Antibiotics

SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor, demonstrating potent antifungal activity with an inhibition concentration (IC50) of 7.2 μg/mL and an

Compound 6d (Antibacterial agent 159) is an antibiotic effective against impetigo and Clostridium difficile infection (CDI), with no observed recurrence for CDI

CcpA-IN-1 is a Staphylococcus aureus antibiotic exhibiting significant bactericidal activity (MICs=460 nM) [1].

Caerulomycin A (Caerulomycin) (Cerulomycin; Caerulomycin) is an antifungal compound.

Myxopyronin A is an inhibitor of bacterial RNA polymerase.

S-Adenosylhomocysteine (SAH) hydrolase is responsible for the reversible hydrolysis of SAH into adenosine and homocysteine. Inhibition of this enzyme leads to the accumulation of SAH within cells, thereby increasing the SAH to S-adenosylmethionine (SAM) ratio and subsequently inhibiting SAM-dependent methyltransferases. (−)-Neplanocin A, a potent and irreversible inhibitor of SAH hydrolase (Ki= 8.39 nM), exhibits significant antitumor activity against mouse leukemia L1210 cells and holds broad-spectrum antiviral properties. Its efficacy notably surpasses that of the reversible inhibitor 3-deazaneplanocin, especially in combating vesicular stomatitis, evidencing a higher potency with ID50 values of 0.07 μg/ml for Neplanocin A versus 0.3 μg/ml for 3-deazaneplanocin.

Annamycin, a semi-synthetic doxorubicin derivative, binds DNA, blocks topoisomerase II, and evades MDR, inhibiting DNA/RNA/protein synthesis.

Nilofabicin (CG-400549) is a potent inhibitor of enoyl-(acyl-carrier-protein) reductase fall(FabI) and can be used in studies about the treatment of complicated

DuP-721: broad-spectrum, oral antibiotic targeting various bacteria, including M. tuberculosis.

Cladosporin, from Cladosporium cladosporioid fungus, halts dermatophyte growth on agar at 75 μg/mL.

N-(3-Oxobutanoyl)-L-homoserine lactone (3-oxo-C4-HSL) serves as an autoregulator for carbapenem antibiotic biosynthesis in Erwinia carotovora ATCC 39048 and induces the expression of rhiI in R. leguminosarum [1].

β-Lactamase-IN-2 is an inhibitor of β-Lactamase with anti-microbial and anti-bacterial effects.

OM173-αA is a quinone bacterial metabolite that inhibits the growth of the bacteria M.

Oseltamivir acid methyl ester, a CES1-convertible neuraminidase inhibitor, serves as an antiviral prodrug.

Carumonam is a synthetic monobactam antibiotic, which is derived from chemically modifying aztreonam to enhance its antimicrobial properties. Its source is entirely synthetic, allowing for precise structural modifications to target specific bacterial pathogens. The mode of action involves the inhibition of bacterial cell wall synthesis. Carumonam binds to penicillin-binding proteins (PBPs) on the surface of bacterial cell walls, disrupting the peptidoglycan cross-linking process necessary for cell wall strength and integrity. This action results in bacterial cell lysis and death, making it effective against a range of Gram-negative bacteria.

Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.

Desoxymycin is an antibiotic product that belongs to the class of aminoglycosides, which is derived from natural sources such as certain species of Streptomyces bacteria. This compound exhibits its mode of action by specifically binding to the bacterial ribosomal RNA, interfering with protein synthesis. As a result, it inhibits the replication and growth of susceptible bacterial strains.

N-Acetylamphotericin B is a derivative of the well-known antifungal agent Amphotericin B, which is derived from the bacterium *Streptomyces nodosus*. This compound is an acetylated version of Amphotericin B, designed to improve certain pharmacokinetic properties. It operates by binding to ergosterol, a key component of fungal cell membranes, leading to the formation of pores that disrupt membrane integrity, causing cell death. The acetylation is intended to reduce the compound's cytotoxicity and improve its solubility in aqueous solutions, potentially allowing for enhanced therapeutic applications.

Gramicidin S hydrochloride is a cyclic peptide antibiotic, which is a derivative of the naturally occurring antibiotic gramicidin S. It is sourced from Bacillus brevis, a type of soil bacterium. This peptide operates through a unique mode of action, whereby it disrupts bacterial cell membranes. By integrating into the lipid bilayer, it increases membrane permeability, leading to leakage of essential ions and molecules, and ultimately causing cell death.