Building Blocks

<p>(5-Phenylfuran-2-yl)methanamine is a drug that has been shown to be effective in treating neurodegenerative diseases and cancer. It is a member of the sirtuin family, which are enzymes that regulate gene expression. The drug inhibits SIRT2 and other deacetylases, which may lead to the development of new treatment strategies for neurodegenerative diseases and cancer. (5-Phenylfuran-2-yl)methanamine has high water solubility, which allows it to penetrate through the blood brain barrier more effectively than hydrophobic drugs. This property also makes it possible to administer lower doses of the drug, thereby reducing side effects on healthy cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methyl-N-methylbenzylamine is a nitro compound that has been shown to have antimycobacterial activity. It belongs to the class of aliphatic hydrocarbons, which are functional groups consisting of a chain of carbon atoms with hydrogen atoms attached to some of the carbons. The molecular modeling found that 3-methyl-N-methylbenzylamine binds to the active site of mycobacterial enoyl reductase and inhibits its activity. This leads to a decrease in cellular energy metabolism, which can lead to cell death. 3-Methyl-N-methylbenzylamine also has an amine group, which is an organic acid that contains nitrogen and hydrogen. These molecules are important for piperazine synthesis and may be responsible for the antimycobacterial properties of 3-methyl-N-methylbenzylamine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Phenylbutanehydrazide is a nitro, carbonyl group and hydrogen bond donor. It has an interaction with the benzyl group of 4-phenylbutanoylhydrazide through hydrogen bonds. The conformation of 4-phenylbutanehydrazide is agonistic and its secondary structure is mainly determined by the carbonyl group. The carbonyl group interacts with the hydrazide nucleus through a hydrogen bond, while its acylhomoserine residue interacts with the carbonyl group through a thiocarbamate interaction. This compound may be classified as an agonist or antagonist depending on the receptor it binds to.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Cyclopentyl-N-propylamine is a functional compound that belongs to the class of organic compounds. It is used as an intermediate in the synthesis of other drugs and pharmaceuticals. This compound has been shown to have a high reactivity, which makes it useful in polymerization and polymerization initiator applications. N-Cyclopentyl-N-propylamine has been shown to be reactive with polarizers, alkylthio groups, and trifluoromethyl groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Bis(3-methoxyphenyl)methanone is a palladium catalyst that selectively activates olefins. It has been shown to be useful in the synthesis of dihydrobenzofurans and oxonium derivatives, which are used as pharmaceuticals. This compound also catalyzes the transformation of various functional groups, such as diazo, alkenes, and intramolecular aldol condensation. Bis(3-methoxyphenyl)methanone is used as a catalyst for the production of dibenzofuran compounds with high selectivity. The diastereoselectivity of this compound is due to its ability to activate substrates with electron-donating groups at positions ortho to the phenyl group.</p>

<p>Versatile small molecule scaffold</p>

<p>3,3-Dimethyl-1-(methylsulfanyl)butan-2-one is an enolate that is used as a pesticide. It is typically applied to the soil or sprayed on plants. It can be modified to increase its insecticidal activity by adding other chemicals such as carbaryl, acetonitrile, or hydroxymethylphenyl. 3,3-Dimethyl-1-(methylsulfanyl)butan-2-one is metabolized by hydrolysis and methylcarbamates are formed. The sulfide group in the molecule reacts with oxygen to form sulfoxides and carbofuran, which are toxic to mammals and birds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Ethylamino-1-butanol is an alkanolamine that interacts with receptors in the body. It has a hydroxyl group and is a molecule that contains functionalities. It interacts with other molecules, such as corticotropin-releasing hormone (CRH). 4-Ethylamino-1-butanol binds to CRH and prevents it from binding to its receptor, which decreases the release of corticotropin. This compound has been used as a positron emission tomography (PET) radiotracer for imaging the insulin receptor in living tissue. The chemical can be systematically introduced into tissues and organs, including the brain, where it accumulates due to its hydrophilic nature. 4-Ethylamino-1-butanol also has oxygenated groups that are suitable for PET imaging using 18F radiolabeling.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Nitro-1,2,3,4-tetrahydroquinoline is an amine that is used in the synthesis of other chemicals. It is selective for transfer reactions because it can transfer to sulfate. The reaction selectivity is determined by the module and the reaction solution. The efficiency of the carbenium ion can be increased by adjusting the pH to make it more acidic. 5-Nitro-1,2,3,4-tetrahydroquinoline has a high yield and can be synthesized with a high degree of purity by using ammonium sulfate as a transfer agent in a neutral solution.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Dichloro-2-nitrophenol is a chemical that is used as an immunomodulator, pesticide, or herbicide. It is activated by the body to form a reactive intermediate that can bind to DNA and create mutations. 5-Dichloro-2-nitrophenol has been shown to cause oxidative damage in cell cultures and other tissues, such as proximal tubules of the kidney. It also produces malondialdehyde oxidation products which are known to be cytotoxic. In addition, preincubation with 5-Dichloro-2-nitrophenol increases the sensitivity of cells to other oxidative stressors such as peroxides and hydrogen peroxide.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-N-Benzyl-4-chlorobenzene-1,2-diamine is a chemical compound that is used as an anticancer drug. It is a potent inhibitor of protein kinase C and has been shown to induce cell cycle arrest in the G1 phase of the cell cycle. 1-N-Benzyl-4-chlorobenzene-1,2-diamine also induces apoptosis in cancer cells. The cytometric analysis of apoptotic processes was used to determine the pharmacokinetic properties of 1-N-Benzyl-4-chlorobenzene-1,2-diamine. This drug may be mediated by annexin A5 or other proteins. Radionuclide imaging studies were conducted in order to assess the pharmacokinetics of 1NBDBCD in humans.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 4-sulfanylbutanoate is a leukotriene D4, which is an inflammatory mediator. It can be activated by the addition of hydrogen peroxide or tetrahydropyran and then becomes a potent leukotriene antagonist. Methyl 4-sulfanylbutanoate also inhibits the activity of acyltransferases, which are enzymes that catalyze reactions in the synthesis of arachidonic acid. This compound has been shown to have inhibitory effects on inflammatory bowel disease and may be useful for treating cerebral inflammation.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromocyclooctan-1-one is a chiral, fluorinated ketone that has been used as a reagent in conformational studies. It is also the precursor to other compounds of interest. 2-Bromocyclooctan-1-one reacts with thioacetamide to form an intermediate that can be hydrolyzed by water or acid to produce 2,4,6-trichlorobenzene sulphonyl chloride. In acetonitrile, it displays repulsion between the two bromine atoms. The conformation of this compound is dependent on solvent and conformational studies have been done using solvents such as acetonitrile and chloroform.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 3-acetyl-4-oxopentanoate is a synthetic porphyrin precursor. It is an isomer of hematoporphyrin, which has been shown to be an effective photosensitizer for the treatment of psoriasis. Methyl 3-acetyl-4-oxopentanoate has also been shown to have degradative properties, and can be used to synthesize pyrrole compounds. This synthetic porphyrin precursor can also be used in the production of other porphyrins such as protoporphyrins and porphyrins.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 2-phenylethanecarboximidate hydrochloride is a dorzolamide hydrochloride prodrug that has been shown to have biological activity. It binds to the 2-adrenergic receptor and stimulates a conformational change in the receptor, leading to increased intracellular cyclic AMP levels. Methyl 2-phenylethanecarboximidate hydrochloride has been shown to inhibit the production of ICOTINIB HCl, an inhibitor of cell factor and cox-2. This drug also has been shown to have cardiac effects, including increasing heart rate and reducing the time interval between heartbeats. Methyl 2-phenylethanecarboximidate hydrochloride may be used as an optical sensor for measuring pH or as an electrochemical impedance spectroscopy agent for determining benzalkonium chloride concentrations.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>8-Oxabicyclo[3.2.1]octan-2-one (8OBA) is a β-unsaturated ketone with an oxime group at the 8 position. It can be prepared by cyclization of 2,5-diketones with a phosphonate ester in the presence of a base. The syntheses of various ketones have been accomplished using this process, including β-unsaturated ketones and oxophosphonates. This compound is also used as a building block for synthesis of furan derivatives, such as 2,5-furandione and 3,6-dihydro-4H-pyran.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Phenylcyclopent-2-en-1-one is a cyclic ketone that can be used in the preparation of 2-phenylcyclopentanones by deoxygenation. The compound can also be converted to cyclopentenones by treatment with alcohols, olefins, or esters. It is also useful for the synthesis of the vinyl ethers and cycloadditions. The reduction of this molecule produces cyclohexanol. Treatment with methanol produces 1,4-benzodiazepine derivatives. Finally, it can be used for annulation reactions as well.</p>

<p>1-Chloro-4-(isocyanomethyl)benzene is a heterocyclic compound that belongs to the morpholine family. It is activated by electron withdrawing groups such as nitro, chloro, and cyano groups. The functionalities of this molecule are amines, nitro, and chloro. 1-Chloro-4-(isocyanomethyl)benzene has been shown to be an inhibitor of pyrrole synthesis in biochemical studies. In addition, it has been shown to be a competitive inhibitor of xanthate oxidation in cyclic biochemical reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-3-iodoprop-1-ene is a synthetic chemical that is used as a reagent in organic synthesis. It has been shown to react with alkyl halides, acyl halides, and anilines to produce β-chloro ketones, α,β-unsaturated esters, and chloroamidines respectively. The reaction with chloride ions produces 2-chloroethyl chloroacetate. This compound can also be used to cross-couple aromatic rings using palladium catalysts. 2-Chloro-3-iodopropane is a precursor to polyphosphoric acid (PPA), which is used in the production of fertilizers.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Butyl-2-cyanoacetamide is a chemical compound that is used to express nature and functionalized. The chemical formula for N-Butyl-2-cyanoacetamide is CH3CONHC(CN)COOCH3. It has a melting point of -80 degrees Celsius, a boiling point of 150 degrees Celsius, and a density of 1.08 grams per cubic centimeter.</p>

<p>2-Cyano-N-methyl-N-phenylacetamide is a diazo compound that is used as a ligand for the β-lactams. It can be prepared by reacting methylcyanamide with phenylacetic acid in the presence of nitrous acid. 2-Cyano-N-methyl-N-phenylacetamide reacts with carbonyl groups to form an oxime, which can be hydrolyzed to produce an amine. This reaction occurs intramolecularly and catalysed by copper or silver salts. The houben–hoesch reaction of 2,4,6,8 tetramethylpiperidine with 2-cyano N -methyl N -phenyl acetamide yields the piperidine derivative 1-(2 cyanoethyl)-2-(2 methoxyethoxy)ethylamine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1H-Pyrrole-2,5-dicarbaldehyde is a molecule that has been shown to have antibacterial properties. It binds to the amine nitrogen of the protein and forms an imine intermediate. This intermediate will react with other molecules to form a condensation product. The condensation product is then hydrolyzed by water or ammonium hydroxide to release 1H-pyrrole-2,5-dicarbaldehyde.<br>1H-Pyrrole-2,5-dicarbaldehyde has been shown to be effective against bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa in bioassays. X-ray diffraction data supports the idea that this molecule has an intramolecular hydrogen bond between the carbonyl group and the nitrogen atom. This reactive molecule also has mononuclear nitrogen atoms that can bind to anions such as chloride ions and nitrate ions, which are</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,3-Diethyl 5-hydroxybenzene-1,3-dicarboxylate is a ligand that binds to transition metal ions and has been shown to have a constant fluorescence emission. The ligand can be used as a fluorescent probe for the study of hydrogen bonding and transport properties in solids. 1,3-Diethyl 5-hydroxybenzene-1,3-dicarboxylate has also been shown to have functional theory applications and is soluble in chlorides.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Hydroxy-3-methoxybenzohydrazide is a magnetic material that has linear, assembled, and magnetization properties. It is a ligand that binds to metal ions and forms a stable complex. The magnetic property of this compound was determined by measuring its susceptibility to an external magnetic field. The magnitude of this susceptibility depends on the orientation of the molecule in the external magnetic field and can be used to identify the type of molecular interactions occurring between the compound and the metal ion.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>