Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Diethylamino)-2,2-dimethyl-propan-1-ol is a psychoactive substance that belongs to the group of phenethylamines. It is structurally related to the precursor molecule 2,5-dihydroxyphenethylamine (or dopamine). 3-(Diethylamino)-2,2-dimethyl-propan-1-ol has been shown to inhibit cytochrome P450 2C19 and metabolize into glucuronidated metabolites through CYP3A4 and other isoforms. This metabolite is excreted in human urine as a result of its metabolism by uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl N-(3-methylphenyl)carbamate is a methylating agent that can be used to modify the epigenome. It is an inhibitor of histone lysine demethylases, which are enzymes that remove methyl groups from the amino acid lysine on histones. Methyl N-(3-methylphenyl)carbamate can also inhibit DNA replication and actin filament formation. This drug has been shown to have a clastogenic effect in mammalian cells and is also an inhibitor of effector proteins.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Ethyl-6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one is a chemical compound containing an iodide group and a nitrogen atom. Iodides can be formed by the iodocyclization of ethyl acetoacetate with ethyl iodide. The resulting 5-ethyl-6-methylpyrimidinecarboxylic acid can be converted to the desired product by treatment with potassium hydroxide in ethanol.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(Mercaptomethyl)benzoic acid is a thiosemicarbazide derivative that has been used as a photosensitizer in photodynamic therapy. This compound has the ability to bind to selenide ions, which are electron acceptors, and is converted to its reactive form by light. 4-(Mercaptomethyl)benzoic acid may be used for the treatment of cancers that have been resistant to other treatments. The compound also shows potential for use in diagnosing or treating other conditions such as carboxylate ligand transfer reactions and cadmium toxicity. The diameter of this drug is around 2 nm.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>3-Methylnaphthalene-2-carboxylic acid is a dicarboxylic acid that can be found in the environment. It has been isolated from Australian soil samples and is produced by some bacterial strains. 3-Methylnaphthalene-2-carboxylic acid has antimicrobial activity, which may be due to its ability to inhibit microbial growth by inhibiting protein synthesis.</p>

<p>1-(Aminomethyl)naphthalene hydrochloride (1-AMN) is an organocatalytic oxidant that is used to oxidize quaternary ammonium salts and quinazolinones. 1-AMN is a white crystalline solid that can be stored at room temperature. It has been shown to have the ability to react with anisidine, amines, and alcohols to produce aniline, nitrosobenzene, and hydroxylamine, respectively. This product also has a functional group which is capable of reacting with chlorides or diazonium ions. The use of this product in biochemistry has been shown in the immobilization of biomolecules such as DNA and RNA.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Quinolin-2-yl)propanoic acid is a quinoline derivative that is used to treat inflammatory diseases. It is thought to have an anti-inflammatory effect by inhibiting the production of the fatty acid arachidonic acid, which is then converted into prostaglandins and leukotrienes. 3-(Quinolin-2-yl)propanoic acid inhibits cellular signaling by binding to specific protein receptors. This drug binds to the fatty acids in cell membranes, which leads to the inhibition of cellular growth factor signal transduction and signal detection. Research has shown that 3-(quinolin-2-yl)propanoic acid has a toxic effect on humans, as well as other animals, including rats and mice. The animal studies showed that this drug inhibited the growth of cancer cells in human colon tumors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>NSC 185058 is a potential cancer therapy that inhibits protein synthesis in the cell. It prevents cells from growing and dividing by inhibiting their ability to synthesize proteins. NSC 185058 also induces apoptotic cell death, which is programmed cell death that occurs as a result of genetic or environmental stress. When cells undergo apoptosis, they are able to destroy themselves without releasing harmful substances into the surrounding area. NSC 185058 has been shown to induce autophagy and autophagy-related proteins in animal models. Autophagy is a process by which cells break down dysfunctional components to recycle nutrients and energy for future use. NSC 185058 has also been shown to inhibit tumor growth in mice with malignant brain tumors when used in combination with other therapies such as radiation and chemotherapy.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,4-Dibromo-2,5-dimethylthiophene is a diphosphinoethane that has been used as a catalyst for the thermal and photochemical activation of methyl groups. It has been shown to have a high reactivity with hexane and form fluorescent polymer films. 3,4-Dibromo-2,5-dimethylthiophene is structurally similar to other diphosphinoethanes that are used in phosphine devices and polymer films. The crystal structure of 3,4-dibromo-2,5-dimethylthiophene has been determined using X-ray crystallography. In this study it was found that the molecule can exist in two different structural isomers.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Ethylthiazol-2-amine is a chemical that yields, on hydrolysis, a mixture of 5-ethylthiazole and 2-aminoethanol. It can be prepared by the reaction of ethyl mercaptan with carbon tetrachloride in the presence of potassium hydroxide. The spectral data for this compound are given in Table 1. The reaction time for this synthesis is about 25 minutes and it is operational at temperatures from 0 to 100°C. This compound reacts with tetracycline, an antibiotic, to yield a yellow solid. It also reacts with solvents such as acetonitrile and amines to give a white precipitate.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Phenyl N-(1,3-thiazol-2-yl)carbamate is a crystal structure stabilizer. It is an oriented, two-dimensional molecule that contains two phenyl rings (-C6H5) connected to each other by a single bond and one thiazole ring (-N=C=S). The orientation of the molecule in space is stabilized by a dihedral angle of 60° between the two phenyl rings. This orientation causes the phenyl rings to point in opposite directions and prevents them from rotating around their axis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>tert-Butyl 2-methyl-3-oxobutanoate is a metabolite of tert-butyl acetate, which is an organic compound that has been used for the production of synthetic rubber and other chemicals. The biosynthesis of tert-butyl 2-methyl-3-oxobutanoate is dependent on the availability of a ketoaldehyde precursor. When tert-butyl acetate is incubated with aspergillus niger, the desired product can be obtained in high yield. Tertiary butyl 2 methyl 3 oxobutanoate can also be synthesized by deuteration of tertiary butyl alcohol with deuterium gas. The product can then be purified using gas chromatography/mass spectroscopy (GC/MS) and identified using nuclear magnetic resonance (NMR) analysis.</p>

<p>Ethyl ±-Bromo-²-phenylpropionate is a thiomorpholine that is used in organic reactions. It has been found to be an effective catalyst for the epoxidation of alkenes, as well as for the acylation of alcohols and amines.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(2-Bromoacetyl)-1H-isochromen-1-one is a heterocyclic compound that can be prepared using the following preparative method.</p>

<p>Versatile small molecule scaffold</p>

<p>1,4,5,6,7,7a-Hexahydro-inden-2-one is a cycloaddition product of two 1,4-dihydrobenzenes. It has been shown to undergo the pauson-khand reaction with diazomethane to produce a cyclopropane ring.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Ethynyl-1-benzofuran is a ligand in organic chemistry that can react with an oxidant to form terminal alkynes. It has been shown to undergo hydrofunctionalization and stereocontrol, which are two of the most commonly studied reactions in organic chemistry. This compound is also used as a precursor for benzofurans, which are important organic compounds that have been studied extensively due to their structural diversity. 2-Ethynyl-1-benzofuran is synthesized from azides and aldehydes or triazoles, which can be obtained through advances in organic chemistry.</p>

<p>Sodium propane-1-sulfinate is a carbonyl group that introduces an amyloid protein with a methyl ketone and hydroxyl group. The presence of the methyl ketone isomers can be explained by the cyclic structure, which consists of six carbons. This functional group has been shown to inhibit the activity of crth2, which is part of a heterocycle. Sodium propane-1-sulfinate also inhibits retinoic acid c1-6 alkylase, which is a functional group found in the human body. The introduction of this functional group may have an inhibitory effect on metabolism.</p>

<p>(5-Phenylfuran-2-yl)methanamine is a drug that has been shown to be effective in treating neurodegenerative diseases and cancer. It is a member of the sirtuin family, which are enzymes that regulate gene expression. The drug inhibits SIRT2 and other deacetylases, which may lead to the development of new treatment strategies for neurodegenerative diseases and cancer. (5-Phenylfuran-2-yl)methanamine has high water solubility, which allows it to penetrate through the blood brain barrier more effectively than hydrophobic drugs. This property also makes it possible to administer lower doses of the drug, thereby reducing side effects on healthy cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methyl-N-methylbenzylamine is a nitro compound that has been shown to have antimycobacterial activity. It belongs to the class of aliphatic hydrocarbons, which are functional groups consisting of a chain of carbon atoms with hydrogen atoms attached to some of the carbons. The molecular modeling found that 3-methyl-N-methylbenzylamine binds to the active site of mycobacterial enoyl reductase and inhibits its activity. This leads to a decrease in cellular energy metabolism, which can lead to cell death. 3-Methyl-N-methylbenzylamine also has an amine group, which is an organic acid that contains nitrogen and hydrogen. These molecules are important for piperazine synthesis and may be responsible for the antimycobacterial properties of 3-methyl-N-methylbenzylamine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Phenylbutanehydrazide is a nitro, carbonyl group and hydrogen bond donor. It has an interaction with the benzyl group of 4-phenylbutanoylhydrazide through hydrogen bonds. The conformation of 4-phenylbutanehydrazide is agonistic and its secondary structure is mainly determined by the carbonyl group. The carbonyl group interacts with the hydrazide nucleus through a hydrogen bond, while its acylhomoserine residue interacts with the carbonyl group through a thiocarbamate interaction. This compound may be classified as an agonist or antagonist depending on the receptor it binds to.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Cyclopentyl-N-propylamine is a functional compound that belongs to the class of organic compounds. It is used as an intermediate in the synthesis of other drugs and pharmaceuticals. This compound has been shown to have a high reactivity, which makes it useful in polymerization and polymerization initiator applications. N-Cyclopentyl-N-propylamine has been shown to be reactive with polarizers, alkylthio groups, and trifluoromethyl groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Bis(3-methoxyphenyl)methanone is a palladium catalyst that selectively activates olefins. It has been shown to be useful in the synthesis of dihydrobenzofurans and oxonium derivatives, which are used as pharmaceuticals. This compound also catalyzes the transformation of various functional groups, such as diazo, alkenes, and intramolecular aldol condensation. Bis(3-methoxyphenyl)methanone is used as a catalyst for the production of dibenzofuran compounds with high selectivity. The diastereoselectivity of this compound is due to its ability to activate substrates with electron-donating groups at positions ortho to the phenyl group.</p>

<p>Versatile small molecule scaffold</p>

<p>3,3-Dimethyl-1-(methylsulfanyl)butan-2-one is an enolate that is used as a pesticide. It is typically applied to the soil or sprayed on plants. It can be modified to increase its insecticidal activity by adding other chemicals such as carbaryl, acetonitrile, or hydroxymethylphenyl. 3,3-Dimethyl-1-(methylsulfanyl)butan-2-one is metabolized by hydrolysis and methylcarbamates are formed. The sulfide group in the molecule reacts with oxygen to form sulfoxides and carbofuran, which are toxic to mammals and birds.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>4-Ethylamino-1-butanol is an alkanolamine that interacts with receptors in the body. It has a hydroxyl group and is a molecule that contains functionalities. It interacts with other molecules, such as corticotropin-releasing hormone (CRH). 4-Ethylamino-1-butanol binds to CRH and prevents it from binding to its receptor, which decreases the release of corticotropin. This compound has been used as a positron emission tomography (PET) radiotracer for imaging the insulin receptor in living tissue. The chemical can be systematically introduced into tissues and organs, including the brain, where it accumulates due to its hydrophilic nature. 4-Ethylamino-1-butanol also has oxygenated groups that are suitable for PET imaging using 18F radiolabeling.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Nitro-1,2,3,4-tetrahydroquinoline is an amine that is used in the synthesis of other chemicals. It is selective for transfer reactions because it can transfer to sulfate. The reaction selectivity is determined by the module and the reaction solution. The efficiency of the carbenium ion can be increased by adjusting the pH to make it more acidic. 5-Nitro-1,2,3,4-tetrahydroquinoline has a high yield and can be synthesized with a high degree of purity by using ammonium sulfate as a transfer agent in a neutral solution.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Dichloro-2-nitrophenol is a chemical that is used as an immunomodulator, pesticide, or herbicide. It is activated by the body to form a reactive intermediate that can bind to DNA and create mutations. 5-Dichloro-2-nitrophenol has been shown to cause oxidative damage in cell cultures and other tissues, such as proximal tubules of the kidney. It also produces malondialdehyde oxidation products which are known to be cytotoxic. In addition, preincubation with 5-Dichloro-2-nitrophenol increases the sensitivity of cells to other oxidative stressors such as peroxides and hydrogen peroxide.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-N-Benzyl-4-chlorobenzene-1,2-diamine is a chemical compound that is used as an anticancer drug. It is a potent inhibitor of protein kinase C and has been shown to induce cell cycle arrest in the G1 phase of the cell cycle. 1-N-Benzyl-4-chlorobenzene-1,2-diamine also induces apoptosis in cancer cells. The cytometric analysis of apoptotic processes was used to determine the pharmacokinetic properties of 1-N-Benzyl-4-chlorobenzene-1,2-diamine. This drug may be mediated by annexin A5 or other proteins. Radionuclide imaging studies were conducted in order to assess the pharmacokinetics of 1NBDBCD in humans.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 4-sulfanylbutanoate is a leukotriene D4, which is an inflammatory mediator. It can be activated by the addition of hydrogen peroxide or tetrahydropyran and then becomes a potent leukotriene antagonist. Methyl 4-sulfanylbutanoate also inhibits the activity of acyltransferases, which are enzymes that catalyze reactions in the synthesis of arachidonic acid. This compound has been shown to have inhibitory effects on inflammatory bowel disease and may be useful for treating cerebral inflammation.</p>

Versatile small molecule scaffold

<p>2-Bromocyclooctan-1-one is a chiral, fluorinated ketone that has been used as a reagent in conformational studies. It is also the precursor to other compounds of interest. 2-Bromocyclooctan-1-one reacts with thioacetamide to form an intermediate that can be hydrolyzed by water or acid to produce 2,4,6-trichlorobenzene sulphonyl chloride. In acetonitrile, it displays repulsion between the two bromine atoms. The conformation of this compound is dependent on solvent and conformational studies have been done using solvents such as acetonitrile and chloroform.</p>