Heterocycles with Nitrogen (N)

<p>Applications Ethyl N-Boc-piperidine-4-carboxylate is used as a reagent to synthesize 3-amino-1-(5-indanyloxy)-2-propanol derivatives as sodium channel blockers to treat stroke patients. Ethyl N-Boc-piperidine-4-carboxylate is also used as a reagent to prepare inhibitors of tumour necrosis factor alpha-converting enzyme.<br>References Levin. J.: Heterocycles, 70, 691 (2006); Seki, M., et al.: Chem. Pharm. Bull., 60, 488 (2012)<br></p>

<p>Applications Pyridinium Chlorochromate is used in the synthesis of potent antitumor antibiotics and agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hurley, L. et al.: Chem. Res. Toxicol., 1, 258 (1988);<br></p>

<p>Applications 5-Chloro-4-(3-pyridinyl)-2-pyrimidinamine is an intermediate in the synthesis of 3-((5-Chloro-4-(pyridin-3-yl)pyrimidin-2-yl)amino)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)benzamide (C179120), an impurity of Nilotinib (N465300), which might be useful in treatment of chronic myelogenous leukemia.<br>References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),<br></p>

<p>Applications 5-Bromo-2-(1H-tetrazol-5-yl)pyridine is a reagent in the synthesis and antibacterial activity of oxazolidinones containing pyridine substituted with heteroaromatic ring.<br>References Jo, Y.W., et al.: Bioorg. Med. Chem., 12, 5909 (2004)<br></p>

<p>Applications Octahydro-6-(phenylmethyl)-1H-Pyrrolo[3,4-b]pyridine-d4 is an isotope labelled intermediate in the synthesis of moxifoxacin (M745000), a fluorinated quinolone antibacterial.<br>References Somisetti, N. et al.: Org. Chem. Indian J., 7, 123 (2011);<br></p>

<p>Applications 1,3-Dibromo-5,5-dimethyl-2,4-imidazolidinedione is a useful synthetic intermediate in aromatic bromination of alkoxybenzoic acids and in bromofluorination of alkenes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Olah, G., et al.: Synthesis, 7, 692 (1993); Auerbach, J., et al.: Tetrahedr. Lett., 34, 931 (1993)<br></p>

<p>Applications Methyl 4-Amino-3,6-dichloropyridine-2-carboxylate is an intermediate in the synthesis of Arylex (A794890), which exhibits potent dicot weed control; Herbicide.<br>References Schmitzer, P. R., et al.: ACS Symp. Ser., 1204, 247-260 (2015); Epp, J. B., et al.: Bioorg. Med. Chem., 24, 362-371 (2016); Zhao, H., et al.: J. Sep. Sci., 38, 1164-1171 (2015)<br></p>

<p>Applications 4-[2-(1-Piperidinyl)ethoxy]-benzenemethanol is an intermediate in the synthesis of Pipendoxifene (P479850), a 2-Ph indole selective estrogen receptor modulator (SERM) that exhibits an excellent preclin. pharmacol. profile and was selected for further development as a treatment for metastatic breast cancer.<br>References Cotreau, M., et al.: J. Clin. Pharm., 42, 157 (2002); Greenberger, L., et al.: Clin. Cancer Res., 7, 3166 (2001)<br></p>

<p>Applications 1-(N,N-Dimethylsulfamoyl)-1H-imidazole-15N2 is a labelled imidazole (I350202) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor.<br>References Wijtmans, M. et al.: J. Med. Chem., 51, 2944 (2008); Georgsson, J. et al.: J. Med. Chem., 50, 1711 (2007)<br></p>

<p>Applications N6-(2-Chloro-6-methyl-4-pyrimidinyl)-2-methyl-4,6-quinolinediamine is an intermediate in the synthesis of NSC 23766 (N900280), which is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.<br>References Gao, Y., et. al.: Proc. Natl. Acad. Sci. U.S.A., 101, 7618, (2004); Akbar, H., et. al.: Methods Enzymol, 406, 554 (2006)<br></p>

<p>Applications 2-Cyano-3-chloropyridine (cas# 38180-46-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Chloro-4-(2,2,2-trifluoroacetyl)benzo[d]oxazol-2(3H)-one is an intermediate in the synthesis of 6-Chloro-4-[3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propyn-1-yl]-2(3H)-benzoxazolone (C365790), a impurity of Efavirenz (E425000) which is a nonnucleoside HIV-1 reverse transcriptase inhibitor.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)<br></p>

<p>Applications 4-(1,2-Benzisothiazol-3-yl)-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of Ziprasidone (Z485010) related compounds.<br>References Huang, M., et al.: Clin. Pharmacol. Ther., 54, 257 (1993), Prakash, C., et al.: Drug Metab. Dispos., 25, 206 (1997), Brosen, K., et al.: Eur. J. Clin. Pharmacol., 44, 349 (1993),<br></p>

<p>Stability Stable<br>Applications 2,4,5-Triamino-6-pyrimidinol-13C2,15N is an intermediate in the synthesis of labelled Guanine (G836000). Guanine is on one of the five nucleobases incorporated into biological nucleic acids. Guanine, along with adenine and cytosine, is present in both DNA and RNA, whereas thymine is usually seen only in DNA, and uracil only in RNA.<br>References Geslain, R., et al.: J. Biol. Chem., 284, 27760 (2009); Manini, P., et al.: Toxicol. Lett., 190, 41 (2009); Gong, B., et al.: Biochem., 48, 11961 (2009); Sugimoto, M., et al.: J. Agric. Food Chem., 58, 374 (2010)<br></p>

<p>Applications An intermediate of Rosuvastatin (R700500).<br></p>

<p>Applications 2,3,7,8-Tetrachloro-[1,4]dioxino[2,3-b:5,6-b']dipyridine is used in analytical studies for the presence and formation of dioxin-like compounds in heat-treated chlorpyrifos herbicide, a potential precursor of pyridine analog of 2,3,7,8-Tetrachloro-p-dioxin (T291370).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sakiyaama, T., et al.: Organohalogen Compounds, 73, 146 (2011);<br></p>

<p>Applications 1-Benzyl-3-(3-(dimethylamino)propoxy)-1H-pyrazole-5-carboxylic Acid Hydrochloride is an intermediate for the synthesis of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase. Inhibits collagen-stimulated platelet aggregation in vitro.<br>References Kotzki, S. et al.: J. Pharm. Exp. Ther., 346, 424 (2013); Selwood, D&gt; et al.: J. Med. CHem., 44, 78 (2001)<br></p>

<p>Applications 5-Methylpyrimidine (cas# 2036-41-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1-(2-Chloroethyl)-2-imidazolidinone (cas# 2387-20-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Piperidineethanol have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAK<br>References Tomita, N., et al.: Bioorg. Med. Chem., 23, 1779 (2013); Negoro, K., et al.: Bioorg. Med. Chem., 20, 6442 (2012); Giang, H.N., et al.: Macromole. Chem. Phy., 213, 982 (2012);<br></p>