Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-4-chloropyridine-3-carboxaldehyde is a synthetic compound that has been shown to inhibit the kinase activity of the tyrosine kinase receptor, a protein that regulates cell growth and differentiation. It was developed as a potential treatment for autoimmune diseases, including erythematosus and rheumatoid arthritis. This drug has been studied in clinical trials as an oral agent with good pharmacokinetic properties and was found to be safe and well tolerated at doses up to 1000mg per day. These studies have shown promising results in early phase 2 clinical trials.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methyl-3-(methylsulfanyl)butan-1-ol is a metabolite of felinine, which is an amino acid that is only found in cats. It has been shown to be a urinary protein in laboratory mice and to have a physiological effect on the animals. The major metabolic pathway of 3-methyl-3-(methylsulfanyl)butan-1-ol is via the enzyme hplc analysis, which converts it into 3-mercapto-3-methyl-1-butanol. 3MSB has also been shown to be an intermediate in the synthesis of amines, such as serotonin and dopamine.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Isopropylphenyl isothiocyanate (4IPI) is a potent inhibitor of leukotriene biosynthesis. It inhibits the enzyme 5-lipoxygenase, which converts arachidonic acid to leukotrienes. 4IPI has been shown to inhibit the production of leukotrienes in animals. This compound has also been shown to be an effective inhibitor of benzothiazole and benzoxazole synthesis in vitro.<br>4IPI is used for research purposes and has not been approved for use as a medication in humans.</p>

<p>Chloramine-T is an organic solvent that can be used as a dehydrohalogenating agent in the synthesis of medicines. It is also used in the production of dichloropyridine, which are medicines. The average particle diameter of chloramine-T is about 1.5 micrometers. This agent has been shown to react with alkali metals and alicyclic compounds, such as benzene and cyclohexane. Chloramine-T has also been shown to react with aromatic hydrocarbons, such as phenol and aniline, forming a product known as chlorophenols. Chloramine-T is soluble in hydrocarbon solvents including aliphatic hydrocarbons (such as hexane) and synthetic solvents (such as tetrahydrofuran).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Oxo-1,3-oxazolidine-4-carboxylic acid is a chemical compound that belongs to the group of organic solvents. It is a racemic mixture of two stereoisomers that are mirror images of one another. This compound has been shown to have antifungal properties, inhibiting the growth of Talaromyces and Curvularia. 2-Oxo-1,3-oxazolidine-4-carboxylic acid has also been shown to be effective against Achromobacter and Racemizea species and to inhibit the growth of Pseudomonas aeruginosa. The conformation of this molecule is an acidic pseudopeptide with a sulfur atom at C2.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(2-Fluorophenyl)-1H-pyrrole is a nucleophilic aromatic amine that reacts with chloride to form the 1-(2-fluorophenyl)pyrrole chloride. It has been used in the synthesis of benzoxazines and alcohols. The product yield is high and it is reusable. It also reacts with choline chloride to form the 1-(2-chlorophenyl)-1H-pyrrole chloride, which can be hydrolyzed into choline and fluorine. This compound can also be used in the preparation of a choline eutectic mixture, which is a liquid mixture of chloroform and ether that freezes at -26°C.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ammonium hydroxide reacts with 5-hydroxymethylfurfural in the presence of a catalyst to produce 5-(hydroxymethyl)furan-2-carbonitrile. The reaction is catalyzed by copper and zinc oxide at high temperature, and the product is obtained as a mixture of cis and trans isomers. The yield of the reaction can be increased by using an excess of ammonia as the nitrogen source. Kinetic experiments have shown that the rate determining step for this reaction is hydration. Furfural oxidation takes place in aerobic conditions in the presence of a refluxing solution of ammonium chloride.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-4-iodopyridine is a molecule that regulates the positioning of molecules. It has two different isomers, which have different conformational and intramolecular hydrogen bonding properties. 3-Bromo-4-iodopyridine is synthesized by reacting 3-bromopyridine with iodine monochloride in the presence of sodium hydroxide. This reaction produces a mixture of the two isomers, which can be separated using fractional crystallization or chromatography. 3-Bromo-4-iodopyridine has been shown to stabilize low efficiency solar cells.</p>

<p>4-Chloro-3-iodopyridine is a heterocyclic compound that has been used in the synthesis of tripeptides. 4-Chloro-3-iodopyridine can be synthesized by the cross-coupling of an unsymmetrical quinoline derivative and an iodide. This reaction is catalyzed by copper and produces a mixture of regioisomers. The isolated yield obtained from this synthesis was low, with only 3% being the desired product. The synthesis of 4-chloro-3-iodopyridine was also shown to have high yields when using anthracene as a starting material and halopyridines as coupling partners.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methyl-1,3-thiazole-5-carbohydrazide (MTZ) is a crystalline solid that has been shown to be stable in water and other polar solvents. It has been used as a precursor for the synthesis of sulfonyl chloride compounds. MTZ can be prepared by reacting benzenesulfonyl chloride with methyl iodide in the presence of potassium carbonate. This reaction results in an intermolecular S2 substitution on the benzene ring, which is stabilized by hydrogen bonding. MTZ reacts with Cl and Br to form chlorides and bromides respectively.</p>

<p>4-Amino-6-methylpyrimidine-2-thiole is a macrocyclic, polyhedra ligand that interacts with the extracellular domain of lipase. It has been shown to be bacteriostatic against Staphylococcus aureus and other bacteria. 4-Amino-6-methylpyrimidine-2-thiole can bind to the active site of the lipase and inhibit its function by preventing the release of fatty acids from chylomicrons and triglycerides. This drug also inhibits bacterial growth by binding to nucleobases, which are essential for DNA synthesis and transcription.</p>

<p>5,6-Dichloropyridazin-4-amine is an aminopyridazine that has been synthesized and studied as a potential therapeutic agent. It is a quinone with an azide group. The synthesis of 5,6-dichloropyridazin-4-amine can be achieved by reacting pyridazine with sulfuric acid, followed by the addition of chlorine and then ammonia. This reaction produces a mixture of the desired product, 5,6-dichloropyridazin-4-amine and other products such as 5,6-dichloroquinoxaline. This compound has shown to have antihypertensive activity in rats and may also have some medicinal properties due to its ability to inhibit the synthesis of betaines.</p>

<p>2-Sulfanyl-1,3-thiazole-4-carboxylic acid is a receptor binding compound that has been shown to bind to the prostaglandin E4 (EP4) receptor. This compound is an analog of prostaglandin F2α and has been shown to inhibit the binding of subtype EP4 receptors in a receptor binding assay. The structure activity relationship (SAR) of 2-sulfanyl-1,3-thiazole-4-carboxylic acid has been evaluated and optimized for maximum binding affinity with the EP4 receptor. These changes were found to be most effective in lowering blood pressure in rats.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(4-Bromo-1H-indol-3-yl)acetonitrile is an organic compound that contains a cyano group, which is a functional group consisting of three carbon atoms and one nitrogen atom. This molecule has an indole ring system with two hydrogen bonds. The acetonitrile chain is four carbons long, while the cyano group is only one carbon long.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-(1H-Pyrazol-3-yl)aniline is a protonated form of fentanyl that interacts with the opioid receptors in the body. It is used as an analgesic, but also has a high risk for abuse and addiction. The drug is not considered to be a controlled substance according to the Controlled Substances Act. 3-(1H-Pyrazol-3-yl)aniline is a synthetic compound that does not have any major side effects other than respiratory depression, which can be reversed with naloxone. This drug has been found to have long lasting effects, making it suitable for chronic pain management. 3-(1H-Pyrazol-3-yl)aniline binds to the endocyclic nitrogen atom on the phenyl ring of fentanyl and causes ionization in water, which may lead to its long lasting effects. 3-(1H-Pyrazol-3-yl)aniline can be administered</p>

<p>Versatile small molecule scaffold</p>