Building Blocks

<p>Versatile small molecule scaffold</p>

<p>1-(4-(Dimethylamino)phenyl)propan-1-one is a planar molecule with a molecular formula of C9H11NO. It has been synthesized in Australia from pyrazine and ammonium acetate. The molecule has the potential for rearrangement to form an ionic intermediate, which is similar in structure to the starting material. The mechanism of this reaction involves a transfer of hydrogen atoms from the hydroxyl group on the pyrazine to the amine group on the 1-(4-(dimethylamino)phenyl)propan-1-one. This process also results in quaternary carbon atoms that are coplanar with one another.</p>

<p>5-Chloro-1-tetralone is an oxime that is used as a topical agent for the treatment of staphylococcal infections. It acts by inhibiting bacterial cell wall synthesis, preventing the formation of cross-links between the peptidoglycan chains. 5-Chloro-1-tetralone has potent antibacterial activity against many bacteria and fungi. This compound has shown to be effective against escherichia coli, pneumoniae, and imidazole derivatives. The mechanism of action is not well understood, but it may involve inhibition of protein synthesis or DNA replication by binding to enzymes involved in these processes.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Bromo-furan-2-carbonyl chloride is a colorless liquid that is soluble in organic solvents. It has a thionyl, polymerized odor and can be used as a feedstock for the production of amines, cyclopentadienyl, and chloride. 5-Bromo-furan-2-carbonyl chloride also has radiation damage properties and can be used in radiochemical synthesis of pyrrole. This chemical has been used to produce glycosides by reacting with diluents such as methanol and ethanol.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>1-(1-Adamantyl)ethanol is an organic solution with a viscosity of 1.06 cP at 20 °C. It has a hydrochloric acid (HCl) content of less than 0.001%. The chemical compound has been shown to be therapeutically effective in autoimmune diseases, such as multiple sclerosis, lupus erythematosus, and rheumatoid arthritis. 1-(1-Adamantyl)ethanol has been shown to inhibit the production of proinflammatory cytokines and chemokines that are associated with these diseases. This compound also inhibits the activation of T cells and B cells, which are immune cells that play important roles in these inflammatory processes. 1-(1-Adamantyl)ethanol can be taken orally in a pharmaceutical dosage form or intravenously as an infusion therapy.</p>

<p>2-Hydroxy-3-methoxybenzamide is an organic molecule that binds to a series of receptors in the central nervous system. It is thought to be an agonist for the D2 receptor, which mediates inhibition of dopamine release from neurons. 2-Hydroxy-3-methoxybenzamide has been synthesized and shown to have high affinity for the D2 receptor, as well as other receptors in the brain. This drug has been shown to have beneficial effects on hyperactivity in rats and could be used for the treatment of Parkinson's disease or schizophrenia.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Bromopentan-2-ol is an additive that is used in lubricating preparations, as well as a solvent in spectroscopy. It has been shown to have antimicrobial properties against fungi and bacteria. 1-Bromopentan-2-ol's antimicrobial effects are due to its ability to inhibit the growth of bacteria by binding to amine groups on proteins and preventing the formation of new cell walls. 1-Bromopentan-2-ol also has the ability to react with formaldehyde, generating formaldehyde gas which inhibits microbial growth.</p>

<p>1-Bromohexan-2-ol is a chiral alcohol that has been used to study the mechanisms of dehydration and stabilization. The molecule is also an epitaxial reagent. It has been shown that 1-bromohexan-2-ol dehydrates in acidic conditions to produce 1,2-dibromohexane. Furthermore, it can be used as an optical resolution agent for chiral molecules and can be used during the synthesis of ionic liquids. 1-Bromohexan-2-ol is a chiral molecule with a high degree of stereospecificity, which can be used in catalysis and bilayered supramolecular assembly.</p>

<p>1-Bromohexan-2-one is a bifunctional monomer that can be used in the synthesis of polystyrene. It has two functional groups, a carboxylic acid and an alcohol. The carboxyl group of the 1-bromohexan-2-one is activated by a strong base such as pyridine to form an ester or an amide. The alcohol group can be converted into a carbonyl group with a strong oxidizing agent such as benzoic acid, which is then reacted with ammonia to form an amine. 1-Bromohexan-2-one is also used in the synthesis of fluorescent compounds. It reacts with various heterocycles to produce fluorescence when irradiated with light at wavelengths of 350 nm or 380 nm.</p>

<p>1-Bromooctan-2-one (BOA) is a lipolytic enzyme inhibitor that blocks the activity of phosphatidylcholine lipase and monoacylglycerol lipase. It also inhibits transport properties and has been shown to inhibit histidine decarboxylase, which converts histidine into histamine. The nitrogen atoms in BOA are substituted with fluorine and can be converted to enantiopure derivatives by chemoenzymatic reactions. These derivatives have been shown to be more potent inhibitors of phosphatidylcholine lipase than BOA itself.</p>

<p>N-Ethyl-m-toluamide is a chemical enhancer that is used to increase the effectiveness of insecticides and other chemicals. It is used in animal urine samples to test for the presence of drugs, such as amphetamines, cocaine, and cannabinoids. N-Ethyl-m-toluamide is also used in wastewater treatment plants to eliminate bacteria and enhance the removal of organic matter. In addition, it has been shown to be active against human liver cells. The second order rate constant was found to be 6.8 x 10^6 M^(-1) s^(-1) at 25 degrees Celsius.<br>N-Ethyl-m-toluamide can cause skin reactions in people who are exposed to it on a daily basis over an extended period of time. This chemical may also have carcinogenic effects on cells, which may be due to its ability to induce DNA mutations in vitro and promote tumor growth in vivo.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Nitro-2-(piperidine-1-yl)pyridine is a product that is formed by the nucleophilic addition of nitric acid to 1,3-diketones. It has been used in the synthesis of phenyl and isoxazole derivatives. The reaction was rationalized using amines as nucleophiles, which attack the electrophilic carbon atom in the ketone. This product has also been shown to be an effective nucleophile for attacking other molecules, such as azides and nitrates. In the Australian outback, 5-Nitro-2-(piperidine-1-yl)pyridine can be found in soils and plants.</p>

<p>Versatile small molecule scaffold</p>

1,1-Dimethylpiperidin-1-ium-4-one iodide is a high yield and efficient transaminating agent that has been used in the synthesis of acrylates. It reacts with dimethylamine to produce acrylate, which can be used to synthesize polymers. This compound is also used as a catalyst in the production of polyethylene terephthalate (PET).

<p>Versatile small molecule scaffold</p>

<p>1-(2-Sulfanylphenyl)ethan-1-one is an activating compound that has been shown to inhibit the growth of cancer cells. It has a strong inhibitory effect on malonic acid and epidermal growth factor, which are factors that stimulate cell proliferation. 1-(2-Sulfanylphenyl)ethan-1-one also inhibits the growth of tumor cells by inhibiting the synthesis of tissue extract and anticancer activity. The compound has been shown to have an inhibitory effect on skin cells and epidermal growth, as well as reducing fatty acids in tissues and sodium sulfide in blood plasma.</p>

<p>Octanoic acid, 8-bromo-, methyl ester is a histone deacetylase (HDAC) inhibitor that belongs to the class of fatty esters. It has been shown to inhibit cancer cell proliferation and induce cell apoptosis in MDA-MB-231 cells by inhibiting HDAC activity. This drug also has inhibitory activities against cyclin D1 and Bcl-2 expression, which are two proteins that regulate the cell cycle. Octanoic acid, 8-bromo-, methyl ester inhibits HDAC activity by forming an amide bond with the catalytic subunit of the enzyme. This inhibition can be reversed by an aziridine in vitro. Octanoic acid, 8-bromo-, methyl ester also possesses a carbonyl group and functional groups that make it a powerful inhibitor of HDACs.</p>

<p>Versatile small molecule scaffold</p>

2,6-Dichloropyrimidine-4-carbonyl chloride is a chemical compound that is used as an intermediate in the synthesis of different drugs. It is also used as an intermediate for the synthesis of 2,6-dichloropyrimidines. This compound is a colorless liquid with a strong odor of chloroform.

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

1-(4-Hydroxyphenyl)imidazolidine-2,4-dione is a liquid at room temperature and pressure. It has a high yield of up to 99% and can be used in the production of styrene. The reaction time for this compound is about one hour. 1-(4-Hydroxyphenyl)imidazolidine-2,4-dione catalyses the conversion of styrene to divinylbenzene by reacting with water and base. This compound can also catalyse the conversion of hydantoin to dione when heated with an acid catalyst.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,5-Bis(propan-2-yl)phenol is an organic compound that has the chemical formula C8H12O. 3,5-Bis(propan-2-yl)phenol can be synthesized from benzene and eugenol by reacting them with a strong base in a high yield. The product is an aromatic ether with a phenyl group. 3,5-Bis(propan-2-yl)phenol is toxic to artemia at concentrations of 2%. It also reacts with triisopropylbenzene to form carvacrol.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

1H,2H,3H,4H-Pyrimido[4,5-b]quinoline-2,4-dione is a small molecule drug that inhibits the activity of complex enzymes. It binds to the enzyme and prevents it from performing its normal function. The compound has been shown to inhibit cancer cells in mammalian cell cultures and in animal studies. 1H,2H,3H,4H-Pyrimido[4,5-b]quinoline-2,4-dione is water soluble and can be hydrolysed by nitro groups. It has been shown to bind to aromatic hydrocarbons such as benzene and phenol. 1H,2H,3H,4H-Pyrimido[4,5-b]quinoline-2,4-dione has not yet been tested for toxicity or carcinogenicity in humans.

Versatile small molecule scaffold

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>1-(Benzyloxy)-1H-1,2,3-triazole is a benzyl substituted heterocyclic compound that can be prepared by oxidative cyclization of the corresponding triazole. It has been used as an intermediate in organic chemistry and as a reagent in silicon chemistry. The benzyl group can be reduced to a phenol group with hydrochloric acid or hydrogenolysis. 1-(Benzyloxy)-1H-1,2,3-triazole can also undergo lithiation or electrophilic substitution reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Benzyl-5-chloro-2,3-dihydro-1H-indole-2,3-dione is a crystalline compound that belongs to the indole family of compounds. The 1H and 13C NMR spectra of this compound show two conformations: one with the dihedral angle alpha of -60º and the other with alpha = +60º. The crystal structure was determined by X ray diffraction and shows that this compound has an asymmetric unit. It is a planar molecule with a dihedral angle alpha = -60º that stacks on top of another molecule in the same class with an alpha angle of +60º. This stacking arrangement creates hydrogen bonds between adjacent molecules in the crystal lattice.</p>

<p>Versatile small molecule scaffold</p>

6-Methyl-5H,6H-isoindolo[2,1-a]quinazolin-5-one is a tricyclic molecule that has the maleimide group attached to the isoindole ring. The maleimide group can react with nucleophiles in a variety of ways. 6-Methyl-5H,6H-isoindolo[2,1-a]quinazolin-5-one has been used as a reagent to produce adducts and reaction products. These adducts and reaction products have been analyzed by x-ray diffraction and molecular modeling techniques.

<p>N-(2,2-Dimethoxyethyl)aniline is a monoamine that is used as an ingredient in a number of drugs. It has shown to be a potent inhibitor of the dopamine transporter (DAT), but also inhibits serotonin and norepinephrine uptake. N-(2,2-Dimethoxyethyl)aniline has been shown to have anticancer effects by inhibiting the growth of tumor cells in culture, while not affecting the normal cells. This compound can bind to cancer cells and inhibit their growth by interfering with cellular functions such as replication and protein synthesis.</p>

<p>4-(Acetyloxy)butanoic acid is a vasoconstrictor that has been shown to be effective in the treatment of autoimmune diseases, cancer, and other types of disorders. This compound has been shown to modulate the immune system by increasing the number of T-cells and natural killer cells. 4-(Acetyloxy)butanoic acid also provides a targetable strategy for the treatment of cancer by implanting radioactive isotopes or chemotherapeutic drugs in proximity to tumor cells. The drug can also be administered through iontophoresis or hyperthermia, which have been shown to increase its effectiveness.</p>

<p>2-Bromoethanesulfonic acid is a chemical inhibitor that inhibits the growth of methanogens by inhibiting methane production. It has been shown to be effective against resistant mutants that have evolved in wastewater treatment systems. 2-Bromoethanesulfonic acid has been used as a model system for studying methanogenesis and the development of methanogenic bacteria in vitro. In these studies, 2-bromoethanesulfonic acid inhibited methane production, but did not inhibit bacterial growth or the polymerase chain reaction (PCR). This drug was also found to be an effective wastewater treatment agent when used at concentrations of 10 mg/L, with a reduction in methane production of up to 50%.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>