Building Blocks

Versatile small molecule scaffold

<p>1,4-Butanediol Bis(3-aminopropyl) Ether is a ether compound that can be used as a chemical reagent. It is a heterobifunctional reagent that can react with two different functional groups to form ether linkages. 1,4-Butanediol Bis(3-aminopropyl) Ether has been shown to be an efficient catalyst for the synthesis of nicotinic acetylcholine in oocytes from the frog Xenopus laevis. More importantly, it has been shown to be an effective catalyst for the synthesis of chiral amines. This chemical reaction occurs through an activating hydrogen atom transfer (HAT) process between nitrogen atoms and chloride ions. The activation energy for this reaction is significantly lower than that of other reactions involving chlorine ions or thallium ions.</p>

<p>Versatile small molecule scaffold</p>

<p>1-[(Pyrrolidin-1-yl)methyl]pyrrolidine is a chemical compound that is structurally related to the neurotransmitter κ-opioid receptor. This drug has been used as a model system to study the effects of nitro, which is an endogenous agonist of the κ-opioid receptor. 1-[(Pyrrolidin-1-yl)methyl]pyrrolidine has been shown to have depressant effects on the central nervous system. The drug also has a direct effect on renal proximal tubules, leading to potassium secretion and natriuresis. 1-[(Pyrrolidin-1-yl)methyl]pyrrolidine also binds with moderate affinity to mineralocorticoid receptors and growth factor receptors.</p>

<p>2-(3-Methoxy-phenoxy)-propionic acid is a chiral compound that is used in organic synthesis. The racemic form of this molecule can be crystallized with the help of other molecules such as cocrystallization, heterodimers, underscores and enantiomers. It crystallizes in two different forms: the α-form and the β-form. The α-form has a melting point of 120 °C, whereas the β-form melts at 138 °C. The polymorphic nature of 2-(3-methoxy-phenoxy)-propionic acid is due to its structural differences in the crystal lattice. These differences are made possible by supramolecular interactions between neighboring molecules.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>5-Vinylbenzo[d][1,3]dioxole is an organic compound that belongs to the amide class. It has been shown to be a potent inhibitor of leishmania and related protozoan parasites. 5-Vinylbenzo[d][1,3]dioxole inhibits these parasites by targeting the amine group on their surface, which is responsible for the conversion of ammonium nitrate into nitric oxide. 5-Vinylbenzo[d][1,3]dioxole also has reactive properties and can form covalent bonds with other molecules in a process called redox chemistry. This property makes it useful as a reactive intermediate in chemical synthesis. 5-Vinylbenzo[d][1,3]dioxole is an example of a primary amino compound because it does not contain any secondary or tertiary amines.</p>

<p>Versatile small molecule scaffold</p>

<p>Diethyl [(oxiran-2-yl)methyl]phosphonate is a monoepoxide that can be used as a nucleophile in organic reactions. The hydroxylamine group of diethyl [(oxiran-2-yl)methyl]phosphonate reacts with a variety of substrates, including polyesters and silicone resins. This reaction is catalyzed by hydrochloric acid or other acids. Diethyl [(oxiran-2-yl)methyl]phosphonate is also known to react with diphenylmethane to produce oxirane.</p>

<p>Versatile small molecule scaffold</p>

<p>1,2-Epoxyhexadecane is a calcium stearate that inhibits the growth of cells. It has been shown to have an inhibitory effect on cell growth when used in combination with piperonyl butoxide and glauberite. 1,2-Epoxyhexadecane can also be used as a cationic surfactant for extraction of intracellular targets with monolayer partitioning. This product is also known to cause cancer.</p>

<p>2-Bromophenyl Methyl Sulfoxide is a chiral molecule that has been studied for its light emission properties. It has potentials as an electrochemical oxidant, which can be used to oxidize organic compounds and hydrogen peroxide. 2-Bromophenyl Methyl Sulfoxide is soluble in solvents such as triflic acid, sulfur dioxide, and carbon tetrachloride. The oxidation of the sulfoxides with 2-bromophenyl methyl sulfoxide yields the corresponding sulfones. This compound has also been studied for its optical properties.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>2-(Aminomethyl)-2-(hydroxymethyl)propane-1,3-diol (DMAPP) is a plant amino acid that is an intermediate in the synthesis of aminobutyric acid. It is also involved in the synthesis of ethylene, which is important for fruit ripening. DMAPP has been shown to be a precursor for the α-subunit of carbonic anhydrase and it has been detected in urine samples and assays. The uptake of DMAPP from water by plants has been studied using gas chromatography and ultracentrifugation. DMAPP has also been used as a biochemical marker for plant physiology studies.</p>

Monomethyl Itaconate is a chemical compound that has been used to synthesize polymers for use in the production of coatings, adhesives, and lubricants. It is a liquid at room temperature with a viscosity of about 4.3 cSt at 25°C. Monomethyl Itaconate is soluble in organic solvents such as benzene, ether, or chloroform and can be stored in temperatures from -30°C to 120°C. The FT-IR spectroscopy has shown that this chemical has an active methylene group and contains one double bond. This product also has high optical purity and low viscosity, which makes it useful for polymerization reactions.

<p>Diphenylprop-2-yn-1-one is a nitro compound that reacts with an acid to produce a terminal alkene. It has been shown to have a high melting point and does not react with light, making it useful for organic solvents. Diphenylprop-2-yn-1-one also binds to the enzyme acetylcholinesterase in Alzheimer's disease, which may help to prevent or delay the development of neurodegenerative diseases. The bond cleavage reaction can be used as a model system for studying the mechanism of alkynes and dialkylamino compounds.</p>

<p>2-Methylbenzyl mercaptan is a covalent probe for the detection of yields. It can be used as an additive in organic chemistry to increase the efficiency of reactions. 2-Methylbenzyl mercaptan has been shown to catalyze the desulfurization of amines and dithiocarbamates. This compound reacts with electrophiles such as oxygen, chlorine, and bromine. The reaction forms a crosslinked structure that is resistant to further reaction with these electrophiles. 2-Methylbenzyl mercaptan has also been shown to react with amines and form desulfurized products through transfer of a methyl group from the mercaptan to the amine.</p>

3-Chloro-1-benzothiophene is a molecule that is used to treat bowel disease. It has been shown to inhibit the proliferation of colon cancer cells in vitro and in vivo, as well as to induce apoptosis. 3-Chloro-1-benzothiophene also inhibits inflammation by blocking chloride channels, which are found on the surface of inflammatory cells in the digestive tract. This drug may have regenerative effects because it has been shown to stimulate the growth of new nerve and muscle cells in mice. 3-Chloro-1-benzothiophene binds to receptor cells and blocks chloride channels, inhibiting the release of inflammatory mediators from these cells.

<p>3,5-Diethyl-1H-1,2,4-triazole is a ligand that has been used for the preparation of coordination compounds. It is a triazole with a 3,5-diethyl substituent. This ligand can be prepared by reacting acetonitrile with anions in the presence of hydrochloric acid. The ligand can be characterized by its diffraction properties and its ability to bind metal ions. 3,5-Diethyl-1H-1,2,4-triazole forms complexes with metals that are hydrophobic in nature and this property can be exploited to prepare synthetic materials. The complex that features this ligand is kinetically stable and crystallographically well defined.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Trans-Sinapic acid is an organic compound with the formula HOCHC(OH)CHCOH. It is a white solid that is soluble in water and ethanol. Trans-Sinapic acid is found in plants, such as the leaves of Vitexin, and has been shown to have various pharmacological activities including anti-inflammatory and anticholinesterase properties. Trans-Sinapic acid also has been shown to be a potent inhibitor of acetylcholinesterase (AChE) activity. AChE inhibitors are used clinically as treatments for Alzheimer's disease and other conditions involving memory loss and cognitive decline. Trans-Sinapic acid binds to AChE with high affinity and inhibits its ability to break down acetylcholine, thereby increasing its concentration at nerve junctions. This may lead to improvement in symptoms associated with Alzheimer's disease, such as memory loss and cognitive decline.</p>

Versatile small molecule scaffold

<p>Methyl 4-ethylbenzoate is an activated sensitizer that is used in the production of polyvinyl chloride. It is isolated from a reaction mixture by distillation and has been shown to be an efficient method for activation of ethylbenzene. The organoleptic properties of methyl 4-ethylbenzoate are dependent on the temperature, with higher temperatures producing a more unpleasant odor. Methyl 4-ethylbenzoate can also be used as a catalyst for electrocatalysis reactions that involve c–h bond activation. This chemical has been found to be useful in the production of polyethylene terephthalate and its derivatives, which are used in many products such as packaging materials, plastic bottles, fibers, and clothing.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(4-Sulfamoylphenoxy)acetic acid is a chemical compound with the formula CHOSO2H. It is a colorless liquid that is soluble in water and polar organic solvents. It can be prepared by treating 4-hydroxybenzoic acid with sulfuryl chloride to produce the ethyl ester, which hydrolyses to give 2-(4-sulfamoylphenoxy)acetic acid. The compound has been used as a model for kinetic studies of reactions involving protonated amines and hydroxyl groups. A microencapsulation technique was developed for preparing stable dispersions of the drug in water with an average particle size of 1.5 micrometres.</p>

<p>Propan-2-yl 2-sulfanylacetate is a chloride that is the magnesium salt of propan-2-yl 2-sulfanylacetic acid. It has been shown to be a film forming polymer with a number of functional groups and has been used as a fixative agent for acrylonitrile. Propan-2-yl 2-sulfanylacetate has also been shown to have anti psychotic effects in patients with chronic schizophrenia, and may be due to its primary amino group.</p>

<p>Benzyl 2-sulfanylacetate is a liquid crystal compound that belongs to the group of aromatic hydrocarbons and fatty acids. It has a high resistance to chloride and an alkylthio group. Benzyl 2-sulfanylacetate can be used as a film-forming polymer, which is used in the stabilizing of pyrimidine compounds and phosphites. Benzyl 2-sulfanylacetate also has neurotrophic effects and can be used for dry extract enzymatic reactions.</p>

<p>Versatile small molecule scaffold</p>

Decahydronaphthalene-1-carboxylic acid is a polyester that is synthesized from a primary alcohol and the carboxylic acid. It is an efficient method to produce naphthalene by oxidation of decahydronaphthalene-1-carboxylic acid with manganese dioxide in the presence of peroxide. The reaction rate can be increased by using a suitable catalyst such as copper, iron, or nickel. Decahydronaphthalene-1-carboxylic acid has been used to synthesize cycloalkanes with high yields. The toxicity of decahydronaphthalene-1-carboxylic acid depends on its metal content.

2-Methyl-3-oxo-3-phenylpropanenitrile is an activated form of acetonitrile. It is a colorless liquid with a strong ammonia odor. 2-Methyl-3-oxo-3-phenylpropanenitrile is used as a reagent in organic synthesis and can be used to catalyze the elimination of hydroxyl groups, activating groups, and carbonyl groups. 2-Methyl-3-oxo-3-phenylpropanenitrile has been shown to be capable of hydrogenating unsaturated bonds during the course of nucleophilic substitution reactions. The compound can also be used to synthesize isoxazoles, which are used as pharmaceuticals or pesticides.

<p>Versatile small molecule scaffold</p>

<p>2-Butylpropanedinitrile is an aliphatic hydrocarbon that is used as a solvent in the manufacture of pesticides and pharmaceutical preparations. It is also used to produce diphenyl ethers, which are used as solvents for dyes and lacquers. This compound has been shown to be sensitive to lithium and is nonaqueous. It reacts with ester compounds, such as pesticides, to form ester products which are reactive. The electrode potential of 2-butylpropanedinitrile is reversibly determined by the electrolyte solution it is in.</p>

Diethyl malonate is an organic compound that is used as a reactant in the synthesis of esters. It is prepared by the elimination of diethyl oxalate from diethyl acetoacetate with sodium hydroxide. Diethyl malonate reacts with propiolic acid to form 1,3-diethyl 2-cyclopropanecarbonylpropanedioate. This compound can also be prepared by reacting ethyl chloroformate with propiolic acid. The elimination reaction of diethyl malonate and propiolic acid yields 1,3-diethyl 2-cyclopropanecarbonylpropanedioate and water.

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Dichloro-1,3,4-thiadiazole is a dipole molecule with a nitrogen atom in the center of two chlorine atoms. It has a molecular electrostatic potential of -0.6 and an efficiency of 73%. Dichloro-1,3,4-thiadiazole is a polar molecule that can be described by three geometries: amide, dimethylformamide, and chlorine. The geometry of dichloro-1,3,4-thiadiazole is optimized using parameters such as the distance between two chlorine atoms (-2.8) and the distance between two nitrogen atoms (1.7).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

2H,3H,4H,5H,6H,7H,8H-Cyclohepta[D][1,3]thiazol-2-one is a synthetic compound that has been modified to produce various derivatives. It is used in the synthesis of oligosaccharides and polysaccharides. This chemical also has potential applications in the treatment of cancer and diabetes.