Biochemicals and Reagents

<p>NGF</p>

<p>H-DELLGAARQDDPTLI-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-DELLGAARQDDPTLI-OH is provided at greater that &gt;80% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-DELLGAARQDDPTLI-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-DELLGAARQDDPTLI-OH at the technical inquiry form on this page</p>

<p>Ferritin antibody was raised in mouse using human ferritin as the immunogen.</p>

<p>Mouse anti Human IgE is a secondary antibody that is commonly used in Life Sciences research. It is specifically designed to bind to and detect human IgE antibodies. This antibody is buffered for stability and can be used in various applications, including immunohistochemistry, Western blotting, and ELISA.</p>

<p>hCG Beta antibody was raised in mouse using human chorionic gonadotropin beta subunit as the immunogen.</p>

<p>Rosuvastatin is a drug that belongs to the group of statins. It is used for the treatment of high cholesterol and as an adjunct therapy for patients with coronary heart disease. Rosuvastatin reduces serum cholesterol by inhibiting HMG-CoA reductase, which is the rate-limiting enzyme in the production of cholesterol. Furthermore, this drug has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis.</p>

<p>SCO-267 is a highly purified chemical compound used as a selective enzyme inhibitor, which is derived from synthetic sources. This compound acts by specifically binding to the active site of its target enzyme, effectively inhibiting its biological activity. Through competitive inhibition, SCO-267 modulates enzymatic pathways, facilitating research into metabolic processes and enzyme kinetics.</p>

<p>GLAST/ EAAT-1 (glutamate-aspartate transporter/ excitatory amino acid transporter 1) (rodent/human nomenclature) is a sodium-dependent plasma membrane glutamate transporter expressed exclusively by astrocytes in the cerebellum and present at high densities near excitatory synapses. The cerebellum is the region of the brain essential for maintaining postural control and coordination of voluntary muscle movement. Glutamate transporters regulate glutamate receptors and limit glutamate accumulation to prevent neurotoxicity whilst ensuring accurate synaptic communication. GLAST is the major transporter expressed during development. Loss of GLAST/EAAT-1 has been linked to the pathogenesis of several disorders affecting the motor system including several subtypes of spinocerebellar ataxia (SCA); SCA1, SCA5, SCA7, episodic ataxia type 6, spinal muscular atrophy and fragile X associated tremor/ataxia syndrome. Furthermore, disrupted GLAST/EAAT-1 has been associated with schizophrenia and cerebellar dysfunction and also is linked to the pathophysiology of Alzheimer's disease, autism and other cognitive and neuropsychiatric disorders. This antibody has AF488 conjugated to it. AF488 is a popular bright green fluorescent dye with high PH-stability.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Gene therapy is potentially an ideal treatment for muscle tissue myopathies but targeting remains an issue. The large volume of muscle in the body versus the requirement for tissue-specificity is of particular concern. This heptapeptide has been shown to preferentially bind skeletal myofibers and thus can be used to study targeting of peptide/gene-delivery to muscle tissue. Research into gene therapy of Duchenne muscular dystrophy (DMD) and spinal muscular atrophy (SMA) has been of particular interest with muscle targeting peptides. This product already shows ideal placement to continue that research to overcome some of these issues.</p>

<p>Please enquire for more information about C.I.Disperse Orange 32 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CKMM antibody was raised in goat using human skeletal muscle CK-MM isoenzyme as the immunogen.</p>

<p>Peptide H-YPIPPPDAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that have been divided into three groups based on sequence, putative signal transduction mechanisms, and pharmacologic properties. mGluR1 is a group I receptor. Group I mGluRs are predominantly expressed in the postsynaptic somatodendritic regions, especially in brain areas highly responsive to psychostimulants. mGluR1 is a pivotal regulator of glutamatergic neurotransmission which is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions._x000D_<br>_x000D_<br>Group I mGluRs are coupled exclusively to Gq protein (Gq/11), a heterotrimeric G protein subunit that activates phospholipase C (PLC) and regulates inositol 1,4,5-tris phosphate (IP3) receptors via association with the synaptic scaffolding protein, Homer._x000D_<br>_x000D_<br>mGluRs modulate neuronal excitability and development, synaptic plasticity and neurotransmitter release underlying optimal cognitive function. Activation of mGluR1 facilitates long-term depression of parallel fiber-Purkinje cell synapses critical for cerebellar motor learning._x000D_<br>_x000D_<br>This antibody is conjugated to Alexa Fluor® 488, a popular bright green fluorescent dye with high pH-stability.</p>

<p>ATP synthase subunit β Heavy is derived from the ATP Synthase (the adenosine triphosphate synthase enzymatic complex) and uses the proton-motive force produced by the electron transfer chain to synthesise ATP from ADP and inorganic phosphate. It functions in the inner mitochondrial membrane, prokaryotic members and chloroplasts.Structurally bacterial ATP synthase contains two multisubunit domains called F1 and F0. F1 which is responsible for the catalytic activity of the ATP synthase is made up of the 5 subunits α3, β3, γ, δ, ε and F0 contains a membrane bound sector which creates a proton channel. F1 and F0 are connected by a peripheral stalk and a central stalk which links proton translocation and catalysis. Eukaryotic ATP synthase is similar to that of bacteria in terms of topology, structure and subunit composition.The Valine residue at position 8 has been isotopically labelled with carbon-13 (5) and nitrogen-15 (1), giving this peptide a mass increase of 6 compared to the unlabelled peptide.</p>

<p>Peptide Ac-CY-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>GLG1</p>

<p>Inhibitor of the Forkhead box M1 (FOXM1), an oncogene and a transcription factor regulating cell cycle progression, DNA damage repair and cell renewal. RCM 1 weakens the FOXM1 activity by inhibiting its nuclear localisation and increasing its degradation in proteasomes. The compound showed potential for asthma treatment since it inhibited goblet cell metaplasia and IL-13 signalling in mice.</p>

<p>Infliximab is a biologic medicine used in the treatment of numerous autoimmune diseases including Crohn disease, rheumatoid arthritis, and ankylosing spondylitis. Infliximab binds with high affinity to tumour necrosis factor-α (TNF-α) blocking most of the cytokine effects, which includes mediating the inflammatory responses. Infliximab is a chimeric human-mouse IgG monoclonal antibody- the constant regions of the heavy and light chains are human-derived. The heavy chain peptide (46-60) has been identified as an antigen for antigen-specific T cell analysis. Numerous methods of immunological analysis can be applied to this peptide to hopefully provide further insight to these autoimmune conditions.</p>

<p>The alpha factor pheromone arrests yeast in the G1 phase of their cell cycle, this allows the opposite mating type cells to synchronise. Alpha factor mating pheromone induces the expression of mating genes, changes in nuclear architecture, and polarizes growth toward the mating partner. STE2 encodes the alpha factor pheromone transmembrane G-protein coupled receptor (GPCR) found on mating-type-A cells in yeast. Alpha factor binds Ste2 and activates prototypic mitogen-activated protein kinase (MAPK) cascade. The dose of pheromone exposure differentially activates the MAPK Fus3 for alternate effects. A high dose of alpha factor leads to growth arrest and schmooing formation for mating, a lower dose causes elongated cell growth.</p>

<p>Histone H3 (1-20)-[S]-Biotin is derived from Histone 3 (H3) which is one of the four core histones (H2A, H2B, H3 and H4) fundamental in compacting eukaryotic DNA into a structure known as the nucleosome. The nucleosome arises when 147 base pairs of DNA wrap around a H3-H4 tetramer and two H2A-H2B dimers, forming the histone octamer core. Both H4 and H3 are highly conserved and perform roles in binding to segments of DNA which enter and leave the nucleosome and in chromatin formation. Similar to the other core histone, H3 has a globular domain and a flexible N-terminal domain, 'histone tail' which can undergo modifications such as acetylation, methylation, phosphorylation and ubiquitination. Due to histones containing a large number of lysine and arginine residues they have a positive net charge which interacts in an electrostatic manner with the negatively charged phosphate groups in DNA. The transcriptional activation or silencing of the chromatin is controlled by ATP-dependent chromatin remodelling factors and histone modifying enzymes which target histone proteins. Both processes function to alter the positioning of the nucleosome, allowing the DNA it to be either available or inaccessible to the transcription machinery.Another modification process histones can undergo is biotinylation where the covalent attachment of a biotin molecule is catalysed by the enzyme Biotinidase. This cleaves biocytin to generate a biotinyl-thiester intermediate. The biotinyl can then be transferred onto the histone lysine ɛ-amino group which in this case it is covalently attached to Histone 3. Overall the biotinylation sites identified in histone 3 are: K4, K9 and K18. The presence of biotinylated histones have been detected in human cells such as lymphocytes and lymphomas.</p>

<p>CID 4921527 is a high-purity research tool that is an inhibitor of ion channels. It binds to the ligand binding site of the Ligand and inhibits activation of the receptor by its natural ligands. CID 4921527 is used to study protein interactions and protein-protein interactions. This compound has been shown to be an activator, as it increases the activity of peptides and antibodies in a wide range of assays, including enzyme-linked immunosorbent assay (ELISA) for the detection of proteins.</p>

<p>PPARγ antagonist</p>

<p>Troponin T antibody (cardiac) was raised in mouse using free human cTnT as the immunogen.</p>

<p>The Osteocalcin Antibody is a highly effective family kinase inhibitor that is widely used in Life Sciences assays. This Monoclonal Antibody specifically targets collagen and has been extensively tested for its serine protease inhibitory activity. It is also known for its ability to neutralize antibodies, making it an essential tool in various research applications. The Osteocalcin Antibody has been proven to effectively bind to alpha-fetoprotein, providing accurate and reliable results in diagnostic tests. With its exceptional protein kinase inhibitory properties, this Antibody offers precise and reproducible data for researchers in the field of chemokine studies. Trust the Osteocalcin Antibody for exceptional performance and reliable results in your experiments.</p>

<p>Mouse monoclonal Heat Labile Enterotoxin antibody</p>

<p>Butyryl cholinesterase antibody was raised in rabbit using cholinesterase isolated from human serum as the immunogen.</p>

<p>Auto-inducing peptide (AIP) is a cyclic thiolactone quorum sensing peptide from Staphylococcus aureus which is responsible for activating the agr response. AIP is released from the bacteria and its extracellular concentration is then sensed by a two-component system on the bacterial surface, AgrC and AgrA. AgrC is the membrane histidine kinase receptor and AgrA is a response regulator- upon binding of AIP, AgrC phosphorylates AgrA.AIP accumulates during growth activating an AgrC and AgrA cascade when it reaches a critical signal level. This cascade activates P2 and P3 promoters which autoactivate the agr system and upregulate RNAIII transcription. RNAIII regulates the expression of virulence factors including toxins, super-antigens, and exo-enzymes. Extensive research to identify AIP:AgrC inhibitors aims to find therapeutics against pathogens.AgrD is the precursor peptide of AIP, and AgrB is an integral membrane endopeptidase essential to biosynthesize AIP. This AIP system is conserved among many Gram-positive bacteria. S. aureus strains are categorized into four groups (I-IV) according to their AIP signal and cognate extracellular receptor, AgrC.AIP-II has the conserved thiolactone macrocycle of the AIP family. Asn-3, Leu-8, and Phe-9 have been shown to be critical for activation of the agr response while inhibition relies on Leu-8 and Phe-9. The reactive thiol ester bond is only necessary for activation of the agr response. Further work may provide further AIP:AgrC inhibitors.</p>

<p>Ac-CHISPSFKDRVA-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CHISPSFKDRVA-NH2 is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CHISPSFKDRVA-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CHISPSFKDRVA-NH2 at the technical inquiry form on this page</p>

<p>Purified recombinant p47 Treponema Pallidum protein</p>

<p>The PSA antibody is a monoclonal antibody that is used for the detection and measurement of prostate-specific antigen (PSA) in human serum. It specifically binds to PSA, which is a growth factor produced by the prostate gland. The PSA antibody can be used in various applications such as immunoassays and bioassays for ultrasensitive detection of PSA levels. It works by utilizing electrochemical impedance spectroscopy, where the antibody-coated electrode reacts with the PSA present in the sample, resulting in a measurable change in electrical properties. This highly reactive monoclonal antibody provides accurate and reliable results, making it an essential tool in prostate cancer screening and diagnosis. Additionally, it has potential applications in research related to collagen and epidermal growth factor. Trust the PSA antibody for precise and efficient detection of PSA levels, aiding in early detection and monitoring of prostate cancer.</p>

<p>Morphine antibody was raised in rabbit using morphine-hemisuccinate as the immunogen.</p>

<p>Inhibitor of CDK2, JAK2 and FLT3; anticancer</p>

<p>H-PYLFWLAAI-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-PYLFWLAAI-OH is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-PYLFWLAAI-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-PYLFWLAAI-OH at the technical inquiry form on this page</p>

<p>Inhibits binding of endogenous ligands to peroxisome proliferator-activated receptor gamma (PPARγ), blocking its activation and transcription. Unlike orthosteric antagonists GW 9662 and T 0070907, SR 16832 blocks both allosteric and orthosteric activation of PPARγ.</p>

<p>Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.</p>

<p>Leptin and melanocortin are well characterised for their roles in energy balance and the regulation of feeding. However, xenin was subsequently isolated from human gastric mucosa and identified as a gastrointestinal peptide hormone. Evidence shows xenin plasma levels rise after meals while administration of xenin leads to feelings of satiation. Unfortunately, the mechanism of xenin regulation on food uptake is still not fully understood. Work has shown xenin negatively effects food intake by a dose dependent manner, the hypothalamus seems to have a key role in this. Furthermore, the signally pathways activated by xenin is independent of those used by leptin or melanocortins. Further work with xenin could provide vital answers to the inhibitory mechanism of this gastrointestinal hormone. It would provide more data to help tackle the ongoing obesity crisis and rise in the number of diabetic patients.</p>

<p>NMDA receptor antagonist</p>

<p>Nangibotide, also referred as LR12, is an antagonist of triggering receptor expressed on myeloid cells (TREM)-1, and was derived from residues 94 to 105 of TREM-like transcript-1 (TLT-1).TREM-1 plays a crucial role in the onset of sepsis by amplifying the host immune response. TLT-1- and TLT-1-derived peptides therefore exhibit anti-inflammatory properties by dampening TREM-1 signalling.  LR12 blocks TREM-1 by binding to the TREM-1 ligand and provides protective effects during sepsis such as inhibiting hyper-responsiveness, organ damage, and death, without causing deleterious effects. The protective effects of modulating TREM-1 signalling are also evident in other models of inflammation such as: pancreatitis- haemorrhagic shock- inflammatory bowel diseases and inflammatory arthritis.</p>

<p>H-QLIVPLIPSIVDR-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-QLIVPLIPSIVDR-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-QLIVPLIPSIVDR-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-QLIVPLIPSIVDR-OH at the technical inquiry form on this page</p>

<p>TORC-2</p>

<p>Desipramine antibody was raised in mouse using Imipramine conjugated to KLH as the immunogen.</p>

<p>H-Tyr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB is a building block that is used in peptide synthesis. It is a thiol-reactive resin with a pendant amine group. H-Tyr(tBu)-2-ClTrt-Resin (100-200 mesh) 1% DVB is soluble in common organic solvents and can be used for the synthesis of peptides with amino acids containing aromatic rings.</p>

<p>Adenovirus antibody was raised in mouse using ADV as the immunogen.</p>

<p>Boc-Dap-OtBu hydrochloride salt is a chemical that is synthesized by anhydride and trifluoroacetic acid. It can be used in the laboratory for protein visualization, as well as to detect proteins using LC-MS. The presence of trifluoroacetic acid makes the Boc-Dap-OtBu hydrochloride salt fluorescent, which makes it possible to visualize the reaction products under UV light. This chemical is often used in fluorescence spectrometry to identify amino acids and other compounds.</p>

<p>(KFF)3K is a cationic cell penetrating peptide which can be conjugated to PNA oligomers to aid in their penetration of the bacterial cell wall to function as anti-microbials. (KFF)3K is labelled at the N-terminus with an alkyne attachment for ease of reaction with an opposite Click reactive partner (azide).</p>

<p>Peptide H-NLFLNHSENATAK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide Ac-CDGPTEIYKLTRKEAQE-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Purified Guinea Pig IgG (Fab'2)</p>

<p>3-O-Octadecyl-2-O-methyl-sn-glycerol is a molecule that has been shown to have apoptotic effects on HL60 human cells. It is also a synthetic compound that functions as an anti-viral agent. 3-O-Octadecyl-2-O-methyl-sn glycerol has been shown to be a factor receptor for uptake in HL60 cells and can inhibit the growth of cancer cells by inducing apoptosis. This molecule was originally synthesized with the intention of highlighting unsaturated alkyl groups.</p>