Biochemicals and Reagents

Applications Labelled L-Ornithine. A non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta.
References Fattori, D. et al.: J. Med. Chem., 50, 550 (2007); Gomez-Alonso, S. et al.: J. Agric. Food Chem., 55, 608 (2007); Subramaniam, R. et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2008);

Applications Tryptophol is a metabolite formed in the liver after disulfiram treatment that induces sleep in humans. It is also a secondary product of alcoholic fermentation.
References Cornford, E.M., et al.: J Clin Invest, 63, 1241-1248 (1979)

Applications L-Thioproline is used to create a monolayer on gold electrodes for the determination Copper(II). L-Thioproline has shown to be an effect inhibitor of proline absorption in Saccharomyces chevalieri.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Cui, X., et. al.: Sci. China Chem., 53, 257 (2010); Magana-Schwenchke, N., Schwencke, J.: BBA-Biomembranes, 173, 313 (1969)

Applications Phloxine B acts as the sensitizers of dye-sensitized solar cells. Also, it is a fluorescein photoactive dye. Dyes and metabolites, Environmental Testing.
References Ren, P., et al.: Int. J. Photoenergy, 2135847/1-2135847/11 (2016);

Applications Glycyl-D-phenylalanine (cas# 34258-14-5) is a useful research chemical.

Applications Terphenyl hydrogenated (cas# 61788-32-7) is a useful research chemical.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-Azidoethanamine Hydrochloride is used as a reagent for pyrrolobenzodiazepine dimers that are used in the treatment of proliferative disorder such as cancer.
References Song, Ho Young. et al., 135 pp. PCT Int. Appl. (2018);

Applications Davis Oxaziridine is an oxidizing agent used in the preparation of wide variety of pharmaceutical compounds.
References Davis, F. et al.: J. Org. Chem., 49, 3241 (1984); Cruz-Almanza, R. et al.: Tetrahed. Lett., 38, 183 (1997);

Applications Abamine is an inhibitor of 9-Cis-Epoxycarotenoid dioxygenase (NCED), the key regulatory enzyme in the plant hormone abscisic acid (ABA) biosynthesis pathway.
References Kitahata, N., et al.: Bioorg. Med. Chem., 14, 5555 (2006); Han, S., et al.: Bioorg. Med. Chem. Lett., 14, 3033 (2004)

Applications L-Glutamic acid 5-methyl ester is a protected form of L-Glutamic acid (G596960). L-Glutamic acid is a nonessential amino acid that is important to the mammalian central nervous system. L-Glutamic acid is also a neurotransmitter for cone photoreceptors in the human brain and is used as a treatment for patients who have liver disease accompanied by encephalopathy (a condition termed ‘hepatic coma’).
References Anderson, H., et al.: J. Nutr., 99, 82 (1969); Brandon, C. & Lam, D.: Proc. Nat. Acad. Sci., 80, 5117 (1983); McDermott Jr, W., et al.: New Engl. J. Med., 253, 1093 (1955)

Stability Hygroscopic
Applications A mixture of 2 metabolites of Styrene. The 2 regioisomers are in a roughly 3: 1ratio
References Ryan, A., et al.: Drug Metab. Dispos., 5, 363 (1977), Delbressine, L., et al.: Xenobiotica, 11, 589 (1981), Truchon, G., et al.: J. Anal. Toxicol., 14, 227 (1990),

Applications Labelled 4-Methyl-2-oxovaleric Acid, an α-ketomonocarboxylic acid that triggers insulin release by acting upon receptor sites which differ from those occupied by amino acids. 4-Methyl-2-oxovaleric Acid is an intermediate in the metabolism of Leucine.
References Panten, U. et al.: Naun.-Schmied. Arch. Pharmacol., 291, 405 (1975); Vague, P. et al.: Diab. Metab., 1, 185 (1975); Francois, G. et al.: Lancet, 1, 858 (1984);

Applications Pararosaniline Hydrochloride is a red dye used for textiles. Dyes and metabolites, Environmental Testing.
References Abadulla, E., et al.: Appl. Environ. Microbiol., 66, 3357 (2000); Nyanhongo, G., et al.: Water Res., 36, 1449 (2002);

Applications Amaranth is a food color additive that induces differential colon DNA damage in rat and mouse. Dyes and metabolites, Environmental Testing. Dyes and metabolites.
References Shimada, C., et al.: J. Toxicol. Sci., 35, 547 (2010); Goda, M., et al.: Shokuhin Eiseigaku Zasshi, 54, 188 (2013); Wang, M., et al.: J. Electroanal. Chem., 809, 117 (2018); Lu, L., et al.: Guangdong Huagong, 43, 117 (2016)

Applications 4-Phenyl-3-buten-2-ol can be used as reagent/reactant for rhodium-catalyzed dynamic kinetic enantio-, chemo- and regioselective allylation of phenols/naphthols/hydroxypyridines with allylic carbonates. It can also be used in biological study for comparative study on quality of soy sauce produced from whole soybeans and defatted soybeans.
References Li, C., and Breit, B.: Chemistry- A European Journal, 22, 14655-14663 (2016); Li, X., et al.: Zhongguo Niangzao, 34, 22-26 (2015);

Applications Labelled analogue of L-Vailne. L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grains, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.
References Choi, C.W. et al.: Anim. Feed Sci. Technol., 102, 15 (2002); Kolarski, D. et al.: Krmiva, 30, 155 (1988); Oba, M. et al.: J. Dairy Sci., 93, 2044 (2010); Mitrega, K. et al.: Pharmacol. Res., 64, 218 (2011);

Applications N-Boc-L-proline is a useful synthetic intermediate. It is used to synthesize Daclatasvir (D101500) which nhibits the HCV protein NS5A. Daclatasvir (D101500) can be used as a drug candidate for the treatment of hepatitis C (HCV).
References Gao, M., et al.: Nature, 465(7294), 96 (2010); Bell, T. W., Chem. Med. Chem., 5(10), 1663 (2010);

Applications 4,4'-Methylenedianiline is used in the production of polyurethane foams and epoxy resins (1). Potential contributor in pulmonary arterial hypertension (PAH) in rats through alteration of the serotenergic transport system (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Dyes and metabolites, Environmental Testing.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References 1. Hebert V. et al.: Cardiovas. Toxicol., 2011 Dec;11(4):316-24.2. Carroll-Turpin, M. et al.: Toxicol. Sci. 2015 Sep;147(1):235-45