Building Blocks

<p>Versatile small molecule scaffold</p>

<p>2-(2,3-Dihydro-1H-indol-3-yl)ethan-1-ol is a crystalline compound that can be prepared by the addition of hydrogen chloride to 2-(2,3-dihydroindol-3-yl)ethanol. It is an enantiomer of 1-(2,3-dihydroindol-3-yl)ethanone. The compound has been used as a reagent in analytical chemistry and as a substrate for oxidases and other enzymes.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Diethyl (methylsulfonylmethyl)phosphonate is a synthetic compound that has been shown to inhibit the mineralocorticoid receptor. This receptor is involved in the regulation of electrolyte and fluid balance. The inhibition of this receptor by diethyl (methylsulfonylmethyl)phosphonate may be due to its ability to bind to the receptor's active site and prevent it from binding with other hormones, such as aldosterone. Diethyl (methylsulfonylmethyl)phosphonate also has antiviral and anti-cancer properties. It can inhibit the proteolytic activity of a virus, such as hepatitis, or protease enzymes found in cancer cells. Diethyl (methylsulfonylmethyl)phosphonate can also act as an allergen for some people and cause skin irritation.</p>

<p>2,2-Dimethyl-1,3-dioxan-5-amine is an organic molecule that utilizes electron affinity to synthesize with a variety of orientations. The hydrophobic and intramolecular orientations are the most common. The 2,2-dimethyl-1,3-dioxan-5-amine molecule has been shown to be capable of utilizing the hydrogen atom in water as an electron acceptor and donor. It can also form a monolayer on a gold electrode surface. This molecule is hydrophilic and therefore prefers hydrophilic environments such as the electrode surface or water. Impurities in this compound may include fluoride ion or chloride ion.</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-[(4-Cyanophenyl)formamido]acetic acid is a secondary metabolite that is found in plants. It has been isolated from the leaves of the plant, Aerva lanata. 2-[(4-Cyanophenyl)formamido]acetic acid has been used as an analytical standard and as a reference material for quality control testing in the pharmaceutical industry. This compound is also being studied for its bioactive properties, including anti-inflammatory and antimicrobial activities.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Oxo-2H-chromene-6-sulfonamide is a coumarin derivative that has been shown to have pro-apoptotic properties. It induces apoptosis, or programmed cell death, in hepg2 cells by inhibiting the synthesis of proteins that are necessary for the growth and survival of cancer cells. 2-Oxo-2H-chromene-6-sulfonamide also inhibits the function of annexin and mcf7, two proteins involved in apoptosis. This drug has been shown to be effective against breast cancer cells in vitro. In addition, 2-Oxo-2H-chromene-6-sulfonamide has been found to inhibit the growth of human ovarian cancer cells in vivo. The toxicity studies on this drug have not yet been conducted on humans; therefore, it is not approved for use as a therapeutic agent.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Phenyl-1,2,4-oxadiazole-5-carbohydrazide (POD) is a heterocycle that has analgesic properties. It is an analgesic agent that belongs to the group of arylidene hydrazides. POD binds to the opioid receptors in the brain, which causes pain relief. POD is structurally related to dipyrone and has similar pharmacological profile. The drug was shown to be effective in reducing constrictions in guinea pigs and rats.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(5-Bromo-2-methylphenyl)ethanone is an aldehyde that is used in the treatment of cancer. It has been shown to have cytotoxic effects on tumour cells by inhibiting the process of mitosis, which is required for cell division. 1-(5-Bromo-2-methylphenyl)ethanone binds to kinesin and prevents it from binding to microtubules, which are necessary for mitosis. 1-(5-Bromo-2-methylphenyl)ethanone also inhibits the production of ATP, which is needed for cellular energy. 1-(5-Bromo-2-methylphenyl)ethanone has not been shown to be mutagenic or carcinogenic.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methanesulfinylbenzoic acid is an active site molecule that catalyzes the demethylation of alkylamines, amides, and cyclic sulfur compounds. The enzyme has been shown to have monooxygenase activity and can be biotransformed by various reactions including n-oxide formation, hydroxylation, sulfoxidation, and deamination. 3-Methanesulfinylbenzoic acid is a bacterial enzyme that has been crystallized in the x-ray crystal structures of both oxidized and reduced forms. The enzyme functions as a homodimer with a molecular weight of approximately 67 kDa.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Ethynylbenzamide is a synthetic compound that serves as an antibiotic. It is biosynthesized from the amino acid phenylalanine and the polyacetylene 4-hydroxyphenylacetone. The antibiotic activity of 4-Ethynylbenzamide has been demonstrated against gram-negative pathogens. The antibiotic inhibits bacterial growth by binding to the ribosomal protein S12, preventing its association with the 30S subunit of the ribosome and blocking protein synthesis. 4-Ethynylbenzamide also inhibits cell wall synthesis in gram-positive bacteria by binding to penicillin binding proteins, inhibiting transpeptidation and cell wall biosynthesis.</p>

<p>Indolizine-1-carboxylic acid (IDCA) is an antimicrobial agent that inhibits bacterial growth by interfering with the synthesis of proteins. IDCA is a fluorescent compound that can be detected using fluorescence spectroscopy. This drug has been shown to have potent cytotoxic effects against cancer cells, as well as antibacterial activity against Staphylococcus aureus and other bacteria.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-(Benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-one is a synthetic tetralone that has been shown to have both estrogenic and antiestrogenic properties. It is an efficient substrate for phosphatases such as protein tyrosine phosphatase (PTP) and can be used in the study of these enzymes. 5-(Benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-one is also a natural product that can be found in plants and animals. The compound's synthesis begins with the reaction of 5 hydroxybenzaldehyde with 1,2,3,4 tetrahydronaphthalene in dioxane under refluxing conditions. This process produces two products: the desired 5-(benzyloxy)-1,2,3,4-tetrahydronaphthalen-1-one and 1-(ben</p>

<p>Versatile small molecule scaffold</p>

<p>7-Chloro-benzo[b]thiophene is a nicotinic acetylcholine receptor antagonist that binds to the receptor and blocks its activation. 7-Chloro-benzo[b]thiophene has been shown to be effective in treating Alzheimer's disease in humans, as well as ameliorating the symptoms of schizophrenia in animals. It has also been shown to bind to acetylcholine receptors with high affinity. This drug is an amide derivative of mercaptoacetic acid and an acetylcholine molecule. 7-Chloro-benzo[b]thiophene binds to the receptor at the site where acetylcholine would normally bind, and blocks its activation by preventing the binding of acetylcholine molecules.</p>

<p>2-Bromo-3-nitrobenzyl alcohol is a lysergic acid derivative that undergoes an intramolecular cyclisation to form a triamide. This reaction can be catalysed by phosphoric acid, chloroform, or mercaptoacetic acid. The hydroxyl group and nitro group are both nucleophilic, making this reaction very useful in organic synthesis. 2-Bromo-3-nitrobenzyl alcohol has been used to synthesise dihydroindoles with high yield.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,5-Naphthyridine-3-carboxylic acid is a member of the group of alkylthio antibiotics. It is mainly used as an antibacterial to treat bacterial infections in the respiratory tract and urinary tract. It has been shown to be effective against gram-positive organisms such as Staphylococcus aureus and Streptococcus pneumoniae. However, it is not active against gram-negative bacteria such as Escherichia coli or Pseudomonas aeruginosa. 1,5-Naphthyridine-3-carboxylic acid can be detected in urine with a high sensitivity, which makes it useful for diagnosis. This compound has been shown to have a benzodiazepine structure with some structural differences. The addition of dimethylformamide to this compound enhances its activity against certain Gram positive organisms such as staphylococci and streptococci.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Formyl-6-methoxy-3-nitrophenoxyacetic acid is a photolabile formylated nitrophenol that is used to study the formation of concentration gradients across cell membranes. 4-Formyl-6-methoxy-3-nitrophenoxyacetic acid has been found to react with proton gradients and formyl groups in the membrane, which produces formaldehyde. The reaction mechanism for this process is not well understood, but it has been proposed that the reaction proceeds through a transducing step in which an electron from the formyl group reacts with a proton gradient to produce a formate ion. This mechanism is supported by experiments that show that the rate of photochemical reactions increases as the pH gradient across the membrane decreases.</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Tert-Butyl 3-hydroxybutanoate is a fatty acid that is found in the mitochondrial matrix. It is an enolate anion, which can be formed by the reaction of an alcohol with an enolate ion. Tert-Butyl 3-hydroxybutanoate has also been shown to have diastereomeric properties. The natural compound tert-butyl 3-hydroxybutanoate has potential use as a respiratory control agent due to its ability to inhibit glutamate from binding to glutamate receptors in lung cells. This may lead to a decreased production of reactive oxygen species and improved respiratory function.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>7-Bromo-5-methoxy-1-benzofuran is a drug that belongs to the group of nootropics, which are drugs that have the ability to enhance cognitive and intellectual functions. This drug has been shown to have regenerative and medicament effects on nerve cells and neurological disorders such as Parkinson's disease. 7-Bromo-5-methoxy-1-benzofuran has been shown to be a nootropic agent in animal studies. It has been shown to increase the activity of nerve cells by preventing the degeneration of neurons in rats with experimentally induced spinal cord injury. 7-Bromo-5-methoxy-1-benzofuran also enhances learning abilities in mice with experimentally induced Alzheimer's disease.</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>