Biochemicals and Reagents

<p>OSU-HDAC 44 is a histone deacetylase inhibitor that binds to the catalytic site of HDAC enzymes in the cell and prevents them from removing acetyl groups from lysine residues on proteins. OSU-HDAC 44 has been shown to suppress tumor growth by suppressing genes that are responsible for cell division and proliferation. It also inhibits cancer cells by inhibiting cycle analysis, which is necessary for the production of DNA. In addition, OSU-HDAC 44 has been shown to be effective against xenograft tumors in mice and human tissues.<br>OSU-HDAC 44 has a basic structure that includes an octamer with 8 lysine residues and a hydroxamic acid group. This drug also interacts with histones, which are proteins found in eukaryotic cells that package DNA into chromosomes. Histones have regions called termini that are rich in lysine residues and may be targets for OSU-HDAC 44.</p>

<p>Vasotocin is a peptide hormone that regulates a variety of physiological processes, including blood pressure, water permeability, and locomotor activity. Vasotocin is synthesized from the precursor arginine vasotocin (AVT) by the enzyme polypeptide chain elongation. AVT can bind to two different receptors: one that is inhibitory and one that is excitatory. The inhibitory receptor for AVT can be activated by vasopressin or oxytocin, while the excitatory receptor for AVT can be activated by atrial natriuretic peptide. Activation of both receptors leads to increased blood flow and decreased blood pressure. Vasotocin has been shown to have an inhibitory effect on the polymerase chain reaction in human serum and to have a model system in rats.</p>

<p>JNK-IN-7 is a compound that inhibits the activity of a kinase enzyme, specifically c-Jun N-terminal kinase (JNK). JNK-IN-7 is a potential drug for bowel disease and injury. It has been shown to inhibit the inflammatory response in animal models by inhibiting the activation of transcription factor NFκB, and blocking the production of proinflammatory cytokines. JNK-IN-7 has antiinflammatory activity and can be used as an inhibitor in certain diseases such as Crohn's disease, ulcerative colitis, or IBD. The molecule also blocks the production of proteins that are involved in inflammation pathways.</p>

<p>TentaGel® HL HMBA Resin is a polystyrene-based solid support that is used for peptide synthesis and building blocks. It provides reactive sites for the attachment of side chains and has an average particle size of 3.5 µm. TentaGel® HL HMBA Resin can be used in crosslinked or non-crosslinked form.</p>

<p>An E.coli expressed recombinant TmpA Treponema pallidum antigen, lyophilised from 20mM Sodium Carbonate buffer, pH 10. Treponema pallidum (T.pallidum) is the Syphilis causing, gram-negative spirochetes bacterium which is transmitted through sexual contact. The bacteria replicates locally generating an inflammatory response and the development of a skin ulcer after 3 weeks. Conscructing the helical shape and corkscrew motility flagella extensions in the periplasmic spaces, allow the bacteria to spread through the blood vessels and lymphatics and transit thought membranes. If left untreated T.pallidumcan spreads through the organs, primarily the skin, inducing a humoral and cellular immune response, leading to secondary syphilis sympotms in patients. It is possible for this to manifest into tertiary syphilis wherec omplications such as neurosyphilis and cardiovascular syphilis may develop.<br>TmpA is the Treponema pallidum membrane protein A, a lipoprotein located in the inner membrane of the bacterium and is encoded for by the Tp0768 gene. Studies have shown that the tissue damage symptoms inflicted on Syphilis patients are caused when TmpA stimulates Endoplasmic reticulum (ER) stress which in turn generates macrophage produced interleukins: IL-1β, IL-6, and IL-8. Again TmpA's mediation of ER stress is involved in ROS/ NF-κB pathway regulation and has been further shown to instigate JNK pathway produced inflammatory cytokines through the activation of IRE1α/XBP-1 signalling.<br>Due to its immunogenicity this infection-dependent antigen (TmpA) can be used along with other Treponema Pallidum recombinant lipoproteins on a panel of diagnostic tests. For example in ELISA assays recombinant TmpA can be used to detect antibodies in syphilis patient's sera, hence testing for primary syphilis, secondary syphilis and early latent syphilis. In addition the reduction of anti-TmpA antibodies in patients undertaking antibiotic treatment means TmpA can be used for syphilis treatment monitoring. Other assays it can be applied to are lateral flow and western blot. It is recommended to reconstitute this antigen to 1mg/ml using ultra-pure water only.</p>

<p>Activates B-cell apoptosis; treatment of B-cell malignancies</p>

<p>A mouse monoclonal antibody (Mab) purified by ion exchange chromatography, presented as a liquid in 0.015M potassium phosphate, 0.85% NaCl, pH 7.2, is a cell-culture derived lysate from strain 17D. Immunoglobulin subclasses IgG1k and IgG2a are available and are potentially suitable for ELISA, rapid lateral flow applications and other immunoassay formats for detection of the Yellow Fever NS1 protein.<br>The occurrence of the viral infection Yellow Fever is largely in Africa and South America where Mosquitoes infected with this Flaviviridae family virus bite humans and transmit the virus. Although symptoms can be mild, severe cases can lead to diseases such as hepatitis and renal failure. The NS1 glycoprotein, complementary to the mouse mab to the Yellow Fever Virus (YFV), is one of 7 non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5) encoded for by the single stranded RNA of the YFV. Interestingly NS1 can be found within the viral cell as a monomer, on the cell surface as a hydrophobic dimer and as a hexameric species when secreted. NS1 plays a role in virus assembly and it's 12 invariant cysteine residues allow it to function within RNA replication and hence contribute to reducing the host's immune response. Monoclonal antibodies complementary to the NS1 protein bind and inhibit activity and hence can be used in vaccine to offer immunity against YF.</p>

<p>This mouse monoclonal antibody is complementary to the Zika envelope protein, with batches of the IgG1k immunoglobulin subclass available. It has been purified by DEAE column chromatography and is presented as a liquid in 0.015M potassium phosphate, 0.85% NaCl, pH 7.2.<br>Transmitted by infected mosquitoes, the Zika virus, although it causes asymptotic and mild symptoms in the majority of cases, it can lead to neurological complications and Guillain-Barré syndrome in adults. Furthermore during pregnancy, infants may be born with microcephaly and congenital malformations, known as Zika syndrome. The envelope protein located on the Zika viral membrane and to which this mouse Mab is complementary, is involved in virus and host cell surface receptor binding. It has 3 domains (I, II and III) and a stem-transmembrane domain. Domain I functions to link Domain III (which is the host cell receptor binding domain) to Domain II in order to dimerise and form a fusion loop.<br>The accessible location of the Envelope protein on the viral membrane means it can be an important target for neutralising antibodies and vaccine development. This product can further be used in the rapid lateral flow detection of Zika envelope protein and other antibody and antigen interaction dependent assays such as ELISA and western blot.</p>

<p>3-[(2Z,5Z)-2-[(2-Chlorophenyl)imino]-4-oxo-1,3-thiazolidin-5-ylidene]-5-fluoro-2,3-dihydro-1H-indol-2-one is an inhibitor of protein interactions. It has been shown to interact with the ligand binding site of a receptor and can be used as a research tool. 3-[(2Z,5Z)-2-[(2-Chlorophenyl)imino]-4-oxo-1,3-thiazolidin-5 -ylidene]-5 -fluoro - 2,3 - dihydro - 1H - indol - 2 - one is a high purity reagent for use in life sciences. 3-[(2Z,5Z)-2-[(2-Chlorophenyl)imino]-4-- oxo - 1</p>

<p>Zatebradine hydrochloride is a drug which is used to treat bowel disease. It belongs to the class of drugs known as beta-blockers. Zatebradine hydrochloride can be administered intravenously and has been shown to cause a decrease in heart rate and ventricular function in humans. It also has an effect on energy metabolism, cardiac effects, and structural heart disease. This drug has been found to be effective at treating congestive heart failure and atrial fibrillation. Zatebradine hydrochloride also has anti-inflammatory properties that may be due to its ability to inhibit the production of inflammatory cytokines such as IL-1β, IL-6, TNFα, IL-8, and IFNγ.</p>

<p>TRAF-STOP inhibitor 6877002 is a molecule inhibitor that inhibits the activity of signalling molecules in chronic inflammation, atherosclerosis, and cardiac hypertrophy. TRAF-STOP inhibitor 6877002 is an inhibitor group that blocks the signalling pathways involved in cardiac function. It has been shown to inhibit cardiac hypertrophy by inhibiting the signaling pathways mediated by TNF-α, IL-1β, and IL-6. This drug also reduces systolic dysfunction in heart failure patients with reduced ejection fraction by suppressing myocardial fibrosis.</p>

<p>Please enquire for more information about BCC-36 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>**SR9011 hydrochloride** is a synthetic compound classified as a Rev-Erb agonist, which is derived from chemical synthesis. Its mode of action involves binding to the Rev-Erbα and Rev-Erbβ nuclear receptors, which play a crucial role in controlling the circadian rhythm and metabolic pathways. By activating these receptors, SR9011 hydrochloride influences the expression of genes involved in lipid and glucose metabolism, leading to enhanced metabolic activity and energy expenditure.<br><br>The primary applications of SR9011 hydrochloride are in research settings, where it is used to investigate the physiological and biochemical effects of Rev-Erb activation. Studies have explored its potential to modulate sleep-wake cycles, reduce fat accumulation, and improve exercise capacity in various animal models. Its ability to alter metabolic functions makes it a valuable tool for probing the pathways underlying obesity, diabetes, and other metabolic disorders. Researchers continue to study SR9011 hydrochloride to uncover further insights into its broader therapeutic potential and mechanistic pathways.</p>

<p>CD 2314 is an innovative compound used as a neuromodulatory agent, derived from advanced synthetic pathways. This compound acts selectively on specific neural receptors through ligand-receptor interactions, making it a valuable tool for elucidating complex neurological pathways. By modulating synaptic transmission and influencing neurotransmitter release, CD 2314 offers potential insights into the synaptic mechanisms underpinning cognitive processes.</p>

<p>Rac Erythro-dihydro bupropion-d9 is a novel, potent inhibitor of the human dopamine transporter. Rac Erythro-dihydro bupropion-d9 is a racemic mixture with an enantiomeric ratio of 1:1. Rac Erythro-dihydro bupropion-d9 has been shown to inhibit the dopamine transporter and to be selective for the D2 receptor. Rac Erythro-dihydro bupropion-d9 may also be used as a research tool in cell biology, pharmacology, and cell biology.</p>

<p>Tunicamycin A1 is an analog of a natural product isolated from Chinese medicinal herbs. It is known for its potent anticancer activity, acting as a kinase inhibitor that induces apoptosis in cancer cells. Tunicamycin A1 has been shown to inhibit the growth of tumors and has potential as a therapeutic agent for cancer treatment. This compound is extracted from urine and has been extensively studied for its medicinal properties. Tunicamycin A1 targets specific kinases and proteins involved in cancer cell growth, making it a promising candidate for the development of new anticancer drugs. Its potent inhibitors have shown great promise in preclinical studies as a potential treatment option for various types of cancers.</p>

<p>AM 114 is a hydroxyl-containing compound that has been found to have antibacterial activity. The primary target of AM 114 is the informational molecule in bacteria, RNA polymerase. It binds to the catalytic site of RNA polymerase and inhibits bacterial growth. This binding leads to a decrease in bacterial cell size and a decrease in the production of proteins in the bacterial cells. AM 114 also inhibits penicillin-binding protein (PBP) from Staphylococcus aureus, which may be an additional mechanism for its antibacterial effects.</p>

<p>Muscarinic receptor antagonist</p>

<p>(R,R)-Sertraline is an enantiomer of the antidepressant drug Sertraline. It is a reactive compound that can form conjugates with nucleophiles and has been shown to be antiviral in vitro. (R,R)-Sertraline binds to the 5-hydroxytryptamine (5-HT) receptor sites, which are located on neurons and musculoskeletal cells. The virus has been shown to be able to bind to these receptors as well, which may lead to a decreased ability of the body's immune system to fight off viral infections. The thermodynamic properties of this drug have also been studied, showing that it has a higher affinity for the (S) form than the (R) form. This means that the drug will tend to convert from one enantiomeric form into another in vivo when given as a racemic mixture.</p>

<p>(S)-1-Cyclohexyl-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-methyl-2-phenylbutan-1-one is a selective serotonin reuptake inhibitor that has shown efficacy in animal models of depression. It acts by binding to the 5HT1A and 5HT2C receptors, which are located in the brain. This drug also blocks dopamine reuptake and increases the release of serotonin in the brain, leading to an antidepressant effect. (S)-1-Cyclohexyl-4-(4-(2-methoxyphenyl)piperazin-1-yl)-2-methyl-2-phenylbutan-1-one appears to have no adverse effects on the cardiovascular system.</p>

<p>GSK180736A is a potent and selective small-molecule inhibitor of the serine/threonine kinase PKCδ with in vitro IC50 values of 0.5 nM. GSK180736A inhibits the phosphorylation of PKCδ substrates by PKCδ and prevents its nuclear translocation, leading to inhibition of cardiac hypertrophy and insulin resistance. The IC50 value for inhibition of PKCδ activity was determined to be 0.5 nM in an internalization assay using cells expressing GFP-tagged human PKCδ (hPKCδ). In addition, GSK180736A inhibits the phosphorylation of PKCα and ε at a concentration of 1 μM in an in vitro kinase assay. These results suggest that GSK180736A is a selective inhibitor for the kinase domain of PKCδ and other members of the PKC family</p>

<p>Cubebin is a racemic mixture of two enantiomers, (-)-Cubebin and (+)-Cubebin. It is a potent activator of TRPV1 receptors and has been shown to inhibit the activity of the protein kinase C (PKC) in cells. Cubebin also binds to the beta-subunit of voltage-gated potassium channels, inhibiting its function as an inhibitor. Cubebin has been used as a research tool for studying protein interactions and as a pharmacological probe for understanding ion channel modulation.</p>

<p>γ-secretase inhibitor of Notch signalling pathway; anti-cancer agent</p>

<p>Amperozide hydrochloride is an amide drug that blocks the 5-HT2 receptors in the brain. It is used to treat Parkinson's disease, which results from dopamine deficiency. Amperozide hydrochloride has been shown to increase the concentration of cortisol and decrease locomotor activity in rats with 5-HT1A agonists. This drug also has a stimulatory effect on the central nervous system, which may be due to its ability to activate dopamine receptors. Amperozide hydrochloride is not effective against infectious diseases such as malaria and tuberculosis because it does not cross the blood-brain barrier.</p>

<p>Inhibitor of PORCN O-acyltransferase; inhibitor of WNT</p>

<p>CS-003 is a leukotriene receptor antagonist that inhibits the effects of leukotrienes on the airways and lungs. It is administered orally to reduce bronchoconstriction and other symptoms related to asthma, allergic rhinitis, and chronic obstructive pulmonary disease. CS-003 has been shown in clinical studies to be effective in inhibiting coughs induced by citric acid. The drug also exhibits a dose-dependent inhibitory effect on airway hyperresponsiveness. CS-003 is a recombinant human protein that binds to the neurokinin receptor 1 (NK1R) on nerve endings in the nose, reducing nasal congestion and other symptoms of allergic rhinitis such as sneezing and itchy nose.<br>CS-003 also blocks chloride channels on cells in the trachea, which may be involved in controlling inflammation following an allergen challenge.</p>

<p>3-Phenyl-1H-quinazoline-2,4-dithione is a cyclic nucleotide phosphodiesterase inhibitor. It inhibits the activity of cyclic nucleotide phosphodiesterases, which are enzymes that break down cyclic nucleotides. Cyclic nucleotides are important in the regulation of cellular processes such as cell growth and differentiation, and 3-phenyl-1H-quinazoline-2,4-dithione has been shown to inhibit these processes. 3-Phenyl-1H-quinazoline-2,4-dithione is used clinically for the treatment of renal injury caused by ischemia reperfusion. It also has been shown to decrease blood pressure and improve blood flow in cases of hypertension. The drug has also been shown to have antiinflammatory properties and can be used for the treatment of inflammatory diseases such as rheumatoid arthritis or Crohn's disease.</p>

<p>P-((4-((1-Oxotetradecyl)amino)phenyl)methyl)-phosphonic acid is a synthetic compound, which is a specialized reagent used primarily in chemical research. It is derived from the modification of phosphonic acid with an aryl amide and a long-chain fatty acid substituent on the phenyl group. This structural configuration imparts the compound with unique physicochemical properties that make it suitable for various scientific studies.</p>

<p>KCC 07 is a synthetic peptide that inhibits the VEGF pathway by functioning as an antagonist to VEGF receptors. It has been shown to inhibit tumor growth and improve survival in mice with glioma, a type of brain tumor. KCC 07 also has anti-angiogenic properties and can inhibit the proliferation of endothelial cells. The peptide can be used as an antibody that binds to the extracellular domain of the receptor, preventing binding to VEGF ligand. This inhibition leads to decreased activation of VEGF receptors and decreased cell proliferation.</p>

<p>Inhibitor of FGFR1 receptor tyrosine kinase</p>

<p>Orotirelin is a peptide that is used as a research tool and in the study of protein interactions. Orotirelin binds to orexin receptors, which are found in neurons of the hypothalamus, and activates them. It has been shown to have a potent inhibitory effect on the release of pituitary hormones from the anterior lobe of the pituitary gland. It also acts as an inhibitor for certain ion channels and can be used as an antibody against other ligands that bind to orexin receptors.</p>

<p>RS 17053 hydrochloride is a compound that belongs to the group of non-steroidal anti-inflammatory drugs. It has functional assays as an inhibitor of cyclooxygenase and protein synthesis, with low potency. RS 17053 hydrochloride has been shown to inhibit the production of eicosanoids in rat cardiomyocytes and to induce cardiac hypertrophy in rats. This drug also has blood disorders effects, which may be due to its ability to interfere with protein synthesis or congestive heart failure.</p>

<p>Inhibitor of cyclin-dependend kinases CDC2, CDK2 and CDK5</p>

<p>WYE-687 is a novel small molecule that inhibits lipid kinase activity and is able to induce senescence in cells. It has potent antitumor activity against cancer cells and potently inhibits the growth of xenograft tumors in mice. WYE-687 also possesses potential as a drug target for autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. The drug has been shown to inhibit angiogenesis, which is the formation of new blood vessels from pre-existing ones, both in vitro and in vivo. WYE-687 has been shown to be well tolerated by animals after oral administration, with no observable side effects.</p>

<p>1-Octadecanoyl-2-(15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine is a bioactive lipid compound, which is derived from natural lipid sources such as cellular membranes. Its mode of action involves participation in complex lipid signaling pathways that play a crucial role in cellular processes. This compound acts as a mediator in signaling cascades associated with inflammation, cellular communication, and homeostasis. As such, it can be integral in studies focused on cell signaling and the physiological roles of lipids.</p>

<p>NP19 is a Chinese medicinal compound that has been found to have potent anticancer properties. It is an analog of kinase inhibitors and has been shown to induce apoptosis in cancer cells. NP19 works by inhibiting protein kinases, which are enzymes that play a crucial role in the growth and proliferation of tumor cells. This compound has been extensively studied for its potential use as an anticancer drug and has shown promising results in preclinical studies. In addition, NP19 can be detected in human urine, indicating that it may have potential as a non-invasive diagnostic tool for cancer. Overall, NP19 represents a promising new avenue for the development of effective cancer therapies.</p>

<p>Please enquire for more information about 1,3-Dipalmitoyl-2-docosahexaenoyl-glycerol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Paliroden is a neurotrophic drug, which means it stimulates the growth of nerve cells. It is also a dopamine-releasing agent that can be used as a treatment for traumatic brain injury. Paliroden binds to cholinesterase and blocks its action, leading to increased levels of acetylcholine in the brain. This leads to increased stimulation of the nervous system, which can improve cognitive function and memory in patients with Alzheimer's disease or Parkinson's disease. The nitrogen atoms on paliroden bind to the enzyme acetylcholinesterase, inhibiting its activity and increasing the concentration of acetylcholine in neural synapses.</p>

<p>Please enquire for more information about Amonafide-d6 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Idelalisib d5 is a research tool that binds to the human Activator and Ligand Receptor. The binding of idelalisib d5 to these receptors inhibits the activation of cells. This inhibition may lead to a decrease in the production of cytokines and chemokines, which are molecules involved in inflammation. Idelalisib d5 has been shown to inhibit ion channels, such as chloride channels, and also interacts with other proteins including antibodies and peptides.</p>

<p>A potent and selective cell-permeable inhibitor of protein phosphatase 1 and protein phosphatase 2A.  Displays &gt; 10,000,000-fold selectivity over PP2B and PP2C.</p>

<p>Furprofen is a sulfonamide that is used to treat inflammatory bowel disease. Furprofen inhibits the synthesis of prostaglandins and leukotrienes, which have been implicated in the development of inflammatory bowel disease. Furprofen also inhibits the activity of cyclooxygenase-1 and cyclooxygenase-2 enzymes, which are responsible for the production of prostaglandins and leukotrienes. Furprofen has shown efficacy in treating inflammatory bowel disease by reducing inflammation, mucosal damage, and colonic ulceration. The analytical method used to detect furprofen is UV absorption at 272 nm. This method can be applied to urine samples or other biological fluids. Furprofen is an n-oxide with a hydroxyl group on its nitrogen atom that links to ester linkages through an oxygen atom on its other nitrogen atom. Furprofen contains a sulfoxide group with two oxygen atoms on its sulfur atom that link to es</p>

<p>Please enquire for more information about MDK34597 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Tiludronic acid is a drug that belongs to the group of non-steroidal anti-inflammatory drugs. It is used for the treatment of bowel diseases such as inflammatory bowel disease, ulcerative colitis, and Crohn's disease. Tiludronic acid binds to the matrix metalloproteinases (MMPs) or collagenase, which are enzymes that break down connective tissue in the digestive system. This binding prevents their activity, thereby reducing inflammation and allowing damaged tissues to heal. Tiludronic acid has also been shown to have an activity index of 2.0 μM with respect to MMPs and collagenase in a model consisting of crystalline cellulose and experimental models. Tiludronic acid inhibits MMPs and collagenase by binding to them at low concentrations (2 μM). This binding prevents their activity, thereby reducing inflammation and allowing damaged tissues to heal. Tiludronic acid has also been shown to have an activity index</p>

<p>Glu17,Gla21,24-Osteocalcin is a peptide that is used as a research tool to study ion channels and receptor interactions. It has been shown to bind to the human insulin receptor and act as an agonist. Glu17,Gla21,24-Osteocalcin also binds to the calcitonin receptor with high affinity. This peptide can be used in pharmacology studies as an inhibitor of insulin-mediated glucose uptake or as an activator of calcium release from intracellular stores.</p>

<p>CD25 antibody (PE-CY7) was raised in rat using alpha chain IL-2 receptor as the immunogen.</p>

<p>Matrix metalloproteinase inhibitor</p>

<p>CD31 antibody (biotin) was raised in rat using murine leukocyte cell line 32D as the immunogen.</p>

<p>CD4 antibody (PE-CY7) was raised in mouse using human CD4 as the immunoge.</p>

<p>AG-17724 is a small molecule that activates the transcription factor NF-κB. This activation leads to the production of proinflammatory cytokines and chemokines, which are associated with inflammation. AG-17724 has been shown to activate NF-κB in cells by inhibiting protein phosphatase 2A (PP2A). It also induces a number of molecular changes that are hallmarks of inflammatory signaling, including modifications to both DNA and protein. These changes activate gene transcription and translation as well as induce the activation of other key molecules involved in inflammation.</p>

<p>Amyloid β (42- 1) SCR is a peptide that inhibits the interaction of amyloid β with its receptor, which may be useful for research purposes. Amyloid β (42- 1) SCR is an inhibitor that prevents the binding of amyloid β to its receptors. This peptide is a high purity product and has been shown to be effective in inhibiting the interaction between amyloid beta and its receptor.</p>

<p>CD45.2 antibody (Allophycocyanin) was raised in mouse using CD45.2 as the immunogen.</p>

<p>CHIR-98023 is a peptide that belongs to the group of activators. It is a cell-permeable and potent inhibitor of potassium channels, which are important in the regulation of neuronal excitability. CHIR-98023 has been shown to inhibit the activity of voltage-gated potassium channels, including Kv1.2, Kv1.3, and Kv1.4, in rat brain tissue. It also inhibits the activity of voltage-gated sodium channels in rat brain tissue. CHIR-98023 binds to the receptor site on neuronal ion channels and blocks their opening and closing, leading to a decrease in their activity. This inhibition leads to an increase in neuronal excitability due to an increase in calcium influx into cells as well as an increased availability of neurotransmitters at synapses.</p>

<p>Albumin heavy tryptic peptide standard for use in protein identification and quantitation studies. Albumin is a globular protein found in plasma and is produced by liver hepatocytes. Serum albumin plays an important role in the regulation of plasma oncotic pressure.</p>

<p>7-BIA is a potent non-competitive phosphatase inhibitor. It inhibits tyrosine phosphatases by binding to the enzyme's ligand-binding site and preventing substrate from binding. This drug has been shown to inhibit phosphatases in vivo and in vitro studies, including cyclopentyl phosphatase, p38 MAP kinase, and PI3K. 7-BIA also blocks cAMP synthesis and reduces the activity of protein kinase A. 7-BIA is a competitive ligand for the pharmacophore site of the enzyme PP2A, which is found in both brain cells and platelets.</p>

<p>CD3e antibody (FITC) was raised in mouse using porcine CD3e as the immunogen.</p>

<p>Safit1 is a small molecule that has been shown to be effective in treating cancer. Safit1 inhibits the activity of glucocorticoid receptors, which are involved in the control of cellular response to stress and inflammation. It also inhibits the PD-L1 receptor, which is involved in cell proliferation and cancer resistance. Safit1 has been shown to have anti-inflammatory properties, as well as an ability to inhibit protein synthesis. Safit1 has also been shown to have a protective effect against metabolic disorders such as diabetes and obesity.</p>

<p>Peptide YY (Human)-EIA Kit (1ea) is an EIA kit for the quantitative analysis of human peptide YY. Peptide YY is a neuropeptide with a role in the regulation of food intake and energy expenditure. The kit contains one vial each of peptide YY antiserum, peptide YY antibody, and standard reference material. The assay can be used to detect the level of peptide YY in tissue samples or cell culture supernatants.</p>

<p>Neuromedin C is a peptide hormone that is involved in the regulation of feeding behavior. It is found in humans, pigs, and dogs. Neuromedin C has been shown to be involved in the regulation of gastric acid secretion and pancreatic secretion. The peptide also plays a role in the regulation of insulin release from the pancreas. In addition, neuromedin C has been shown to be an effective treatment for diabetes-related neuropathy.</p>

<p>TentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel; resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.<br>These resins are designed for single bead synthesis and single bead analysis (mean particle size 280-320 µm: capacity 02-03 meq/g) and substitutional functional group: -CH2-CH2-SH.</p>

<p>Neuromedin U is a neuropeptide that has been found to bind to the receptor neuromedin U receptor. It is a potent activator of ion channels and ligand for the neuromedin U receptor. Neuromedin U is also an inhibitor of angiotensin II, histamine, and serotonin release. The purified recombinant human neuromedin U protein is supplied at &gt;98% purity with no detectable endotoxin contamination.</p>

<p>TentaGel® R PHB Resin (90 um) can be used for the preparation of peptide acids; particle size 90 µm; capacity: 018-023 meq/g and is specially designed for difficult and long sequences.<br>TentaGel, is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.</p>

<p>Vn96 scramble peptide is a negative control peptide that is used in pharmacological and cell biology research. It is an inhibitor of protein interactions and can also be used as a research tool for identifying the ligand or receptor of a protein. Vn96 scramble peptide has been shown to inhibit ion channels, including potassium channels, which are involved in nerve transmission.</p>

<p>Nucleoside Diphosphate Kinase E.coli (recombinant) is a research peptide that belongs to the group of protein kinases. It is used in scientific studies and experiments to investigate various cellular processes and signaling pathways. This recombinant protein kinase has been shown to play a crucial role in the phosphorylation of nucleoside diphosphates, which are important molecules involved in energy metabolism and cell signaling. By catalyzing the transfer of phosphate groups, Nucleoside Diphosphate Kinase E.coli regulates the balance of nucleotide triphosphates, which are essential for DNA replication, RNA synthesis, and protein synthesis. Its unique properties make it an invaluable tool for researchers studying cellular mechanisms and developing new therapeutic strategies.</p>

<p>KPT is a drug for the treatment of inflammatory diseases. It is a particle-based drug delivery system that delivers active ingredients through the skin. KPT consists of a class of drugs called protein inhibitors, which are designed to inhibit the growth factor receptor EGFR. This receptor plays an important role in tumor cell growth and survival by regulating cellular function, including cell proliferation, differentiation, and apoptosis. The detection sensitivity of KPT is low enough to allow targeting of cancer cells without affecting healthy cells. KPT has been shown to inhibit the growth of melanoma cells in culture and reduce tumor size in mice with experimental cancer.</p>

<p>2,2'-(Azanediylbis(ethane-2,1-diyl))bis(1H-benzo[de]isoquinoline-1,3(2H)-dione) is a ligand that can activate Ion channels and Ligands. It has been shown to bind to the receptor site of Protein interactions, Receptor proteins, Peptides and Antibodies. 2,2'-(Azanediylbis(ethane-2,1-diyl))bis(1H-benzo[de]isoquinoline-1,3(2H)-dione) is an inhibitor of Cell Biology. The CAS number for this compound is 281224-40-6.</p>

<p>BIO 5192 is a receptor-binding molecule that may be used to treat autoimmune diseases and blood disorders, such as hemolytic anemia. It binds to the CD81 receptor on cells, which prevents the binding of inhibitory molecules and blocks the activation of T cells. BIO 5192 has been shown to have no long-term toxicity in mice and does not cause any weight loss or organ damage in these animals. It has also been shown to stimulate hematopoietic cells (cells that produce blood) in vitro. BIO 5192 is currently being investigated for its potential use in treating inflammatory diseases such as rheumatoid arthritis.</p>

<p>Please enquire for more information about Fructose-1,6-Bisphosphatase 1, human, recombinant including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>This is a recombinant human Leukocyte-Associated Ig-Like Receptor 2 (LAIR2) protein. It is an activator of the LAIR2 receptor, which is a member of the immunoglobulin superfamily. LAIR2 is expressed on activated T cells and NK cells. This protein also can interact with other receptors, such as CD4 and FcRγ, to inhibit ion channels and activate cell signaling pathways. LAIR2 has been shown to be involved in immune responses, including antibody production and cytokine release by activated lymphocytes.</p>

<p>Canadine is an alkaloid and the major active ingredient in the herbal medicine berberine. It has been used for the treatment of metabolic disorders, such as diabetes mellitus. Canadine can cause drug interactions with other drugs that are metabolized by cytochrome P450 enzymes and may increase oxidative injury to cells. Canadine has also shown efficacy against oral pathogens in animal models. Toxicological studies have been conducted on rats, showing that it may cause liver damage and energy metabolism disturbances. This drug has been found to be effective for treating some experimental models of liver disease such as chronic hepatitis or cirrhosis.</p>

<p>TFF1 is a protein that belongs to the TNF family of cytokines. It is a homodimer with two identical chains that are linked by disulfide bonds at specific positions. TFF1 has been shown to be secreted by monocytes, macrophages, and lymphocytes in response to LPS stimulation. TFF1 binds to the cell membrane of target cells and induces proinflammatory responses such as cytokine production and the activation of NF-κB. These effects are mediated through its ability to activate the transcription factor nuclear factor-κB (NF-κB) which regulates gene expression in immune cells.<br>DISULFIDE BONDS: The covalent linkage between two polypeptide chains or between two amino acid residues <br>CHROMATOGRAPHY: A process for separating mixtures based on molecular weight, size, shape, or other physical properties <br>RECOMBINANT: Produced by recombining genetic material from different</p>

<p>N-{[4'-({3-Butyl-5-Oxo-1-[2-(Trifluoromethyl)Phenyl]-1,5-Dihydro-4H-1,2,4-Triazol-4-Yl}Methyl)-2-Biphenylyl]Sulfonyl}-3-Methyl--2 -Thiophenecarboxamide is a reactive molecule that inhibits the production of prostaglandin E2 (PGE2). It binds to the PGE2 receptor and blocks its activation. N-[{4'-({3-Butyl--5--Oxo-[1-(2-(trifluoromethyl)phenyl]-1,5--dihydro--4H--1,2,4--triazol--4--y l}methyl)-2--biphenylylsulfonyl}] 3methyl 2thiop</p>

<p>Eif-2α inhibitor II, sal003 is a peptide antibody that blocks the translation of eukaryotic initiation factor-2α (eIF-2α), which has been shown to be involved in many cellular processes. EIF-2α inhibitor II, sal003 is a highly purified antibody with no background staining. This antibody has been shown to inhibit the production of nitric oxide by binding to eIF-2α and inhibiting its phosphorylation. It can also block the action of bacteria, such as Escherichia coli, by interfering with protein synthesis. This antibody can be used for research purposes in cell biology, pharmacology, and immunology.</p>

<p>CD11b antibody (Allophycocyanin) was raised in rat using C57BL/10 murine splenic T cells and concanavalin A-activated C57BL/10 splenocytes as the immunogen.</p>

<p>Please enquire for more information about 11-Cis-acitretin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>KLRG1 antibody (Azide free) was raised in hamster using activated NK (A-LAK) cells from B6 mice as the immunogen.</p>

<p>CD3e antibody (PE) was raised in rat using CD3e as the immunogen.</p>

<p>CD38 antibody (PE) was raised in rat using CD38 as the immunogen.</p>

<p>CD44 antibody (Allophycocyanin) was raised in rat using murine CD44 as the immunogen.</p>

<p>2-[3-[[(3′,4-Difluoro[1,1′-biphenyl]-3-yl)carbonyl]amino]phenoxy]acetic acid is a small molecule that binds to and inhibits the receptor for Substance P (NK1), which is involved in various functions such as nociception, neurogenic inflammation and host defense. The binding of 2-[3-[[(3′,4-Difluoro[1,1′-biphenyl]-3-yl)carbonyl]amino]phenoxy]acetic acid with the NK1 receptor leads to a decrease in the production of proinflammatory cytokines such as TNFα and IL6. 2-[3-[[(3′,4-Difluoro[1,1′-biphenyl]-3-yl)carbonyl]amino]phenoxy]acetic acid has been shown to</p>

<p>Isrib is a sodium citrate that has been shown to inhibit the growth of an experimental bacterial strain in vitro. Isrib has also been shown to have inhibitory properties on neuronal death in vivo. This agent has pluripotent cells that are able to differentiate into any cell type, including neurons, and can be used for the treatment of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and diabetic neuropathy. Isrib has also been shown to have beneficial effects on the immune system by stimulating antibody production and regulating inflammatory responses. It is absorbed orally with high bioavailability and its pharmacokinetic properties are similar to those of other sodium citrates.</p>

<p>Relamorelin is a peptide hormone that binds to the growth hormone-releasing factor receptor. It has been shown to activate this receptor and stimulate the release of growth hormone from the anterior pituitary gland. Relamorelin has been used as a research tool to study protein interactions, ligand binding, and inhibition of ion channels. It is also used in cell biology as an inhibitor of protein synthesis and DNA replication. Relamorelin is a potent inhibitor of ligand binding to the GABA type A receptor (CAS No. 661472-41-9).</p>

<p>Covalent antagonist of estrogen receptor</p>

<p>Diflapolin is a synthetic pharmaceutical compound, which is a non-steroidal anti-inflammatory drug (NSAID) derived from laboratory-synthesized chemical precursors. Its mode of action involves the inhibition of specific enzymes, particularly cyclooxygenase (COX) enzymes, which play a crucial role in the biosynthesis of pro-inflammatory mediators like prostaglandins. By impeding these enzymes, Diflapolin effectively reduces inflammation, alleviates pain, and decreases fever.</p>

<p>CD20 antibody (PE) was raised in mouse using human CD20 as the immunogen.</p>

<p>ML204 hydrochloride is a selective TRPC4/5 ion channel inhibitor, which is a synthetic compound designed to modulate specific biological pathways. It is derived from a series of chemical modifications tailored to target the transient receptor potential canonical (TRPC) family of ion channels, particularly TRPC4 and 5.</p>

<p>CD122 antibody (Azide free) was raised in rat using rat myeloma YB2/0 transfected with truncated murine IL-2RB cDNA as the immunogen.</p>

<p>CAY10681 is a senolytic agent that eliminates senescent cells in the lung. Senescent cells are cells that have stopped dividing and accumulate with age and during chronic inflammation. CAY10681 has been shown to reduce pulmonary fibrosis in mice and to inhibit the growth of atherosclerosis lesions in mouse models. The mechanism of action of CAY10681 is not yet known, but it seems to specifically target senescent cells without affecting normal cells. CAY10681 has also been shown to inhibit the production of gene products associated with senescence, such as IL-6, IL-8, and TNF-α.</p>

<p>Brobactam sodium is a β-lactamase inhibitor, which is a chemically synthesized compound with the primary function of inactivating β-lactamase enzymes produced by certain bacteria. These enzymes can degrade β-lactam antibiotics, such as penicillins and cephalosporins, rendering them ineffective. Brobactam sodium functions by forming a covalent bond with the active site of β-lactamase enzymes, thus inhibiting their activity and allowing the concomitantly administered β-lactam antibiotic to exert its bactericidal effect on the susceptible pathogens.</p>

<p>Inhibits factor Xa; anti-thrombotic</p>

<p>BMS 470539 Dihydrochloride is a humanized anti-inflammatory monoclonal antibody that inhibits tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). This drug is used for the treatment of eye disorders, bowel disease, and other conditions. BMS 470539 Dihydrochloride binds to TNF receptors and blocks the interaction between TNF-α or IL-1β with their receptors, which prevents the production of inflammatory cytokines. This drug also has neuroprotective effects in animal studies. It is believed that this effect may be due to inhibition of microglial activation, which are cells in the central nervous system that release inflammatory cytokines. The molecule does not bind to macrophages or erythrocytes, so it does not have an effect on platelet aggregation or coagulation.</p>

<p>CD90.2 antibody (Allophycocyanin) was raised in rat using CD90.2/`Thy-1.2 alloantigen as the immunogen.</p>

<p>CD45.1 (Allophycocyanin-CY7) antibody was raised in mouse using CD45.1 as the immunogen.</p>

<p>5α-Androstan-3α,17β-diol-17β-glucuronide is a metabolite of dihydrotestosterone, which is a type of androgenic steroid. It is primarily sourced from the metabolic pathways involving the action of enzyme systems on testosterone and its derivatives within the body. This compound is formed through the conjugation of 5α-androstanediol with glucuronic acid, a process mediated by the enzyme UDP-glucuronosyltransferase.</p>

<p>Please enquire for more information about 2-Dibromomethyl-benzonitrile including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about CORM-3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CD56 antibody (Spectral Red) was raised in mouse using human CD56 as the immunogen.</p>

<p>Glucokinase activator 1 (GKA1) is a protein that activates glucokinase, which is an enzyme that promotes the phosphorylation of glucose to glucose-6-phosphate. GKA1 has been shown to activate glucokinase in a mutant strain of E. coli, which has been shown to have increased lipoprotein lipase activity and enhanced uptake of glucose. This protein is also able to stimulate the production of insulin by increasing transcriptional regulation and messenger RNA levels. GKA1 may be used as a potential therapy for diabetes and as a diagnostic tool for measuring insulin resistance.</p>

<p>Nicomol is a drug that belongs to the class of dextran sulfates. It is used in the treatment of cardiac disorders, including angina pectoris, congestive heart failure, and myocardial infarction. Nicomol also has hypoglycemic activity and can be useful for treating metabolic disorders. Nicomol is administered intravenously and has been shown to increase the uptake of glucose by the body, which may be due to its ability to inhibit potassium dichromate-induced protein gene expression in heart tissue. The drug also promotes mitochondrial function by increasing fatty acid oxidation and reducing fat cell size.</p>

<p>CD45R antibody (PE-CY5.5) was raised in rat using abelson murine leukemia virus-induced pre-B tumor cells as the immunogen.</p>