Biochemicals and Reagents

Applications Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Manaker, et al.: Antibiot. Ann., 55, 853 (1954), Jain, S., et al.: J. Mol. Biol., 114, 317 (1977), Nakajima, K., et al.: Pept. Chem., 19, 143 (1981), Shereda, R., et al.: J. Biol. Chem., 282, 19247 (2007),

Stability Light Sensitive, Hygroscopic
Applications A water soluble bifunctional fluorogenic reagent for the sensitive and specific detection of thiols in biological specimens or proteins.SBD-F has high reactivity to thiol compounds to attain low detection limits; no flourescence in itself; biological buffer solublility; stability at RT in water for >1 week. The optimal condition for reaction was 60oC and pH 9.5 for 1 h.Please refer to the following references for more specific information regarding the application of SBD-F as a fluorogenic reagent for detection of cysteine containing peptides.Fluorescence: max Abs. l = 380 nm, max Em. l = 515 nm; Molar Abs. > 4x103 (ca. 317nm)
References Imai, K., et al.: Anal. Biochem., 128, 471 (1983); Sueyoshi, T., et al.: J. Biochem., 97, 1811 (1985), Lagana, A., et al.: Anal. Biochem., 215, 266 (1993); Singh, B.K., et al.: J. Liq. Chromatogr., 17, 4469 (1994); Bishop, A.P., et al.: Free Radical Biol. Med., 18, 617 (1995);

Stability Light Sensitive
Applications Olivetol is a precursor in various syntheses of tetrahydrocannabinol.
References Kumano, T., et al.: Bioorg. Med. Chem., 16, 8117 (2008), Appendino, G., et al.: J. Nat. Prod., 71, 1427 (2008), Sampietro, D., et al.: Food Chem., 115, 1170 (2009),

Applications 2-(Hydroxyamino)acetic Acid is a novel lactase inhibitor.
References Hattori, M., et al.: J. Insect Physiol., 51, 1359 (2005); Murao, S., et al.: Biosci. Biotech. Biochem., 56, 987 (1992)

Applications N-Methylformamide-d5 (CAS# 863653-47-8) is a useful isotopically labeled research compound.

Applications Butyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).
References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),

Applications 4-Amino-nicotinonitrile

Applications Pipecolic acid is involved in synaptic transmission in the central nervous system. The l-form occurs in plants.
References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),

Stability Light Sensitive
Applications Rhodamine B is used in biological studies for an anti-reactive oxygen species/hepatic fibrosis drug delivery system based on salvianolic acid B loaded mesoporous silica nanoparticles. Dyes and metabolites, Environmental Testing.
References He, Q., et al.: Biomaterials, 31, 7785 (2010)

Applications DL-2-aminobutyric acid

Applications It is used in cosmetic composition for application to the skin, lips, and/or body surface. Dyes and metabolites, Environmental Testing.
References Yaghi, B., et al.: Mutat. Res., 401, 153 (1998), Rabow, A., et al.: J. Med. Chem., 45, 818 (2002), Dix, D., et al.: Toxicol. Sci., 95, 5 (2007),

Applications 3’,5’-Diiodo-L-thyronine is a thyroid hormone that has been shown to increase malic enzyme activity, and the activity of glucose-6-phosphate dehydrogenase in teleost Anabas testudineus. Thus, showing short term effect on lipid metabolism.
References Davey, K.G.: Insect Biochem. Mol. Bio., 30, 877 (2000); Shameena, B., et. al.: Endocr. Res., 26, 431 (2000)

Applications A mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700).
References Bohl, C., et al.: J. Med.Chem., 47, 3765 (2004), Smith, J., et al.: Steroids, 73, 1160 (2008),

Applications Cytosine-5,6-d2 (CAS# 106391-24-6) is a useful isotopically labeled research compound.

Applications Dipyrrometheneboron Difluoride is a fluorescent dye and is used for the imaging of cadmium in cells.
References Bergstrom, F., et al.: J. Am. Chem. Soc., 124, 196 (2002); Yuan, L., et al.: Chem. Soc. Rev., 42, 622 (2013);

Applications Leuco Gentian Violet-d6 (Major), is a labelled metabolite of Gentian Violet in seafood products.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rushing, L., et al.: J. Chromatogr., 700, 223 (1997), Ohtsu, H., et al.: J. Med. Chem., 45, 5037 (2002), Yin, D., et al.: Mol. Pharmacol., 63, 211 (2003),

Impurity Didanosine EP Impurity C
Applications 2'-Deoxyinosine (Didanosine EP Impurity C) is an Inosine (I661000) analog with hypotensive activity. An impurity of the antiviral drug 2’,3’-Dideoxyinosine (D440950).
References Maling, S.J. et al.: J. Appl. Biochem., 2, 130 (1980); Rao, D.V.N.S. et al.: J. Pharmac. Biomed. Anal., 45, 516 (2007);