Building Blocks

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Heat shock factor 1A (HSF1A) is a transcription factor that binds to regulatory elements in the DNA, and is also involved in the regulation of protein synthesis. HSF1A regulates gene expression during periods of cellular stress such as heat shock or oxidative stress. It is found in both cytosolic and nuclear compartments, and its binding domains are found in both cytosolic and nuclear compartments. HSF1A has a role in the specific treatment of HIV infection at physiological levels. It has been shown to regulate gene expression by binding to response elements on DNA, which is important for regulating the growth of cells. HSF1A can also act as a molecular chaperone, helping other proteins fold correctly.</p>

<p>Versatile small molecule scaffold</p>

(2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-7-[(4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-- 8-methylnonanamide butanedioic acid is a degradable drug that has vasodilatory effects on the circulatory system. It is used in clinical studies for the treatment of cardiovascular disorders such as cardiac hypertrophy and hypertension. This drug is also used to diagnose diseases such as aortic aneurysms and myocardial infarctions. The drug can be taken orally or intravenously via a solid oral formulation. (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2,2-dimethylethyl)-4hydroxy

Versatile small molecule scaffold

CU-T12-9 is a molecule that belongs to the group of toll-like receptor (TLR) agonists. It activates TLRs and has potent inhibitory activity against IL-10, TNF-α, and other inflammatory cytokines. CU-T12-9 also prevents the growth of cancer cells by inhibiting the production of tumor necrosis factor alpha (TNFα). CU-T12-9 is highly specific for human macrophages, which makes it an excellent candidate for drug development in the treatment of inflammatory conditions such as cancer. This chemical has been shown to activate TLRs on human macrophages and reduce the production of inflammatory cytokines such as IL-10, TNFα, and other inflammatory cytokines.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

2-(2-Nitro-1H-imidazol-1-yl)acetic acid is a potential drug candidate that has been shown to be an inhibitor of DNA gyrase and topoisomerase IV, which are enzymes that maintain the integrity of bacterial DNA. The linker can be attached to the 2-nitroimidazole ring in order to optimize its pharmacological profile. In addition, a nitroimidazole conjugate can be synthesized to provide a diagnostic tool for the detection of bacterial infections.

3H,4H,5H-Pyridazino[4,5-b]indol-4-one is a drug that has been shown to inhibit the angiogenic activity of endothelial cells. It also inhibits the production of factor receptor by cancer cells, which may be responsible for its anti-cancer effects. 3H,4H,5H-Pyridazino[4,5-b]indol-4-one also inhibits the growth of endothelial cells and reduces the formation of new blood vessels in an experimental model of angiogenesis. This drug has been shown to have a protective effect on neuronal cells in an animal model of Alzheimer's disease. 3H,4H,5H-Pyridazino[4,5-b]indol-4-one can be used as a treatment for diabetes mellitus type II and diabetic neuropathy because it is believed to promote the regeneration of nerve fibers by blocking the

Versatile small molecule scaffold

2-(3,4-Dichloro-benzyl)-isothiourea hydrochloride (2DICH) is a sulfinyl compound that has been shown to be an effective inhibitor of bacterial growth. It binds to the C1-6 alkyl group in the amino acid cysteine and inhibits the synthesis of proteins. 2DICH is bactericidal against organisms such as P. aeruginosa, Staphylococcus aureus and Gram-negative bacteria. The mechanism of action by which 2DICH kills bacteria is not yet known, but it may involve hemolytic activity or interaction with the cell membrane. 2DICH was found to have no effect on stenotrophomonas maltophilia and other Gram-positive bacteria such as Bacillus subtilis or Enterococcus faecalis.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>4'-(Methylsulfonyl)acetanilide is an organic compound that has been shown to have antibacterial and antiviral activity. It targets the benzene nucleus, and inhibits the synthesis of nucleic acids by inhibiting the enzyme ribonucleotide reductase. 4'-(Methylsulfonyl)acetanilide also inhibits viral replication, by binding to the active site of a viral protein (a DNA polymerase), which blocks the incorporation of nucleotides into the virus's DNA. In addition, 4'-(methylsulfonyl)acetanilide is an anti-helminthic agent, as it can inhibit worm motility and kill larvae in vitro. The structure-activity relationships between this molecule and other benzimidazole derivatives were analysed in order to identify new potential drugs for treating diseases caused by viruses or parasites.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>3-(3-Bromophenyl)pyrrolidine-2,5-dione is a targetable iontophoretic drug that binds to the skin. It is used for the treatment of inflammatory and neuropathic pain. 3-(3-Bromophenyl)pyrrolidine-2,5-dione has been shown to be effective in both hydrophobic and hydrophilic environments, meaning it can be used in both diluents and in water. The drug is insoluble in water and has an activity index of 0.9. 3-(3-Bromophenyl)pyrrolidine-2,5-dione has a molecular electrostatic potential of -1.7eV, which makes it a good candidate for use with iontophoresis devices (devices that deliver drugs through the skin by passing a current across the skin). The drug is also targeted to specific cells or tissues because of its high concentration.</p>

<p>Versatile small molecule scaffold</p>

Ethanone, 1-(2,4,6-trimethylphenyl)-, oxime (1) is an electron-rich oxime with a geometry of C(3)h. It has a dihedral angle of 194.5° and a rotational constant of 3.037 cm-1. The major substituents on the benzene ring are methyl groups at positions 2 and 6, which have constants of 0.898 and 1.922 Å respectively. The molecule has a crystal structure with space group P21/n with unit cell dimensions of a = 12.738 Å, b = 12.738 Å, c = 13.096 Å and β = 102°

Versatile small molecule scaffold

<p>4-Methanesulfinylaniline is a chemical compound that has been used as an inhibitor of cyclooxygenase-2 (COX-2) and COX-1. This drug has been shown to be effective in animal models of inflammation and hyperalgesia. 4-Methanesulfinylaniline is a regioisomeric inhibitor of COX, which means that it binds to the enzyme at a different location from other drugs. The pharmacological effects of this drug are due to its ability to inhibit the production of prostaglandins, leading to anti-inflammatory effects.</p>

<p>5-Piperidin-1-yl-furan-2-carbaldehyde is a compound that was first isolated from tobacco. It is an organic chemical that can be used as a solvent and in the manufacture of other chemicals. The analytical method for 5-Piperidin-1-yl-furan-2-carbaldehyde includes gas chromatography/mass spectrometry. This technique separates the compound by its different boiling points, which are then analyzed by mass spectrometry to determine the identity and quantity of each component.</p>

5-Nitroisophthalic acid monoethyl ester is an organic compound that belongs to the group of nitro compounds. It has a molecular weight of 188.1 g/mol and the chemical formula C6H4(NO2)2OCH2CH3. The crystallographic data were collected in two different crystallization experiments and show a monoclinic crystal structure with space group P21/n, lattice constants a = 8.852(3) Å, b = 7.959(3) Å, c = 11.411(4) Å, β = 98.532(10)°, and Z = 4. The molecular structure was determined by X-ray diffraction analysis with Bruker D8 Advanced Diffractometer at 100 Kv using CuKα radiation (λ=0.1542 nm). This compound is an isotropic solid that is soluble in benzene and methanol, but

Versatile small molecule scaffold

<p>2-[(p-chlorobenzyl)amino]-pyridine is a chemical compound that belongs to the group of aliphatic alcohols. It can be prepared by reacting 2-aminopyridine with sodium borohydride and an inorganic acid. This reaction yields a mixture of 2-[(p-chlorobenzyl)amino]-pyridine, hydroxylamine hydrochloride, and sodium chloride. Hydroxylamine hydrochloride can be removed from the mixture by azeotropic distillation. The product is used as a reducing agent for reductive amination reactions or as a catalyst for aliphatic hydrocarbon reductions.</p>

<p>(1S,2S)-2-Nitrocyclopropanecarboxylic acid is a β-unsaturated carboxylic acid that catalyzes the cyclopropanation of 1,3-dienes. It is used as a catalyst to produce synlett products by asymmetric addition to α,β-unsaturated carbonyls with thiourea. (1S,2S)-2-Nitrocyclopropanecarboxylic acid has been shown to be an effective organocatalyst for asymmetric synthesis of chiral compounds.</p>

<p>4-Ethyl-2-hydroxybenzoic acid is a molecule that has been shown to inhibit the growth of tumor cells by binding to tubulin and preventing polymerization. 4-Ethyl-2-hydroxybenzoic acid also inhibits the formation of colchicine binding sites on tubulin, which prevents colchicine from binding and inhibiting microtubule assembly. This compound has potent antiproliferative activity against a variety of cell lines and may be useful in elucidating the mechanism of action of colchicine.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>(1S,4S)-4-(Propan-2-yl)cyclohexan-1-ol is a synthetic compound that has been used in skin care products. It is more potent than cyclohexanol and it has been shown to be stereoselective. In addition, it is hydrolyzed by alcohol dehydrogenases to form hydrochloric acid, which can activate chloride ions. (1S,4S)-4-(Propan-2-yl)cyclohexan-1-ol has also been shown to react with the skin protein ankyrin, leading to a change in the kinetic parameters of the reaction.</p>

<p>2-Deoxy-D-riboside is a natural product that is an intermediate in the synthesis of ribose and deoxyribose. It has shown hypotensive and anti-inflammatory effects, as well as being an activator of ribose and galactose metabolism. In addition, it has been shown to inhibit tumor cell growth in culture. 2-Deoxy-D-riboside also inhibits the activity of the enzyme glycosyl transferase, which is involved in the synthesis of glycoproteins from a variety of sugars. It has been shown to inhibit recrystallization in reaction solutions.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(2-Bromoethoxy)-4-methoxybenzene is a compound that has various applications in different industries. It is commonly used in the synthesis of histidine, an essential amino acid, and collagen, a protein found in connective tissues. This compound can also be used as a reactant in industrial processes and as a reagent for the synthesis of other chemicals.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

6-Chloro-N2-cyclopropyl-N4-(propan-2-yl)-1,3,5-triazine-2,4-diamine is a herbicide that belongs to the chemical family of triazines. It is a potent inhibitor of the herbicide transporter (HTP) and has been shown to inhibit mouse liver microsomal drug metabolism. The optical rotation of 6CNTD is negative (-14.7°). It can react with nucleophiles such as water or amines by nucleophilic attack to produce reaction products. 6CNTD inhibits the growth of plants by inhibiting the synthesis of chlorophyll and other plant pigments, which leads to an abnormal coloration in plant leaves. This herbicide is also used as an adjuvant in insecticides and fungicides. The proposed reaction mechanism for 6CNTD is through a nucleophilic attack on the pyrazole ring followed by a Michael addition

Versatile small molecule scaffold

<p>5-Methylpyridin-2-yl)methanol is a heterocyclic compound that can be synthesized by the reaction of sodium ethoxide with hydrogen. This reaction produces the intermediate product 2-(5-methylpyridin-2-yl)ethanol, which can be reacted with potassium to produce (5-methylpyridin-2-yl)methanol. The synthesis of 5-methylpyridin-2-yl)methanol can also be achieved by reacting sodium hydride with 5-(chloromethyl)-2-(4,4,5,5,-tetramethyl-[1,3,2]dioxaborolan-2yl)pyridine. 5-(chloromethyl)-2-(4,4,5,5,-tetramethyl-[1,3,2]dioxaborolan-2yl)pyridine is reacted with methyl iodide</p>

<p>2-(2-Methoxybenzoyl)pyridine is a synthetic compound that is a 5-HT1A receptor agonist. It has been shown to stimulate the release of guanosine from ovary cells, which may be due to its ability to activate the G protein. 2-(2-Methoxybenzoyl)pyridine has been shown to inhibit the effects of antipsychotic haloperidol in vitro and in vivo. This may be due to its ability to antagonize the 5-HT1A receptor. This drug also inhibits ovary cell proliferation and induces apoptosis, which may be related to its ability to inhibit protein synthesis by binding with ribosomes and preventing translation.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

4-Sulfamoyl-phenylacetic acid (SPAA) is a potent and selective Cox-2 inhibitor. SPAA has been found to inhibit the polymerase activity of the virus, leading to apoptosis. This drug also inhibits the COX-2 enzyme and prevents the formation of prostaglandins, which are inflammatory mediators. SPAA has shown inhibitory activities against prostate cancer cells and may be effective in treating prostate cancer. SPAA also inhibits COX-2 enzyme activity in human prostate cancer cells, suggesting that it may be useful for preventing metastasis.

2,2-Dimethyl-1,3-dioxaindan-4-ol is a yellow crystalline solid that is soluble in water. It reacts with formaldehyde to give 2,2-dimethyl-1,3-dioxane dicarboxylic acid. This compound has been used as an insecticide and as a reagent in organic synthesis. It is also expressed by some mammalian cells and can be measured using immunological techniques. The antibody reacts strongly with the carboxyl group of the molecule.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

N,N'-Dihydroxynaphthalene-2-carboxamide is a ligand that binds to the covid-19 pandemic. It has been shown to have magnetic properties and can be used for accessing metal salts. Covid-19 is a metal salt with transition metal ions such as iron or cobalt, which can be accessed using N,N'-dihydroxynaphthalene-2-carboxamide. The carboxylate group in this ligand allows it to bind to metals and form complexes. Covid-19 also has chemistry and stoichiometry properties that make it suitable for polynuclear coordination compounds. Covid-19 belongs to the divalent family of ligands, which are characterized by two donor atoms.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>2-Hydroxyethylphosphonic acid (2-HEP) is a bifunctional reagent that reacts with hexadecanoic acid (16:0) to form 2-hydroxyethylhexadecanoic acid (2-HEHA). This reaction is catalyzed by the enzyme pyridoxal phosphate, which acts as a cofactor. The carbonyl group of 2-HEP reacts with the hydroxyl group of 2-HEHA to form an ester linkage, which can be cleaved by bond cleavage because it is a carboxylic acid. This process is used in analytical chemistry and has been shown to improve the quality of transgenic crops and chemical structures. The crystal structure of 2-HEP was obtained using x-ray diffraction and showed that the molecule has a flat shape with two hydroxyl groups at opposite ends.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>3-(3-Chlorophenyl)propan-1-ol is a chemical that is used as an intermediate in the synthesis of epoxides. It has been shown to be a useful asymmetric epoxidation reagent for the syntheses of natural products and pharmaceuticals. 3-(3-Chlorophenyl)propan-1-ol is typically used as a racemic mixture or as an enantiomerically pure compound. The use of this reagent allows for the synthesis of stereocenters with high levels of diastereoselectivity, which can then be converted into enantiomers.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>4-Chloro-2-nitrobenzyl alcohol is an organic compound that is a reactive nucleophile and isomer. It undergoes slow reactions with water and other nucleophiles. The reactivity of 4-chloro-2-nitrobenzyl alcohol is dependent on the solvent, pH, and temperature. This chemical does not react with most substances, including proteins and carbohydrates. 4-Chloro-2-nitrobenzyl alcohol inhibits the growth of bacteria by reacting with bacterial cytoplasmic membrane lipids, which disrupts its integrity. 4-Chloro-2-nitrobenzyl alcohol also inhibits the synthesis of proteins in bacterial cells by binding to ribosomes and interfering with translation.</p>

4-Methyl-2-nitrobenzylalcohol is a reagent used in organic synthesis. It is an acyl halide that can be prepared by the reaction of an aliphatic or aromatic alcohol with nitrous acid. 4-Methyl-2-nitrobenzylalcohol has been used to prepare acyl halides, such as acetyl chloride and benzoyl chloride, from aliphatic and aromatic alcohols respectively. This compound has also been used to convert ketones into alpha,beta-unsaturated carbonyl compounds, such as 1,3-diketones.

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold