Biochemicals and Reagents

<p>Inhibitor of ataxia telangiectasia mutated (ATM) kinase and AKT kinase with anti-cancer activity. ATM is a nuclear protein kinase and a signal transducer sensing DNA damage as well as controlling double strand DNA break (DSB) repair. It is a radiotherapy and chemotherapy sensitizer, especially in tumors sensitive to DNA alkylating agents (such as temozolomide). Moreover, KU 55933 inhibits phosphorylation of cytoplasmic AKT kinase, downregulates synthesis of cyclin D1 and induces cell cycle arrest in G1 phase.</p>

<p>Inhibitor of oxidative phosphorylation which acts on the F0F1 ATP synthase in the inner mitochondrial membrane and causes acute increase in mitochondrial membrane potential. Gboxin was shown to accumulate in mitochondria of cancer cells, to cause cellular toxicity and cell growth inhibition in mouse glioblastoma. However, Gboxin did not inhibit growth of mouse embryonic fibroblasts or neonatal astrocytes.</p>

<p>H-CNEKGMSSRRKESSD-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-CNEKGMSSRRKESSD-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-CNEKGMSSRRKESSD-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-CNEKGMSSRRKESSD-OH at the technical inquiry form on this page</p>

<p>Transferrin antibody was raised in rabbit using human transferrin as the immunogen.</p>

<p>Peptide H-GNLDFVQPPR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Mycoplasma pneumoniae antibody was raised in mouse using purified Mycoplasma pneumoniae as the immunogen.</p>

<p>H-LGKRGSKPK-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-LGKRGSKPK-OH is provided at greater that &gt;98% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-LGKRGSKPK-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-LGKRGSKPK-OH at the technical inquiry form on this page</p>

<p>Prasugrel is a thienopyridine prodrug that inhibits the enzyme ADP-dependent P2Y purinergic receptor. Prasugrel inhibits platelet aggregation and the formation of blood clots by blocking the conversion of ADP to ATP on the surface of platelets, thus preventing the release of serotonin from platelets. The reaction products formed by prasugrel are similar to those formed by clopidogrel and include hydrogen sulfate ions and a thiol-containing metabolite. It has also been shown to have potent cytotoxic activity against melanoma cells and anti-inflammatory properties. <br>Prasugrel is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Ac-GTLTVTSTLPC-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-GTLTVTSTLPC-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-GTLTVTSTLPC-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-GTLTVTSTLPC-NH2 at the technical inquiry form on this page</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Peptide H-FSISWAR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Modifier of the SMN2 gene splicing</p>

<p>Elesclomol is an investigational anticancer agent, which is a small-molecule compound. It functions by targeting the cellular oxidative stress pathway; specifically, it enhances the production of reactive oxygen species (ROS) within cancer cells. By elevating ROS levels beyond the threshold tolerable by cancer cells, Elesclomol induces apoptosis through the disruption of mitochondrial function, making it selective for environments with heightened oxidative stress.</p>

<p>Peptide H-VGTQFTR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Purified recombinant EBNA1 protein (His tag)</p>

<p>Peptide H-DFTFVCPTEI-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>DNA antibody was raised in mouse using calf thymus DNA as the immunogen.</p>

<p>Candesartan is an anti-hypertensive drug used in the treatment of hypertension. This drug is an antagonist of the GPCR angiotensin II receptor I and works to relax smooth muscles and lower blood pressure.<br>Candesartan cilexetil is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Rabbit polyclonal GPRIN3 antibody</p>

<p>Peptide H-ITCAEEGWSPTPK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>H-GTEDIPSKI-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-GTEDIPSKI-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-GTEDIPSKI-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-GTEDIPSKI-OH at the technical inquiry form on this page</p>

<p>HBeAg antibody is a powerful tool used in Life Sciences research. It is an antibody that specifically targets and binds to the HBeAg protein, which is an important marker for hepatitis B virus infection. This antibody can be used in various applications, such as immunohistochemistry, western blotting, and enzyme-linked immunosorbent assays (ELISA). The HBeAg antibody has been shown to effectively neutralize the activity of HBeAg, preventing its interaction with host cells and inhibiting viral replication. Additionally, this antibody has demonstrated cytotoxic effects on infected cells, making it a potential therapeutic option for treating hepatitis B virus infections. Its high specificity and affinity make it a valuable tool for researchers studying the mechanisms of viral infections and developing new treatments.</p>

<p>Gefitinib is an inhibitor of the epidermal growth factor receptor (EGFR) protein. This inhibition is on the EGFR tyrosine kinase domain, where Gefitinib bindings to the ATP-binding site. As a a tyrosine kinase inhibitor, Gefitinib blocks tumor growth and has led to its use in slowing the progression of non-small cell lung cancer. Gefitinib also inhibits invasion and metastasis through inhibition of macrophage receptor interacting protein kinase 2 (RIPK2), rather than EGFR.</p>

<p>Topoisomerase II inhibitor; chemotherapeutic drug</p>

<p>Ac-CWPSQTAEPGPAQ-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CWPSQTAEPGPAQ-NH2 is provided at greater that &gt;85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CWPSQTAEPGPAQ-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CWPSQTAEPGPAQ-NH2 at the technical inquiry form on this page</p>

<p>Peptide Fluor-SDKP-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>STAMBPL1 antibody was raised in mouse using recombinant Human Stam Binding Protein-Like 1 (Stambpl1)</p>

<p>Mouse Monoclonal Cyfra21-1 antibody (HRP conjugated)</p>

<p>Streptococcus group A antibody was raised in mouse using group A streptococci as the immunogen.</p>

<p>Mevastatin is a drug that inhibits the synthesis of cholesterol and has been used to treat hypercholesterolemia. It binds to the hydroxyl group at position 3 on the mevalonate molecule, which prevents the formation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) and consequently reduces the production of cholesterol. Mevastatin has been shown to inhibit mitochondrial functions in wild-type strain yeast cells and myeloma cell lines, which may be due to receptor activity.</p>

<p>Oxcarbazepine metabolite; anticonvulsant; sodium channel blocker</p>

<p>Peptide H-AVL^TIDEK-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Ac-CDDGSYSVTAILFRGE-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CDDGSYSVTAILFRGE-NH2 is provided at greater that &gt;85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CDDGSYSVTAILFRGE-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CDDGSYSVTAILFRGE-NH2 at the technical inquiry form on this page</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>The MDMA antibody is a monoclonal antibody that is used in Life Sciences research. It has the ability to specifically bind to MDMA (3,4-methylenedioxymethamphetamine), commonly known as ecstasy. This antibody can be used for various applications, such as detecting MDMA in biological samples or studying its effects on different systems.</p>

<p>Inhibitor of lipoprotein-associated phospholipase A2</p>

<p>The Testosterone monoclonal antibody is a highly specialized product in the field of Life Sciences. It belongs to the category of Monoclonal Antibodies and is specifically designed to target testosterone, a hormone found in both males and females.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>3-o-Methyldopa d3 is an isotopically labeled analog of 3-o-Methyldopa, which is a deuterated compound used primarily in biochemical and pharmacokinetic research. This compound is a synthetic derivative where three hydrogen atoms are replaced by deuterium, offering a stable and non-radioactive isotopic tracer. The source of 3-o-Methyldopa d3 is chemical synthesis, where precise isotopic labeling techniques are employed.</p>

<p>2-((3-(acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl)amino)-2-deoxy-D-glucitol (NU7441) is a potent inhibitor of P-glycoprotein and a potential therapeutic agent for bowel disease. NU7441 also inhibits mitochondrial ATPase activity and nitric oxide production in vitro, which may contribute to its cytotoxicity. NU7441 has been shown to produce significant cytotoxicity in cultured cells and to inhibit hepatitis virus replication in cell cultures. It also has potent inhibitory properties against Toll-like receptor 4 (TLR4), which is involved in the recognition of bacterial lipopolysaccharides. It has been shown that this drug is effective against autoimmune diseases such as multiple sclerosis (MS).</p>

<p>Zika virus NS1 protein is a cytotoxic protein that plays a crucial role in the pathogenesis of Zika virus infection. It has been shown to interact with various molecules and cellular processes, including oncostatin, angptl3, e-cadherin expression, β-catenin, taxol, and osteopontin. This recombinant protein is widely used in the field of Life Sciences for research purposes, such as hybridization studies and monoclonal antibody development. The Zika virus NS1 protein is highly activated and can induce significant cellular responses. Its study provides valuable insights into the mechanisms of Zika virus infection and potential therapeutic targets.</p>

<p>Please enquire for more information about Troponin T Positive Human Plasma (Li Heparin) including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Inhibits EZH2 methyltransferase; antineoplastic</p>

<p>Ranitidine is classified as a histamine antagonist that reduces gastric acid section by blocking the H2- receptor. It decreases the amount of acid in the stomach. It is used to treat conditions such as ulcers, Zollinger-Ellison syndrome and GERD.</p>

<p>Dopamine receptor ligand; anti-parkinsonian</p>

<p>This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&amp;D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>

<p>Please enquire for more information about Low Hemolyzed Human Plasma from Cadaver including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about CCP Antibody Positive Human Serum including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>