Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(1s,3s)-3-(Benzyloxy)cyclobutanol (BOC) is a prodrug that has been shown to inhibit proliferation of cancer cells in vitro. BOC has also been shown to inhibit tumor growth by blocking the cellular uptake of glucose, which is an important source of energy for cancer cells. The use of positron emission tomography (PET) and radiolabeling with BOC can be used as a model system to study cancer metabolism and metastasis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Dimethylamino)pyridin-3-ol is a nucleophilic reagent that can be used to modify biomolecules with azide and alkyne functionalities. It can be used for the synthesis of peptide receptor agonists and antagonists, as well as for labeling proteins and nucleic acids. This compound also has bifunctional characteristics, which means it can act as both a precursor in the synthesis of prosthetic groups and peptides, as well as an intermediate in the preparation of organic compounds. 2-(Dimethylamino)pyridin-3-ol is a commercially available chemical that yields high purity (&gt;99%) when synthesized from 2-amino-5H-pyridin-2-one.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(2-Amino-ethyl)-urea hydrochloride is a ligand that binds to the nitro group of the aromatic amine, phenylhydrazine. This binding prevents the formation of reactive oxygen species, which are involved in neurodegeneration and cancer. The affinity for the ligand is determined by steric factors, with methyl ester being more potent than ethyl ester. The 2-aminoethyl urea ligand binds to the carboxylate region of phenylhydrazine and inhibits its activity.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>2-Oxaspiro[4.5]decan-3-one is a chemical that is structurally related to the neurotransmitter gamma-aminobutyric acid (GABA). It has been shown to be an effective treatment for chronic pain, with a relatively low incidence of adverse effects. 2-Oxaspiro[4.5]decan-3-one inhibits the activity of protein kinase C, which may contribute to its analgesic effect. GABA receptors are present in the detrusor muscle and urethral sphincter, which may explain some of the drug's efficacy. 2-Oxaspiro[4.5]decan-3-one also binds to gabapentin binding sites on the alpha2 delta subunit of voltage dependent calcium channels and inhibits Ca2+ entry into cells, thereby reducing intracellular Ca2+ levels and lowering the excitability of neurons.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Nitrophenyl N,N-dimethylcarbamate is an enzyme that catalyses the chemical reaction: anions + NADPH → nitrite + NADP. The enzyme can be inactivated by chloral and aldehyde dehydrogenase. It is labile in the cytosol but stable when bound to follicle cells. 4-Nitrophenyl N,N-dimethylcarbamate has been used to measure the activity of this enzyme in follicle cells, which are found in the ovaries and testes. The protein is active only when it binds to follicle cells.</p>

<p>1-Nitro-4-propoxybenzene is a covalent inhibitor of aspartic acid proteases. It is an aspartic acid analog that competes with the natural substrate for the active site and inhibits the transpeptidation reaction. This compound has been shown to be highly selective against renin, which is a key enzyme in the blood coagulation cascade. The 1-nitro group can be replaced by other groups to modulate potency or selectivity. These modifications may also improve water solubility, stability, or bioavailability.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>2-Amino-4-chloromethylthiazole (2ACMT) has been shown to be an effective antifilarial agent in pyridinium, acanthocheilonema, and refluxed mice. 2ACMT is a nucleophilic compound that binds to the active site of the enzyme DNA gyrase, inhibiting DNA synthesis. This drug also has antibacterial activity, which may be due to its ability to inhibit protein synthesis in bacteria.</p>

Ethyl 3-hydroxy-1H-pyrazole-4-carboxylate is a hypoglycemic agent that binds to the ATP receptor in the body. It has been shown to reduce blood sugar levels in diabetic mice and has also been used to treat cancer. Ethyl 3-hydroxy-1H-pyrazole-4-carboxylate is an amide with a hydrogen bond, which may be responsible for its ability to bind to the ATP receptor. This drug is not effective against bladder, hepatitis, or nervous system diseases. Ethyl 3-hydoxy-1H-pyrazole-4-carboxylate is effective against neurodermatitis and inflammatory diseases, but only at high doses.

<p>Versatile small molecule scaffold</p>

<p>3-Methoxybenzenepropanol is an organic compound that belongs to the group of hydrocarbons. It is made by reacting allylsilane with chloride in a hydroboration reaction to form a single-crystal x-ray analysis. 3-Methoxybenzenepropanol has been shown to react with cyclopropanes, forming intramolecular cyclopropanation and ring-opening reactions to yield x-ray products. This product has also been used as a precursor for the synthesis of tetralin and biomolecules.</p>

Versatile small molecule scaffold

<p>(2-Aminoethyl)(decyl)amine is an orthogonal and metallic amino acid that can be used as a ligand for monolayer formation. This amino acid is synthesized from the reaction of 2-aminopropane and decanol, which are both readily available in industry. The unique properties of (2-aminoethyl)(decyl)amine make it an ideal candidate for use in tailored nanoparticles to form a monolayer.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(Cyclopentylideneamino)thiourea is a chemical compound that is also known as CPT. CPT is a tautomer of the amino acid cysteine and has been shown to have anti-cancer properties in vitro. It chelates with ferric ions, forming a redox cycle that produces reactive oxygen species (ROS). This leads to lipid peroxidation and cell death. CPT has been shown to be effective against neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, it does not work on cancer cells that are resistant to chemotherapy drugs such as 5-fluorouracil or cisplatin. The mechanism of action for these types of cancers is not yet fully understood.</p>

<p>Ethyl 5-hydroxy-2-methyl-1-benzofuran-3-carboxylate (EHMBFC) is a novel photocurrent sensitizer that has been shown to be effective in the treatment of prostate cancer cells. It is formed by the formylation of an ethyl ester of 5,6,7,8-tetrahydroquinoline. EHMBFC is capable of inducing demethylation reactions with DNA glycosylases and polymerases. The quantum efficiency of this compound has been determined to be greater than 0.5%. This efficiency can be increased by adding ruthenium nanoparticles as a catalyst. EHMBFC is also used in solar cell technology because it can generate charge carriers from visible light and can function as an electron donor or acceptor in organic semiconductors.</p>

<p>1-(2-Methylphenyl)ethanol is a colorless liquid with a pleasant odor. It can be used as an intermediate in the synthesis of various pharmaceuticals, such as diazepam and lorazepam. 1-(2-Methylphenyl)ethanol is oxidized to produce toxic metabolites that have been shown to have cytotoxic effects on mitochondria. In addition, 1-(2-Methylphenyl)ethanol has been shown to inhibit the formation of cyclic amides from carboxylic acids and amines by competing for the same enzyme binding site. The toxicity of this compound was studied in rats using acute toxicity tests, and it induced hematological parameters indicative of renal toxicity.</p>

<p>Versatile small molecule scaffold</p>

2-[(4-Nitrophenyl)methyl]-1H-1,3-benzodiazole (NPDB) is an antioxidant that can be used to protect cells against free radical damage. It has significant antioxidant activity and can inhibit the production of reactive oxygen species (ROS). NPDB has been shown to have a protective effect on cells by inhibiting lipid peroxidation and the oxidation of thiadiazole. The antioxidant activities of NPDB are due to its ability to inhibit the activity of various enzymes, such as oxidase, triazole or moieties that significantly affect ROS production.

<p>Versatile small molecule scaffold</p>

<p>4-(1,3-Dioxaindan-5-yl)butan-2-yl]hydrazine hydrochloride (4ODBH) is a selective inhibitor of the enzyme dopamine β-hydroxylase. It is used in the treatment of inflammatory bowel disease and has been shown to decrease symptoms of this disease. 4ODBH has also been shown to inhibit adipose tissue inflammation, increase weight loss in obese subjects, and reduce inflammation in the epididymal adipose tissue. This drug can cause toxic epidermal necrolysis and Stevens-Johnson syndrome when taken at high doses. 4ODBH has also been shown to have effects on toll-like receptor signaling pathways and may be an effective drug for treating diabetic neuropathy.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>5'-Acetamido-2'-hydroxyacetophenone is a monoclonal antibody that has been shown to inhibit the growth of cancer cells. The antibody elicits its effect by binding to the benzofuran derivatives, which are oncogenic proteins that promote the development of cancer. In vitro assays have shown that 5'-Acetamido-2'-hydroxyacetophenone inhibits the activity of cromakalim and prognosis in patients with malignant melanoma. There is also evidence suggesting that this drug may be effective against other types of cancer, including prostate, breast, lung, and colon cancers. 5'-Acetamido-2'-hydroxyacetophenone binds to the benzofuran derivatives oncogenic proteins by preventing them from interacting with their receptor and inhibiting protein synthesis. This process leads to cell death by inhibiting the production of proteins vital for cell division.<br>!--END--&gt;/p&gt;</p>