Building Blocks

<p>Versatile small molecule scaffold</p>

<p>2-(1-Chloroethyl)-5-(thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one is a small molecule that has been shown to inhibit the activity of calcium channels. It is also known as an inhibitor for research and antibody production. 2-(1-Chloroethyl)-5-(thiophen-2-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-one is a ligand that binds to ion channels and activates them by binding to the receptor on the cell surface. This compound can be used in pharmacology and protein interactions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Amino-N-(2-chlorophenyl)-3-(hydroxyimino)propanamide is a potent inhibitor of voltage-gated potassium channels. It was developed as an antibody and has been used as a research tool to study protein interactions, ion channel function, cell biology, pharmacology, and receptor function. 3-Amino-N-(2-chlorophenyl)-3-(hydroxyimino)propanamide binds to the extracellular domain of the potassium channel Kv1.5 and inhibits its activity with an IC50 of 1 nM. The crystal structure of 3-amino-N-(2-chlorophenyl)-3-(hydroxyimino)propanamide bound to the extracellular domain of the potassium channel Kv1.5 has been determined at 2.4 Å resolution by X-ray crystallography.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ellagic acid is a potent inhibitor of the uptake of carbon nanotubes in animals. It also has antiviral properties, which may be due to its reactive oxygen species-generating properties. Ellagic acid has been shown to inhibit the proliferation of human T cells in vitro and induce apoptosis. This compound also inhibits the growth of cervical cancer cells and blocks viral replication by inhibiting viral protein synthesis. Ellagic acid can be used as a structural biology probe to investigate the reaction between cellulose derivatives and molecules. It is also used in pharmaceutical preparations such as anti-cancer drugs and treatments for herpes simplex type I virus infections.</p>

<p>(2-(Trifluoromethyl)thiazol-4-yl)methanol is a benzimidazole derivative that inhibits the activity of imidazopyridine N-acetyltransferase, which is an enzyme involved in the synthesis of histamine. It has shown to be selective for this enzyme and not affect other enzymes related to histamine synthesis. (2-(Trifluoromethyl)thiazol-4-yl)methanol does not show mutagenicity or genotoxicity in f344 rats and has a low safety profile when tested on humans. This drug has been shown to have antiobesity effects, which are likely due to its inhibition of histamine synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Ritonavir is a protease inhibitor that belongs to the class of HIV-1 protease inhibitors. It inhibits the activity of the virus by binding to the active site of the enzyme and blocking it from cleaving proteins. Ritonavir is used with other antiretroviral drugs as part of highly active antiretroviral therapy (HAART). This drug is also used in combination with other protease inhibitors, such as indinavir and saquinavir, to treat HIV infections that are resistant to these drugs. In some cases, ritonavir can be administered without a booster agent such as cobicistat or lopinavir/ritonavir. This drug has been shown to have pharmacokinetic parameters that are similar in healthy volunteers and patients infected with HIV-1.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,2-Difluoropropane-1,3-diamine-2hcl is a potent inhibitor of efflux pumps. This compound binds to the protein in the pump and prevents it from functioning properly. 2,2-Difluoropropane-1,3-diamine-2hcl is active against inhibitors that bind to the cytoplasmic side of the membrane and are transported out of the cell by means of an efflux pump. It has been shown to inhibit interactions with both hydrogen bond and covalent binding sites on proteins. 2,2-Difluoropropane-1,3-diamine-2hcl also inhibits permeability of cells to drugs that are normally transported by these pumps.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(Dimethylsulfamoyl)pyrazole is a synthetic compound that is used as a catalyst in the coupling of aryl groups. It is an effective catalyst for the synthesis of pyrazoles and other substituted pyrazoles. This compound also has been found to be an effective catalyst for the bromo-arylation of benzene and other aromatic substrates, which allows for the introduction of substituents at various positions on the aromatic ring. 1-(Dimethylsulfamoyl)pyrazole has shown to be effective in bond cleavage reactions, specifically those with aliphatic C-H bonds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>The emission of this dye is quenched by the presence of an electron donor, such as a solvent or a biomolecule. When the electron donor is removed, it can emit light. This property makes it a good fluorescent probe for biological systems. The fluorescence of this dye is enhanced by introducing a red-shifted excitation wavelength and increased quantum yield. It has been shown to be selective for proteins in the presence of other biomolecules, such as nucleic acids and lipids.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-[(1-Methyl-1H-imidazol-2-yl)sulfanyl]aniline is a research tool that inhibits antibody production by binding to the enzyme immunoglobulin E (IgE) and preventing its activation. It also has been shown to inhibit the production of peptides, which are important in cell biology, pharmacology, and ligand binding. 2-[(1-Methyl-1H-imidazol-2-yl)sulfanyl]aniline has shown to be an activator for ion channels as well as a receptor for proteins.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-4-iodophenol is a synthetic compound that is used in the synthesis of medicines. It is also used to study biological properties and population dynamics. 2-Bromo-4-iodophenol has been shown to interact with adenine nucleotide, which provides it with a radioisotopic skeleton that can be detected by chromatography. This substance has also been found to be able to catalyze the decomposition of bromophenols, which are functional groups in some medicines. 2-Bromo-4-iodophenol can be used as an intermediate for donepezil, a medicine for Alzheimer's disease and other neurodegenerative diseases.</p>

<p>Methyl 2-(bromomethyl)-4-nitrobenzoate is a nitro compound that is used as the starting material for the synthesis of polyglutamate. It has been shown to be an analog of glutamine, which may have chemotherapeutic effects by blocking tumor cells from proliferating. Methyl 2-(bromomethyl)-4-nitrobenzoate is catalytically reduced to yield methylene dinitrobenzene, which reacts with ammonia and formaldehyde in the presence of a reductive coupling catalyst to give polyglutamate. The amide group can be converted into an ester or an amine by acidolysis or reductive amination.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>