Heterocycles with Nitrogen (N)

<p>Applications 3-Piperidinesulfonic Acid is an isomer of piperidine-4-sulfonic acid, a new specific GABA agonist.<br>References Krogsgaard-Larsen, P., et al.: J. Neurochem., 34, 756 (1980)<br></p>

<p>Applications Intermediate for heterocyclic compounds as tyrosine kinase inhibitors and anticancer agents.<br>References McLean, A., et al.: J. Chem. Phys., 72, 5639 (1980), Watts, J., et al.: J. Biol. Chem., 276, 43197 (2001),<br></p>

<p>Applications 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic Acid Ethyl Ester is used in various studies of stimulators of soluble guanylate cyclase.<br>References Straub, A., et al.: Bioorg. Med. Chem. Lett., 11, 781 (2001); Mittendorf, J., et al.: ChemMedChem, 4, 853 (2009); Straub, A., et al.: Bioorg. Med. Chem., 10, 1711 (2002)<br></p>

<p>Applications 2,2-Dimethylpiperazine is a chemical reagent used in the preparation of non-covalent NAAA inhibitors used as a protective agent for the development of multiple sclerosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Migliore, M. et al.: Angew. Chem. Int. Ed., 55, 11193 (2016);<br></p>

<p>Applications 5-phenyl-1H-1,2,3-triazole-4-carboxylic acid (cas# 830-78-4) is a useful research chemical.<br></p>

<p>Applications 2-​(Methoxy-​d3)​-​3-​(1-​methylethyl)​pyrazine is a useful compound in the study of isotope effect in gas liquid chromatography separation of deuterated and nondeuterated compounds using ionic liquid stationary phases.<br>References Schmarr, H., et al.: J. Chromatogr. A., 1270, 310 (2012);<br></p>

<p>Applications 3-​Methoxy-​4-​methyl-​1H-​1,​2,​4-​triazol-​5(4H)​-​one Hydrate, is a Triazole (T767410) derivative that was used in microwave synthesis of 1,2,4-triazolone derivatives possessing antifungal activity. 3-​Methoxy-​4-​methyl-​1H-​1,​2,​4-​triazol-​5(4H)​-​one is also a key intermediate for sulfonylurea herbicides, such as flucarbazone.<br>References Su, J., Shang, Z.: Nongyao, 49, 563 (2010); Sun, N., et al.: BioMed Res. Int., 1 (2015);<br></p>

<p>Applications Methyl Dl-2-(1-Boc-Piperidin-4-Yl)-Beta-Glycinate (cas# 362703-57-9) is a useful research chemical.<br></p>

<p>Applications 4-(chloromethyl)-2-phenyl-1,3-oxazole (cas# 30494-97-4) is a useful research chemical.<br></p>

<p>Applications Pyridine-15N, is the labeled analogue of Pyridine (P991280), a basic six-membered heterocyclic ring. Pyridine is a base structure present in many biologically active compounds like the vitamins niacin and pyridoxal. Pyridine is used in dehalogenation reactions and can be used as a base in condensation reactions.<br>References Egyed, J. et al.: Bull. Soc. Chim. Fra., 11, 3014 (1973); Li, Y. et al.: Wuli HUa. Xueb., 14, 1048 (1998);<br></p>

<p>Applications N-[4-(Aminocarbonyl)phenyl]-2-methyl-4-oxazolecarboxamide (cas# 1119444-26-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Ethyl-3-piperidinamine is an intermediate of 4-Amino-N-(1-ethyl-3-piperidinyl)-5-(ethylsulfonyl)-2-methoxybenzamide (A609495).<br>References Elslager, E.F., et al.: J. Med. Chem., 24, 127 (1981),<br></p>

<p>Applications tert-butyl 6-chloropyridazine-3-carboxylate (cas# 1340506-55-9) is a useful research chemical.<br></p>

<p>Applications Phenyl (4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamate Hydrochloride is an intermediate in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications 2-Chloro-3-nitropyridine (cas# 5470-18-8) is a useful research chemical.<br></p>

<p>Applications 4,4-Difluoropiperidine<br></p>

<p>Applications 2-((5-Chloropyridin-2-yl)amino)-2-oxoacetic Acid is a reactant or reagent used in the synthesis of the blood coagulating enzyme factor Xa (FXa) inhibitor.<br>References Xue, T., et al.: J. Med. Chem., 57, 7770 (2014);<br></p>

<p>Applications 2,5-Diacetamido-2,3-dihydrothiazolo[4,5-d]pyrimidine-7-(6H)-one (cas# 22365-29-3) is a compound useful in organic synthesis.<br></p>

<p>Applications (S)-3-Aminopiperidin-2-one-D6 is a labelled analogue of (S)-3-Aminopiperidin-2-one (A627940). (S)-3-Aminopiperidin-2-one, is an building block , used in the synthesis of various pharmaceutical compounds. It is an intermediate in the synthesis of calpinactam derivatives, possessing antimycobacterial activity.<br>References Kenichiro, N., et al.: Bioorg. Med. Chem. Lett., 22, 7739 (2012);<br></p>

<p>Applications Ethyl-2-ethoxy-1-[[(2'-cyanobiphenyl-4-yl) methyl] benzimidazole]-7-carboxylate<br></p>

<p>Applications 2-Bromo-N-[4-bromo-2-(2-pyridinylcarbonyl)phenyl]-acetamide is a derivative of 2-(2-Amino-5-bromobenzoyl)pyridine (A601785); an intermediate in the preparation of Bromazepam (B678500).<br>References Panderi, I., et al.: J. Pharm. Biomed. Anal., 17, 327 (1998); El-Haj, B., et al.: J. Anal. Toxicol., 25, 316 (2001); Hansen, S., et al.: J. Pharm. Biomed. Anal., 39, 322 (2005)<br></p>

<p>Applications 4-bromo-1-propan-2-ylpyridin-2-one (cas# 1646570-98-0) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications 3,5-Dimethyl-1H-pyrazol-4-amine<br></p>

<p>Applications 6-Amino-5-(4-bromophenyl)-4(3H)-pyrimidinone is a degradation product of Macitentan (M105005).<br>References Thummar, Mohit, et al.: Chromatographia, 81(3), 525-531 (2018)<br></p>

<p>Applications 3,5-Diethyl 1H-pyrazole-3,5-dicarboxylate<br></p>

<p>Applications 4-Bromo-2-(methoxymethyl)pyridine (cas# 864412-04-4) is a useful research chemical.<br></p>

<p>Impurity Irbesartan Bromo N2-Trityl Impurity<br>Stability Moisture Sensitive<br>Applications An intermediate in the synthesis of Losartan and Valsartan.<br></p>

<p>Applications Octahydro-6-(phenylmethyl)-1H-Pyrrolo[3,4-b]pyridine is an intermediate in the synthesis of moxifoxacin (M745000), a fluorinated quinolone antibacterial.<br>References Somisetti, N. et al.: Org. Chem. Indian J., 7, 123 (2011);<br></p>

<p>Applications 5-Chloro-3-nitro-pyrazolo[1,5-a]pyrimidine is used in the preparation of (S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide, a tyrosine kinase (TRK) inhibitor for treating cancer.<br>References Reynolds, M., et al.: PCT Int. Appl. (2017), WO 2017201241 A1 20171123<br></p>

<p>Applications N-[1-(pyridin-3-yl)ethyl]hydroxylamine (cas# 887411-44-1) is a useful research chemical.<br></p>

<p>Applications 4-Pyridinecarboxamide 1-Oxide (cas# 38557-82-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 5,6-Diamino-2-hydroxybenzimidazole (cas# 55621-49-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Nitro-2-(propylthio)pyrimidin-4-ol is an intermediate used in the synthesis of 4-Chloro-5-nitro-2-(propylthio)pyrimidine (C374095), which is an impurity of the drug Ticagrelor (T437700), the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007)<br></p>

<p>Applications 6-(Aminocarbonyl)pyridine-3-boronic Acid is a reagent in the identification of highly potent compounds against human malaria parasite Plasmodium falciparum.<br>References Le Manach, C., et al.: J. Med. Chem., 59, 9890-9905 (2016);<br></p>

<p>Applications 3-chloropyridazine hydrochloride (cas# 856847-77-3) is a useful research chemical.<br></p>

<p>Applications 2-(Difluoromethoxy)pyridin-4-amine (cas# 1211587-46-0) is a useful research chemical.<br></p>

<p>Applications 5-[2-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxylic acid (cas# 1003561-80-5) is a useful research chemical.<br></p>

<p>Applications Benzimidazole-4,5,6,7-d4 (CAS# 64531-29-9) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications Methyl 1-BOC-(2S,4S)-4-Aminopyrrolidine-2-carboxylate<br></p>

<p>Applications 2-hydroxy-N-pyridin-3-ylbenzamide (cas# 118623-71-5) is a useful research chemical.<br></p>

<p>Applications Imidazole rings are found in numberous natural compounds such as enzymes, nucleic acid, and alkaloids that play a role in biological processes.<br></p>

<p>Applications L, L'-Bisuccinimide is great oil antioxidant detergent compound.<br>References Wen, Y., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications H-D-Phe-Homopro-Arg-pNA.2 Acetate is a useful organic reagent.<br></p>

<p>Stability Light Sensitive<br>Applications A reagent for the determination of aldehydes and other reactive chemicals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dickinson, R.G. and Jacobsen,N.W. : Chem. Commun., 1719, (1970), Del Nozal, M.J. et al.: J. Liq. Chromatography, 16, 1105 (1993),<br></p>

<p>Applications [5-(pyridin-2-yl)-1H-imidazol-2-yl]methanamine trihydrochloride (cas# 2060007-34-1) is a useful research chemical.<br></p>

<p>Applications 1-(2,6-Dichlorophenyl)piperazine-d8 Hydrochloride is the isotope analog of 1-(2,6-Dichlorophenyl)piperazine Hydrochloride. 1-(2,6-Dichlorophenyl)piperazine Hydrochloride is used in the preparation of pyrazolopyrimidones and pyrazolopyridones as tankyrase inhibitors which are useful in the treatment of cancer.<br>References Feng, J., et al.: PCT Int. Appl., 2013:1906020 (2013)<br></p>

<p>Applications 4-(6-hydrazinylpyrimidin-4-yl)morpholine (cas# 5767-36-2) is a useful research chemical.<br></p>

<p>Applications (3E)-4-(5-Ethoxy-3-pyridinyl)-3-buten-1-ol is an intermediate in the synthesis of TC 2559 Fumarate (T012005), which is a partial agonist for AChR α4β2.<br></p>

<p>Applications 1-[4-Bromo-2-(1,1-dimethylethyl)phenyl]-1H-pyrrole-2,5-dione is derived from 2-(tert-Butyl)aniline (B809793), which is used as an intermediate in various reactions including towards substituted indole-2-carboxylic acids as inhibitors of bacterial metallo-beta-lactamases, which ultimately results in the potential for the use in the treatment of bacterial infection.<br>References Brem, J.; et al.: PCT Int. Appl. 171pp. Patent 2017 CODEN:PIXXD2<br></p>