Heterocycles with Nitrogen (N)

Applications Ethyl Imidazole-2-carboxylate is an intermediate used to synthesize tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). It is also used to prepare imidazoindenopyrazinone carboxylic acid derivatives as AMPA antagonists with anticonvulsant activities.
References Miyashiro, J., et al.: Bioorg. Med. Chem. Lett., 19, 4050 (2009); Pratt, J., et al.: Bioorg. Med. Chem. Lett., 10, 2749 (2000)

Applications [1,2,4]Triazolo[1,5-a]pyridin-8-ol can be used to prepare aminopyridine derivatives as glucokinase activators useful to treat diseases.
References Aicher, T. D., et al.: PCT Int. Appl., 145, (2008);

Applications 5-(trifluoromethyl)dihydropyrimidine-2,4(1H,3H)-dione (cas# 2145-56-4) is a useful research chemical.

Applications 4-amino-1-propylpyrrolidin-2-one hydrochloride (cas# 1255717-37-3) is a useful research chemical.

Applications 3-Fluoro-6-bromopyridine is used in the synthesis of mGluR5 antagonist for the treatment of neuropathic pain.
References Son, M.H., et al.: Bioorg. Med. Chem. Lett., 23, 1472 (2013);

Applications Pyridine-4-d1 (CAS# 10259-15-1) is a useful isotopically labeled research compound.

Applications 4-Hydroxypiperidine-3,3,4,5,5-d5-N-t-BOC (CAS# 1523606-18-9) is a useful isotopically labeled research compound.

Applications 1-(N,N-Dimethylsulfamoyl)-1H-imidazole is an Imidazole (I350200) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor.
References Wijtmans, M. et al.: J. Med. Chem., 51, 2944 (2008); Georgsson, J. et al.: J. Med. Chem., 50, 1711 (2007)

Applications 2,2'-Bipyridine-4,4'-dicarboxamide

Applications pyrrolo[1,2-a]pyrazine-1-carboxylic acid (cas# 1895300-97-6) is a useful research chemical.

Applications 5-Amino-3,4-dimethylisoxazole (cas# 19947-75-2) is a compound useful in organic synthesis.
References Tellew, J., et al.: Bioorg. Med. Chem. Lett., 13, 1093 (2003),

Applications Pyrimidin-4-ylboronic Acid is an intermediate used to prepare aldosterone synthase inhibiting pyrimidinylnaphthalenes via Suzuki cross-coupling reactions. It is also used in the synthesis of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine as a potent, orally active Src kinase inhibitor with antitumor activity.
References Voets, M., et al.; J. Med. Chem., 48, 6632 (2005); Noronha, G., et al.: Bioorg. Med. Chem. Lett., 17, 602 (2007)

Applications 4-Hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-oxyl (CAS# 100326-46-3) is a useful isotopically labeled research compound.

Applications A pyrolopyrimidine derivative used in the preparation of the antibiotic tubercidin (7-deazadenosine).
References Ektova, L.V. et al.: Bioorg. Khim., 4, 1250 (1978);

Applications 6-METHYL-5-PROPYL-4(1H)-PYRIMIDINONE (cas# 103980-68-3) is a useful research chemical.

Applications Used in the preparation of indoline derivatives as PERK inhibitors.

Applications Diethyl(pyridin-​4-​yl)​borane is a powerful reducing agent used in the synthesisof non-basic compounds as factor Xa inhibitors. Diethyl(pyridin-​4-​yl)​borane is used for the synthesis of 4-aryl- and 4-heteroarylpyridines by the palladium-catalyzed cross-coupling reaction.
References Komoriya, S. et al.: Bioorg. Med. Chem. 13, 3927 (2005); Ishikura, Minoru., et al.: Chem. Pharm. Bull., 33, 4755(1985)

Applications 3-Amino-1,4-dimethylpyrazole is used in the preparation of peptides as cysteine protease inhibitors.

Applications 4,5-Dimethyl-4H-1,2,4-triazole-3-acetic Acid is a useful synthetic intermediate.

Applications imidazo[1,2-a]pyridin-7-amine hydrobromide (cas# 1630906-80-7) is a useful research chemical.

Applications Ethyl 1-Ethylpyrazole-4-carboxylate is used as a reactant in the preparation of N-heteroaryl benzenesulfonamides as CCR9 inhibitors.
References Bakthavatchalam, Rajagopal, et al.: PCT Int. Appl., WO 2015097122 A1 20150702 (2015)

Applications 2,3-Dichloro-5-(trifluoromethyl)pyridine is a reactant that has been used in the synthesis of a 17β-HSD1 inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zhou, Q., et. al.: Tetrahedron, 69, 10996 (2013)

Applications 2,4-difluoro-5-(2-oxoimidazolidin-1-yl)benzoic acid (cas# 1178351-23-9) is a useful research chemical.

Applications 2-(Methylsulfonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole is a useful reagent for developing dipeptidyl peptidase IV inhibitors for treatment or prevention of diabetes.
References Nakajima, Y., et al.: J. Mol. Cell Cardiol., 129, 257-265 (2019)

Applications 2,6-Dibromo-3-fluoropyridine is a useful reagent for making GLP-1 receptor agonists.
References Aspnes, G. E., et al.: PCT Int. Appl. (2019), WO 2019239371 A1

Applications α,α,1,6-Tetramethyl-3-piperidinemethanol, has shown to be able to facilitate new modes of reactivity via constrictive binding in a supramol.-assembly-catalyzed aza-Prins cyclization.
References Kaphan, D. M., et al.: Journal of the American Chemical Society, Vol. 137, P: 9202-9205 (2015);

Applications 2-[3-(chloromethyl)phenyl]pyrimidine (cas# 898289-51-5) is a useful research chemical.

Applications 6-cyclopropyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid (cas# 150190-28-6) is a useful research chemical.

Applications 2-ETHYNYLPYRIDINE (cas# 1945-84-2) is a useful research chemical.

Applications 5-(3-methylphenyl)imidazolidine-2,4-dione (cas# 187978-79-6) is a useful research chemical.

Applications N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine is used as a reactant in the synthesis of Pimavanserin.
References Wan, Yongqing, et al.: Faming Zhuanli Shenqing, CN 106588753 A 20170426 (2017)