Heterocycles with Nitrogen (N)

<p>Applications Methyl 3-(Imidazol-4-yl) Propionate (cas# 31434-93-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Cyanopyrimidine (cas# 40805-79-6) is a compound useful in organic synthesis.<br></p>

<p>Applications (S)-5-Chloro-3-(cyclopropylethynyl)-3-(trifluoromethyl)-1,3-dihydrobenzo[c]isoxazole is a proposed intermediate in the synthesis of (4S)-6-Chloro-4-(3-((4-chloro-2-((S)-4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl)amino)pent-1-yn-1-yl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one (Mixture of Diastereomers) (C360045) which is an impurity of Efavirenz (E425000) which is a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>

<p>Applications N-[2-(S)-Methyl-d3-butyryl]-4-(S)-phenylmethyl-2-oxazolidinone (cas# 1073232-99-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 5,6-Diamino-2,4-dihydroxypyrimidine-13C2, Hydrochloride Salt (cas# 1346605-20-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Pyridine hydrobromide (cas# 18820-82-1) is a useful research chemical.<br></p>

<p>Applications Ethyl (5-Ethyl-2-pyridinyl)-1,1-d2-acetate (cas# 1189654-25-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,1-Dimethylethyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate-d4 is an isotope labelled intermediate in the synthesis of labelled Flupentixol.<br>References Panteleev, J., et al.: Synlett., 26, 953 (2015); Liang, Y.K., et al.: Euro. J. Med. Chem., 84, 505 (2014);<br></p>

<p>Stability Very Moisture Sensitive<br>Applications Cyanoacetic Acid N-Hydroxysuccinimide Ester is used as a pharmaceutical intermediate. It is used in the preparation of substituted pyrrolopyrimidinamines as selective Janus kinase inhibitors for the treatment of autoimmune diseases and organ transplant rejection.<br>References Flanagan, M. E., et al.: J. Med. Chem., 53, 8468 (2010)<br></p>

<p>Applications (S)-Benzyl 2-(5-Bromo-1H-indole-3-carbonyl)pyrrolidine-1-carboxylate is an intermediate in the synthesis of ent-Eletriptan (E505005), an enantiomeric impurity of the serotonin 5-HTIB/ID receptor agonist Eletriptan (E505000).<br>References Orita, A., et al.: Green Chem., 3, 13 (2001);<br></p>

<p>Applications 4-Piperidineethanol have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAK<br>References Tomita, N., et al.: Bioorg. Med. Chem., 23, 1779 (2013); Negoro, K., et al.: Bioorg. Med. Chem., 20, 6442 (2012); Giang, H.N., et al.: Macromole. Chem. Phy., 213, 982 (2012);<br></p>

<p>Applications 2,4-Dinitro-3-pyridinol is an impurity in the synthesis of 2,6-Diamino-5-hydroxy-3-(phenylazo)pyridine which is a novel metabolite of Phenazopyridine (P313751).<br>References Bailey, K., et al.: Drug Metab. Dispos., 11, 277 (1983), Thomas, B. H., et al.: J. Pharm. Sci., 79, 321 (1990), Thomas, B.H., et al.: Xenobiotica, 23, 99 (1993),<br></p>

<p>Applications 3-(Chloromethyl)pyridine Hydrochloride has been used as a reactant for the synthesis of (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-one derivatives as Polo-like kinase 4 (PLK4) inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Laufer, R., et. al.: J. Med. Chem., 56, 6069 (2013)<br></p>

<p>Applications N-Boc-N-methylpiperazine-d8 (cas# 1189436-83-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(2-Mercapto-1H-imidazol-4-yl)pyridine (cas# 93103-29-8 ) is a compound useful in organic synthesis.<br></p>

<p>Applications Tris(p-tolyl)-1,3,5-triazine is an intermediate in synthesizing p-Cyanobenzoic Acid Trimer (C955200), which is used in the synthetic preparation of Terbium Triazinetribenzoate Formate Metal Organic Framework (MOF).<br>References Han, Y., et al.: J. Mater. Chem. A Mater. Energy Sustain., 3, 24525 (2015);<br></p>

<p>Applications Ethyl N-Boc-piperidine-4-carboxylate is used as a reagent to synthesize 3-amino-1-(5-indanyloxy)-2-propanol derivatives as sodium channel blockers to treat stroke patients. Ethyl N-Boc-piperidine-4-carboxylate is also used as a reagent to prepare inhibitors of tumour necrosis factor alpha-converting enzyme.<br>References Levin. J.: Heterocycles, 70, 691 (2006); Seki, M., et al.: Chem. Pharm. Bull., 60, 488 (2012)<br></p>

<p>Applications Reagent used to synthesize many pyrrole derivatives<br></p>

<p>Applications 2,4-Dihydroxy-6-amino-5-diethoxyethylpyrimidine (cas# 102879-75-4) is a compound useful in organic synthesis.<br></p>