Heterocycles with Nitrogen (N)

<p>Applications 1-(1-Oxidobenzo[d]isothiazol-3-yl)piperazine 1-Oxide Hydrochloride is an intermediate in the synthesis of Ziprasidone (Z485010) related compounds.<br>References Huang, M., et al.: Clin. Pharmacol. Ther., 54, 257 (1993), Prakash, C., et al.: Drug Metab. Dispos., 25, 206 (1997), Brosen, K., et al.: Eur. J. Clin. Pharmacol., 44, 349 (1993),<br></p>

<p>Applications 6-[[2-(tert-Butyldimethylsilyloxy)ethyl]methylamino]pyridin-3-ol (cas# 326496-02-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(2,3-Dichlorophenyl)piperazine 1-Oxide is an intermediate in the synthesis of Aripiprazole (A771000) related compound.<br>References Satyanarayana, Bollikonda. et al., Heterocyclic. Commun., 11, 485 (2005);<br></p>

<p>Applications Ethyl (5-Ethyl-2-pyridinyl)-1,1-d2-acetate (cas# 1189654-25-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 5H,6H,7H-cyclopenta[b]pyridine-7-carboxylic acid hydrochloride (cas# 1610919-99-7) is a useful research chemical.<br></p>

<p>Applications 2,5-Dihydro-3-(hydroxymethyl)-2,2,5,5-tetramethyl-4-(3-pyridinyl)-1H-pyrrol-1-yloxy is an intermediate in the synthesis of highly active spin labelling reagents.<br>References Fawzi, N.L., et al.: J. Biomolec. NMR., 51, 105 (2011);<br></p>

<p>Applications Methyl 3-(Imidazol-4-yl) Propionate (cas# 31434-93-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Iodopyrazole is used in the synthesis of (pyrazolyl)oxobenzocycloheptapyridinyl acetamides that act as inhibitors of c-Met.<br>References Northrup, A. et al.: J. Med. Chem., 56, 2294 (2013);<br></p>

<p>Applications Protected N-Benzylpiperazine-d8<br>References Bannwarth, W., et al.: Bioorg. Med. Chem., Lett., 6, 1525 (1996), Greenwald, R., et al.: J. Med. Chem., 43, 475 (2000), Wills, A., et al.: Curr. Opin. Chem. Biol., 7, 346 (2003), Heidler, P., et al.: Bioorg. Med. Chem., 13, 585 (2005),<br></p>

<p>Applications 2,4-Dinitro-3-pyridinol is an impurity in the synthesis of 2,6-Diamino-5-hydroxy-3-(phenylazo)pyridine which is a novel metabolite of Phenazopyridine (P313751).<br>References Bailey, K., et al.: Drug Metab. Dispos., 11, 277 (1983), Thomas, B. H., et al.: J. Pharm. Sci., 79, 321 (1990), Thomas, B.H., et al.: Xenobiotica, 23, 99 (1993),<br></p>

<p>Applications An intermediate for the synthesis of labelled thiazolidinedione anti-diabetic drugs<br>References Cantello, B., et al.: Bioorg. Med. Chem. Lett., 4, 1181 (1994),<br></p>

<p>Applications N-[2-(S)-Methyl-d3-butyryl]-4-(S)-phenylmethyl-2-oxazolidinone (cas# 1073232-99-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Amino-3-(1-naphthyl)-4-cyano-1-tert-butylpyrazole (cas# 221243-34-1) is a compound useful in organic synthesis.<br>References Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999)<br></p>

<p>Applications Ethyl N-Boc-piperidine-4-carboxylate is used as a reagent to synthesize 3-amino-1-(5-indanyloxy)-2-propanol derivatives as sodium channel blockers to treat stroke patients. Ethyl N-Boc-piperidine-4-carboxylate is also used as a reagent to prepare inhibitors of tumour necrosis factor alpha-converting enzyme.<br>References Levin. J.: Heterocycles, 70, 691 (2006); Seki, M., et al.: Chem. Pharm. Bull., 60, 488 (2012)<br></p>

<p>Applications 2-Oxo-N-(pyridin-4-yl)butanamide is an intermediate in synthesizing 2-Hydroxy-N-(pyridin-4-yl)butanamide (H953495). It is a is a useful synthetic intermediate.<br></p>

<p>Stability Very Moisture Sensitive<br>Applications Cyanoacetic Acid N-Hydroxysuccinimide Ester is used as a pharmaceutical intermediate. It is used in the preparation of substituted pyrrolopyrimidinamines as selective Janus kinase inhibitors for the treatment of autoimmune diseases and organ transplant rejection.<br>References Flanagan, M. E., et al.: J. Med. Chem., 53, 8468 (2010)<br></p>

<p>Applications [4-(4-Fluorophenyl)-6-(1-methylethyl)-2-(methylsulfinyl)-5-pyrimidinyl]-ethyl Ester-d6 (cas# 1189487-47-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 5,6-Diamino-2,4-dihydroxypyrimidine-13C2, Hydrochloride Salt (cas# 1346605-20-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,6-Dibromopyridine is used as a starting material to synthesize 2,2’-bipyridines (such as 5-Cyano-1,6-dihydro-6-oxo-[3,4'-bipyridine]-2-carboxylic Acid [C979150]) via a Stille-type cross-coupling reaction. 2,6-Dibromopyridine is also used as a reagent to synthesize pyridylpyrimidine fungicides, compounds that eliminate fungi by cycling copper through the cell membrane, where it reaches toxic levels.<br>References Hargreaves, S., et al.: Tetrahedron Lett., 41, 1653 (2000); Heller, M. &amp; Schubert, U.: J. Org. Chem., 67, 8269 (2002); Simkovsky, N., et al.: J. Chem. Soc. Perk. Trans. 1, 16, 1847 (2002)<br></p>

<p>Applications Labelled Anabaseine intermediate.<br></p>