Heterocycles with Nitrogen (N)

<p>Applications 2-Amino-3-pyridinecarbonitrile is used as a reagent in the synthesis of novel imidazo[1,2-a]pyridine derivatives as potent c-Met inhibitors and antimycobacterials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, C., et al.: ACS Med. Chem. Lett., 6, 507 (2015); Ramachandran, S., et al.: Bioorg. Med. Chem. Lett., 23, 4996 (2013)<br></p>

<p>Applications Contains up to 5 % Sodium Acetate by weight.<br></p>

<p>Applications N-(3-(2-Methylpiperidin-1-yl)propyl)-2-(p-tolyl)benzo[d]imidazo[2,1-b]thiazole-7-carboxamide is a useful synthetic intermediate in organic synthesis and pharmaceuticals.<br></p>

<p>Applications 1-(2-Ethoxy-2-oxoethyl)pyridin-1-ium-d5 Chloride is an intermediate used in the synthesis of Girard’s Reagent P-d5 (G388502), which is a labeled girard’s reagent used in the identification and quantification of protein carbonylation as well as in the modification of nucleosides and nucleotides. Used in the preparation of potent photoactive agents.<br>References Mirzaei, H. et al.: J. Chrom. A, 1134, 122 (2007); Kanofsky, J.R. et al.: Photochem. Photobiol., 73, 349 (2001);<br></p>

<p>Applications 2-(Tributylstannyl)oxazole is a useful reactant in preparation of potent, selective and efficacious reversible α-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boger, D., et al.: J. Med. Chem., 48, 1849 (2005);<br></p>

<p>Stability Moisture Sensitive<br>Applications N,N′-Disuccinimidyl Carbonateis a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of ligands to proteins. The coupling reagent property of N,N’-Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.<br>References Rebane, R., et al.: J. Chromatography., 904, 99 (2012);<br></p>

<p>Applications 3-Benzylpiperazine-2,5-dione (cas# 5037-75-2) is a useful research chemical.<br></p>

<p>Applications Pioglitazone (P471000) intermediate.<br>References Kletzien, R., et al.: Mol. Pharmacol., 41, 393 (1992),<br></p>

<p>Applications 5-acetyl-6-hydroxy-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (cas# 58713-03-4) is a useful research chemical.<br></p>

<p>Applications 5-Amino-1,3-diphenyl-1H-pyrazole is a reagent for the preparation of molecular switches within GIRK activator scaffold that afford selective GIRK inhibitors.<br>References Wen, W., et al.: Bioorg. Med. Chem. Lett., 23, 4562 (2013); Karschin, C., et al.: J. Neurosci., 16, 3559 (1996)<br></p>

<p>Applications ethyl 4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxylate (cas# 1013-14-5) is a useful research chemical.<br></p>

<p>Applications 4-BROMO-2-PYRIDINECARBOXAMIDE (cas# 62150-46-3) is a useful research chemical.<br></p>

<p>Applications (R)-Benzyl 2-((5-bromo-1H-indol-3-yl)methyl)pyrrolidine-1-carboxylate is used in the preparation of indole-derivative serotoninergic receptor agonists.<br></p>

<p>Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol-d3 is the isotope labelled analog of α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol (D473780); a reagent in the synthesis of Medetomidine (M203250) which is an α2-adrenergic agonist. Also a sedative and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010<br></p>

<p>Applications A useful synthetic intermediate<br></p>

<p>Applications 2,3-Diamino-4-chloropyridine<br></p>

<p>Applications tert-Butyl 2-cyanopiperazine-1-carboxylate (cas# 1053656-76-0) is a useful research chemical.<br></p>

<p>Applications 4-Piperidinemethanol, is a building block that can be used for the synthesis of selective inhibitors of sphingosine kinase 1 (SK1), that may serve as therapeutic agents for proliferative diseases, including hypertension.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baek, D., et al.: Chem.l Commun., 49, 2136 (2013);<br></p>

<p>Applications methyl 1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyrazole-5-carboxylate (cas# 929899-20-7) is a useful research chemical.<br></p>

<p>Applications 4-(Dimethylamino)pyridin-1-ium ((2-Nitrophenyl)sulfonyl)(phenoxycarbonyl)amide is an intermediate used in the synthesis of Monosulfuron (M567185), which is a sulfonylurea herbicide that inhibits Acetohydroxyacid synthase enzyme.<br>References Wang, J., et al.: J. Comput. Aided Mol. Des., 19, 801 (2005);<br></p>

<p>Applications Pyrazinoic Acid Ethyl Ester (cas# 6924-68-1) is a compound useful in organic synthesis.<br></p>

<p>Applications {6-[(Oxolan-3-yloxy)methyl]pyridin-2-yl}methanamine Dihydrochloride is the acid form of {6-[(Oxolan-3-yloxy)methyl]pyridin-2-yl}methanamine (CAS: 1701690-73-4) which is a useful reagent for making triazolo pyrimidine intermediates.<br>References By, K., et at.: PCT Int. Appl. (2018), WO 2018183965 A1 20181004<br></p>

<p>Applications Used in the preparation of Eszopiclone (E889150) impurity.<br>References Sha, Y. et al.: Molecules 13, 1817(2008).<br></p>

<p>Applications 6-Amino-2-chloro-5-nitropyridine (cas# 27048-04-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Bromo-2-(ethyl-d3)pyridine is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications Ethyl 7-aminothieno[2,3-b]pyrazine-6-carboxylate<br></p>

<p>Applications 2-Fluoro-5-pyrimidinol is a structural analog of 2-Methyl-5-pyrimidinol (M326115); a pyrimidinyl derivative used as an insecticide intermediate.<br>References Cox, R., et al.: J. Phys. Chem., 72, 1646 (1968); Norton, R., et al.: Mol. Cell Biochem., 12, 103 (1976); Imai, E., et al.: Science, 283, 831 (1999)<br></p>

<p>Applications (αR)-α-[[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-4-hydroxy-benzeneacetic Acid is an intermediate used to prepare Cephalosporin derivatives with activities against both Gram-positive and Gram-negative bacteria.<br>References Albrecht, H., et al.: J. Med. Chem., 37, 400 (1994)<br></p>

<p>Applications Reagent used to prepare biosynthetic polymer surfactants designed for shear-stable endothelialization.<br>References Schaefer, A., et al.: J. Bacteriol., 178, 2897 (1996), Ruegsegger, M., et al.: J. Biomed. Mat. Res., 56, 159 (2001), Abdu-Allah, H., et al.: J. Med. Chem., 51, 6665 (2008), Georgiades, S., et al.: Bioorg. Med. Chem. Lett., 18, 3117 (2008),<br></p>

<p>Stability Moisture Sensitive, Air Sensitive<br>Applications pyrimidine-2-sulfonyl fluoride (cas# 35762-87-9) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2-(Hydroxymethyl)pyridine N-Oxide (cas# 10242-36-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 3-(2-Pyrrolyl)propanoate (cas# 69917-80-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Benzylpyridine is a benzylpyridine with antifungal properties. 4-Benzylpyridine has been used as a reactant in the synthesis of bis(alkylpyridinium)alkanes as antifungal agents.<br>References Takeshiba, H. et al.: Sank. Kenk. Nen., 23, 225 (1971)<br></p>

<p>Applications 2-Amino-5-ureido-4,6-pyrimidinedione (cas# 21823-25-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(6-Oxo-3-pyridin-4-ylpyridazin-1(6H)-yl)propanoic acid (cas# 1283108-08-6) is a useful research chemical for organic synthesis.<br></p>

<p>Applications 3-Bromo-5-(1-hydroxyethyl)pyridine<br></p>

<p>Applications 2-Benzotriazol-1-yl-propionic acid is used in the synthesis of N-substituted benzotriazole/morpholine derivatives which has antiinflammatory anthelmintics properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Upadhyay, R. K., et al.: J. In. Coun. Chem., 9, 36 (1993);<br></p>

<p>Applications 6,7-Dihydro-5H-pyrrolo[3,4-d]pyrimidine Dihydrochloride is a useful reagent for synthesis of the bicyclic secondary amines via dimethylaminomethylene derivatives of 3-pyrrolidone and 3-piperidone.<br>References Fukui, H., et al.: Heterocycles, 56, 257 (2002);<br></p>

<p>Applications 4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride (cas# 62002-31-7) is a useful research chemical.<br></p>

<p>Applications 4-amino-1,2,4-triazolidine-3,5-dione (cas# 21531-96-4) is a useful research chemical.<br></p>

<p>Applications (1-Ethyl-piperidin-3-yl)-carbamic Acid tert-Butyl Ester is an intermediate in the synthesis of 4-Amino-N-(1-ethyl-3-piperidinyl)-5-(ethylsulfonyl)-2-methoxybenzamide (A609495), which is an impurity of Amisulpride (A633250). Amisulpride EP Impurity G.<br>References Elslager, E.F., et al.: J. Med. Chem., 24, 127 (1981)<br></p>

<p>Applications 2,4,5-Triamino-6-hydroxypyrimidine-13C2 Sulfate Salt is an intermediate used in the preparation of labelled 2-Amino-6,8-dihydroxypurine Hydrochloride (A604920). A labelled substituted 5-aminopyrimidines with antioxidative activity.<br>References Prochazkova, E. et al.: Free Radical Res., 46, 61 (2011); Lin, S. et al.: J. Med. Chem., 22, 741 (1979)<br></p>

<p>Applications n-Hexadecylpyridinium-d5 Bromide (CAS# 143715-91-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-tert-butyl-1H-pyrrole-3-carboxylic acid (cas# 1266364-46-8) is a useful research chemical.<br></p>

<p>Applications 5-Aminomethyl-2-bromopyridine<br></p>

<p>Applications 3,5-Diphenylpyrazole (cas# 1145-01-3) is a useful research chemical.<br></p>

<p>Applications 1H-pyrrolo[2,3-b]pyridin-1-amine (cas# 161264-46-6) is a useful research chemical.<br></p>

<p>Applications 1-[(2-Nitrophenyl)sulfonyl]-1H-pyrrole is used in the preparation of various 2-​substituted N-​nosylpyrroles.<br>References Shibata, M. et al. Tetrahedron. 71, 4495 (2015);<br></p>

<p>Applications 2-(1H-pyrazol-4-yl)aniline (cas# 1342757-33-8) is a useful research chemical.<br></p>

<p>Applications 3-tert-Butylthio-2-carboxypyridine (cas# 178811-41-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,4-Dimethyl-5-pyrazolone (cas# 6628-22-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,4-Di(tert-butoxy)pyrimidine-5-boronic acid<br></p>

<p>Applications 4-Cyanopyrazole is used to catalyze epoxidation of ethene by hydrogen peroixde.<br>References Alder, R.W.: J. Mol. Model., 12, 649 (2006)<br></p>

<p>Applications 5-Ethylpyridine-2-carboxylic Acid (cas# 770-08-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-(3-aminophenoxy)pyridine-3-carbonitrile (cas# 1099689-56-1) is a useful research chemical.<br></p>

<p>Applications (4-Acetyl-Piperazin-1-Yl)-Acetic Acid is a useful research chemical. It is used in the preparation of phenylpiperidines as neurokinin NK1 and NK3 antagonists for treatment of neurokinin-mediated diseases<br>References O'Neill, B. T., et al.: From U.S. Pat. Appl. Publ. (2005), US 20050256164 A1 20051117<br></p>