Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-fluoro-1H-pyrazolo[3,4-b]pyridine is a medicament for the treatment of cardiovascular diseases and cardiovascular disorders. It is in the form of a powder that is to be taken orally. 5-fluoro-1H-pyrazolo[3,4-b]pyridine has been shown to have an effect on inhibition of platelet aggregation and vasodilation.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>(E)-2,6-Dichlorobenzaldehyde oxime is an oxime that has a high affinity for electron-rich molecules. It is a toxicant that targets toxicants with electron-donating groups such as benzene. This compound also has physicochemical properties such as solubility in water and lipids which make it suitable for mucosal administration. (E)-2,6-Dichlorobenzaldehyde oxime is used as a herbicide to control weeds in crops like soybeans and corn.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-5-methylhexane is a homologous series of compounds with an alkylating agent that can inhibit cholinesterase and cause cancer. This compound has been shown to have anti-inflammatory properties, which may be due to its ability to modulate fatty acid metabolism. 2-Bromo-5-methylhexane also has been found to be effective in the treatment of prostate cancer cells. It is believed that this compound inhibits chloride channels, which are involved in the regulation of cell volume, and sodium channels, which are involved in nerve transmission. 2-Bromo-5-methylhexane also has fluorescence properties and can be used as a stain for sternal glands.</p>

<p>2-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-4-oxo-, is an organic compound that is a derivative of naphthalene. It can be synthesized by reacting benzene with acetic anhydride in the presence of a base catalyst. This product is used as a solvent and antioxidant in plastics manufacturing.</p>

<p>2-Iodoquinoline is a quinoline derivative that has been shown to be a potent inhibitor of the uptake of amyloid protein in vitro. 2-Iodoquinoline is also able to inhibit the growth of cancer cells and induce apoptosis. The mechanism by which 2-Iodoquinoline inhibits tumor cell growth may be due to its ability to activate epidermal growth factor receptor (EGFR). This compound has also been shown to stimulate epidermal growth through the activation of EGFR and other signaling pathways, such as phosphatidylinositol 3 kinase (PI3K) and mitogen-activated protein kinase (MAPK).</p>

<p>Versatile small molecule scaffold</p>

<p>3-Methylimidazo[1,5-a]pyridine is a chemical compound that binds to the gamma-aminobutyric acid receptor. It has been used in diagnostic tests for myocardial infarction and congestive heart failure. 3-Methylimidazo[1,5-a]pyridine has been shown to inhibit the activity of lipid kinases and growth factors, which may be beneficial in the treatment of coronary heart diseases. The drug is also known to be an HIV inhibitor.</p>

<p>Versatile small molecule scaffold</p>

Cycloheptanecarbonyl chloride (CHCl) is a chemical compound that has been shown to inhibit the growth of cancer cells. It is a pyrimidine compound with a basic structure and an active agent that inhibits the CB2 receptor. CHCl also reacts with nitro groups in benzimidazole compounds, which may lead to proliferation inhibitors. The heterocycle structures in CHCl are biologically active agents, especially for the treatment of leukemia. The high resistance of this compound makes it suitable for use in cancer treatments. Cycloheptanecarbonyl chloride can be synthesized by reacting sodium carbonate with cycloheptanone and hydrochloric acid.

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

Versatile small molecule scaffold

Versatile small molecule scaffold

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5H-chromeno[2,3-b]pyridin-5-one is a truncated aromatic ketone that has been synthesized by the cyclodehydration of 5-hydroxybenzaldehyde. This compound can be used in the synthesis of analogues and it can also be used for cross coupling, hydrazine and hydroxylamine synthesis. 5H-chromeno[2,3-b]pyridin-5-one has been shown to react with amines to form substituted pyridines. The substituent on the aryl ring determines the type of substitution that will occur. This product may also be used as a palladium catalyst in cross coupling reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>7-Methoxy-2H-benzo[b][1,4]oxazin-3(4H)-one (7MB) is a hydroxamic acid that has been shown to be an effective inhibitor of β-glucosidase. 7MB leaves the glucosides intact and only affects the substrate by attacking the carbonyl group. The enzyme β-glucosidase is responsible for hydrolyzing these glycosides into glucose, which can then be absorbed by the body. 7MB has been shown to inhibit glucosidase activity in insect and bacterial cells. It also inhibits esculin, which is a drug used as a skin test for allergies, and has been shown to have antiinflammatory properties.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(2-Methyl-4,5-dihydro-1H-imidazol-1-yl)ethan-1-amine is an organic compound that has been used as a catalyst. It crystallizes in the triclinic system and exhibits high catalytic activity. The hydrothermal synthesis of 2-(2,4,5-trimethylphenyl)-N,N′,N″,N″′-[2(2,4,5-trimethylphenyl)ethenyl]-tetrahedrane (Cp*TiMe3) was achieved by using diethylenetriamine (DETA) as a starting material. This product catalyzes the cyclization of acetaldehyde to form benzaldehyde with high catalytic activity. The probe 2-(2,4,5-trimethylphenyl)-N,N′-[2(2,4,5-trimethylphenyl</p>

<p>4-(Benzyloxy)-3,5-dimethoxybenzaldehyde is a phosphonium salt that can be used in vitro assays for the determination of the activity of glyceric, hydrochloric acid, colchicine, catechol-o-methyltransferase and asymmetric synthesis. This compound has also been shown to be a ligand for the receptor protein of several viruses. 4-(Benzyloxy)-3,5-dimethoxybenzaldehyde has been shown to inhibit the growth of virus in vivo through its interaction with the receptor protein.</p>

<p>2-Amino-N,N-dimethylbenzamide is an organic compound with the chemical formula CH3CONH2. It is a white solid with a pungent odor. 2-Amino-N,N-dimethylbenzamide is used as an industrial chemical in the synthesis of selenium oxide and carbon monoxide. It also acts as a catalyst for various reactions such as the synthesis of acetaldehyde from ethanol and oxygen gas or the conversion of ammonia to nitric acid.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,5,6-Trichloro-2-pyridinol (3,5,6-TCP) is an intermediate in the production of chlorpyrifos. It is also a metabolite of chlorpyrifos and has been detected in urine samples. 3,5,6-TCP can be determined by titrimetric analysis using sodium carbonate as a reagent. 3,5,6-TCP is toxic to both humans and animals at high doses. The process optimization for the synthesis of 3,5,6-TCP was investigated in order to reduce the amount of wastewater produced during production. In this study it was found that reaction solution pH was significantly lower when anhydrous sodium carbonate was used instead of water saturated sodium carbonate. This discovery would allow for more efficient wastewater treatment because less wastewater would need to be treated per unit product.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>L-152,804 is a potent inhibitor of the dopamine receptor. It has been shown to have an inhibitory effect on wild-type mice and functional assays in vitro. L-152,804 inhibits locomotor activity in wild type mice and increases energy metabolism in adipose tissue. L-152,804 binds to the dopamine receptor by competitive inhibition and inhibits the binding of glutamate and dopamine to the receptor. This drug has also been shown to have anti-inflammatory effects in a rat model of arthritis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid is a reactive compound that has been shown to be cytotoxic and induce apoptosis in mouse melanoma cells. The setup for this study was a section of the colon from mice with inflammatory bowel disease. 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid induces apoptosis by inhibiting protein synthesis, which leads to cell death. 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid is also an antiinflammatory drug that inhibits prostaglandin synthesis by blocking cyclooxygenase and lipoxygenase pathways. It has been shown to be effective in vivo treatment for bowel disease in mice.

<p>Versatile small molecule scaffold</p>

<p>N-(2-Aminopropyl)aniline is a voltage-gated sodium channel blocker that inhibits the voltage-gated sodium channels. It has been shown to be effective in treating chronic pain, especially in animal models. N-(2-Aminopropyl)aniline is not used for the treatment of cough because it does not have any effect on the vagal nerve. The drug also shows some inhibitory activity against voltage-gated sodium channels, which are found in neurons and play an important role in pain signaling.</p>

<p>N-Aminomorpholine-4-carbothioamide is a ligand that binds to the carboxylates of chloroform. It is produced by the enzyme subtilisin from the amino acid L-alanine and the compound 2-acetylpyridine. This ligand has been found in microorganisms such as Escherichia coli, Staphylococcus aureus, and Saccharomyces cerevisiae. N-Aminomorpholine-4-carbothioamide has been shown to be an effective inhibitor of yeast growth but not bacterial growth. The molecular weight of this ligand is 226.2 g mol−1 and it is a dimer at room temperature with two molecules linked together by hydrogen bonds.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(5-Methyl-4-isoxazolyl)-1-ethanone is a natural product that has been shown to inhibit the growth of prostate cancer cells. It is a conformationally selective inhibitor of cyclooxygenase 2 (COX-2) that has shown activity in tumor models. The molecular modeling studies suggest that the compound binds to the COX-2 enzyme in a stereoselective manner, and it may be possible to alter its conformation to make it more potent. This research also suggests that 1-(5-methyl-4-isoxazolyl)-1-ethanone could serve as a lead compound for future drug development.</p>

<p>1-Ethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (ETP) is a potent inhibitor of pyrimidine biosynthesis. It has been shown to inhibit the growth of cancer cells in vitro and in vivo. ETP binds to the enzyme dihydroorotate dehydrogenase and prevents the formation of orotic acid from l-tartaric acid. This inhibition leads to an accumulation of orotic acid and l-tartaric acid in the cell which inhibits cellular respiration. ETP also inhibits other enzymes involved in DNA replication, such as ribonucleotide reductase and thymidylate synthase. This inhibition leads to decreased synthesis of DNA and RNA molecules that are necessary for cell division. ETP has also been shown to be effective against hepatitis B virus by inhibiting viral DNA synthesis and causing viral DNA degradation.</p>

Versatile small molecule scaffold