Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride is a piperazine derivative that has been shown to have pharmacokinetic properties such as selectivity. It is a molecule with profiles of potency. Octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride has been shown to inhibit the activity of the enzyme phosphodiesterase type 3 (PDE3). The inhibition of PDE3 leads to an increase in intracellular cAMP levels and the activation of protein kinase A (PKA), which are important for smooth muscle relaxation and vasodilation. Octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride also has affinity for other enzymes such as cyclooxygenase-2 (COX-2) and nitric oxide synthase (NOS).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Phosphonic acid, (2-amino-2,3-dihydro-1H-inden-2-yl)- is a type of organic compound that has been shown to have an inhibitory effect on the growth of bacteria. The linear regression analysis showed that phosphonic acid had a greater inhibitory effect on the growth rate of chlorogenic acids than cinnamic acid derivatives. Phosphonic acid also inhibits the growth of bacteria by binding to endogenous enzymes and inactivating them. It binds to methyl transferase and prevents it from transferring a methyl group onto 5′ carbon atoms in methionine, which is an essential step for protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-(3,4-Dimethoxyphenyl)prop-2-enoyl chloride is a lactone that can be used for coupling reactions. It is a triester of quinic acid and 3,4-dimethoxybenzene propionic acid. 3-(3,4-Dimethoxyphenyl)prop-2-enoyl chloride is prepared by the reaction of 3,4-dimethoxyphenol with chloroacetic acid and sodium ethoxide in ethanol. This product has been shown to inhibit the growth of bacteria by inhibiting protein synthesis and cell division.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Bromo-1-propyl-1H-pyrazole is a pyrazole derivative. It is synthesized from the reaction of 4-bromobenzaldehyde and propyl hydrazine, followed by reduction with sodium borohydride. This compound has been shown to be effective against E. coli in an express test. The mechanism of action for this compound is not yet known.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(2S)-2-(2-Chlorophenyl)oxirane is an aromatic hydrocarbon that is used to make organic chemicals. It is a racemate and can be used as an enantioselective epoxide hydrolase substrate, which has been shown to have microbial activity. The enzyme catalyzes the formation of an epoxide from (2S)-2-(2-chlorophenyl)oxirane. This reaction can be performed with high enantioselectivity and in low yields for the synthesis of chiral epoxides.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(S)-(+)-Methyl indoline-2-carboxylate is a synthetic, isosteric molecule that inhibits transcription. It has been shown to be an active inhibitor of the transcriptional factor, flavopiridol, and also inhibits microbial cell growth. This compound has been optimized for use as a substrate in microbial assays where it inhibits the growth of Escherichia coli and Salmonella enterica. The structure of this molecule is similar to that of peptidomimetic compounds and may function by mimicking the binding site of transcription factors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Hydroxy-1-(methylsulphonyl)piperidine is a novel linker molecule that has been designed to be orally bioavailable. It is hydrophobic and has been optimized for interaction with protein-coupled receptors. This linker molecule has shown excellent plasma glucose lowering effects in animal studies, which may be due to its ability to reduce insulin resistance and increase insulin sensitivity. The conformational and conformationally dependent interactions of this compound with the receptor are expected to improve oral bioavailability. 4-Hydroxy-1-(methylsulphonyl)piperidine also inhibits the activity of protein kinase C (PKC), although it does not inhibit phosphodiesterase or adenylate cyclase activities.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Bromo-1-methyl-1H-imidazole-5-carbaldehyde (4BMICA) is a prodrug that has been shown to inhibit the growth of cancer cells by binding to the active site residues of the protein guanine nucleotide exchange factor (GEF) mcf-7. It is an analog of etoposide, which can act as a competitive inhibitor for the GEF. 4BMICA binds to and inhibits the activity of epidermal growth factor receptor (EGFR). This drug has been shown to have anti-inflammatory properties, as it inhibits lipid peroxidation and protein tyrosine nitration in rat liver microsomes.</p>

<p>Versatile small molecule scaffold</p>

<p>1,5-Diamino-1H-imidazole-4-carbonitrile is an amino compound that belongs to the group of primary amines. It is a colorless solid with a strong ammonia odor. 1,5-Diamino-1H-imidazole-4-carbonitrile has a cyano group and two amino groups.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methyl-1-phenyl-1H-pyrazole-3-carboxylic acid is a polyfunctional pyrazole with the general structure of a carboxylic acid. It is hydrolyzed in an alkaline environment to form a peroxide and hydrogen peroxide. This compound can be used as a reagent for the preparation of esters. 4-Methyl-1-phenyl-1H-pyrazole-3-carboxylic acid has been shown to be an effective catalyst for the synthesis of polyfunctional esters, such as ethylene carbonate.</p>

<p>Versatile small molecule scaffold</p>