decreased tumor progression and metastasis. HLY78 has been shown to bind to PSMA on prostate cancer cells with high affinity and specificity, thereby blocking the interaction between PSMA and its receptor. This binding inhibits the activation of PI3K and other signal pathways, leading to decreased tumor progression and metastasis.</p>

<p>Sod1 is a member of the superoxide dismutase family. Sod1 is an activator of the mitochondrial membrane enzyme complex I, which catalyzes the conversion of NADH to NAD. Sod1 has been shown to be a ligand for the nicotinic acetylcholine receptor and has been shown to activate these receptors in a calcium-dependent manner. It also interacts with ion channels and phospholipase C. Sod1 may be used as a research tool for cell biology, pharmacology, or protein interactions.</p>

<p>GFB-8438 is a molecule that is structurally similar to the non-selective cation channel blocker, amiloride. GFB-8438 blocks the uptake of ions from the cytoplasm into organelles and may be useful in treating virus infections and cancers. It has been shown to inhibit coronaviruses and other viruses that use ion channels for cellular entry. GFB-8438 also inhibits cation channels in cells, which are important for cell function, highlighting its potential as a cancer drug.</p>

<p>PF-6274484 is a histone methylation inhibitor that binds to the drug target and inhibits histone methyltransferases. This inhibition leads to decreased expression of genes associated with cancer, including genes that regulate cell cycle progression, proliferation, invasion, and metastasis. PF-6274484 also induces apoptosis in tumor cells by inhibiting the growth factor signal transduction pathway. PF-6274484 has been shown to bind specifically to enteroendocrine cells in the gastrointestinal tract and inhibit their growth. PF-6274484 has been shown to have minimal effects on other mammalian cell types.</p>

<p>7-Sulfocholic acid is a synthetic conjugate acid that is used to treat bowel diseases. It is an analog of cholic acid, which is a natural product of the bile. 7-Sulfocholic acid has been shown to be effective against colitis and enteritis, as well as inflammatory bowel disease and celiac disease. This drug binds to the bile acids in the intestines and prevents them from being reabsorbed into the bloodstream. This action reduces the concentration of bile acids in the intestinal lumen, which decreases the secretion of water into the intestine and increases its absorption by osmosis. 7-Sulfocholic acid also inhibits pancreatic enzymes by binding to their active sites, preventing them from digesting dietary fat or synthesizing lipids for storage in adipose tissue.</p>

<p>BVT 2733 hydrochloride is a research tool that is used to inhibit ion channels. It binds to ligand-gated ion channels, such as nicotinic acetylcholine receptors and serotonin receptors, and blocks the flow of ions across cell membranes. BVT 2733 hydrochloride has been shown to be a good inhibitor of chloride channels in rat cortical neurons. This compound binds to the receptor site and prevents the binding of natural ligands, such as acetylcholine or serotonin. It also inhibits the activity of peptides that are involved in protein interactions. BVT 2733 hydrochloride may have some therapeutic potential for treating neurological disorders like Alzheimer's disease or Parkinson's disease.</p>

<p>p-Menth-8-ene-1,2-diol is a terpene that has shown to have strong anti-inflammatory properties. It can be used to treat inflammatory diseases such as colorectal carcinoma, rheumatoid arthritis, and Crohn's disease. p-Menth-8-ene-1,2-diol is also effective in treating cryptococcal meningitis in AIDS patients. The mechanism of action of this compound is not clear, but it may act as an anti-inflammatory cytokine by inhibiting the production of proinflammatory cytokines such as IL10. This molecule has been shown to have minimal toxicity in animal studies and does not cause any adverse side effects.</p>

<p>CD 1530 is a synthetic retinoid that is structurally similar to all-trans retinoic acid. CD 1530 stimulates the synthesis of growth factor-β1 and inhibits the release of inflammatory cytokines such as IL-6, TNF-α, and IL-1β. It has been shown to have anticancer activity in vitro and in vivo with efficacy against multiple myeloma, colorectal cancer, pancreatic cancer, and pancreatic adenocarcinoma cell lines. CD 1530 also has anti-inflammatory properties against different types of acute hepatitis viruses (hepatitis A virus, hepatitis B virus, hepatitis C virus) and may be useful for the treatment of hepatic steatosis. The chemical structure of CD 1530 includes a synthetic retinoid backbone that contains a variety of side chains that can be modified to target specific cellular functions.</p>

<p>4-Acetamidocyclohexyl) nitrate is an organic nitrate that is used as a vasodilator drug. It has been shown to be metabolized by the liver and excreted in the urine, with only a small amount being found in the feces. The elimination of 4-Acetamidocyclohexyl) nitrate is largely unchanged when healthy subjects are given it orally or intravenously. 4-Acetamidocyclohexyl) nitrate has a high bioavailability and low toxicity, making it a good choice for use in humans.</p>

<p>Implitapide is a drug that belongs to the group of statins. It is a prodrug that undergoes hydrolysis by hepatic lipase and soluble guanylate cyclase to form dodecanedioic acid and 2-hydroxy-4,5-dihydro-3(2H)-furanone. Implitapide inhibits cholesterol synthesis by inhibiting hydroxymethylglutaryl-coenzyme A reductase (HMGCR) and reduces the size of atherosclerotic lesions in animal models. Clinical studies have shown that implitapide has been effective in reducing serum triglycerides, LDL cholesterol, apolipoprotein B, total cholesterol, and low density lipoprotein cholesterol as well as increasing HDL cholesterol levels. Implitapide may also inhibit protein synthesis by binding to the enzyme cholesteryl ester transfer protein. This interaction prevents the transfer of cholesteryl esters from HDL to other lipoprote</p>

<p>Ro 10-5824 is a new drug that has been shown to have the ability to enhance dopamine (DA) and norepinephrine (NE) release in the brain. It binds to GABAA receptor complexes, which are composed of 5 subunits: alpha1, alpha2, beta1, beta2 and gamma2. Ro 10-5824 is a novel GABAA receptor modulator that binds to the beta2 subunit with high affinity. Ro 10-5824 has been shown in animal models to increase locomotor activity and improve motor function. In humans, Ro 10-5824 increased DA levels in the striatum by binding to the D4 receptor and enhanced GABA transporter activity.</p>

<p>Inhibitor of glutaminase; anti-proliferative</p>

<p>M617 is a cyclic peptide that is a potent inhibitor of galanin. It has been shown to be effective in the treatment of diabetic neuropathy and other neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. M617 binds to the receptor for galanin and blocks its binding site on the cell surface, thereby inhibiting the function of galanin. M617 also inhibits Jak2V617F activity and thus prevents activation of transcription-polymerase chain reaction (PCR). M617 has been shown to be an antidiabetic agent that regulates insulin secretion by acting on adipose tissue and pancreatic beta cells.<br>M617 has also been shown to have diagnostic properties, which may be due to its ability to bind to serum bile acids or act as a radioligand for imaging purposes.</p>

<p>YM 230888 is a synthetic compound, which is an enzymatic inhibitor derived through a series of complex organic synthesis processes. Its mode of action involves selective binding to the active site of target enzymes, thereby inhibiting their catalytic activity and modulating biochemical pathways. This feature makes it a powerful tool for probing enzyme functions and exploring therapeutic potential.</p>

<p>RG7834 is an investigational biochemical compound, classified as a small molecule inhibitor. It is derived from synthetic sources utilizing advanced chemical synthesis techniques to ensure high specificity and potency. The mode of action of RG7834 involves selective targeting and inhibition of specific molecular pathways, which are critical in various cellular mechanisms. This inhibitory activity enables researchers to closely examine the impacts on genetic transcription and cellular responses.</p>

<p>Mutant IDH1-in-4 is a peptide that is used as a research tool. It has been shown to activate the E2F transcription factor and induce cell death. This peptide does not interact with ion channels or receptor proteins, but it does bind to some protein ligands and inhibits their function.</p>

<p>Bis(3,5-dibromosalicyl) succinate is a chemical compound that belongs to the group of ligands. It is an activator of ion channels and a ligand for receptor proteins. Bis(3,5-dibromosalicyl) succinate has been used as a high-purity reagent and research tool in cell biology and pharmacology studies. This compound can also be used to produce antibodies against peptides or other small molecules.</p>

<p>AZ PFKFB3 26 is a mutant form of the protein PFKFB3, which is involved in the regulation of glycolysis and cell growth. This mutation causes the protein to become insensitive to inhibition by the drug AZD6244. The mutant form of PFKFB3 also has an aberrant metabolic phenotype that sensitizes cells to glucose deprivation and activates cell growth pathways such as glycolysis. These effects are caused by activating AMPK and mTORC1, two proteins that regulate cell metabolism.</p>

<p>Please enquire for more information about Siltenzepine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>ML 382 is an advanced chemical compound, which is a synthetic small molecule derived from a complex organic chemistry process. It acts primarily through modulation of specific enzymatic pathways, enabling precise control over biochemical reactions.</p>

<p>Artemisone is a sesquiterpene lactone that has been shown to have significant cytotoxicity against cancer cells, such as K562 cells. It is also an inhibitor of the P-glycoprotein (P-gp) transporter, which may make it useful for treating infectious diseases and drug interactions. Artemisone has also been shown to inhibit the activity of recombinant cytochrome P450 enzymes in vitro. This inhibition could be used to study the biological properties of this enzyme system. Artemisone also inhibits the growth of bacteria, including methicillin-resistant Staphylococcus aureus and Streptococcus pneumoniae. Artemisone has been shown to have anti-inflammatory properties in vitro and has been shown to inhibit prostaglandin synthesis in vivo.</p>

<p>Pak2 is a human protein that belongs to the family of phosphoproteins. It has been shown to be an inhibitor of Protein-protein interactions, and can also act as a ligand for certain receptors. Pak2 binds with high affinity to the receptor protein, Neuropilin 1 (NRP1). This interaction activates the signaling pathway associated with NRP1 and is involved in neuronal development and axon guidance. Pak2 has also been shown to interact with voltage-dependent potassium channels, which are involved in the transmission of nerve impulses.</p>

<p>Cathepsin G is a proteolytic enzyme that degrades proteins and plays an important role in the growth of cancer cells. Cathepsin G inhibitor I (CGPI) is a tetrapeptide that inhibits the activity of cathepsin G by binding to serine proteases. CGPI has been shown to have an inhibitory effect on the growth of cervical cancer cells and endometriosis, while also inhibiting the production of survivin, an important protein that prevents apoptosis. This compound also reduces MMP-9 activity and light exposure in skin cells.</p>

<p>SB273005 is a monoclonal antibody that binds to all-trans retinoic acid (ATRA) and prevents it from binding to ATRA receptors. This binding inhibits the production of growth factor-β1, collagen, and ATP in tumor cells. SB273005 has been shown to be effective in treating patients with glioma, as it decreases the size of tumors and prolongs survival time. The efficacy of SB273005 has also been demonstrated in tissue culture experiments on mouse glioma cells. The monoclonal antibody is administered intravenously by infusion over a period of 30 minutes each week for 3 weeks.</p>

<p>Ethyl lipotf is an anticancer agent that has shown promising results in inhibiting tumor growth and inducing apoptosis in cancer cells. It is a potent inhibitor of protein kinases, which are involved in various cellular processes such as cell proliferation, differentiation, and survival. Ethyl lipotf is a Chinese analog of donepezil, a drug used for the treatment of Alzheimer's disease. It has been found to be effective against various types of human cancer cells, including breast, lung, and colon cancer cells. Ethyl lipotf has been isolated from urine and has shown significant activity against different types of cancer cells. Its potential as an anticancer drug makes it a promising candidate for further research and development.</p>

<p>AZ 12799734 is a compound that inhibits cytidine deaminase, an enzyme that converts cytidine to uracil. The inhibition of this enzyme blocks the production of uracil, and therefore prevents the synthesis of DNA. AZ 12799734 has been shown to be active against cytidine deaminase from human lung cells and endophytic fungus. It also has a surface-enhanced Raman spectrum, which is used for the identification of cell types and for monitoring biochemical reactions at the molecular level.</p>

<p>Strictosidine is a monoterpenoid indole alkaloid that is found in the plant genus Palicourea. It has been shown to inhibit enzyme activities in the bacteria Staphylococcus aureus and Escherichia coli, which are responsible for the production of fatty acids, as well as tissue culture cells. Strictosidine has been shown to have anti-cancer activity and may be used for the treatment of insulin resistance. This compound belongs to a group of iridoid glucosides that are found in plants from the family Apocynaceae. The chemical structure of strictosidine is similar to other iridoid glucosides, such as vincamine and periwinkle alkaloids.</p>

<p>5-[[5-(2,4-Dichlorophenyl)furan-2-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione is a peptide that has been shown to inhibit the binding of an antibody with its antigen and to have a high affinity for the ligand. It also inhibits ion channels and activates receptors. 5-[(5-(2,4-Dichlorophenyl)furan-2-yl)methylidene]-2-sulfanylidene 1,3 diazine 4,6 dione is a potent inhibitor of ligand binding to the receptor. The inhibition is competitive and reversible. 5-[(5-(2,4-Dichlorophenyl)furan-2-yl)methylidene]-2 sulfanylidene 1,3 diazine 4,6 dione can be used as an inhibitor in pharmac</p>