Building Blocks

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-(2-Methylprop-2-en-1-yl)piperidin-4-amine is an inhibitor that blocks the activity of ion channels. It is a competitive antagonist at the NMDA receptor and has been shown to inhibit the binding of glutamate, which is a neurotransmitter involved in synaptic transmission. 1-(2-Methylprop-2-en-1-yl)piperidin-4-amine also inhibits β 2 -adrenergic receptors and has been shown to be a potent activator of G protein coupled receptors. This chemical may also be used as a research tool for studying the effects of ligands on cell biology, peptides, pharmacology, or life science. It has high purity and CAS No. 1082454-34-9.

Versatile small molecule scaffold

The Opn4 antagonist is a chemical that blocks the activity of the protein melanopsin, which is involved in regulating circadian rhythms. It has been shown to inhibit melatonin synthesis and muscle fiber contraction when applied intravitreally. These effects may be mediated by membrane channels that are activated by chloride ions. The effect of the Opn4 antagonist on photoreceptor cells is not yet known.

Versatile small molecule scaffold

2-Bromo-6-methylnicotinonitrile is a reactive heterocyclic compound that has been used as a palladium catalyst. It undergoes substitution reactions with halides and polyhalogenated compounds. The yield of this reaction depends on the substituents and functional groups present. 2-Bromo-6-methylnicotinonitrile can also be used to form alkynes, alkynes, and heterocycles.
2-Bromo-6-methylnicotinonitrile is an alkyne that has two functional groups: a nitrile group and a bromine group. It reacts with nucleophiles such as ammonia or amines to form the corresponding amide or amine in good yields.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

1-Hydroxycyclopentane-1-carbonitrile is a monomer that is hydrolyzed to form benzoin and cyanohydrins. It can be used in the production of scifinder as a monomer or dimerizer.

Versatile small molecule scaffold

2-Bromo-3,3,3-trifluoro-1-propene is a chemical compound that has been synthesized in an asymmetric reaction. The reactant is bromopropane and the product is 2,2,2-trifluoropropene. The methylene group on the propene molecule is activated by the nucleophilic attack of a fluoride ion from hydrogen fluoride to form a cavity with a highly strained bond. The kinetic study of this reaction revealed that the activation energy for the reaction is 42 kJ/mol. Palladium-catalyzed coupling reactions are catalyzed by palladium and require nonpolar solvents such as toluene or dichloromethane. This type of reaction has been shown to be exothermic with an isolated yield of 1%.

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3-Hydroxy-5-methylpyridine (3HMP) is a chemical substance that has been classified as an amine. It is a product of the metabolism of purines, which are nitrogenous bases found in DNA and RNA. 3HMP is produced by aerogenic bacteria (such as Enterobacter), and can be used to estimate the number of these bacteria present in water samples. 3HMP has been shown to have antiviral properties against influenza virus, and can be used as a biomarker for the presence of other viruses in animals. 3HMP also has mineralization properties, which have been studied extensively, particularly with regards to pancreatic disease.

4,5-Dihydroxy-2,3-pentanedione is a carbonyl compound that is the product of the oxidation of ascorbic acid. It is used in wastewater treatment and has antimicrobial properties against infectious diseases. This compound has been shown to inhibit protein synthesis by binding to the ribosome and preventing the formation of peptide bonds between amino acids. 4,5-Dihydroxy-2,3-pentanedione has also been shown to bind to plasma proteins, which may be due to its acyl chain structure. 4,5-Dihydroxy-2,3-pentanedione can be synthesized in a catalytic mechanism that involves dehydroascorbic acid and molecular oxygen.

Piperyline is an alkanoic acid that has shown to be effective against skin cancer. It also has antimicrobial properties, which may be due to its ability to bind metal ions and form polymeric compounds. Piperyline inhibits microbial growth by inhibiting the synthesis of proteins and nucleic acids. The antimicrobial activity is related to its cationic polymerization with hydroxyl groups, which forms a structure that can inhibit microbial enzymes and disrupt microbial cell membranes. This compound also interacts with the skin's natural lipids, making it difficult for microorganisms to attach and grow on the skin. Piperyline is synthesized in organic chemistry laboratories as an amide precursor of other pharmaceuticals such as penicillin.