Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-1-(1-pyrrolidinyl)-1-ethanone (2BP) is an acetylcholine analog that inhibits the cck-a, or acetylcholine receptor. It is a prodrug that is converted by thiourea into the active 2BP analog. 2BP has been shown to inhibit the binding of both nicotinic and muscarinic acetylcholine receptors in rat brain tissue. The affinity of this drug for the human cck-a receptor was found to be approximately 10 times less than for rat cck-a receptor. This indicates that 2BP may not be effective in humans because it does not bind well to the human receptor.</p>

<p>2-Amino-3-(4-hydroxyphenyl)propanoic acid is a proteinogenic amino acid that is essential for humans and other animals. It can be synthesized by the human body in sufficient quantities from the amino acid phenylalanine, so it is not considered an essential dietary component. This amino acid can also be found in dairy products, eggs, soybeans, and peanuts. 2-Amino-3-(4-hydroxyphenyl)propanoic acid (2S)-2-(Carbamoylamino)-3-(4-hydroxyphenyl)propanoic acid) has been shown to reduce insulin resistance in diabetic rats. In addition, it has been shown to increase the uptake of glucose into muscle cells. 2S)-2-(Carbamoylamino)-3-(4-hydroxyphenyl)propanoic acid is formed as a result of carbamylation of lys</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Aminonaphthalen-2-ol is a synthetic reagent that is used in organic chemistry. It can be prepared from the reaction of chlorides and benzofurans, which are synthesized from an electrophilic aromatic substitution reaction with sodium hydroxide. The efficiency of this process can be enhanced by using imidazole as a solvent or as a catalyst for the reaction. 4-Aminonaphthalen-2-ol is also used in the synthesis of imidazole derivatives, such as 2-(4-aminophenyl)imidazo[1,2-a]pyridine.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Propoxyphenyl Methanol is a nonnutritive sweetener that is approximately 200 times sweeter than sucrose. It is used as an additive to sugar substitutes, tabletop sweeteners, and soft drinks. 4-Propoxyphenyl Methanol is not metabolized by the body and has no known health risks.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1H-Pyrrole-3-carbothioamide is a non-nucleoside inhibitor of HIV reverse transcriptase. It is hypothesized to work by binding to the active site of the enzyme and inhibiting the formation of covalent bonds between the enzyme and its substrate, which prevents DNA synthesis. The mechanism for inhibition has been studied using molecular dynamics simulations and kinetic studies. 1H-Pyrrole-3-carbothioamide inhibits viral replication in vitro by inhibiting the function of HIV reverse transcriptase. This compound also shows activity against other RNA viruses such as Hepatitis C virus, Influenza A virus, and West Nile Virus.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5H,6H-[1,2,4]Triazolo[4,3-c]pyrimidin-5-one is a potent antitumor agent that is structurally similar to the cytotoxic agents mcf-7 and doxorubicin. It has been synthesized by the reaction of an enaminone with diazonium salt. The synthesis of 5H,6H-[1,2,4]Triazolo[4,3-c]pyrimidin-5-one has been carried out using a number of techniques including halide exchange reactions with amines and enaminones. This compound has been shown to be active against breast cancer cells in culture and induces apoptosis by interfering with DNA replication.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Aminomethylbenzene-1,3-diol hydrochloride (4AMBD) is a carbamoylating agent that inhibits protein synthesis. It reversibly binds to the active site of the ribosome and blocks the peptidyl transferase activity, which prevents polypeptide chain elongation. 4AMBD has been shown to have a cytotoxic effect on rat cardiomyocytes and leukemia cells. The molecular modelling studies indicate that it interacts with dithioerythritol in the ribosome's active site. The binding of 4AMBD to the ribosomal protein S6 kinase 1 inhibits cellular proliferation and induces apoptosis in cancer cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(4-Chlorophenyl)-2-methyl-5-(trifluoromethyl)-2,3-dihydro-1H-pyrazol-3-imine is a planar molecule with an amino substituent on the benzene ring. It has a five membered ring with one methyl group and one trifluoromethyl group. The geometry of this molecule is linear and it has four substituents that are oriented in the same direction. This molecule is substituted by an amino group that has a substituent of 4 chloro phenyls.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-[[4-[2-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-1-(formylhydroxyamino)ethyl]phenyl]methyl]methanesulfonamide is a synthetic, nonsteroidal drug product. It is metabolized by CYP3A4 and CYP2D6 to the active form. The N-[[4-[2-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-1-(formylhydroxyamino)ethyl]phenyl]methyl]methanesulfonamide drug product has an analytical impurity of 4-[3-[(E)-[(E)-N′,N′′′-(dimethylamino)methylidene]-5′-(2′,5′-dioxoimidazolidinium)]bis[(Z)-formylhydrazono]]benz</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>