Immunology Antibodies
Immunology antibodies are crucial for detecting and studying components of the immune system, including cytokines, chemokines, immune cell markers, and other regulatory proteins. They are widely used in research on autoimmune diseases, infectious diseases, and immune response modulation. At CymitQuimica, we offer a diverse range of immunology antibodies to enhance your research in immune system function and dysfunction.
Found 2585 products of "Immunology Antibodies"
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Ara h1 (555-577) peanut allergen
Ara h 1 is one of the major allergenic proteins from peanut (Arachis hypogaea) which contains approximately 13 potential allergenic proteins.Ara h 1 is a member of the 7/8 S globulin (vicilin) family of seed storage proteins belonging to the cupin superfamily and is the most abundant allergen present in the peanut kernel. Ara h 1 plays an important role in the allergy sensitising procedure and can be recognised by 90% of patients with a peanut allergy.This peptide represents a tryptic peptide of Ara h 1.Purity:Min. 95%Color and Shape:PowderMolecular weight:1,375.7 g/molPip6a
Pip6a is part of a novel series of transduction peptides termed Pips (PNA/PMO internalisation peptides). Pip peptides were designed around an original R6-penetratin cell penetrating peptide (CPP) and are able to transport PNA/PMO molecules across cell membranes. Pip peptides can be covalently conjugated to PNAs/PMOs to deliver them to a variety of adult tissues, including liver, kidney, skeletal muscle, diaphragm, and heart.Due to its ability to target the heart, pip6a has important implications for the development of therapeutic antisense oligonucleotide therapy using PMOs for diseases such as Duchenne muscular dystrophy (DMD). DMD causes progressive muscle weakening and often results in cardiac failure and death. Pip6a has also been studied for delivery of antisense oligonucleotide therapy in spinal muscular atrophy (SMA).
Purity:Min. 95%Color and Shape:PowderMolecular weight:2,952.6 g/molOVA (323-339)
CAS:Ovalbumin (OVA) is the primary protein in egg-white, and is involved in initiating food allergies and asthma. It is a highly immunogenic protein and can be used for peptide conjugation in the development of antibodies.OVA (323-339) is a class I (Kb)-restricted peptide epitope of OVA. The ovalbumin fragment is presented by the class I MHC molecule, H-2Kb.Formula:C74H120N26O25Purity:Min. 95%Color and Shape:PowderMolecular weight:1,773.93 g/molhsBCL9CT-24
Blocks the Wnt pathway and inhibits the expression of TGFb1 in CT26 colon carcinoma cells, leading to the reduction of CCL20 and CCL22, two TGF-b- dependent chemokines critical for Treg cell recruitment into the tumour microenvironment. hsBCL9CT-24 shows robust antitumour efficacy across multiple in vivo models.
Purity:Min. 95%Color and Shape:PowderMolecular weight:1,629 g/molCyclo(RGDfK)
The cyclic pentapeptide cyclo(Arg-Gly-Asp-[D-Phe]-Lys) is a highly potent and selective inhibitor for the alphavβ3 integrin receptor. A related compound, cyclo(Arg-Gly-Asp-[D-Phe]-Val), is a promising anticancer drug candidate- it inhibits angiogenesis and induces apoptosis in vascular cells.Cyclic RGD-containing peptides are selective antagonists of integrins, proteins that play important roles in cell-cell and cell-matrix interactions. In a suitably labelled form, these peptides may serve as useful tools for diagnostic imaging and peptide targeted therapy of some types of cancer.Color and Shape:PowderMolecular weight:603.3 g/molELA Elabela/Toddler-32
Elabela/Toddler-32 (ELA-32) has been identified as a new endogenous ligand for the apelin G protein coupled receptor (GPCR). Apelin levels have been shown to be reduced in heart failure and pulmonary arterial hypertension (PAH). ELA-32 delivery could be used to supplement the deficit of apelin. It can be cleaved to shorter forms Elabela/Toddler-21, and Elabela/Toddler-11. Apelin and ELA-32 share almost no sequence homology which is unusual for receptor ligands, it suggests a future for apelin receptor biased agonist design.Exogenous administration of ELA-32 to rats has been shown to compensate for the downregulation of apelin seen in PAH. Further research into the potential of this peptide as an endogenous agonist reducing the severity of PAH could provide vital therapeutics in the future for cardiovascular disease.Color and Shape:PowderMolecular weight:3,965.1 g/molOVA (250-264)
Ovalbumin (OVA) is the primary protein in egg-white, and is involved in initiating food allergies and asthma. It is a highly immunogenic protein and can be used for peptide conjugation in the development of antibodies.OVA (250-264) is a class I (Kb)-restricted peptide epitope of OVA. The ovalbumin fragment is presented by the class I MHC molecule, H-2Kb.Molecular weight:1,718.9 g/molCyclo(-RGDyK)
The cyclic pentapeptide cyclo(-Arg-Gly-Asp-d-Phe-Lys-) is a highly potent and selective inhibitor for the alphavβ3 integrin receptor. A related compound, cyclo(-Arg-Gly-Asp-d-Phe-Val), is a promising anti-cancer drug candidate- it inhibits angiogenesis and induces apoptosis in vascular cells.Cyclic RGD-containing peptides are selective antagonists of integrins, proteins that play important roles in cell-cell and cell-matrix interactions. In a suitably labelled form, these peptides may serve as useful tools for diagnostic imaging and peptide targeted therapy of some types of cancer.
Molecular weight:619.3 g/molFibrinopeptide
Fibrinogen is a large plasma glycoprotein with a complex structure, and one of the most abundant proteins in blood. Fibrinogen is important in fibrin clot formation, haemostasis, and inflammatory responses. Increased plasma fibrinogen indicates a proinflammatory state and is a risk factor for vascular inflammatory diseases including hypertension and atherosclerosis. Fibrinogen cleavage products act as inflammatory activators in the pathophysiology of allergic asthma.The conversion of monomeric fibrinogen into polymeric fibrin is mediated by thrombin, which binds to fibrinogen and catalyses cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB). Fibrinopeptide B is protected from modifications such as carbamylation by pyroglutamination of the N-terminal amino acid.Color and Shape:PowderMolecular weight:1,551.7 g/molAra h 2 (147-155) peanut Allergen
Ara h 2 is one of the major allergenic proteins from peanut (Arachis hypogaea) which contains approximately 13 potential allergenic proteins.Ara h 2 is a member of the 2S albumins (conglutinins) belonging to the prolamin superfamily which also includes Ara h 6. 2S albumins contain major food allergens from seeds of many mono- and dicotyledon plants and share a common compact structure that renders the proteins highly resistant to proteolysis.In mouse models Ara h 2 and Ara h 6 are the main cause of effector responses such as mast cell degranulation and anaphylaxis. Ara h 2 has a high predictive value for diagnosis of clinical peanut allergy and is also more potent than Ara h 1 or Ara h 3 in histamine release assays and skin prick tests.This peptide represents a tryptic peptide of Ara h 2.Color and Shape:PowderMolecular weight:1,027.5 g/molHuman PD - L1 inhibitor V
PD-1 inhibitors and PD-L1 inhibitors are a group of checkpoint inhibitors being developed for the treatment of cancer.PD-1 and its ligand PD-L1 are critical in regulating T cell activation, tolerance and immunopathology. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells. Several types of cancer cells overexpress PD-L1 in order to escape from the PD-1/PD-L1 immunosurveillance mechanism. In this way, Human PD - L1 inhibitor V could be used in the treatment of cancers that overexpress PD-L1.Color and Shape:PowderMolecular weight:1,484.8 g/molAnnexin A1 (2-12)
Annexin A1 (2-12) is derived from the Annexin A1 protein which is a member of the Ca2+ dependent phospholipid binding protein family of Annexins A1 to A13. Structurally Annexin is comprised of a C-terminal core region and an N-terminal region. Calcium binding sites featured in the core region allow Annexin A1 to bind to cell membranes to induce membrane aggregation in a calcium dependent manner. Furthermore Annexin A1's N-terminal region performs extracellular signalling through forming complexes with SH2 domain containing proteins. Different lengths of the Annexin family's N-terminus contributes to how the Annexins effect key processes such as cell proliferation, apoptosis, growth and differentiation.Annexin A1 can be categorised as being both anti-inflammatory and pro-inflammatory. One example of how Annexin A1 demonstrates anti-inflammatory properties is through activating the formyl peptide receptor family's (FGRs) downstream cascade. Consequently the extracellular regulated kinase (ERK) and mitogen-activated protein kinase (MAPK) are phosphorylated, causing subsequent transcription factors involved in the regulation of T cells to generate anti-inflammatory effects. Another is through inhibiting phospholipase A2 which prevents the release of inflammatory factors and the formation of arachidonic acid precursors. This property has contributed to inflammation studies such as where the inhibition of pro-inflammatory prostaglandins by Annexin A1 was used to investigate leukocyte aggregation.During its anti-inflammatory role Annexin A1 uses the active peptide Ac2-26 located on its N-terminus. It is evident Annexin A1 can be labelled as being pro-inflammatory due to it inducing pro-inflammatory cytokines, following its phosphorylation by PKC. This results in its translocation into the nucleus of BV-2 microglial cells.Color and Shape:PowderMolecular weight:1,351.59 g/molTetanus Toxin P2 (830 - 844)
Tetanus Toxin P2 (830 - 844) is a protein that is derived from the single-chain polypeptide neurotoxin produced by Clostridium tetani. The neurotoxins produced by Clostridium tetani are among the most potent molecules known to humankind. Once in the body, the toxin binds to the basal lamina at the neuromuscular junction. From here, the toxin is transported to inhibitory interneurons in the spinal cord, where it prevents the release of neurotransmitters, which causes spastic paralysis.The P2 protein has antigenic properties that are reflective of the neurotoxin released by Clostridium tetani. Therefore, P2 is a suitable epitopes for CD4+ T cells and can be used to stimulate the release of IFNg, which is a cytokine that promotes macrophage activity and coordinates lymphocyte endothelium interactions.
Color and Shape:PowderMolecular weight:1,724 g/molSMAP-18
SMAP -18 is a truncated form of sheep myeloid anti-microbial peptide-29 (SMAP-29). SMAP-29 displays extremely high anti-microbial activity against fungi and gram-negative bacteria including Pseudomonas strains and multidrug-resistant pathogens, however it also has high cytotoxic activity to human cells. The carboxyl terminal is more hydrophobic and may be responsible for higher hemolytic activity of SMAP-29, whereas the anti-microbial activity has been attributed to the N-terminal amphipathic alpha-helix region (residues 1-18). SMAP-18 displays much higher cell selectivity as compared to parental SMAP-29 because of their decreased hemolytic activity and retained anti-microbial activity.The cathelicidins are a large family of structurally diverse host defence peptide (HDP- formerly called antimicrobial peptides) found in mammalian species including humans. All members of the cathelicidin family contain an N-terminal cathelin domain and a C-terminal domain of varied structure that displays anti-microbial activity.Molecular weight:2,063.3 g/molS2-16
Myocarditis is an inflammatory heart disease often associated with a previous viral infection. Evidence has suggested that myocarditis may be due to autoimmune responses directed against cardiac tissue. The inflammatory immune response caused after infection may break tolerance by mechanisms of molecular mimicry, bystander activation, and loss of immune regulation. Experimental autoimmune myocarditis (EAM) is a model of inflammatory heart disease generated by immunizing susceptible rats or mice with cardiac myosin or its myocarditic epitopes. In the EAM model, cellular infiltrates consist primarily of T cells and macrophages, and T lymphocytes responsive to cardiac myosin can transfer disease. Cardiac myosin is a large peptide, which is composed of two H chains and two pairs of L chains. Proteolysis of myosin yields three subfragments including a globular head or subfragment 1 (S1) region, an alpha helical coiled coil rod comprised of subfragment 2 (S2), and light meromyosin (LMM). In the Lewis rat, the S2 subfragment has been shown to produce the most severe myocarditis.Color and Shape:PowderMolecular weight:2,971.6 g/mol
