Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Spiro[2.2]pentane-1-carboxylic acid is an organic compound with the chemical formula C8H14O4. It is a white solid that is soluble in water, alcohols, and ethers. This compound's stereoisomerism can be determined by its ability to rotate plane-polarized light in either the clockwise or counterclockwise direction. Spiro[2.2]pentane-1-carboxylic acid has been used as an acaricide (a chemical agent that kills ticks and mites) against ticks, lice, and fleas. The insecticidal activity of this compound may be due to its ability to disrupt chitin synthesis because it contains carboxylic acid groups that react with amino groups at the chitin chain's end.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methoxy-2-pyridinecarboxylic acid N-oxide is a ligand that can form complexes with proton, which is an organic solvent. It has been shown to be able to form ternary complex formation with picolinic acid and a variety of acceptors. 4-Methoxy-2-pyridinecarboxylic acid N-oxide has been shown to catalyze the transfer reactions of hydride and catalysis.</p>

<p>2-Phenylpent-4-en-1-amine is an organic compound that is synthesized by the bond cleavage of an amine and a terminal alkyne. It has been used in ligand design, which is the process of creating molecules to bind to a specific biological target. 2-Phenylpent-4-en-1-amine can be used as a chiral catalyst for asymmetric synthesis, making it enantiopure and optically active. The crystal structure of 2-phenylpentaene was determined by X-ray crystallography, which revealed that it has a c–h bond between its two phenyl groups. This bond may have been formed from an interaction with zirconium.</p>

<p>2-Chloro-3,4-dihydronaphthalen-1(2H)-one is a sulfoxide with significant antifungal activity. It has been shown to be effective against Candida albicans and other fungi, including Aspergillus niger and Mucor racemosus. It is commonly used as an electrolyte in electroluminescent devices, such as light emitting diodes (LEDs). The reaction time for the formation of 2-chloro-3,4-dihydronaphthalen-1(2H)-one from potassium sulfate is dependent on the acid catalyst used. Organic chemists have shown that the use of 2-chloro-3,4-dihydronaphthalen-1(2H)-one can inhibit leukotriene synthesis.</p>

<p>1,3-Bis(1-naphthalenyloxy)-2-propanol is a solvated molecule with 1,3-diphenylpropane as the solvent. It has a basicity of 5.4 and an entropy of -10.5 J mol(-1) K(-1). The solubility of 1,3-bis(1-naphthalenyloxy)-2-propanol in organic solvents ranges from 0.03 to 10 g/L. This compound is soluble in acetone, methanol, ethanol and toluene. The experimentally determined enthalpy of vaporization for 1,3-bis(1-naphthalenyloxy)-2-propanol was found to be -12 J mol(-1) K(-1).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>9H-Carbazol-9-amine is an amine used as a fluorescent probe in the study of Alzheimer's disease. It has been shown to quench fluorescence from other substances, and can be used to detect the presence of chloride ions. 9H-Carbazol-9-amine has been shown to bind to DNA via hydrogen bonding, which may help elucidate the mechanism by which it inhibits the production of amyloid beta peptides and prevents neuronal cell death. 9H-Carbazol-9-amine is also a cholinergic agent that binds to acetylcholine receptors on nerve cells and increases their activity.</p>

<p>N-Methyl-1H-benzo[d]imidazol-2-amine is a drug that has analgesic and antiinflammatory effects. It is used in the treatment of pain, inflammation, or fever. This active form has been shown to inhibit prostaglandin synthesis by oxidizing cyclooxygenase. N-Methyl-1H-benzo[d]imidazol-2-amine also inhibits the synthesis of inflammatory mediators such as leukotrienes and prostaglandins. The compound has significant activity against carrageenan induced paw edema in rats. The oral bioavailability of this compound is high and it can be taken orally with no adverse side effects.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(4-Methylphenyl)-1,3-thiazole-4-carboxylic acid is a chlorinated compound that has been shown to have anticancer activity. It is structurally modified to increase its potency and has been shown to inhibit cancer cell proliferation in vitro. 2-(4-Methylphenyl)-1,3-thiazole-4-carboxylic acid has been used in the treatment for breast cancer and prostate cancer. This drug also has anticancer effects on the mcf7 cell line, which is an immortalized human mammary epithelial cell line. The mechanism of action of this drug is very similar to that of other anticancer agents: inhibiting DNA synthesis by interfering with DNA replication or by inducing apoptosis.</p>

<p>Versatile small molecule scaffold</p>

<p>3,5-Dichlorothiophenol is a potent inhibitor of the enzyme acetylcholinesterase. As an inhibitor of the enzyme, it blocks the breakdown of acetylcholine and leads to accumulation of acetylcholine at nerve endings. This can lead to death by asphyxiation. Acetylcholinesterase inhibitors such as 3,5-dichlorothiophenol are used in insecticides and chemical warfare agents. 3,5-Dichlorothiophenol has been shown to inhibit the enzyme acetycholinesterase in a dose-dependent manner in vitro with an IC50 of 8 μM. It has also been shown that 3,5-dichlorothiophenol can be used in surface-enhanced Raman spectroscopy (SERS) for detection of metal ions on surfaces.</p>

<p>2,3-Dichlorobenzenethiol is an organic compound that is used as a reagent in the synthesis of polymers. It inhibits HIV infection by inhibiting viral replication through the inhibition of reverse transcriptase and protease enzymes. This chemical has been used as a standard in analytical methods for estimating the inhibitory effect of substances on these enzymes. 2,3-Dichlorobenzenethiol also has an inhibitory effect on cyclohexane ring formation and polymerization initiation. It is also an important intermediate for the synthesis of naphthalene.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,​3-​Dihydro-3-​thiopheneacetic acid 1,​1-​dioxide is a nucleophilic reagent that can be used to synthesize amides. It reacts with amines to form 2,​3-​dihydro-3-​thiophenecarboxylic acid 1,​1-diamide. Reactions of this compound with heterocycles such as pyridine and quinoline result in the formation of heterocyclic amines.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,4-Dichlorothiophene is a quinonoid compound that is synthesized from 3,4-dichlorobenzene and hydrogen sulphide. The reaction of the two compounds with persulphate, followed by hydrolysis and silver nitrate, yields 3,4-dichlorothiophene as a yellow liquid. This product can be treated with alkanoic acid or alkylated with an alkyl halide to produce homologues. 3,4-Dichlorothiophene reacts with ammonia in the presence of sodium amide to produce a mixture of amides. The reaction can also be carried out in the presence of diazotisation and nitration to form heterocycles.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Amino-4-chloro-2-methyl-2,3-dihydropyridazin-3-one is a metabolite of carbamazepine and caffeine. It is not an active compound, but it has been found to be a potent inhibitor of the enzyme aromatase. This inhibition prevents the conversion of androstenedione to estrone and testosterone to estradiol, which are hormones that regulate sex characteristics in humans. It is possible that this inhibition may be responsible for some of the side effects associated with high doses of these medications. 5-Amino-4-chloro-2 methyl 2,3 dihydropyridazine has also been shown to inhibit the growth of bacteria in vitro.</p>

<p>3-Chloro-4,6-dimethylpyridazine is a chlorinated derivative of the pyridine family of compounds. It has been synthesized by the reaction of azides with sulfur and aminopyridazines with cinnolines. 3-Chloro-4,6-dimethylpyridazine can be used in research as a medicinal agent for treating bacterial infections. It also has anti-inflammatory properties that are related to its ability to inhibit prostaglandin synthesis. The compound was found to have potent antibacterial activity against methicillin resistant Staphylococcus aureus (MRSA) and Clostridium perfringens.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Cyclohexyl-1-propanol is an organic compound that is a colorless liquid with a sweet, etherial odor. It has been used in pharmaceutical preparations as a solvent and as an intermediate for the production of other compounds. 1-Cyclohexyl-1-propanol has been shown to have effects on the bladder muscle and detrusor muscle, which may be due to its ability to inhibit the activity of amines. The compound also forms enantiomers, which are stereoselective and react differently in multiphase reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Butyl-2-methylphenol is a phenolic compound that is found in the essential oils of plants such as rosemary. It has been shown to inhibit the growth of animal cells, and this effect may be due to its ability to induce apoptosis. 4-Butyl-2-methylphenol also inhibits the production of basic fibroblast growth factor and epidermal growth factor by inhibiting protein synthesis and DNA synthesis. This chemical is an analog of platelet derived growth factor and has been shown to stimulate angiogenesis in vitro. 4-Butyl-2-methylphenol has been found to increase vessel density in animals when applied topically.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,3,5-Trichloro-2-(chloromethyl)benzene (TCMB) is a chemical compound that inhibits the synthesis of proteins and is used in cancer therapy. TCMB has been shown to inhibit protein synthesis by binding to the polymerase chain reaction enzyme transcriptase polymerase chain reaction. It also inhibits the activity of enzymes involved in lipid metabolism, such as lipases and cholesterol esterases. The serum bilirubin levels were found to be lower in mice treated with TCMB than in those not treated with TCMB. This may be due to the ability of this drug to inhibit the enzyme fatty acid synthase, which is responsible for synthesizing fatty acids. TCMB has been shown to induce apoptosis in bladder cells, which may be due to its inhibition of DNA synthesis and repair.</p>

<p>2-Phenylcyclobutan-1-amine is a synthetic compound. It is a white crystalline solid that can be soluble in water, ethanol, and acetone. The compounds are chiral and exist as two stereoisomers: (S)-2-phenylcyclobutan-1-amine and (R)-2-phenylcyclobutan-1-amine. The two isomers have different effects on the central nervous system. The (S)-isomer is an analog of amphetamine and interacts with the serotonin receptor 5HT2A, while the (R)-isomer is an analog of methamphetamine which interacts with the dopamine receptors D1 and D2. 2-Phenylcyclobutan-1-amine has been shown to be more effective than cocaine in animal studies for Parkinson's disease treatment, but it has not been tested in humans. It also has properties that make it worthwhile for use as an insecticide or herbicide.</p>

<p>2-Phenylcyclohexanamine is a synthetic, experimental compound. It has been shown to have high energy content and the ability to cross over from the gas phase to the liquid phase. 2-Phenylcyclohexanamine can be used as a thermodynamic probe in analytical research and has an efficient method for synthesis. The synthesis of 2-phenylcyclohexanamine is done by heating 1,1-diphenyl cyclopropane with cyclohexylamine, producing a mixture that can be purified with column chromatography. The analytical methodology for this compound includes GC/MS analysis of the raw material, reaction product, and final product.</p>

<p>2'-Methoxybiphenyl-2-carboxylic acid is a benzene carboxylic acid that is used as a precursor for biphenyl-2-carboxylic acids. 2'-Methoxybiphenyl-2-carboxylic acid can be synthesized by refluxing 2'-hydroxybiphenyl with peroxides in the presence of benzene, followed by cyclisation and decarboxylation. Alternatively, 2'-methoxybiphenyl-2-carboxylic acid can be obtained by thermally decomposing 3,4,5,6-tetramethylbenzoic acid. This compound has been shown to react intramolecularly and intermediacy with triphenylene to form triphenyltetracarboxylic acids.</p>

<p>1-(Bromomethyl)cyclohexan-1-ol is an organic solvent that is used in xerographic processes. It has been shown to be a good binder for active substances and can also be used as a stabilizer in the production of butyral and radical chain resins. This substance has hydroxy groups, which are responsible for the solubility of 1-(bromomethyl)cyclohexan-1-ol in water. It also has two benzyl radicals, which increase the solubility of this substance in organic solvents. This is an active substance with a valency of 2 and 4, so it can bind with up to 8 other molecules.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Formyl-2-thienylboronic acid is an organometallic compound that has a variety of bioactivities. It reacts with boronic acids to form cross-coupled products, which can be used in the synthesis of pharmaceuticals. 3-Formyl-2-thienylboronic acid has been shown to selectively react with a variety of boronic acids and produce highly substituted products. The constant nature of 3-Formyl-2-thienylboronic acid makes it suitable for introducing formyl groups into organic molecules for chemical ligation reactions. This compound is found in nature as an isomeric mixture of two enantiomers: R and S, which are chemically identical but have different biological properties.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 2-(ethylamino)benzoate is a chemical compound that can be synthesized from anilines and aminophenols. It is an intermediate in the synthesis of aminobenzamides and yields high yields when methylated. The reactivity is highly dependent on the reaction conditions. For example, in the presence of strong acids, such as hydrochloric acid, it reacts to form dialkylamines. This compound has also been shown to be useful for the preparation of carbonyl compounds and five-membered rings.</p>

<p>3-Iodo-6-methoxypyridazine is a type of diazine that is also known as 3,6-dimethoxy-N-(1,2,4-triazol-1-ylmethyl)pyridine. It is an agrochemical that has been shown to inhibit the growth of plants by interfering with nitrogen metabolism. The compound inhibits protein synthesis and nucleic acid synthesis through a nucleophilic attack on the nitrogen atom in the heterocycle. This compound has been used as an analog of pyridazine and cinnoline in the synthesis of other natural products.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Thiourea is a compound that can be found in the amino acid threonine. It is also produced by certain bacteria, such as Lactobacillus acidophilus. Thiourea has been shown to have a variety of potential health benefits, including relief from celiac disease symptoms and the formation of body tissues. Thiourea may also serve as a nutritional supplement for animals and humans, although it is not well-studied in this area. The low molecular weight and divalent nature of thiourea makes it soluble in water and thus highly absorbable by the intestines.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Patent US20100287939</p>

<p>(2-Chloroethyl)trimethylsilane is an organosilicon compound with a molecular weight of 98.06 g/mol. It is synthesized from ethylene and chlorine, and has been shown to inhibit the activity of tyrosine kinase in chronic pain and depression models. (2-Chloroethyl)trimethylsilane also inhibits adenosine receptors, which are involved in the development of chronic pain. This drug has been shown to be effective against depression by inhibiting the binding of adenosine to its receptor site. The kinetic properties of this drug have been studied using molecular modelling, and it has been found that conformational changes are induced in the purinergic receptor when this drug binds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(2S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propanoic acid is a potent antagonist of the ryanodine receptor (RYR), which is a calcium release channel in the sarcoplasmatic reticulum. It has been shown to inhibit neuronal death induced by oxidative injury and also to protect against mitochondrial dysfunction. This compound has also been found to be an antinociceptive agent and is detectable at low concentrations in vivo. The pharmacokinetic properties of this drug are not well understood, but it appears to be rapidly absorbed from the gastrointestinal tract and eliminated via the urinary system.</p>

<p>2,2,2-Trifluoroethoxybenzene is an acid catalyst that is used in the production of chlorobenzene. This organic compound has been shown to produce a number of products when heated with dihydroxybenzene. These products include acid chlorides and benzoyl chloride that can be used as intermediates in other chemical reactions. 2,2,2-Trifluoroethoxybenzene has also been shown to react with alkali metals to produce inorganic acids. In addition to acting as an acid catalyst, this compound may be used in the synthesis of flecainide, which is an antiarrhythmic drug. This product also reacts with carbonyl groups and acidic molecules such as halogens to form alkali metal carboxylates and alkanes.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(5-Methyl-1H-pyrazol-3-yl)ethanone is an experimental compound that belongs to the class of pyridazines. The molecule was first synthesized in 1933 and it has been studied for its photochemical properties. The structure of 1-(5-methyl-1H-pyrazol-3-yl)ethanone consists of a pyrazole ring fused to an ethanone bearing a methyl substituent. It has been shown that irradiation with UV light causes the molecule to react with dichloromethane, leading to the formation of a series of intermediates, such as chloromethanes, dichloroethylenes, and benzene.</p>

<p>Versatile small molecule scaffold</p>

<p>(2S)-3-Methyl-2-(4-methylbenzenesulfonamido)butanoic acid is a serine protease inhibitor that binds to the active site of serine proteases, such as those found in Alzheimer's Disease and other neurodegenerative diseases. The compound has been shown to inhibit amyloid beta peptide production and to have an inhibitory effect on the progression of Alzheimer's disease. It has also been shown to prevent neuronal death following traumatic brain injury. The mechanism by which (2S)-3-Methyl-2-(4-methylbenzenesulfonamido)butanoic acid inhibits amyloid beta peptide production is not yet clear, but it may be due to its ability to inhibit enzymes involved in histidine metabolism or its ability to bind with a catalytic site on the enzyme.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Cinnolin-3-amine is a pyrimidine compound that inhibits the proliferation of cells and has been shown to be effective in treating hyperproliferative diseases. It binds to chloride ions, protonation, or aromatic hydrocarbons, which are typically found in inflammatory diseases. Cinnolin-3-amine can also react with hydrochloric acid and aliphatic hydrocarbons and form zirconium oxide. Cinnolines are nitrogen atoms that have a receptor subtype, coordination chemistry, and hydroxyl group. These features play a role in cancer treatment by inhibiting the growth of tumor cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methyl-1-benzothiophene-3-carboxylic acid is a sulfur containing compound that can be found in many natural products. It is the product of the oxidation of sulfites by hydrogen peroxide and can be found in soil, water, and plants. This compound is synthesized by pseudomonas strains and has shown to have microbial activity against Pseudomonas aeruginosa isolates. 2-Methyl-1-benzothiophene-3-carboxylic acid also exhibits antibacterial activity against other bacteria such as Escherichia coli, Salmonella enterica, and Proteus mirabilis. This compound is an isomer of a number of other thiophenes such as benzothiophene and thiobenzamide.</p>

<p>2-(Benzylsulfanyl)acetonitrile is an intermediate in the synthesis of a number of biologically active compounds, including ornithine and paraformaldehyde. It is also an intermediate in the synthesis of 2-methyl-2-nitrosopropane, which is used as a reagent to prepare nitrosobenzene. 2-(Benzylsulfanyl)acetonitrile can be reacted with various organic compounds to produce a variety of products. For example, when it reacts with paraformaldehyde, it yields 2-benzylthioacetonitrile and 2-hydroxyethyl methacrylate. When reacted with acetone, it yields methyl 3-(2-acetonylbenzylthio)-3-cyanopropionate. This product has been used as a synthase inhibitor in inflammation research and as an adrenergic receptor blocker for the treatment of asthma.</p>

<p>N-Benzyl-4-methoxyaniline is an organic compound that is used in the manufacture of dyes and pharmaceuticals. This chemical has been shown to be a substrate for glutamate dehydrogenase, which is an enzyme that converts it into 2,3-dihydroxyphenylalanine (DOPA). N-Benzyl-4-methoxyaniline also reacts with trifluoroacetic acid, generating benzaldehyde. The reaction mechanism of this molecule is nucleophilic attack by the hydroxyl group on the benzene ring.<br>The detection sensitivity of this compound was improved through x-ray crystal structures and FTIR spectroscopy studies. It has been shown to have a m2 phenotype, which is associated with cancer.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>