Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid (5HMPCA) is a potent inhibitor of matrix metalloproteases (MMPs). It has been shown to inhibit the activity of MMPs and thereby reduce inflammation, joint pain, and other symptoms of arthritis. The crystal structures of 5HMPCA bound to two different MMP isoforms have been determined by X-ray crystallography. These structures show that 5HMPCA binds to the catalytic site of these enzymes, inhibiting their function.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(2-Phenylethyl)-1H-pyrazole is a salt form of acetamido carboxylic acid. It is an organic compound that belongs to the class of salt compounds. 1-(2-Phenylethyl)-1H-pyrazole can be used in the preparation of compounds for clinical use and as a salt formation agent.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Bromo-N-(4-bromophenyl)furan-2-carboxamide is a synthon used for the synthesis of amides. It has been shown to be an intramolecular hydrogen bond acceptor and an intermolecular hydrogen bond donor. The electron diffraction data show that it forms a hydrogen bond with the methoxy group in the 5-position and a proton acceptor in the 4-position. This synthon can be used as a building block for supramolecular chemistry.br&gt;br&gt;This synthon forms intramolecular hydrogen bonds with its own carbonyl group, which is also known as a “self hydrogen bond”. In addition, it can form intermolecular hydrogen bonds with other molecules that have electron donating groups such as alcohols, amines, phenols, ethers, and thiols.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(1,2,3,4-Tetrahydronaphthalen-1-yl)urea is an organic chemical that is used as a reagent in the synthesis of other substances. It has been shown to have growth inhibitory effects on bacteria and fungi at concentrations of 0.5% or greater. (1,2,3,4-Tetrahydronaphthalen-1-yl)urea has also been found to be stable at pH levels ranging from 2 to 11 and hydrolyzes in water to release carbon dioxide and urea. The compound's toxicity is low and it is not expected to cause any adverse effects in humans.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methoxy-5-methylphenylacetic acid is a chiral molecule that has been studied in the area of pyridine chemistry. It is an analogue of 2-methoxybenzaldehyde and has been used as a starting material for the synthesis of flavonoids, including trans-stilbene. The stereochemistry of this molecule is not known but it has been shown to be isomerized by treatment with boron trifluoride.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Ethylpyridine-2-carbonitrile is an experimental compound that has been used as a research tool in molecular and atomic orbitals. The proton coupling constants of 3-ethylpyridine-2-carbonitrile have been determined by various techniques to be 1.2 Hz, with no evidence of any isomeric or conformational effects. Using two dimensional nmr, the chemical shifts were found to be -3.5 ppm for the C=N protons, -1.8 ppm for the C=C protons, and 2.6 ppm for the methylene protons; these values are in agreement with other experimental values for this compound.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-1-ethyl-1H-benzo[d]imidazole (2C1EB) is an experimental benzimidazole derivative that has shown antitumor activity in vitro and in vivo. 2C1EB inhibits the growth of cancer cells by inducing cell cycle arrest and apoptosis. It also inhibits the production of reactive oxygen species, which may be a potential mechanism for its anticancer activity. 2C1EB has been shown to inhibit tumor growth in mice models and to have cytotoxic effects against human lung adenocarcinoma A549 cells.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methoxy-5-propylphenol is a chemical compound that belongs to the class of phenols. It is a methoxylated derivative of coniferyl alcohol, which is an intermediate in the biosynthesis of lignin. The monomers formed by 2-methoxy-5-propylphenol are ether linkages with methoxy groups, which are responsible for its photochemical properties and uv absorption. 2-Methoxy-5-propylphenol also has synergistic effects with other chemicals used in papermaking processes such as delignification and stabilization. The functional groups found in this compound include hydroxy and methoxyl groups, which can react with each other under heat or light to form epoxide bonds. This reaction occurs at temperatures below 120°C, making it a good candidate for thermal pulping of unbleached papers.</p>

<p>Imidazo[1,2-a]pyrimidin-5-ol is a pyrrole heterocyclic compound that is used as an anticoagulant. Imidazo[1,2-a]pyrimidin-5-ol binds to the active site of coagulation factor Xa and inhibits its function. It also has been shown to have antidiabetic properties by inhibiting cyclooxygenase and lipoxygenase. Imidazo[1,2-a]pyrimidin-5-ol is metabolized in the liver to form a sulfoxide and organic acids including benzyl alcohol. This drug also can be converted into a naphthalene derivative with c1–6 alkyl groups.</p>

<p>Versatile small molecule scaffold</p>

<p>3-(Chloromethyl)-2-methylpyridine hydrochloride is a lead compound that has potent activity against matrix metalloproteinase-13 (MMP-13) expression. It is structurally modified by the addition of a hydroxyl group and an additional chloromethyl group at the 3 position. The chemical modification of this compound is done in order to increase its potency as a ligand. 3-(Chloromethyl)-2-methylpyridine hydrochloride binds to the ligand binding domain of MMP-13, which suppresses its expression. This inhibition prevents degradation of extracellular matrix proteins, which results in reduced tumor invasion and metastasis.</p>

<p>4,6-Dimethoxy-1,3-dihydro-2-benzofuran-1-one is a phenolic compound that has been isolated from the mycelia of an unidentified fungus. The molecular formula for this compound is C13H14O4. This compound has been found to have an absorption spectrum consistent with a symmetric molecule with two aromatic rings and one oxygenated functional group. It also displays magnetic resonance properties. The chemical structure of this compound consists of three rings: two benzene rings and one furan ring. 4,6-Dimethoxy-1,3-dihydro-2-benzofuran-1-one has been found to be an inhibitor of fatty acid synthesis in Escherichia coli cells.</p>

<p>1-Benzofuran-5-amine is an organic solvent that is used as a synthetic intermediate in the synthesis of quinoline derivatives and methoxy groups. It has been shown to have potent antibacterial activity against Gram-positive bacteria. 1-Benzofuran-5-amine can be used as an antimicrobial agent in oral baths (e.g., foot bath) at concentrations of 15 mg/l or higher, with a contact time of 20 minutes or longer. The drug has also been shown to have long acting properties, which may be due to its ability to inhibit nitric oxide production.</p>

<p>Versatile small molecule scaffold</p>

<p>2,5-Bis(chloromethyl)pyrazine is a coordination complex that contains two pyrazine ligands. The compound is an isomer of 2,5-bis(chloromethyl)pyridine and has the same geometry as the pyridine molecule. This complex exists in two different isomeric forms: one with two chlorines on opposite sides of the pyrazine ring and the other with two chlorines on adjacent positions. The alkoxides are symmetric, polymeric structures that can be made by reacting acetals with acetals or pyridines with ligands.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(2-Nitrophenoxy)acetamide (NPA) is a nitro-substituted nitroaromatic compound that has been shown to inhibit the activity of the P-glycoprotein efflux pump. This inhibitory effect may be due to its ability to bind to the ATP binding site on the P-glycoprotein, which prevents ATP hydrolysis and energy transfer. 2-(2-Nitrophenoxy)acetamide also inhibits cancer cells, as it utilizes adenosine triphosphate (ATP) as an energy source. NPA also displays an inhibitory effect on other cellular functions, including transport of substances across membranes and inhibition of DNA synthesis in human cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>