Biochemicals and Reagents

<p>Chlamydia Trachomatis IgG/IgA/IgM Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Chlamydia Trachomatis IgG/IgA/IgM Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>CMV IgM seroconversion panel 1 is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about CMV IgM seroconversion panel 1 including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Entamoeba Histolytica IgG Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Entamoeba Histolytica IgG Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Enterovirus IgG Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Enterovirus IgG Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Chagas Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Chagas Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Peptide H-LHDFRHQIL^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-NYLNYGEEGAPGK^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>HSV-1/2 Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about HSV-1/2 Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>tTg IgA/IgG Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about tTg IgA/IgG Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>An inhibitor of E2F1 and 3a transcription, with a D substituted arginine which confers resistance to proteolysis after pre-incubation in serum. Cytotoxic to several malignant cell lines and human prostate and small cell lung cancer xenografts.</p>

<p>ANA/SLE Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about ANA/SLE Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Giardia lamblia antibody was raised in rabbit using whole organism homogenates; G. lamblia (E1) grown in tissue culture after isolation from human donor, as the immunogen.</p>

<p>Cardiolipin/Beta-2-glycoprotein-1 IgM Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Cardiolipin/Beta-2-glycoprotein-1 IgM Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Type 1 Diabetes/Stiff Person Syndrome Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Type 1 Diabetes/Stiff Person Syndrome Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Coxiella Burnetti (Q-fever) Phase 2 IgG Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Coxiella Burnetti (Q-fever) Phase 2 IgG Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>West Nile Virus IgG Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about West Nile Virus IgG Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Ac-CPRKMAGEMVEGLRYVPRS-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CPRKMAGEMVEGLRYVPRS-NH2 is provided at greater that &gt;85% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CPRKMAGEMVEGLRYVPRS-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CPRKMAGEMVEGLRYVPRS-NH2 at the technical inquiry form on this page</p>

<p>The RGD peptide is a ligand for cell-surface integrin receptors, which are used by most cells to attach to and sense the extracellular environment and to establish a cytoskeleton. RGD peptide can be attached to biologically important molecules, such as nanoparticles, to enable active targeting of drugs or gene delivery. Model substrates presenting immobilised RGD peptide can be used to promote the adhesion and spreading of cells which have been engineered to expresses integrin receptors such as the platelet cell-surface integrin receptor, alphaIIbβ3. Cells growing in these conditions appear to have well developed cytoskeletons suggesting that binding to the integrin receptor mediates biologically relevant adhesion and RGD substrates are able to support cell survival. Peptide is labelled with an N-terminal 5-carboxyfluorescein (5-FAM), a widely used green fluorescent tag.</p>

<p>Vasopressin analog; vasoactive agent</p>

<p>Ac-CMDEELHYASLN-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-CMDEELHYASLN-NH2 is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-CMDEELHYASLN-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-CMDEELHYASLN-NH2 at the technical inquiry form on this page</p>

<p>Mycoplasma Hominis IgM Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Mycoplasma Hominis IgM Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Aspergillus Fumigatus IgG Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Aspergillus Fumigatus IgG Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>PM/Scl Antibody Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about PM/Scl Antibody Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>Cardiolipin IgG/Beta-2-glycoprotein-1 IgG Positive Human Plasma is a life science tool for use in pharmaceutical and diagnostic applications. Please enquire for more information about Cardiolipin IgG/Beta-2-glycoprotein-1 IgG Positive Human Plasma including the price, delivery time and more detailed product information at the technical inquiry form on this page.</p>

<p>The Mouse Monoclonal Antibody to Metapneumovirus is a highly specific and effective tool for the detection and research of human metapneumovirus (HMPV). This mouse monoclonal antibody is produced using recombinant metapneumovirus antigen, ensuring its high affinity and specificity for HMPV. It can be used in various applications such as ELISA, Western blotting, immunohistochemistry, and flow cytometry. With its exceptional sensitivity and reliability, this antibody enables accurate detection and identification of HMPV in clinical samples. It plays a crucial role in understanding the pathogenesis of HMPV infections and developing effective diagnostic methods. Researchers and healthcare professionals can rely on this mouse monoclonal antibody to advance their studies on HMPV and contribute to the development of preventive measures and therapeutics against this respiratory virus. Order the Mouse Monoclonal Antibody to Metapneumovirus today.</p>

<p>This peptide is recognised and cleaved by the enzyme Sortase A (SrtA) from-Staphylococcus aureus. The catalytic cysteine residue in the active site of SrtA, serves as a nucleophile to cleave the peptide bond between threonine and glycine. Cleavage results in the formation of a thioacyl intermediate between the peptide and SrtA. This intermediate is then resolved by the N-terminus of an (oligo)glycine nucleophile, resulting in the creation of a new peptide bond that links the peptide and its biotin tag to the incoming nucleophile.- This method of protein labelling is known as sortagging.This peptide contains an N-terminal biotin tag for detection and purification.</p>

<p>Human γHV Epstein-Barr virus (EBV) is host-specific, making it challenging to study. Evidence suggests EBV infection provides an enhanced immune response against other future heterologous infections. Murid herpesvirus 4 (MuHV-4) in mice can be used as a model to help understand herpesviruses. The peptide provided here (ORF65131-140) has been used in CTL assays to show that MuHV-4 improves the effector CD8+ T cells response against a heterologous virus. MuHV-4 ORF65131-140 epitope can stimulate interleukin production ex vivo and be detected by tetramer staining to MHC. Further work with MuHV-4 ORF65131-140 could be crucial for understanding the reactivity of the human immune system to other viruses after infection with γHV Epstein-Barr virus (EBV).</p>

<p>Trofinetide is a neuroprotective compound that acts as an antioxidant. Trofinetide has been shown to reduce oxidative stress and protect against neuronal death in cells. It also has been shown to improve the clinical response in patients with Alzheimer's disease, and may be used for the treatment of other neurodegenerative disorders such as Parkinson's disease. Trofinetide is orally administered and is metabolized by cytochrome P450 enzymes, which makes it a suitable candidate for specific treatments. The pharmacokinetic properties of trofinetide are not well understood due to its short half-life.</p>

<p>Peptide H-VLNQFDDAGIVTR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>C.I. Direct Red 89 is a water-soluble dye that belongs to the group of organic compounds called sulfonated naphthol dyes. It has an absorption spectrum in the region of 540-580 nm and is used as a neutral red dye for inkjet and recording applications, as well as for textile printing. C.I. Direct Red 89 can be used with other dyes for pigments, especially blue, green, and violet dyes, to produce a wide range of colors from yellow through green to blue-green. The dye is also used in pharmaceuticals, cosmetics, food coloring agents, and industrial paints.</p>

<p>Competitive oxytocin receptor antagonist. Inhibits oxytocin-induced uterine contractions in vitro and in in vivo models of preterm labor.  Acts via Gαi signalling and activates NF-κB and MAPK pathways to elicit proinflammatory effects in the amnion.</p>

<p>Please enquire for more information about C.I.Basic Yellow 96 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Peptide H-GFPGIQGR^-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide H-AISEELDHAL^NDMTSI-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>DNA antibody was raised in mouse using calf thymus DNA as the immunogen.</p>

<p>Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool</p>

<p>Arginine vasopressin (AVP) is a neurohypophysial hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. The major function of AVP is to regulate extracellular fluid volume and electrolyte homeostasis via its anti-diuretic action. It is also a vasoconstrictor and pressor agent. AVP is important to the central nervous system (CNS) and also has physiological actions in the peripheral organs, such as the kidney, heart and vascular beds.</p>

<p>Amyloid β precursor-like protein 2 (APLP2) (also known as YWK-II) is a type I transmembrane protein belonging to the amyloid precursor protein (APP) gene family. The APP gene family also contains APP and APLP1 and has been associated with Alzheimer's disease pathogenesis as well as playing a pivotal role in processes underlying normal brain development and postnatal survival. APLP2 is ubiquitously expressed during embryonic development and in most adult tissues, in a pattern largely overlapping with APP. APLP2 is processed by alpha-, β- and γ-secretase and its cleavage is regulated by insulin-like growth factor 1 (IGF-1), epidermal growth factor, phorbol 12-myristate 13-acetate (PMA), and retinoic acid.APLP2 has been linked to the development and progression of a number of cancer types, including pancreatic, Ewing's sarcoma, colon, breast, lung and prostate cancer where it is often overexpressed, although significant downregulation of APLP2 is seen in neuroendocrine lung tumours. APLP2 expression is often associated with abnormal growth, migration and invasion in cancer cells. APLP2 expression may increase gradually with the advancement of cancer progression. Different APLP2 splice isoforms may have an influence on cancer development.The Lysine residue at position 17 of this peptide is isotopically labelled with carbon-13 (6) and nitrogen-15 (2), giving this peptide a mass increase of 8 compared to the unlabelled peptide.</p>

<p>Cytokeratin 9 (164-170) is derived from the cytoskeleton component cytokeratin, a family of intermediate filamentous proteins which have structural and mechanical functions in the cell. The cytokeratin family contains cytokeratins 1-20, where cytokeratins 1-8 are categorised as being type II basic, while cytokeratins 9-20 are categorised as being type I acidic. Cytokeratins 1 to 20 have been ordered regarding their molecular weight, where cytokeratin 1 has the highest molecular weight and cytokeratin 20 has the smallest.The expression of Cytokeratins in the epithelial tissues is dependent on where it is located in the body and at which stage of differentiation and development the organism is at. Consequently cytokeratins can be used as tissue specific markers (for example an ocular surface epithelia marker) and to investigate cell differentiation progression.The lysine residue at position 7 is isotopically labelled with carbond-13 (6) and nitrogen-15 (2).</p>

<p>Pro-opiomelonocortin  (POMC) is cleaved into many products including β-Lipotropin.  β-Lipotropin is a precursor of several peptides including β- melanocyte-stimulating hormone (β-MSH). β-MSH is primarily found in the pituitary gland. β-MSH regulates feeding and levels change with the nutritional status. β-MSH is a melanocortin receptor agonist, particularly MC4R. The hypothalamic melanocortin system provides the most robust neural signals to inhibit caloric intake. A better understanding may provide novel methods of manipulation to tackle obesity.β-MSH directly stimulates the corticotropic axis and cortisol inhibits β-MSH. β-MSH's role is to optimize the general catabolic activity of the organism in an immediate manner. β-MSH stimulates cortisol release without the aid of adrenocorticotropic hormone (ACTH) and pulls thyroid activity outside the vertical feedback information of thyroid releasing hormone (TRH) and thyroid stimulating hormone (TSH).β-MSH(1-18) levels have been shown to significantly reduce following cells' exposure to fatty acid palmitate. LC-MS/MS is effective at detecting POMC-derived peptides and shows fatty acids can dramatically reduce the production of POMC-derived peptides including β-MSH(1-18). Hypothalamic inflammation triggered by dietary fats can affect POMC neurons. The work with β-MSH(1-18)  helps provide insight into the mechanism behind diet-induced obesity.This β-MSH(1-18) phenylalanine residue is isotopically labelled with carbon-13 (9) and nitrogen-15 (1), giving this peptide a mass increase of 10 compared to the unlabelled peptide. This will allow absolute quantification applications such as quantitative proteomics, the quantification of complex protein mixture at very low concentrations, or NMR studies.</p>

<p>Carbamazepine is an anticonvulsant that is used to treat epilepsy and nerve pain from trigeminal neuralgia. The mechanism of action for Carbamazepine is not well understood but it is theorized that carbamazepine reduces seizure activity by preventing sodium channel activation. This interaction reduces the frequency and duration of sodium channel opening, slowing down nerve impulses and helping to prevent seizures Studies on animals have shown that carbamazepine works by reducing polysynaptic nerve response and preventing post-tetanic potentiation.</p>

<p>Peptide H-SSKITHR^IHWESASLLR-OH is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice.</p>

<p>Peptide derived from the Gastric inhibitory polypeptide (GIP), an inhibiting hormone of the secretin family of hormones. While GIP is a weak inhibitor of gastric acid secretion, its main role is to stimulate insulin secretion - in a glucose-dependent mechanism. Therefore, GIP is referred to as a glucose-dependent insulinotropic peptide.GIP is derived from a 153-amino acid pro-protein encoded by the GIP gene and circulates as a biologically active 42-amino acid peptide. It is synthesised by K cells, which are found in the mucosa of the duodenum and the jejunum of the gastrointestinal tract. GIP receptors are seven-transmembrane proteins found on β-cells in the pancreas. These β-cells are those that are able to simultaneously detect glucose and release insulin as a result to GIP binding.The clinical relevance of GIP is related to type 2 diabetes mellitus (T2DM)- studies have found that T2DM diabetics are unresponsive to GIP and have lower levels of GIP secretion after a meal when compared to non-diabetics. In research involving knockout mice, it was found that absence of the GIP receptors correlates with resistance to obesity.</p>

<p>H-CGGAGNRVRRSVGSSLSS-OH is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. H-CGGAGNRVRRSVGSSLSS-OH is provided at greater that &gt;95% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer H-CGGAGNRVRRSVGSSLSS-OH in bulk quantities in addition to our standard pack sizes.Please enquire for more information about H-CGGAGNRVRRSVGSSLSS-OH at the technical inquiry form on this page</p>

<p>Tiapride is a dopamine receptor antagonist that is used in the treatment for anxiety and chorea in Huntington’s disease. It also is used to ease agitation in elderly patients. Although its mechanism of action is not fully understood, this drug is believed to modulate dopamine receptors in the brain, particularly D2 and D3 receptors, which can help regulate dopamine transmission and balance in the central nervous system.</p>

<p>ACTH is a member of the melanocortins peptide family, this tropic hormone is produced and secreted by the anterior pituitary gland. ACTH is an important component of the hypothalamic-pituitary-adrenal (HPA) axis and is often produced in response to biological stress. ACTH acts to increase the production and release of cortisol via its interaction with ACTHR. Receptor activation increases the intracellular concentration of cAMP via adenylyl cyclase. Abnormal ACTH levels in the body have been linked to primary adrenal insufficiency/Addison's disease, Cushing's disease and secondary adrenal insufficiency.It contains 5-Carboxyfluorescein (5-FAM), a widely used green fluorescent tag.</p>

<p>Goat anti Canine IgE (HRP) was raised in goat using canine IgE as the immunogen.</p>

<p>A small molecule inhibitor of polycomb complex protein BMI-1, a gene often overexpressed in tumors and therefore a popular therapeutic target in cancer. Anti-tumor effects of PTC 209 have been demonstrated in colorectal carcinoma, acute myeloid leukemia, multiple myeloma and head neck squamous cell carcinoma. As a regulator of self-renewal, inhibition of BMI-1 by PTC 209 also reduces growth of colorectal cancer initiating cells.</p>

<p>Ac-SPELQRTPLHKSTTC-NH2 is a custom peptide that can be synthesized rapidly by our peptide experts in under 2 weeks. Ac-SPELQRTPLHKSTTC-NH2 is provided at greater that &gt;90% purity (HPLC) from Cymit Quimica for a variety of research applications. We also offer Ac-SPELQRTPLHKSTTC-NH2 in bulk quantities in addition to our standard pack sizes.Please enquire for more information about Ac-SPELQRTPLHKSTTC-NH2 at the technical inquiry form on this page</p>

<p>Inhibitor of GSK3 kinase; activator of Wnt signalling</p>