Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chlorothiophene-3-carboxaldehyde is a colorless liquid. This chemical belongs to the group of thiophenes and has an isoindolone ring. It can be synthesized by cyclization of 2-chlorothiophene with 3,4-dimethoxybenzoyl chloride. It has been used in the synthesis of isoindolone as well as other compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(1-Methylcyclohexyl)acetic acid is a heterocyclic compound with a molecular weight of 136.22 g/mol, a melting point of -7.5 °C, and a boiling point of 115 °C at 760 mmHg. It has a density of 1.038 g/cm3 and solubility in water at 20°C of less than 0.2 mg/L. 2-(1-Methylcyclohexyl)acetic acid is an organic compound that belongs to the class of acetic acid derivatives and isomers thereof. It has two chiral centers and six stereoisomers, all of which are racemic mixtures with no single stereoisomer being present in greater quantity than any other. The conformation of the molecule can be changed by rotation about the C2-C3 bond, which has been shown to have a rate constant for conversion from one conformation to another (k) at</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(2S)-2-Methyl-3-phenylpropanoic acid is a chiral organic compound that can be catalysed to produce enantioenriched products. It has been shown to be an efficient catalyst for the ester hydrolysis reaction, with a rate constant of 10.8 x 10 M s. The enzyme lipase catalyzes this reaction by hydrolyzing ester bonds in (2S)-2-methyl-3-phenylpropanoic acid, producing a mixture of the enantiomers 2R-(+)-2-methyl-3-phenylpropanoic acid and 2S-(−)-2-methyl-3-phenylpropanoic acid. Lipases are proteins that specifically hydrolyze fats, which means they only work on one specific type of molecule. This is advantageous because it allows for higher stereoselectivity in the production of the desired product. Pseudomonas fluorescens produces lipases that are</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>6-Chloro-3-methoxypyridazin-4-amine is an acidic compound with a pKa of 4.6. It is hydrolyzed in water and alkaline solutions, with the reaction being faster in alkaline solutions. 6-Chloro-3-methoxypyridazin-4-amine interacts with thiourea and hydrazine, forming a yellow compound. This compound reacts with ethanol to form an orange precipitate, which is soluble in potassium acetate.</p>

<p>Ethyl 4-oxoheptanoate (E4OH) is an inhibitor of tyrosine hydroxylase, which converts the amino acid tyrosine to the neurotransmitter L-DOPA. It is a trisubstituted, high stereoselective, and hydroxylase inhibitor. E4OH inhibits the enzyme tyrosine hydroxylase and prevents the synthesis of L-DOPA in a stereospecific manner. This compound also has been shown to inhibit diastereoisomeric synthses of L-DOPA.</p>

<p>Versatile small molecule scaffold</p>

<p>Exo-norbornylamine hydrochloride is a metabolite of amantadine and is produced by acetylation of the aromatic ring. It has been shown to be a substrate for epoxide hydrolase, which catalyzes the conversion of this compound to an epoxide. It has been shown to inhibit influenza virus replication in vitro and in vivo, possibly by regulating ion channels or inhibiting viral RNA synthesis. Exo-norbornylamine hydrochloride also inhibits lung epithelial cell proliferation, which may be due to its ability to inhibit the production of inflammatory mediators such as prostaglandins and leukotrienes.</p>

<p>2-Isocyanatobicyclo[2.2.1]heptane is a natural product that has been shown to be a potent inhibitor of the soluble epoxide hydrolase and an epoxide hydrolase enzyme, which are responsible for the degradation of epoxides. This compound is structurally similar to aniline and amine compounds, which have been shown to inhibit the virus that causes SARS or severe acute respiratory syndrome (SARS-CoV). 2-Isocyanatobicyclo[2.2.1]heptane has also been shown to inhibit coronavirus, which is one of the most common causes of upper respiratory infections in humans.</p>

<p>Ethyl 3-hydroxy-1H-indole-2-carboxylate is a dimer that is produced by the condensation of two molecules of diazomalonate. This product can be used in the synthesis of esters, such as acid esters or cyclization reactions. It has been shown to yield high yields at high temperatures and is an Australian product. This compound can also be used as a precursor for carbene catalysts.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Hydroxy-4,5-dimethoxybenzaldehyde (2HMB) is a natural product that belongs to the group of methides. It has been isolated from plants belonging to the genus Neorautanenia. This compound has been shown to inhibit target enzymes such as neorautanenia amboensis, methides, eupatorium, spathulenol, chalcone, benzofuran derivatives and conjugates. 2HMB also inhibits bacterial growth by binding to ribosomes and preventing protein synthesis. 2HMB can be synthesized from corydine or skeletons by borohydride reduction. The skeleton structure of 2HMB is the same as that of the synthetic drug neorautanenia amboensis and is used for treatment of sepsis in humans.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4H,5H-[1,2,4]Triazolo[1,5-a]pyrimidin-5-one is a heterocyclic compound that is structurally related to the purines. It has been shown to bind to phenanthroline and bipyridine as ligands. The X-ray structure reveals that the molecule consists of two bridging pyridine rings with an azopyrimidine ring in the center. 4H,5H-[1,2,4]Triazolo[1,5-a]pyrimidin-5-one binds anionic ligands such as trimethylammonium ions and formates through its nitrogen atoms.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(1H-Tetrazol-5-yl)pyridine (TPZ) is a hydrogen bonding molecule that has been extensively used as a probe to study the coordination geometry of metal ions. The TPZ molecule has a trigonal planar structure with three nitrogen atoms and one chloride ligand. The TPZ molecule is a strong base with a pKb value of 8.6, which makes it a good candidate for protonating other molecules. The TPZ molecule can be synthesized in various forms, including the hydrochloride salt form.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Bromo-2-methylbenzene-1-thiol is a chemical compound that is not found in nature. It can be accessed via the etoricoxib reaction with 4,4'-biphenylsulfonyl chloride in the presence of sodium hydroxide. The compound has anisotropic properties and its magnetic resonance data show methyl sulfonyl groups with Covid-19 at 3.3 ppm and Covid-19 Pandemic at 5.8 ppm as well as intermediates at 2.6 and 2.8 ppm. It also shows resonance peaks for an element at 8.0 ppm and diamagnetic properties at 1.5ppm.</p>

<p>4-Bromo-3-methyl-benzenethiol is an experimental compound that belongs to the class of fluorine compounds. It has a molecular weight of 221.8 and a chemical formula of C6H5BrSCH2. 4-Bromo-3-methyl-benzenethiol contains a methoxy substituent, which is located on the central carbon atom. This compound also contains two bromine atoms, which are located on either side of the central sulfur atom. 4-Bromo-3-methyl-benzenethiol has been shown to have sulfhydryl group in its structure, and can form couplings with other molecules through this group.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Hydroxy-cyclohexyl)-acetic acid (1HCAA) is a polystyrene-based monomer that is used in the production of polymers such as vinyl ethers. 1HCAA has been shown to undergo mechanistic reactions with solvents and alkali metal chlorides, which are both required for its synthesis. The 1HCAA molecule can react with water molecules and form monocarboxylic acids, carboxylic acids, or recemic products. 1HCAA also catalyzes cross-linking reactions when it reacts with an oxidizing agent such as iodine.</p>

<p>Versatile small molecule scaffold</p>

<p>1,4-Diamidino-benzene dihydrochloride (DABD) is a synthetic, crystalline organic compound that is insoluble in water. This chemical compound has been shown to be a reactive electron donor towards carbamazepine and its derivatives. DABD has also been immobilized on an electrode surface for use as a stable and sustainable electrode material. The immobilization of DABD on an electrode surface was done by covalently binding the DABD molecule to the surface with triazine molecules by covalent bonds. This process resulted in a stable and functional electrode material that can be used for up to 12 hours.</p>

<p>Prop-2-ene-1-sulfonyl chloride is an organic compound that is used as a pharmaceutical intermediate. It has been shown to have potent inhibitory activity against pancreatic lipase, which makes it a potential treatment for inflammatory diseases such as arthritis. The active form of prop-2-ene-1-sulfonyl chloride binds to the receptor site of the molecule and prevents it from binding with other molecules, thereby blocking the inflammatory response. Prop-2-ene-1-sulfonyl chloride also binds to cholesterol esters in cells and prevents them from being transferred. This inhibits cholesterol production and reduces inflammation caused by high levels of cholesterol.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Benzyl-(4-methoxy-benzyl)-amine is a chemical compound that has the molecular formula CHNO. It is an organic compound with a nitrate group, which are common in esters and phenolates. This compound can be synthesized by debenzylating benzyl amines and reacting them with nitric acid. Benzyl-(4-methoxy-benzyl)-amine may also be prepared by reacting benzaldehyde with ammonium hydroxide or ammonia gas. The synthesis of this compound is chemoselective, meaning it only reacts at one point on the molecule, rather than two. Benzyl-(4-methoxy-benzyl)-amine is used as a precursor to other compounds such as ammonium nitrate, esters, phenolates, and amides.</p>

<p>2-(4-Chloro-2-formylphenoxy)acetic acid is a chemical compound that is found in microalgae. The compound has been shown to inhibit the growth of bacteria by binding to glucose transporters and inhibiting their ability to absorb glucose. This process leads to a decrease in ATP levels, energy depletion, and cell death. In addition, this compound has been shown to have trophic effects on microalgae. This compound also inhibits the expression of malic enzyme genes and ammonium transporter genes in bacteria. 2-(4-Chloro-2-formylphenoxy)acetic acid is a steerable molecule that can be used for sectioning biological material with ultrafast lasers due to its high fluorescence.</p>

<p>2-{[2-({2-[(2-Hydroxyethyl)sulfanyl]ethyl}sulfanyl)ethyl]sulfanyl}ethan-1-ol is a polymer with a heterocyclic ring that is soluble in organic solvents. It has been used as an activator, coactivator and/or stabilizer for the thermal treatment of inorganic acids to produce imidazolines and halogens. 2-{[2-({2-[(2-Hydroxyethyl)sulfanyl]ethyl}sulfanyl)ethyl]sulfanyl}ethan-1-ol has been shown to be effective in the production of polymeric materials with good stability and low volatility.</p>

<p>3-Propoxypyridine-2-carboxylic acid is a benzene ring containing piperidine with a carboxamide substituent. It has shown to be selective for human eosinophils, and is an antagonist at the benzodiazepine site of GABAA receptors. 3-Propoxypyridine-2-carboxylic acid can also be derivatized to form a potent antagonist of benzodiazepine sites on GABAA receptors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Benzyl propiolate is a molecule that is structurally related to propiolic acid. It has been shown to act as an adrenergic receptor agonist, which leads to platelet aggregation and thrombocytopenia. Benzyl propiolate also forms methyl esters with alcohols and is synthesized by methyl esterification of benzyl alcohol and propionic acid. This compound is electron deficient, which allows it to react with electron-rich substances, such as thromboplastin in the reaction solution for heparin-induced thrombocytopenia.</p>

<p>Benzyl 2-cyanoacetate is an aliphatic hydrocarbon that has been used in the synthesis of various quinoline derivatives. It can be prepared by the reaction of malonic acid with hydrochloric acid, followed by borohydride reduction and the addition of active methylene. Benzyl 2-cyanoacetate is also a precursor to a number of other compounds, including β-amino acids, which are used as pharmaceutical preparations. The chloride ions in benzyl 2-cyanoacetate react with nitro groups to form chloroquinolines. This compound is also an efflux pump inhibitor that blocks bacterial cells from exporting antibiotic molecules out of the cell.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Phenyl-prop-2-ynyl-amine is a primary amine with neuroprotective properties. It can be activated to the corresponding aniline by treatment with a base. Phenyl-prop-2-ynyl-amine has been shown to have neuroprotective effects in a model system of Parkinson's disease. It also possesses ring-opening activity on quinoline derivatives and gold nanoparticles. This reaction is slow, but it can be accelerated by the addition of a carboxylic acid. The use of this method for the synthesis of phenylpropene derivatives provides an efficient route for the construction of complex molecules with functional groups in their skeletons.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Bromopentanenitrile is a medicinal molecule that has been shown to have oral bioavailability. This compound is an antagonist of the chemokine receptor CXCR4 and blocks the binding of SDF-1α and other ligands to this receptor, which inhibits the migration of lymphocytes from bone marrow into peripheral tissues. 4-Bromopentanenitrile has also been shown to inhibit cell proliferation in vitro and in vivo, which may be due to its ability to block DNA replication. 4-Bromopentanenitrile has been tested for its ability to inhibit the growth of cancer cells in mice models.</p>

<p>Versatile small molecule scaffold</p>

<p>(E)-3-(m-Tolyl)acrylic acid is a natural flavonoid compound found in plants. It is an intermediate in the biosynthesis of phenylpropanoids, which are a group of plant secondary metabolites. (E)-3-(m-Tolyl)acrylic acid has been shown to inhibit the production of heterocyclic amines, which are carcinogenic compounds formed during the cooking process of meat and fish. In addition, this compound has been shown to have cytotoxic effects on cancer cells and inhibitory effects on malonic acid production in plants. (E)-3-(m-Tolyl)acrylic acid is synthesized from cinnamic acid derivatives and hydroxyl groups. It is also produced by sulfonation of eugenol with sulfuric acid followed by oxidation with hydrogen peroxide.</p>

<p>3-Chlorocinnamic acid is a potential anticancer agent that has been shown to stimulate the growth of epidermal cells. It inhibits the activity of epidermal growth factor (EGF) and is active against some forms of cancer. 3-Chlorocinnamic acid binds to an activated form of the epidermal growth factor receptor and prevents its activation. 3-Chlorocinnamic acid also inhibits pro-apoptotic protein kinase activities, which may be useful for treating conditions such as tuberculosis. The chemical group in this compound is responsible for its optical properties and its ability to bind to proteins with cinnamoyl groups.</p>

<p>3,5,5-Trimethyl-2-pyrrolidinone is a cyclic hydrocarbon that is produced by the photolysis of acetonylacetone. It undergoes hydrolysis to form 3,5,5-trimethyl-3-oxazolidinone and 2-oxopropanal. The former reacts with nitrones to form oxaziridines and pyrrolidinones. 3,5,5-Trimethyl-2-pyrrolidinone can be used as a protecting group for hydroxyl groups in organic synthesis.</p>

<p>1-Amino-1,2,3,4-tetrahydropyrimidine-2,4-dione is an alkynyl amine that is used in the agricultural industry as a binding agent for acid. It has been shown to bind to cyanoalkyl, haloalkyl and aminouracil groups. The compound also has a variety of other uses in the pharmaceutical industry including use as a nerve toxin. 1-Amino-1,2,3,4-tetrahydropyrimidine-2,4-dione is also used as a spectrum diluent and can be used in refluxing reactions with nitro compounds.</p>

<p>2-(Acetyloxy)-4-methylbenzoic acid (AMBA) is a compound that is used in the field of health care. It has been shown to have neuroprotective effects and to reduce neuronal apoptosis, which may be due to its ability to attenuate proinflammatory responses. AMBA has also been shown to inhibit the formation of amyloid plaques in Alzheimer's disease. This compound has also shown anti-inflammatory properties and can be used as a treatment for neuroinflammation. AMBA inhibits the activation of caspases, which are responsible for initiating the apoptosis pathway by cleaving proteins necessary for cell survival, such as PARP1 or Bcl-2. The mechanism of action is not fully understood but it appears that AMBA alters mitochondrial function and reduces intracellular calcium levels.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Benzoyl-2H-1,2,3,4-tetrazole is a pyrazole compound that can be synthesized by reacting an aliphatic azide with a sulfoxide. The reaction of the sulfoxide with potassium hydroxide and dimethylbenzoyl chloride produces the desired product. 5-Benzoyl-2H-1,2,3,4-tetrazole is used in research as a short term substrate for enzymes such as diazo compounds and tetrazole. It has also been shown to be capable of forming covalent bonds with alkali metal ions such as sodium and potassium. This compound is also useful for the synthesis of 2H-1,2,3,4-tetrazoles via diazotization.</p>

<p>5H,6H,7H,8H-Imidazo[1,5-c]pyrimidin-5-one is a marine alkaloid that belongs to the family of histamine. It is found in the sponge pseudoceratina and has been shown to have antifouling properties. 5H,6H,7H,8H-Imidazo[1,5-c]pyrimidin-5-one can be used as a treatment for hyperhistaminemia and may inhibit tyrosine hydroxylase activity.</p>

<p>8-Hydroxy-4-quinolinecarboxaldehyde is an alkaloid that is found in the bark of Broussonetia papyrifera, a tree native to Asia. Alkaloids are nitrogenous organic compounds that contain basic properties. 8-Hydroxy-4-quinolinecarboxaldehyde can be synthesized by reacting oxime with hydroquinone. This compound has been studied using spectroscopic methods and can be used as a starting point for the synthesis of other alkaloids.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Spiro[4.5]dec-6-en-8-one is a natural product isolated from the leaves of plants in Madagascar. It has an inhibitory effect on insects and was sampled by researchers at the University of Florida. Spiro[4.5]dec-6-en-8-one can be extracted from camphene, naphthalene, and solenopsis. The compound inhibits the growth of insects through its inhibitory effects on protein synthesis by binding to ribosomal RNA. This activity is more pronounced in insect cells than in human cells, which may be due to a lower expression of ribosomal RNA in human cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(2,6-Dimethylphenoxy)acetohydrazide is a herbicide that inhibits the growth of monocotyledon and dicotyledon plants. It is used to control weeds in fields of soybeans, rice, corn, wheat, oats, barley and rye. The compound was found to be the most effective herbicide for the control of weeds in bioassays conducted with various types of plants. 2-(2,6-Dimethylphenoxy)acetohydrazide has been shown to inhibit the growth of Brassica species such as cabbage and broccoli by interfering with phenol synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 3-Fluorophenylacetate is an alkali, cyclopropene carboxamide that has a nucleophilic functionality. It is positioned strategically in biomolecular chemistry and biomolecular function. Methyl 3-Fluorophenylacetate has been used as a building block to synthesize bioactive molecules such as peptides and polymers. In addition, it can be used as a fluorescent probe for the identification of nucleophilic functionalities.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Acetyl-1,2,3,4-tetrahydroquinolin-4-one is a chemical compound that can be prepared by nitration of quinolin-4-one with concentrated sulfuric acid. This chemical has the following constants:</p>

<p>3-Phenyl-cyclopentanone is a conformational chiral reagent that is used in the synthesis of enantiomerically pure compounds. It is a substrate for many enzymatic reactions, such as alkylation, and can be used to prepare one of the two possible stereoisomers. 3-Phenyl-cyclopentanone has been shown to show positive dichroism in the visible region and negative dichroism in the near infrared region. This compound also has potential for use as an analytical reagent due to its ability to separate solutes based on their chromatographic properties.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(iodomethyl)-1,4-dioxane is a cytotoxic moiety that binds to the capsid protein of a virus. It has been shown to be an antiviral agent against HIV-1 and other retroviruses. 2-(iodomethyl)-1,4-dioxane is hydrophobic, connecting and binds to hydrophobic regions in proteins. The compound was also observed to have antiviral activity against HIV-2 and SIV. 2-(iodomethyl)-1,4-dioxane was found to form hydrogen bonds with the capsid proteins of both HIV-1 and HIV-2, which are important for viral infectivity. This compound has been used as a linker for attaching cytotoxic molecules such as doxorubicin or camptothecin to liposomes or nanoparticles.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>