Building Blocks

<p>4-Formyl-3-methoxybenzoic acid is a sulfamic acid derivative that has been used in the treatment of asthma. It is a prodrug that converts to its active form, methanesulfonic acid, by enzymatic transfer. The target product of this reaction is zafirlukast, which competitively blocks leukotrienes at the cysteinyl leukotriene receptor. Methanesulfonic acid acts as an inhibitor of hydrogen transfer and may also act as a proton ionophore in the lungs. 4-Formyl-3-methoxybenzoic acid can be synthesized on a large scale with chemical products that are readily available. This agent reacts with proline and protonates it.</p>

<p>Versatile small molecule scaffold</p>

<p>2-{[(2-Methoxybenzyl)oxy]methyl}oxirane is a monoclonal antibody that binds to the follicle-stimulating hormone receptor (FSHR) and blocks its activity. It has been shown to be effective in autotransplantation, which is a treatment for infertility in women. The antibody can be used as an anti-apoptotic agent and may have potential use as a cancer therapy. 2-{[(2-Methoxybenzyl)oxy]methyl}oxirane has shown promising results in vivo in mouse models of skin cancer, leukocytes, and murine melanoma. This drug also has the ability to inhibit the proliferation of tumor cells by inducing apoptosis through binding to annexin V.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Amino-pentanoic acid hydrochloride is a glycine analog, which blocks the glycine receptor of the NMDA type and inhibits glutamate binding. 3-Amino-pentanoic acid hydrochloride has been shown to have synergistic interaction with aminooxyacetic acid, an inhibitor of the glycine transporter. This increases the concentration of glycine in the synapse and leads to an anticonvulsant effect. 3-Amino-pentanoic acid hydrochloride also interacts with γ-aminobutyric acid (GABA) receptors and taurine receptors, which may be due to its structural similarity to these compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,6-Naphthyridin-1(2H)-one is a potent and selective inhibitor of the chemokine receptor CXCR4. It is a novel and innovative compound that has been shown to have neuropathic pain activity in animal models. This agent has also been shown to inhibit the growth of cancer cells in vitro. The substitution pattern on this molecule may be responsible for its binding affinity to CXCR4 receptors as well as its selectivity over other chemokine receptors. 2,6-Naphthyridin-1(2H)-one has been shown to be an antagonist of the chemokine receptor CXCR4, which may be beneficial for treatment of chronic inflammatory diseases or cancer.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(3-Bromo-5-methylthiophen-2-yl)trimethylsilane is a compound that can be used to synthesize triazole derivatives using copper. It is an alkyne and azide precursor. The photophysical properties of (3-bromo-5-methylthiophen-2-yl)trimethylsilane have been studied in detail and it has been shown to be a good choice for use in the preparation of triazole derivatives. Using this compound, researchers have been able to optimize their synthetic procedures.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Amino-3-phenylbutanoic acid hydrochloride is a chelating agent that binds to metal ions and prevents their participation in reactions. This compound rearranges to form an enamine, which then reacts with the metal ion to form an intermediate. The intermediate can be stabilized by the formation of a metal-amino acid complex or through rearrangement. These reactions are stereospecific, diastereoselective, and diastereoisomeric. 2-Amino-3-phenylbutanoic acid hydrochloride is typically used as a catalyst for organic reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>1,4-Dimethyl 2-(chlorosulfonyl)benzene-1,4-dicarboxylate is a potential herbicide. It is a chlorinated hydrocarbon that has been shown to inhibit plant growth by interfering with the production of ethylene. The mechanism of action for 1,4-dimethyl 2-(chlorosulfonyl)benzene-1,4-dicarboxylate is as an inhibitor of the enzyme acetolactate synthase (ALS). ALS catalyzes the first step in the biosynthesis of both branched and linear chains of amino acids. This inhibition leads to reduced levels of the amino acids proline and glutamic acid in plants. These amino acids are important regulators of plant growth and development.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Dimethyl 2-bromo-1H-imidazole-4,5-dicarboxylate is an alkylating agent that reacts with DNA by the alkylation of guanine. This causes a break in the DNA strands, which leads to cell death. Dimethyl 2-bromo-1H-imidazole-4,5-dicarboxylate is used as a hydrazine precursor in the synthesis of hydrazine and hydrogen peroxide. The oxidized form of this compound is also used as a stabilizer for polyurethane coatings.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>