Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Octahydro-1H-isoindol-4-ol is a potent, cisplatin-like antagonist of tachykinin receptors. It has high affinity for the NK2 receptor and low affinity for the NK1 receptor. Octahydro-1H-isoindol-4-ol also has an antiemetic effect in rats that is not blocked by the NK1 receptor antagonist, piperidine. The dose range for octahydro-1H-isoindol-4-ol is from low doses to high doses. The drug has been shown to be potent in animal studies; it had a 50% inhibitory concentration (IC50) of 0.2 nM for the rat NK2 receptor, which is lower than cisplatin's IC50 of 2 nM. In human cells, octahydro-1H-isoindol-4-ol inhibited the binding of [3H]neurokinin A</p>

<p>The invention relates to a combination of two or more triazolopyridines, wherein the individual compounds are selected from the group consisting of 2H,3H,5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-one and pharmaceutically acceptable salts thereof. This invention also relates to a pharmaceutical composition comprising the combination of two or more triazolopyridines as well as a pharmaceutically acceptable carrier. This invention also relates to methods for treating lung inflammation by administering a therapeutically effective amount of the combination of two or more triazolopyridines. This invention also relates to methods for prophylaxis against lung inflammation by administering an effective amount of the combination of two or more triazolopyridines.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,2-Diphenylpropan-2-amine is a compound that is used in the clinical setting to treat epilepsy and other neurological disorders. It has been shown to have neuroprotective effects by decreasing the concentrations of Ca2+ in cells and may have anti-epileptic effects due to its ability to inhibit glutamate release. The molecular mechanism of action of 1,2-Diphenylpropan-2-amine has been studied using computational modeling and whole cell recordings. This drug also shows neuroprotective properties in animal models through chronic oral administration.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-[2-(2-Hydroxyethoxy)ethyl]acetamide is a molecule that is structurally similar to the chloride ion. It has been found to be bactericidal in both Gram-positive and Gram-negative bacteria at concentrations of 10 μg/mL or less, and it has been shown to inhibit the growth of cancer cells by interaction with their DNA. N-[2-(2-Hydroxyethoxy)ethyl]acetamide also has an amide group that interacts with metal ions such as copper, nickel, and cobalt, as well as ligands such as phellodendron amurense. The chemical structure of this molecule allows for absorption spectroscopy studies.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Cyano-3-[2,5-dimethyl-1-(2-methylphenyl)-1H-pyrrol-3-yl]prop-2-enoic acid is a potent and selective activator of the TRPA1 ion channel. It has been shown to inhibit both bacterial and human TRPA1 channels. 2Cyano-3-[2,5-dimethyl-1-(2-methylphenyl)-1H-pyrrol-3-yl]prop-2 -enoic acid is a high purity reagent that is available in bulk quantities.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Cyano-3-[1-(2,3-dichlorophenyl)-2,5-dimethylpyrrol-3-yl]prop-2-enoic acid is a research tool that activates or inhibits ion channels. It is a ligand for the receptor and can be used to study the effects of drugs on cells. This chemical may inhibit protein interactions by binding to peptides and proteins. 2-Cyano-3-[1-(2,3-dichlorophenyl)-2,5-dimethylpyrrol-3-yl]prop-2-enoic acid has been used as an antibody in cell biology research.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-N-[4-(morpholin-4-ylsulfonyl)phenyl]propanamide is a potent and selective activator of the nicotinic acetylcholine receptor. It is used in research for its ability to activate this receptor, which is found in the brain, spinal cord, and other tissues. The protein interactions of 2-chloro-N-[4-(morpholin-4-ylsulfonyl)phenyl]propanamide have been studied using antibodies that recognize the ligand binding sites on the receptor.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

3-Chloro-5-ethoxy-4-propoxybenzaldehyde is a natural product with a variety of bioactive properties. It is a secondary metabolite that is present in plants and has been used as an analytical reference material. 3-Chloro-5-ethoxy-4-propoxybenzaldehyde can be used to produce high purity HPLC standards for the analysis of other natural products, such as phytochemicals and primary metabolites.

<p>Benzoic acid is a carboxylic acid that is found naturally in plants and animals. It can be made synthetically or obtained from benzoic acid salt by hydrolysis. Benzoic acid has many industrial uses such as in the production of dyes, perfumes, and preservatives. It also has many medical applications such as for the treatment of acne, ringworm, and bacterial vaginosis. In addition to its antibacterial properties, it has been shown to increase the activity of certain enzymes that break down toxins in the liver and kidneys.</p>