Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 2-phenylethanecarboximidate hydrochloride is a dorzolamide hydrochloride prodrug that has been shown to have biological activity. It binds to the 2-adrenergic receptor and stimulates a conformational change in the receptor, leading to increased intracellular cyclic AMP levels. Methyl 2-phenylethanecarboximidate hydrochloride has been shown to inhibit the production of ICOTINIB HCl, an inhibitor of cell factor and cox-2. This drug also has been shown to have cardiac effects, including increasing heart rate and reducing the time interval between heartbeats. Methyl 2-phenylethanecarboximidate hydrochloride may be used as an optical sensor for measuring pH or as an electrochemical impedance spectroscopy agent for determining benzalkonium chloride concentrations.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

8-Oxabicyclo[3.2.1]octan-2-one (8OBA) is a β-unsaturated ketone with an oxime group at the 8 position. It can be prepared by cyclization of 2,5-diketones with a phosphonate ester in the presence of a base. The syntheses of various ketones have been accomplished using this process, including β-unsaturated ketones and oxophosphonates. This compound is also used as a building block for synthesis of furan derivatives, such as 2,5-furandione and 3,6-dihydro-4H-pyran.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Phenylcyclopent-2-en-1-one is a cyclic ketone that can be used in the preparation of 2-phenylcyclopentanones by deoxygenation. The compound can also be converted to cyclopentenones by treatment with alcohols, olefins, or esters. It is also useful for the synthesis of the vinyl ethers and cycloadditions. The reduction of this molecule produces cyclohexanol. Treatment with methanol produces 1,4-benzodiazepine derivatives. Finally, it can be used for annulation reactions as well.</p>

<p>1-Chloro-4-(isocyanomethyl)benzene is a heterocyclic compound that belongs to the morpholine family. It is activated by electron withdrawing groups such as nitro, chloro, and cyano groups. The functionalities of this molecule are amines, nitro, and chloro. 1-Chloro-4-(isocyanomethyl)benzene has been shown to be an inhibitor of pyrrole synthesis in biochemical studies. In addition, it has been shown to be a competitive inhibitor of xanthate oxidation in cyclic biochemical reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-3-iodoprop-1-ene is a synthetic chemical that is used as a reagent in organic synthesis. It has been shown to react with alkyl halides, acyl halides, and anilines to produce β-chloro ketones, α,β-unsaturated esters, and chloroamidines respectively. The reaction with chloride ions produces 2-chloroethyl chloroacetate. This compound can also be used to cross-couple aromatic rings using palladium catalysts. 2-Chloro-3-iodopropane is a precursor to polyphosphoric acid (PPA), which is used in the production of fertilizers.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Butyl-2-cyanoacetamide is a chemical compound that is used to express nature and functionalized. The chemical formula for N-Butyl-2-cyanoacetamide is CH3CONHC(CN)COOCH3. It has a melting point of -80 degrees Celsius, a boiling point of 150 degrees Celsius, and a density of 1.08 grams per cubic centimeter.</p>

<p>2-Cyano-N-methyl-N-phenylacetamide is a diazo compound that is used as a ligand for the β-lactams. It can be prepared by reacting methylcyanamide with phenylacetic acid in the presence of nitrous acid. 2-Cyano-N-methyl-N-phenylacetamide reacts with carbonyl groups to form an oxime, which can be hydrolyzed to produce an amine. This reaction occurs intramolecularly and catalysed by copper or silver salts. The houben–hoesch reaction of 2,4,6,8 tetramethylpiperidine with 2-cyano N -methyl N -phenyl acetamide yields the piperidine derivative 1-(2 cyanoethyl)-2-(2 methoxyethoxy)ethylamine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1H-Pyrrole-2,5-dicarbaldehyde is a molecule that has been shown to have antibacterial properties. It binds to the amine nitrogen of the protein and forms an imine intermediate. This intermediate will react with other molecules to form a condensation product. The condensation product is then hydrolyzed by water or ammonium hydroxide to release 1H-pyrrole-2,5-dicarbaldehyde.<br>1H-Pyrrole-2,5-dicarbaldehyde has been shown to be effective against bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa in bioassays. X-ray diffraction data supports the idea that this molecule has an intramolecular hydrogen bond between the carbonyl group and the nitrogen atom. This reactive molecule also has mononuclear nitrogen atoms that can bind to anions such as chloride ions and nitrate ions, which are</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,3-Diethyl 5-hydroxybenzene-1,3-dicarboxylate is a ligand that binds to transition metal ions and has been shown to have a constant fluorescence emission. The ligand can be used as a fluorescent probe for the study of hydrogen bonding and transport properties in solids. 1,3-Diethyl 5-hydroxybenzene-1,3-dicarboxylate has also been shown to have functional theory applications and is soluble in chlorides.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Hydroxy-3-methoxybenzohydrazide is a magnetic material that has linear, assembled, and magnetization properties. It is a ligand that binds to metal ions and forms a stable complex. The magnetic property of this compound was determined by measuring its susceptibility to an external magnetic field. The magnitude of this susceptibility depends on the orientation of the molecule in the external magnetic field and can be used to identify the type of molecular interactions occurring between the compound and the metal ion.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methyl-3-(methylsulfanyl)butan-1-ol is a metabolite of felinine, which is an amino acid that is only found in cats. It has been shown to be a urinary protein in laboratory mice and to have a physiological effect on the animals. The major metabolic pathway of 3-methyl-3-(methylsulfanyl)butan-1-ol is via the enzyme hplc analysis, which converts it into 3-mercapto-3-methyl-1-butanol. 3MSB has also been shown to be an intermediate in the synthesis of amines, such as serotonin and dopamine.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Isopropylphenyl isothiocyanate (4IPI) is a potent inhibitor of leukotriene biosynthesis. It inhibits the enzyme 5-lipoxygenase, which converts arachidonic acid to leukotrienes. 4IPI has been shown to inhibit the production of leukotrienes in animals. This compound has also been shown to be an effective inhibitor of benzothiazole and benzoxazole synthesis in vitro.<br>4IPI is used for research purposes and has not been approved for use as a medication in humans.</p>

<p>Chloramine-T is an organic solvent that can be used as a dehydrohalogenating agent in the synthesis of medicines. It is also used in the production of dichloropyridine, which are medicines. The average particle diameter of chloramine-T is about 1.5 micrometers. This agent has been shown to react with alkali metals and alicyclic compounds, such as benzene and cyclohexane. Chloramine-T has also been shown to react with aromatic hydrocarbons, such as phenol and aniline, forming a product known as chlorophenols. Chloramine-T is soluble in hydrocarbon solvents including aliphatic hydrocarbons (such as hexane) and synthetic solvents (such as tetrahydrofuran).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Oxo-1,3-oxazolidine-4-carboxylic acid is a chemical compound that belongs to the group of organic solvents. It is a racemic mixture of two stereoisomers that are mirror images of one another. This compound has been shown to have antifungal properties, inhibiting the growth of Talaromyces and Curvularia. 2-Oxo-1,3-oxazolidine-4-carboxylic acid has also been shown to be effective against Achromobacter and Racemizea species and to inhibit the growth of Pseudomonas aeruginosa. The conformation of this molecule is an acidic pseudopeptide with a sulfur atom at C2.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(2-Fluorophenyl)-1H-pyrrole is a nucleophilic aromatic amine that reacts with chloride to form the 1-(2-fluorophenyl)pyrrole chloride. It has been used in the synthesis of benzoxazines and alcohols. The product yield is high and it is reusable. It also reacts with choline chloride to form the 1-(2-chlorophenyl)-1H-pyrrole chloride, which can be hydrolyzed into choline and fluorine. This compound can also be used in the preparation of a choline eutectic mixture, which is a liquid mixture of chloroform and ether that freezes at -26°C.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ammonium hydroxide reacts with 5-hydroxymethylfurfural in the presence of a catalyst to produce 5-(hydroxymethyl)furan-2-carbonitrile. The reaction is catalyzed by copper and zinc oxide at high temperature, and the product is obtained as a mixture of cis and trans isomers. The yield of the reaction can be increased by using an excess of ammonia as the nitrogen source. Kinetic experiments have shown that the rate determining step for this reaction is hydration. Furfural oxidation takes place in aerobic conditions in the presence of a refluxing solution of ammonium chloride.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-4-iodopyridine is a molecule that regulates the positioning of molecules. It has two different isomers, which have different conformational and intramolecular hydrogen bonding properties. 3-Bromo-4-iodopyridine is synthesized by reacting 3-bromopyridine with iodine monochloride in the presence of sodium hydroxide. This reaction produces a mixture of the two isomers, which can be separated using fractional crystallization or chromatography. 3-Bromo-4-iodopyridine has been shown to stabilize low efficiency solar cells.</p>

<p>4-Chloro-3-iodopyridine is a heterocyclic compound that has been used in the synthesis of tripeptides. 4-Chloro-3-iodopyridine can be synthesized by the cross-coupling of an unsymmetrical quinoline derivative and an iodide. This reaction is catalyzed by copper and produces a mixture of regioisomers. The isolated yield obtained from this synthesis was low, with only 3% being the desired product. The synthesis of 4-chloro-3-iodopyridine was also shown to have high yields when using anthracene as a starting material and halopyridines as coupling partners.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methyl-1,3-thiazole-5-carbohydrazide (MTZ) is a crystalline solid that has been shown to be stable in water and other polar solvents. It has been used as a precursor for the synthesis of sulfonyl chloride compounds. MTZ can be prepared by reacting benzenesulfonyl chloride with methyl iodide in the presence of potassium carbonate. This reaction results in an intermolecular S2 substitution on the benzene ring, which is stabilized by hydrogen bonding. MTZ reacts with Cl and Br to form chlorides and bromides respectively.</p>

<p>4-Amino-6-methylpyrimidine-2-thiole is a macrocyclic, polyhedra ligand that interacts with the extracellular domain of lipase. It has been shown to be bacteriostatic against Staphylococcus aureus and other bacteria. 4-Amino-6-methylpyrimidine-2-thiole can bind to the active site of the lipase and inhibit its function by preventing the release of fatty acids from chylomicrons and triglycerides. This drug also inhibits bacterial growth by binding to nucleobases, which are essential for DNA synthesis and transcription.</p>

<p>5,6-Dichloropyridazin-4-amine is an aminopyridazine that has been synthesized and studied as a potential therapeutic agent. It is a quinone with an azide group. The synthesis of 5,6-dichloropyridazin-4-amine can be achieved by reacting pyridazine with sulfuric acid, followed by the addition of chlorine and then ammonia. This reaction produces a mixture of the desired product, 5,6-dichloropyridazin-4-amine and other products such as 5,6-dichloroquinoxaline. This compound has shown to have antihypertensive activity in rats and may also have some medicinal properties due to its ability to inhibit the synthesis of betaines.</p>

<p>2-Sulfanyl-1,3-thiazole-4-carboxylic acid is a receptor binding compound that has been shown to bind to the prostaglandin E4 (EP4) receptor. This compound is an analog of prostaglandin F2α and has been shown to inhibit the binding of subtype EP4 receptors in a receptor binding assay. The structure activity relationship (SAR) of 2-sulfanyl-1,3-thiazole-4-carboxylic acid has been evaluated and optimized for maximum binding affinity with the EP4 receptor. These changes were found to be most effective in lowering blood pressure in rats.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>