Biochemicals and Reagents

<p>MTMR6 antibody was raised in Rabbit using Human MTMR6 as the immunogen</p>

<p>Purified Polyclonal Histone Deacetylase 1 antibody</p>

<p>FGF basic antibody (biotin) was raised in rabbit using highly pure recombinant human FGF-basic as the immunogen.</p>

<p>DDX42 antibody was raised using a synthetic peptide corresponding to a region with amino acids PLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYM</p>

<p>The PFKL antibody is a molecule drug that is widely used in the field of Life Sciences. It plays a crucial role in various biological processes, including insulin signaling and endothelial growth. This antibody has been shown to be highly effective in activating anticoagulant pathways and preventing blood clot formation. Additionally, it has been found to have a positive impact on albumin levels and stimulate endogenous hematopoietic activity.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of MGST3 antibody, catalog no. 70R-10042</p>

<p>This antibody reacts with heavy chains on human IgM (mu chain).</p>

<p>Adducin beta 2 antibody was raised using a synthetic peptide corresponding to a region with amino acids VVNGREEEQTAEEILSKGLSQMTTSADTDVDTSKDKTESVTSGPMSPEGS</p>

<p>Akt, also known as Protein Kinase B (PKB), is a serine/threonine-specific protein kinase that plays a central role in various cellular processes. It's a key player in the PI3K/Akt/mTOR pathway, which is essential for regulating cell growth, survival, metabolism, and proliferation.Structure: Akt has three main isoforms in humans (Akt1, Akt2, and Akt3), each encoded by different genes. Activation: Akt activation is typically initiated by external signals, such as growth factors or insulin, that bind to cell surface receptors. This activates phosphoinositide 3-kinase (PI3K), which then produces phosphatidylinositol (3,4,5)-trisphosphate (PIP3) on the cell membrane. PIP3 then recruits Akt to the membrane where it is activated by two key phosphorylation events at Thr308 and Ser473. Once fully activated, Akt can move to different parts of the cell to phosphorylate its target proteins.The key functions of Akt include:Cell Survival and Anti-Apoptosis: Akt inhibits apoptosis by phosphorylating and inactivating several pro-apoptotic proteins, such as BAD and Caspase-9.Cell Growth and Proliferation: By promoting protein synthesis and inhibiting pathways that would otherwise halt the cell cycle, Akt encourages cell growth. It activates mTOR, a major regulator of protein synthesis and cellular growth.Metabolic Regulation: Akt influences metabolism by increasing glucose uptake and glycolysis, primarily through GLUT4 translocation and hexokinase activation, which is especially important in muscle and adipose tissues.Angiogenesis: Akt can stimulate the growth of new blood vessels by increasing the expression of VEGF (vascular endothelial growth factor), supporting tissue growth and repair.Cell Migration and Invasion: Akt is involved in processes that facilitate cell motility, aiding in wound healing and, unfortunately, in the spread of cancer cells.Given its role in promoting cell survival and growth, Akt is frequently hyperactivated in cancers, leading to uncontrolled cell division and tumor growth. Many cancer therapies target the PI3K/Akt/mTOR pathway to suppress this hyperactivity. Furthermore Akt's role in regulating glucose metabolism links it to insulin signaling. Defects in this pathway can impair glucose uptake, contributing to insulin resistance and type 2 diabetes.</p>

<p>Rabbit polyclonal KCNIP3 antibody</p>

<p>AWAT1 antibody was raised using the N terminal of AWAT1 corresponding to a region with amino acids LLTFGAFCNFCTEATGFSKTFPGITPHLATLSWFFKIPFVREYLMAKGVC</p>

<p>STS antibody was raised using a synthetic peptide corresponding to a region with amino acids EPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHY</p>

<p>Rabbit polyclonal ZBP1 antibody</p>

<p>Mouse monoclonal IRF6 antibody</p>

<p>Mouse monoclonal NRBP1 antibody</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of BTF3L1 antibody, catalog no. 70R-8077</p>

<p>Rabbit polyclonal XRCC3 antibody</p>

<p>Ngcgm3 is a ganglioside that is found in the human brain and has been shown to be associated with tumorigenesis. Ngcgm3 has been shown to be a marker for the diagnosis of breast cancer. The glycan structure of Ngcgm3 is composed of sialic acid, galactose, and mannose. It also has biological properties related to autoimmune diseases, urothelial carcinoma, and myeloma cell lines. Ngcgm3 can be detected by monoclonal antibody (mAb) that recognizes Ngcgm3 in breast cancer cells or tumor tissue. The antibody response to Ngcgm3 may have diagnostic value for certain cancers such as prostate cancer, bladder cancer, lung cancer, and urothelial carcinoma.</p>

<p>HARS antibody was raised in Rabbit using Human HARS as the immunogen</p>

<p>Rabbit polyclonal RPL24 antibody</p>

<p>GAD65 Monoclonal Antibody (RPE)</p>

<p>Rabbit polyclonal TMEM185A antibody</p>

<p>Purified recombinant BRCA1 protein (His tag)</p>

<p>Rabbit polyclonal TGOLN2 antibody</p>

<p>The 6-Fluoro-3-indoxyl-beta-D-galactopyranoside is a powerful antituberculosis drug belonging to the class of rifamycins. It is highly effective in treating tuberculosis infections due to its bactericidal activity. This active compound works by binding to DNA-dependent RNA polymerase, inhibiting transcription and replication, thereby preventing the growth of bacteria. Its efficacy has been demonstrated through extensive studies using advanced techniques such as patch-clamp on human erythrocytes. The drug undergoes various metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Additionally, it specifically targets markers expressed at high levels in Mycobacterium tuberculosis strains and inhibits their cell growth in culture.</p>

<p>Rabbit polyclonal ZBTB40 antibody</p>

<p>Mouse monoclonal MPP3 antibody</p>

<p>Rabbit polyclonal TIMM23 antibody</p>

<p>Sin3b antibody was raised in rabbit using the N terminal of SIN3B as the immunogen</p>

<p>CCNL2 antibody was raised in Rabbit using Human CCNL2 as the immunogen</p>

<p>The WWOX antibody is a synthetic antibody that has been developed as an inhibitor for certain autoimmune disorders. It specifically targets autoantibodies that are responsible for causing endotoxemia, a condition characterized by the presence of harmful toxins in the bloodstream. The WWOX antibody works by binding to these autoantibodies and neutralizing their cytotoxic effects on the body's cells.</p>

<p>MMACHC antibody was raised in Rabbit using Human MMACHC as the immunogen</p>

<p>The Fukutin antibody is a specific antibody that belongs to the group of Polyclonal Antibodies. It is an immunosuppressant and growth factor that plays a crucial role in various biological processes. This antibody can be used in research laboratories for studying protein-protein interactions, as well as in clinical settings for diagnostic purposes.</p>

<p>Rabbit polyclonal Zap 70 antibody</p>

<p>GDE1 antibody was raised using the N terminal Of Gde1 corresponding to a region with amino acids LRVFSFEPVPSCRALQVLKPRDRISAIAHRGGSHDAPENTLAAIRQAAKN</p>

<p>Mouse monoclonal DNAJA2 antibody</p>

<p>Sheep polyclonal Carboxymethyl LSD antibody</p>

<p>Rabbit polyclonal TBCB antibody</p>

<p>MSH2 antibody was raised in Mouse using a purified recombinant fragment of human MSH2 expressed in E. coli as the immunogen.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of Twf1 antibody, catalog no. 70R-9403</p>

<p>IFNA13 antibody was raised in rabbit using the C terminal of IFNA13 as the immunogen</p>

<p>KIF1A antibody was raised using the N terminal of KIF1A corresponding to a region with amino acids TTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQH</p>

<p>Purified recombinant Human EDF1 protein</p>

<p>Purified native Feline Infectious peritonitis protein</p>

<p>Affinity purified Rabbit polyclonal UKHC antibody</p>

<p>C17ORF80 antibody was raised using the N terminal Of C17Orf80 corresponding to a region with amino acids MSDNPPRMEVCPYCKKPFKRLKSHLPYCKMIGPTIPTDQKVYQSKPATLP</p>

<p>Rabbit polyclonal STARD8 antibody</p>

<p>SUVN-502 dimesylate is a pharmaceutical combination that contains the acetylcholinesterase inhibitor donepezil and the 5-HT6 receptor antagonist pruvincamine. It is used for the treatment of dementia symptoms, with an effective dose of 40 mg/day. SUVN-502 dimesylate has a dual mechanism of action by inhibiting acetylcholinesterase and antagonizing 5-HT6 receptors. The 5-HT6 receptor is involved in memory consolidation and learning, as well as cognition. This drug may be useful in treating people who have moderate to severe dementia, particularly if they are already taking donepezil or other acetylcholinesterase inhibitors.</p>

<p>APOL5 antibody was raised in rabbit using the C terminal of APOL5 as the immunogen</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of GGT2 antibody, catalog no. 70R-8808</p>

<p>DVL2 antibody was raised in Rabbit using Human DVL2 as the immunogen</p>

<p>Affinity purified Rabbit polyclonal GPRC6A antibody</p>

<p>Purified native Mouse IgG2b protein</p>

<p>TIE1 antibody was raised in rabbit using a 20 amino acid peptide of human TIE1 as the immunogen.</p>

<p>The MKK3 antibody is a highly specialized monoclonal antibody used in Life Sciences research. It is designed to specifically target and bind to alpha-fetoprotein, a glycoprotein that plays a crucial role in various biological processes. This antibody can be used in a variety of assays, including immunohistochemistry and Western blotting, to detect and quantify the presence of alpha-fetoprotein in samples.</p>

<p>Purified recombinant SVIP protein (His tag)</p>

<p>The NFKB1 antibody is a highly specialized protein that belongs to the Life Sciences category. It is a monoclonal antibody that specifically targets and interacts with the NFKB1 protein. This antibody has been extensively studied and proven to be effective in various research applications.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of TSPAN32 antibody, catalog no. 70R-1910</p>

<p>Nirtetralin is a lignan with an inhibitory effect on the binding of receptor to its ligand, which is found in plants such as phyllanthus and niranthin. It has been shown to have potent inhibition of insulin resistance in K562 cells, an effect that may be due to changes in mitochondrial membrane potential. Nirtetralin also inhibits the ATPase activity of hexane-insensitive, liver-type pyruvate dehydrogenase kinase, which is involved in the regulation of hepatic glucose production and lipid metabolism. Nirtetralin has been shown to have anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and lipopolysacharide (LPS) induced nitric oxide production from macrophages.</p>

<p>Rabbit polyclonal MYH15 antibody</p>

<p>Rubella virus antibody (FITC) was raised in goat using Rubeola strain HPV77 as the immunogen.</p>

<p>Rabbit polyclonal ZNF24 antibody</p>

<p>Rabbit polyclonal PM20D2 antibody</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of JMJD2B antibody, catalog no. 70R-2881</p>

<p>FMOD antibody was raised in Rabbit using Human FMOD as the immunogen</p>

<p>Rabbit Polyclonal JunD antibody (Ser255)</p>

<p>The Cathepsin D antibody is a highly effective polyclonal antibody that is used in the field of life sciences. It acts as a CDK4/6 inhibitor and has been shown to inhibit p38 MAPK activation. This antibody is derived from human serum and contains excipients that enhance its stability and effectiveness. The Cathepsin D antibody specifically targets adipose tissue and globulin, making it an ideal tool for studying factors involved in adipose metabolism. Additionally, this antibody has anti-VEGF properties, neutralizing the activity of vascular endothelial growth factor (VEGF), a key regulator of angiogenesis. Its monoclonal nature ensures high specificity and reliability in experimental studies. With its ability to bind to specific acid residues, the Cathepsin D antibody can effectively block the activity of growth factors, providing valuable insights into cellular processes related to growth and development.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ZNF700 antibody, catalog no. 70R-8989</p>

<p>EYA2 antibody was raised in rabbit using the middle region of EYA2 as the immunogen</p>

<p>C16ORF78 antibody was raised using the middle region of C16Orf78 corresponding to a region with amino acids GVEQKGKHLSMVPGSYIKDGPKKSDTDIKDAVDPESTQRPNPFRRQSIVL</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of PBEF1 antibody, catalog no. 70R-1027</p>

<p>The Connexin 43 antibody is a polyclonal antibody that is used in the field of Life Sciences. It specifically targets Connexin 43, a protein that plays a crucial role in cell communication. This antibody can be used to study the function and localization of Connexin 43 in various biological systems.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of TTC6 antibody, catalog no. 70R-2757</p>

<p>Mouse monoclonal alpha beta TcR antibody (biotin)</p>

<p>Ret antibody was raised in Mouse using a purified recombinant fragment of Ret (aa896-1063) expressed in E. coli as the immunogen.</p>

<p>Affinity purified Rabbit polyclonal Myotubularin related protein 4 antibody</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ABHD13 antibody, catalog no. 70R-6377</p>

<p>SUMO3 antibody was raised using a synthetic peptide corresponding to a region with amino acids MRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVPESSLAGHSF</p>

<p>Rabbit anti-human IgA was raised in rabbit using human IgA alpha heavy chain as the immunogen.</p>

<p>Mouse monoclonal IgG2b Isotype Control Fc fusion protein (FITC)</p>

<p>Akt, also known as Protein Kinase B (PKB), is a serine/threonine-specific kinase essential for regulating cellular growth, survival, metabolism, and proliferation. Functioning within the PI3K/Akt/mTOR pathway, Akt responds to signals from growth factors or insulin to help cells adapt and maintain function. There are three Akt isoforms in humans—Akt1, Akt2, and Akt3—each encoded by distinct genes. Akt activation begins when these signals bind to receptors on the cell surface, activating phosphoinositide 3-kinase (PI3K), which produces PIP3 on the cell membrane. This attracts Akt to the membrane, where it becomes fully active through phosphorylation at Thr308 and Ser473, allowing it to move within the cell to phosphorylate proteins in key pathways.Akt’s primary roles include promoting cell survival by inhibiting apoptosis through inactivation of pro-apoptotic proteins like BAD and Caspase-9. It also drives cell growth and proliferation by activating mTOR, a main regulator of protein synthesis, while suppressing growth-inhibiting pathways. In metabolic regulation, Akt increases glucose uptake and glycolysis, particularly in muscle and fat tissues, through GLUT4 translocation and hexokinase activation. Additionally, Akt promotes angiogenesis by upregulating VEGF to support tissue repair and contributes to cell migration, aiding wound healing and, in cancers, tumor spread. Its broad role in cell growth and survival often leads to hyperactivation in cancers, making it a target in cancer therapies, while its influence on glucose metabolism links it to insulin signaling, where pathway defects can lead to insulin resistance and type 2 diabetes.</p>

<p>Purified recombinant Human TXNL1 protein</p>

<p>EIF2S3 antibody was raised in Rabbit using Human EIF2S3 as the immunogen</p>

<p>The hnRNP A1 antibody is a highly activated antibody that possesses protease activity. It is widely used in the field of Life Sciences for various research purposes. This antibody specifically targets hnRNP A1, a glycoprotein involved in RNA processing and transport. The hnRNP A1 antibody can be used as an active agent in experiments to study the function and localization of hnRNP A1 within cells.</p>

<p>OVA conjugated SAH Hapten</p>

<p>LRRC59 antibody was raised using the N terminal of LRRC59 corresponding to a region with amino acids TKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATILDLSCNKL</p>

<p>Rabbit polyclonal RBM4 antibody</p>

<p>Affinity purified Rabbit polyclonal RAG2 antibody</p>

<p>Rat monoclonal CD4 antibody (PE); mouse target; IgG2b kappa; clone RM4-4</p>

<p>24-402 amino acids: MGSSHHHHHH SSGLVPRGSH MVHHPPSYVA HLASDFGVRV FQQVAQASKD RNVVFSPYGV ASVLAMLQLT TGGETQQQIQ AAMGFKIDDK GMAPALRHLY KELMGPWNKD EISTTDAIFV QRDLKLVQGF MPHFFRLFRS TVKQVDFSEV ERARFIINDW VKTHTKGMIS NLLGKGAVDQ LTRLVLVNAL YFNGQWKTPF PDSSTHRRLF HKSDGSTVSV PMMAQTNKFN YTEFTTPDGH YYDILELPYH GDTLSMFIAA PYEKEVPLSA LTNILSAQLI SHWKGNMTRL PRLLVLPKFS LETEVDLRKP LENLGMTDMF RQFQADFTSL SDQEPLHVAQ ALQKVKIEVN ESGTVASSST AVIVSARMAP EEIIMDRPFL FVVRHNPTGT VLFMGQVMEP</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of RBP1 antibody, catalog no. 70R-1274</p>

<p>DUS1L antibody was raised using a synthetic peptide corresponding to a region with amino acids EEEEGGTEVLSKNKQKKQLRNPHKTFDPSLKPKYAKCDQCGNPKGNRCVF</p>

<p>FYTTD1 antibody was raised in rabbit using the middle region of FYTTD1 as the immunogen</p>

<p>Mouse monoclonal GSTT2 antibody</p>

<p>Mouse monoclonal MOBKL1A antibody</p>

<p>Purified Sheep IgG (Fab'2) FITC conjugate</p>

<p>NARG1 antibody was raised in mouse using recombinant Human Nmda Receptor Regulated 1 (Narg1)</p>

<p>Mouse RBC antibody (Texas Red) was raised in rabbit using mouse erythrocytes as the immunogen.</p>

<p>A synthetic peptide for use as a blocking control in assays to test for specificity of ATP2B3 antibody, catalog no. 70R-6327</p>

<p>The CD51 antibody is a highly specific monoclonal antibody that can be used for ultrasensitive detection of protease activity. It is commonly used in Life Sciences research, particularly in flow immunoassays and electrode-based assays. This antibody binds to CD51, a surface protein expressed on human cells, and neutralizes its function. The CD51 antibody has been extensively validated and shown to provide accurate and reliable results in various experimental settings. Its high affinity and specificity make it an ideal tool for studying protease activity and its role in various biological processes. Additionally, the CD51 antibody can be easily modified for surface immobilization using techniques such as collagenase treatment or surface modification for electrochemical impedance spectroscopy. With its exceptional sensitivity and versatility, the CD51 antibody is a valuable asset in any research laboratory seeking to investigate protease activity with precision and accuracy.</p>