Heterocycles with Nitrogen (N)

Applications 2,4-Dimethyl-1H-pyrrole-3-carboxylic Acid Ethyl Ester is used as an intermediate in the synthesis of receptor tyrosine kinase (RTK) inhibitors and their metabolites.
References Elsinghorst, P. et al.: J. Lab. Comp. Radiopharm., 52, 360 (2009); Sun, L. et al.: J. Med. Chem., 41, 2588 (1998);

Applications 2-Amino-5-bromopyrazine (cas# 59489-71-3) is a compound useful in organic synthesis.
References Shi, Z., et al.: J. Med. Chem., 51, 3684 (2008), Onda, K., et al.: Bioorg. Med. Chem., 16, 5452 (2008),

Applications N-(2-(2-Nitro-1H-imidazol-1-yl)ethyl)acrylamide is a useful synthesis intermediate.

Applications 3-Bromopicolinic Acid Sodium Salt (cas# 1189933-55-8) is a compound useful in organic synthesis.
References See mercaptopicolinic acid file

Applications (2R)-4-Oxo-2-(3-thiazolidinylcarbonyl)-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is a useful synthetic compound.

Applications 2,5-Dimethyl-piperidine is a useful synthetic intermediate in synthesizing chromen-2-ones and chromen-4-ones derivatives. These compounds are inhibitors that act against DNA-PK.
References Griffin, R.J., et al.: J. Med. Chem., 48, 569 (2005)

Applications Methyl (αS)-α-(2-chlorophenyl)-2,6,7,7a-tetrahydro-2-oxothieno[3,2-c]pyridine-5(4H)-acetate is the essential intermediate metabolite from which the active metabolite of Clopidogel is formed.
References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)

Applications 1-Pyridin-3-yl-piperazine Hydrochloride is a reactant used in discovery of N-aryl Piperazines as selective mGluR5 potentiators. It was also used in the synthesis of piperazine-pyridazinone derivatives that have binding affinity toward α1-, α2-adrenergic and 5-HT1A receptors.
References Betti, L., et al.: Bioorg. Med. Chem., 14, 2828 (2006); Zhou, Y., et al.: ACS Med. Chem. Lett., 1, 433 (2010);

Applications 4-Chloro-2-(trifluoromethoxy)pyrimidine (cas# 1261494-46-5) is a compound useful in organic synthesis.

Applications 7-Bromo-5-(pyridin-2-yl)-1H-benzo[e][1,4]diazepine-2(3H)-thione is used in the preparation of triazolobenzodiazepines with antianxiety and antidepressant activity.
References Hester, J.B., et. al.: J. Med. Chem., 23, 392 (1980)

Applications 4,6-Dichloro-5-nitropyrimidine (cas# 4316-93-2) is a compound useful in organic synthesis.