Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>PB-22 is a synthetic cannabinoid, which can be classified as a CB1 receptor agonist. It is one of the many cannabinoids that have been created in an attempt to circumvent drug laws by creating compounds that are similar to those found in cannabis but have different chemical structures. PB-22 has shown to increase locomotor activity and stimulate the cb1 receptor in mice. Magnetic resonance spectroscopy (MRS) and assays were used to determine the binding affinity of PB-22 for the CB1 receptor. The MRS data showed that PB-22 bound with high affinity to the CB1 receptor and had a lower affinity for CB2 receptors. This suggests that PB-22 may be more potent than other synthetic cannabinoids, such as JWH-018 and CP 55,940, which bind better with CB2 receptors than CB1 receptors.<br>PB-22 is an analog of JWH-073 and has been shown to have a stronger effect on locomotor activity than JWH</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Sodium 2-hydroxyethoxyacetate is a cross-linker that is used to immobilize proteins and enzymes. It has been shown to be effective in the treatment of autoimmune diseases, such as rheumatoid arthritis. This chemical can also be used as a cross-linking agent for the production of biodegradable polymers. The synthesis of this chemical was first reported in 1874 and it has been used for copolymerization with other compounds to form particles with potential biomedical applications.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Methoxy-4H-chromen-3-one is an organic compound that belongs to the group of organocopper compounds. It has been extracted from plants and animals, such as leaves and fruit. This chemical can be used in the production of ethyl esters, which are a type of organic compound. 5-Methoxy-4H-chromen-3-one can also be used in the synthesis of trackable acid ethyl esters, which are used in the detection and identification of drugs.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Hydroxymethyl)cyclobutan-1-one is a synthetic piperazine derivative that has been shown to have antitumor and antimycobacterial activities. It is a selective inhibitor of the enzyme purine nucleoside phosphorylase (PNP), which catalyzes the conversion of inosine monophosphate (IMP) to xanthosine monophosphate (XMP). This inhibition results in an accumulation of IMP and deoxyinosine monophosphate (dIMP) in tumor cells. 3-(Hydroxymethyl)cyclobutan-1-one also inhibits Mycobacterium tuberculosis, but not other bacteria such as Escherichia coli or Staphylococcus aureus. The product is synthetically produced by reacting cyclobutanone with hydroxylamine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine is a reactive and labile compound that has been shown to inhibit the nuclear factor kappa B (NF-κB). It is an analog of 2,4,6,-trichlorophenyl-1,3,5-triazine. 4,6-Dichloro-N-phenylsulfonyl triazin-2 amine is a chlorinated derivative of 4,6 dichloro triazin 2 amine. The chlorine atom in the molecule may be replaced with a cyanuric or chloride group. This chemical compound is used in dyestuffs and as a precursor for other chemicals. The effect varies depending on the dose administered.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Naphthalene-2-carboximidamide is a benzamidine derivative that interacts with the active site of serine proteases. It was shown to have potent inhibitory potency against a number of proteinases, including urokinase-type plasminogen activator (uPA), matrix metalloproteinase-9 (MMP-9), and cathepsin G. The interaction of naphthalene-2-carboximidamide with uPA was specific and led to inhibition of its catalytic activity. Naphthalene-2-carboximidamide has been tested in clinical trials for the treatment of influenza.</p>

<p>2,4-Dimethoxyphenyl isothiocyanate (DMITC) is a molecule that has been shown to have pro-apoptotic activity against human colorectal carcinoma cells. It also inhibits the growth of the colon cancer cells by inducing apoptosis. DMITC has been shown to inhibit the synthesis of DNA and RNA in a dose-dependent manner. This molecule is efficiently synthesized by reacting an imine with an isothiocyanate. DMITC has cytometric analysis for mechanistic studies and can be used as a chemotherapeutic agent for cancer treatment.</p>